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In vitro modelling of alveolar repair at the air-liquid interface using alveolar epithelial cells derived from human induced pluripotent stem cells.

van Riet S, Ninaber DK, Mikkers HMM, Tetley TD, Jost CR, Mulder AA, Pasman T, Baptista D, Poot AA, Truckenmüller R, Mummery CL, Freund C, Rottier RJ, Hiemstra PS.

Sci Rep. 2020 Mar 26;10(1):5499. doi: 10.1038/s41598-020-62226-1.


Diesel exhaust particle and dust mite induced airway inflammation is modified by cerium dioxide nanoparticles.

Meldrum K, Robertson S, Römer I, Marczylo T, Gant TW, Smith R, Tetley TD, Leonard MO.

Environ Toxicol Pharmacol. 2020 Jan;73:103273. doi: 10.1016/j.etap.2019.103273. Epub 2019 Oct 11.


Airway and alveolar epithelial cells in culture.

Hiemstra PS, Tetley TD, Janes SM.

Eur Respir J. 2019 Nov 7;54(5). pii: 1900742. doi: 10.1183/13993003.00742-2019. Print 2019 Nov. No abstract available.


Tyrosine Kinase Inhibitor Gold Nanoconjugates for the Treatment of Non-Small Cell Lung Cancer.

Cryer AM, Chan C, Eftychidou A, Maksoudian C, Mahesh M, Tetley TD, Spivey AC, Thorley AJ.

ACS Appl Mater Interfaces. 2019 May 8;11(18):16336-16346. doi: 10.1021/acsami.9b02986. Epub 2019 Apr 25.


Molecular analysis of HIF activation as a potential biomarker for adverse reaction to metal debris (ARMD) in tissue and blood samples.

Nyga A, Hart A, Tetley TD.

J Biomed Mater Res B Appl Biomater. 2019 Jul;107(5):1352-1362. doi: 10.1002/jbm.b.34227. Epub 2018 Sep 27.


Cerium dioxide nanoparticles exacerbate house dust mite induced type II airway inflammation.

Meldrum K, Robertson SB, Römer I, Marczylo T, Dean LSN, Rogers A, Gant TW, Smith R, Tetley TD, Leonard MO.

Part Fibre Toxicol. 2018 May 23;15(1):24. doi: 10.1186/s12989-018-0261-5.


Multimetallic Microparticles Increase the Potency of Rifampicin against Intracellular Mycobacterium tuberculosis.

Ellis T, Chiappi M, García-Trenco A, Al-Ejji M, Sarkar S, Georgiou TK, Shaffer MSP, Tetley TD, Schwander S, Ryan MP, Porter AE.

ACS Nano. 2018 Jun 26;12(6):5228-5240. doi: 10.1021/acsnano.7b08264. Epub 2018 May 22.


Cytotoxicity and cellular mechanisms of toxicity of CuO NPs in mussel cells in vitro and comparative sensitivity with human cells.

Katsumiti A, Thorley AJ, Arostegui I, Reip P, Valsami-Jones E, Tetley TD, Cajaraville MP.

Toxicol In Vitro. 2018 Apr;48:146-158. doi: 10.1016/j.tiv.2018.01.013.


Genotoxicity of fine and coarse fraction ambient particulate matter in immortalised normal (TT1) and cancer-derived (A549) alveolar epithelial cells.

Jarvis IWH, Enlo-Scott Z, Nagy E, Mudway IS, Tetley TD, Arlt VM, Phillips DH.

Environ Mol Mutagen. 2018 May;59(4):290-301. doi: 10.1002/em.22166. Epub 2018 Jan 25.


Response to 'Effects of diesel exhaust particles on coagulation'.

Smyth E, Solomon A, Birrell MA, Smallwood MJ, Winyard PG, Tetley TD, Emerson M.

Br J Pharmacol. 2017 Nov;174(22):4200. doi: 10.1111/bph.14032. Epub 2017 Oct 10. No abstract available.


Mechanistic link between diesel exhaust particles and respiratory reflexes.

Robinson RK, Birrell MA, Adcock JJ, Wortley MA, Dubuis ED, Chen S, McGilvery CM, Hu S, Shaffer MSP, Bonvini SJ, Maher SA, Mudway IS, Porter AE, Carlsten C, Tetley TD, Belvisi MG.

