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Items: 1 to 50 of 85

1.

[Translational medicine and innovation in health: mechanisms and perspectives].

Valdés IP, Ramírez-Santana M, Basagoitía A, Testar X, Vásquez JA.

Rev Med Chil. 2018 Jul;146(7):890-898. doi: 10.4067/s0034-98872018000700890. Review. Spanish.

2.

Insulin-mimetic compound hexaquis (benzylammonium) decavanadate is antilipolytic in human fat cells.

Carpéné C, Garcia-Vicente S, Serrano M, Marti L, Belles C, Royo M, Galitzky J, Zorzano A, Testar X.

World J Diabetes. 2017 Apr 15;8(4):143-153. doi: 10.4239/wjd.v8.i4.143.

3.

Autophagy-regulating TP53INP2 mediates muscle wasting and is repressed in diabetes.

Sala D, Ivanova S, Plana N, Ribas V, Duran J, Bach D, Turkseven S, Laville M, Vidal H, Karczewska-Kupczewska M, Kowalska I, Straczkowski M, Testar X, Palacín M, Sandri M, Serrano AL, Zorzano A.

J Clin Invest. 2014 May;124(5):1914-27. doi: 10.1172/JCI72327. Epub 2014 Apr 8.

4.

Oral insulin-mimetic compounds that act independently of insulin.

García-Vicente S, Yraola F, Marti L, González-Muñoz E, García-Barrado MJ, Cantó C, Abella A, Bour S, Artuch R, Sierra C, Brandi N, Carpéné C, Moratinos J, Camps M, Palacín M, Testar X, Gumà A, Albericio F, Royo M, Mian A, Zorzano A.

Diabetes. 2007 Feb;56(2):486-93.

5.
6.

Short- and long-term insulin-like effects of monoamine oxidases and semicarbazide-sensitive amine oxidase substrates in cultured adipocytes.

Carpéné C, Daviaud D, Boucher J, Bour S, Visentin V, Grès S, Duffaut C, Fontana E, Testar X, Saulnier-Blache JS, Valet P.

Metabolism. 2006 Oct;55(10):1397-405.

PMID:
16979412
7.

The release of soluble VAP-1/SSAO by 3T3-L1 adipocytes is stimulated by isoproterenol and low concentrations of TNFalpha.

García-Vicente S, Abella A, Viguerie N, Ros-Baró A, Camps M, Testar X, Palacín M, Zorzano A, Marti L.

J Physiol Biochem. 2005 Jun;61(2):395-401.

PMID:
16180338
8.

Methylamine but not mafenide mimics insulin-like activity of the semicarbazide-sensitive amine oxidase-substrate benzylamine on glucose tolerance and on human adipocyte metabolism.

Iglesias-Osma MC, Bour S, Garcia-Barrado MJ, Visentin V, Pastor MF, Testar X, Marti L, Enrique-Tarancon G, Valet P, Moratinos J, Carpéné C.

Pharmacol Res. 2005 Dec;52(6):475-84. Epub 2005 Aug 30.

PMID:
16135411
9.

The Charcot-Marie-Tooth type 2A gene product, Mfn2, up-regulates fuel oxidation through expression of OXPHOS system.

Pich S, Bach D, Briones P, Liesa M, Camps M, Testar X, Palacín M, Zorzano A.

Hum Mol Genet. 2005 Jun 1;14(11):1405-15. Epub 2005 Apr 13.

PMID:
15829499
10.

Exploring the binding mode of semicarbazide-sensitive amine oxidase/VAP-1: identification of novel substrates with insulin-like activity.

Marti L, Abella A, De La Cruz X, García-Vicente S, Unzeta M, Carpéné C, Palacín M, Testar X, Orozco M, Zorzano A.

J Med Chem. 2004 Sep 23;47(20):4865-74.

PMID:
15369390
11.

Tyramine and benzylamine partially but selectively mimic insulin action on adipose differentiation in 3T3-L1 cells.

Subra C, Fontana E, Visentin V, Testar X, Carpéné C.

J Physiol Biochem. 2003 Sep;59(3):209-16.

PMID:
15000452
12.

Stimulation of glucose transport by semicarbazide-sensitive amine oxidase activity in adipocytes from diabetic rats.

Abella A, Marti L, Carpéné C, Palacín M, Testar X, Zorzano A.

J Physiol Biochem. 2003 Sep;59(3):153-60.

PMID:
15000445
13.

Semicarbazide-sensitive amine oxidase activity exerts insulin-like effects on glucose metabolism and insulin-signaling pathways in adipose cells.

Zorzano A, Abella A, Marti L, Carpéné C, Palacín M, Testar X.

Biochim Biophys Acta. 2003 Apr 11;1647(1-2):3-9. Review.

PMID:
12686100
14.

Semicarbazide-sensitive amine oxidase/vascular adhesion protein-1 activity exerts an antidiabetic action in Goto-Kakizaki rats.

Abella A, Marti L, Camps M, Claret M, Fernández-Alvarez J, Gomis R, Gumà A, Viguerie N, Carpéné C, Palacín M, Testar X, Zorzano A.

Diabetes. 2003 Apr;52(4):1004-13.

15.

Tyramine stimulates glucose uptake in insulin-sensitive tissues in vitro and in vivo via its oxidation by amine oxidases.

Morin N, Visentin V, Calise D, Marti L, Zorzano A, Testar X, Valet P, Fischer Y, Carpéné C.

J Pharmacol Exp Ther. 2002 Dec;303(3):1238-47.

PMID:
12438548
16.
17.

Amine oxidase substrates mimic several of the insulin effects on adipocyte differentiation in 3T3 F442A cells.

Fontana E, Boucher J, Marti L, Lizcano JM, Testar X, Zorzano A, Carpéné C.

Biochem J. 2001 Jun 15;356(Pt 3):769-77.

18.

Substrates of semicarbazide-sensitive amine oxidase co-operate with vanadate to stimulate tyrosine phosphorylation of insulin-receptor-substrate proteins, phosphoinositide 3-kinase activity and GLUT4 translocation in adipose cells.

Enrique-Tarancón G, Castan I, Morin N, Marti L, Abella A, Camps M, Casamitjana R, Palacín M, Testar X, Degerman E, Carpéné C, Zorzano A.

Biochem J. 2000 Aug 15;350 Pt 1:171-80.

19.

Factors involved in GLUT-1 glucose transporter gene transcription in cardiac muscle.

Santalucía T, Boheler KR, Brand NJ, Sahye U, Fandos C, Viñals F, Ferré J, Testar X, Palacín M, Zorzano A.

J Biol Chem. 1999 Jun 18;274(25):17626-34.

20.
21.

High glucose concentrations inhibit glucose phosphorylation, but not glucose transport, in human endothelial cells.

Viñals F, Gross A, Testar X, Palacín M, Rösen P, Zorzano A.

Biochim Biophys Acta. 1999 Jun 8;1450(2):119-29.

22.

Benfluorex improves muscle insulin responsiveness in middle-aged rats previously subjected to long-term high-fat feeding.

Sevilla L, Gumà A, Muñoz P, Testar X, Palacín M, Zorzano A.

Life Sci. 1999;64(1):25-36.

PMID:
10