J Allergy Clin Immunol. 2018 Mar;141(3):1074-1084.e9. doi: 10.1016/j.jaci.2017.04.038. Epub 2017 May 19.


The histone deacetylase inhibitor, romidepsin, as a potential treatment for pulmonary fibrosis.

Conforti F, Davies ER, Calderwood CJ, Thatcher TH, Jones MG, Smart DE, Mahajan S, Alzetani A, Havelock T, Maher TM, Molyneaux PL, Thorley AJ, Tetley TD, Warner JA, Packham G, Ganesan A, Skipp PJ, Marshall BJ, Richeldi L, Sime PJ, O'Reilly KMA, Davies DE.

Oncotarget. 2017 Jul 25;8(30):48737-48754. doi: 10.18632/oncotarget.17114.


Chemical and biological assessment of metal organic frameworks (MOFs) in pulmonary cells and in an acute in vivo model: relevance to pulmonary arterial hypertension therapy.

Mohamed NA, Davies RP, Lickiss PD, Ahmetaj-Shala B, Reed DM, Gashaw HH, Saleem H, Freeman GR, George PM, Wort SJ, Morales-Cano D, Barreira B, Tetley TD, Chester AH, Yacoub MH, Kirkby NS, Moreno L, Mitchell JA.

Pulm Circ. 2017 Jul-Sep;7(3):643-653. doi: 10.1177/2045893217710224. Epub 2017 Jun 27.


Influence of inflammation and nitric oxide upon platelet aggregation following deposition of diesel exhaust particles in the airways.

Smyth E, Solomon A, Birrell MA, Smallwood MJ, Winyard PG, Tetley TD, Emerson M.

Br J Pharmacol. 2017 Jul;174(13):2130-2139. doi: 10.1111/bph.13831. Epub 2017 May 27.


Inactivation, Clearance, and Functional Effects of Lung-Instilled Short and Long Silver Nanowires in Rats.

Chung KF, Seiffert J, Chen S, Theodorou IG, Goode AE, Leo BF, McGilvery CM, Hussain F, Wiegman C, Rossios C, Zhu J, Gong J, Tariq F, Yufit V, Monteith AJ, Hashimoto T, Skepper JN, Ryan MP, Zhang J, Tetley TD, Porter AE.

ACS Nano. 2017 Mar 28;11(3):2652-2664. doi: 10.1021/acsnano.6b07313. Epub 2017 Feb 24.


Effect of pulmonary surfactant on the dissolution, stability and uptake of zinc oxide nanowires by human respiratory epithelial cells.

Theodorou IG, Ruenraroengsak P, Gow A, Schwander S, Zhang JJ, Chung KF, Tetley TD, Ryan MP, Porter AE.

Nanotoxicology. 2016 Nov;10(9):1351-62. doi: 10.1080/17435390.2016.1214762. Epub 2016 Aug 11.


Pulmonary effects of inhalation of spark-generated silver nanoparticles in Brown-Norway and Sprague-Dawley rats.

Seiffert J, Buckley A, Leo B, Martin NG, Zhu J, Dai R, Hussain F, Guo C, Warren J, Hodgson A, Gong J, Ryan MP, Zhang JJ, Porter A, Tetley TD, Gow A, Smith R, Chung KF.

Respir Res. 2016 Jul 19;17(1):85. doi: 10.1186/s12931-016-0407-7.


Pulmonary surfactant mitigates silver nanoparticle toxicity in human alveolar type-I-like epithelial cells.

Sweeney S, Leo BF, Chen S, Abraham-Thomas N, Thorley AJ, Gow A, Schwander S, Zhang JJ, Shaffer MSP, Chung KF, Ryan MP, Porter AE, Tetley TD.

Colloids Surf B Biointerfaces. 2016 Sep 1;145:167-175. doi: 10.1016/j.colsurfb.2016.04.040. Epub 2016 Apr 27.


Translocation of Functionalized Multi-Walled Carbon Nanotubes across Human Pulmonary Alveolar Epithelium: Dominant Role of Epithelial Type 1 Cells.

Ruenraroengsak P, Chen S, Hu S, Melbourne J, Sweeney S, Thorley AJ, Skepper JN, Shaffer MS, Tetley TD, Porter AE.

ACS Nano. 2016 May 24;10(5):5070-85. doi: 10.1021/acsnano.5b08218. Epub 2016 Apr 21.


Safety and Tolerability of Alveolar Type II Cell Transplantation in Idiopathic Pulmonary Fibrosis.

Serrano-Mollar A, Gay-Jordi G, Guillamat-Prats R, Closa D, Hernandez-Gonzalez F, Marin P, Burgos F, Martorell J, Sánchez M, Arguis P, Soy D, Bayas JM, Ramirez J, Tetley TD, Molins L, de la Bellacasa JP, Rodríguez-Villar C, Rovira I, Fiblà JJ, Xaubet A; Pneumocyte Study Group.

Chest. 2016 Sep;150(3):533-43. doi: 10.1016/j.chest.2016.03.021. Epub 2016 Mar 25.


Modulation of Human Macrophage Responses to Mycobacterium tuberculosis by Silver Nanoparticles of Different Size and Surface Modification.

Sarkar S, Leo BF, Carranza C, Chen S, Rivas-Santiago C, Porter AE, Ryan MP, Gow A, Chung KF, Tetley TD, Zhang JJ, Georgopoulos PG, Ohman-Strickland PA, Schwander S.

PLoS One. 2015 Nov 18;10(11):e0143077. doi: 10.1371/journal.pone.0143077. eCollection 2015.


Low-dose AgNPs reduce lung mechanical function and innate immune defense in the absence of cellular toxicity.

Botelho DJ, Leo BF, Massa CB, Sarkar S, Tetley TD, Chung KF, Chen S, Ryan MP, Porter AE, Zhang J, Schwander SK, Gow AJ.

Nanotoxicology. 2016;10(1):118-27. doi: 10.3109/17435390.2015.1038330. Epub 2015 Jul 7.


Static and Dynamic Microscopy of the Chemical Stability and Aggregation State of Silver Nanowires in Components of Murine Pulmonary Surfactant.

Theodorou IG, Botelho D, Schwander S, Zhang J, Chung KF, Tetley TD, Shaffer MS, Gow A, Ryan MP, Porter AE.

Environ Sci Technol. 2015 Jul 7;49(13):8048-56. doi: 10.1021/acs.est.5b01214. Epub 2015 Jun 25.


Silver nanowire interactions with primary human alveolar type-II epithelial cell secretions: contrasting bioreactivity with human alveolar type-I and type-II epithelial cells.

Sweeney S, Theodorou IG, Zambianchi M, Chen S, Gow A, Schwander S, Zhang JJ, Chung KF, Shaffer MS, Ryan MP, Porter AE, Tetley TD.

Nanoscale. 2015 Jun 21;7(23):10398-409. doi: 10.1039/c5nr01496d.


Functional consequences for primary human alveolar macrophages following treatment with long, but not short, multiwalled carbon nanotubes.

Sweeney S, Grandolfo D, Ruenraroengsak P, Tetley TD.

Int J Nanomedicine. 2015 Apr 23;10:3115-29. doi: 10.2147/IJN.S77867. eCollection 2015.


An investigation of the carbon nanotube--Lipid interface and its impact upon pulmonary surfactant lipid function.

Melbourne J, Clancy A, Seiffert J, Skepper J, Tetley TD, Shaffer MS, Porter A.

Biomaterials. 2015 Jul;55:24-32. doi: 10.1016/j.biomaterials.2015.03.023. Epub 2015 Apr 9.


Multi-walled carbon nanotube length as a critical determinant of bioreactivity with primary human pulmonary alveolar cells.

Sweeney S, Berhanu D, Misra SK, Thorley AJ, Valsami-Jones E, Tetley TD.

Carbon N Y. 2014 Nov 1;78:26-37.


Pulmonary toxicity of instilled silver nanoparticles: influence of size, coating and rat strain.

Seiffert J, Hussain F, Wiegman C, Li F, Bey L, Baker W, Porter A, Ryan MP, Chang Y, Gow A, Zhang J, Zhu J, Tetley TD, Chung KF.

PLoS One. 2015 Mar 6;10(3):e0119726. doi: 10.1371/journal.pone.0119726. eCollection 2015.


Modeling Population Exposures to Silver Nanoparticles Present in Consumer Products.

Royce SG, Mukherjee D, Cai T, Xu SS, Alexander JA, Mi Z, Calderon L, Mainelis G, Lee K, Lioy PJ, Tetley TD, Chung KF, Zhang J, Georgopoulos PG.

J Nanopart Res. 2014 Nov;16(11). pii: 2724.


Importance of the HIF pathway in cobalt nanoparticle-induced cytotoxicity and inflammation in human macrophages.

Nyga A, Hart A, Tetley TD.

Nanotoxicology. 2015;9(7):905-17. doi: 10.3109/17435390.2014.991430. Epub 2015 Feb 13.


Avoiding artefacts during electron microscopy of silver nanomaterials exposed to biological environments.

Chen S, Goode AE, Skepper JN, Thorley AJ, Seiffert JM, Chung KF, Tetley TD, Shaffer MS, Ryan MP, Porter AE.

J Microsc. 2016 Feb;261(2):157-66. doi: 10.1111/jmi.12215. Epub 2015 Jan 21.


Modeling physicochemical interactions affecting in vitro cellular dosimetry of engineered nanomaterials: application to nanosilver.

Mukherjee D, Leo BF, Royce SG, Porter AE, Ryan MP, Schwander S, Chung KF, Tetley TD, Zhang J, Georgopoulos PG.

J Nanopart Res. 2014 Oct 1;16(10):2616.


Modeling in vitro cellular responses to silver nanoparticles.

Mukherjee D, Royce SG, Sarkar S, Thorley A, Schwander S, Ryan MP, Porter AE, Chung KF, Tetley TD, Zhang J, Georgopoulos PG.

J Toxicol. 2014;2014:852890. doi: 10.1155/2014/852890. Epub 2014 Oct 9.


Inhalation of silver nanomaterials--seeing the risks.

Theodorou IG, Ryan MP, Tetley TD, Porter AE.

Int J Mol Sci. 2014 Dec 22;15(12):23936-74. doi: 10.3390/ijms151223936. Review.


Nanoparticles modulate surfactant protein A and D mediated protection against influenza A infection in vitro.

McKenzie Z, Kendall M, Mackay RM, Tetley TD, Morgan C, Griffiths M, Clark HW, Madsen J.

Philos Trans R Soc Lond B Biol Sci. 2015 Feb 5;370(1661):20140049. doi: 10.1098/rstb.2014.0049.


Adsorption of surfactant protein D from human respiratory secretions by carbon nanotubes and polystyrene nanoparticles depends on nanomaterial surface modification and size.

Marchetti M, Shaffer MS, Zambianchi M, Chen S, Superti F, Schwander S, Gow A, Zhang JJ, Chung KF, Ryan MP, Porter AE, Tetley TD.

Philos Trans R Soc Lond B Biol Sci. 2015 Feb 5;370(1661):20140038. doi: 10.1098/rstb.2014.0038.


Abraham ("Abe") Guz: a life devoted to breathing and breathlessness.

Chung KF, Partridge M, Tetley TD.

Eur Respir J. 2014 Dec;44(6):1423-5. doi: 10.1183/09031936.00171714. No abstract available.


Critical determinants of uptake and translocation of nanoparticles by the human pulmonary alveolar epithelium.

Thorley AJ, Ruenraroengsak P, Potter TE, Tetley TD.

ACS Nano. 2014 Nov 25;8(11):11778-89. doi: 10.1021/nn505399e. Epub 2014 Nov 4.


Nano-titanium dioxide bioreactivity with human alveolar type-I-like epithelial cells: Investigating crystalline phase as a critical determinant.

Sweeney S, Berhanu D, Ruenraroengsak P, Thorley AJ, Valsami-Jones E, Tetley TD.

Nanotoxicology. 2015 May;9(4):482-92. doi: 10.3109/17435390.2014.948518. Epub 2014 Aug 19.


Induction and enhancement of platelet aggregation in vitro and in vivo by model polystyrene nanoparticles.

Smyth E, Solomon A, Vydyanath A, Luther PK, Pitchford S, Tetley TD, Emerson M.

Nanotoxicology. 2015 May;9(3):356-64. doi: 10.3109/17435390.2014.933902. Epub 2014 Jul 17.


Variability in bioreactivity linked to changes in size and zeta potential of diesel exhaust particles in human immune cells.

Sarkar S, Zhang L, Subramaniam P, Lee KB, Garfunkel E, Strickland PA, Mainelis G, Lioy PJ, Tetley TD, Chung KF, Zhang J, Ryan M, Porter A, Schwander S.

PLoS One. 2014 May 13;9(5):e97304. doi: 10.1371/journal.pone.0097304. eCollection 2014.


Aqueous cationic, anionic and non-ionic multi-walled carbon nanotubes, functionalised with minimal framework damage, for biomedical application.

Chen S, Hu S, Smith EF, Ruenraroengsak P, Thorley AJ, Menzel R, Goode AE, Ryan MP, Tetley TD, Porter AE, Shaffer MS.

Biomaterials. 2014 Jun;35(17):4729-38. doi: 10.1016/j.biomaterials.2014.02.002. Epub 2014 Mar 14.


Imaging single nanoparticle interactions with human lung cells using fast ion conductance microscopy.

Novak P, Shevchuk A, Ruenraroengsak P, Miragoli M, Thorley AJ, Klenerman D, Lab MJ, Tetley TD, Gorelik J, Korchev YE.

Nano Lett. 2014 Mar 12;14(3):1202-7. doi: 10.1021/nl404068p. Epub 2014 Feb 24.


Physicochemical and toxicological profiling of ash from the 2010 and 2011 eruptions of Eyjafjallajökull and Grímsvötn volcanoes, Iceland using a rapid respiratory hazard assessment protocol.

Horwell CJ, Baxter PJ, Hillman SE, Calkins JA, Damby DE, Delmelle P, Donaldson K, Dunster C, Fubini B, Kelly FJ, Le Blond JS, Livi KJ, Murphy F, Nattrass C, Sweeney S, Tetley TD, Thordarson T, Tomatis M.

Environ Res. 2013 Nov;127:63-73. doi: 10.1016/j.envres.2013.08.011. Epub 2013 Nov 20.


High-resolution analytical electron microscopy reveals cell culture media-induced changes to the chemistry of silver nanowires.

Chen S, Theodorou IG, Goode AE, Gow A, Schwander S, Zhang JJ, Chung KF, Tetley TD, Shaffer MS, Ryan MP, Porter AE.

Environ Sci Technol. 2013 Dec 3;47(23):13813-21. doi: 10.1021/es403264d. Epub 2013 Nov 20.


Impacts of a nanosized ceria additive on diesel engine emissions of particulate and gaseous pollutants.

Zhang J, Nazarenko Y, Zhang L, Calderon L, Lee KB, Garfunkel E, Schwander S, Tetley TD, Chung KF, Porter AE, Ryan M, Kipen H, Lioy PJ, Mainelis G.

Environ Sci Technol. 2013 Nov 19;47(22):13077-85. doi: 10.1021/es402140u. Epub 2013 Nov 7.


The stability of silver nanoparticles in a model of pulmonary surfactant.

Leo BF, Chen S, Kyo Y, Herpoldt KL, Terrill NJ, Dunlop IE, McPhail DS, Shaffer MS, Schwander S, Gow A, Zhang J, Chung KF, Tetley TD, Porter AE, Ryan MP.

Environ Sci Technol. 2013 Oct 1;47(19):11232-40. doi: 10.1021/es403377p. Epub 2013 Sep 18.


Sulfidation of silver nanowires inside human alveolar epithelial cells: a potential detoxification mechanism.

Chen S, Goode AE, Sweeney S, Theodorou IG, Thorley AJ, Ruenraroengsak P, Chang Y, Gow A, Schwander S, Skepper J, Zhang JJ, Shaffer MS, Chung KF, Tetley TD, Ryan MP, Porter AE.

Nanoscale. 2013 Oct 21;5(20):9839-47. doi: 10.1039/c3nr03205a.


New perspectives in nanomedicine.

Thorley AJ, Tetley TD.

Pharmacol Ther. 2013 Nov;140(2):176-85. doi: 10.1016/j.pharmthera.2013.06.008. Epub 2013 Jun 25. Review.


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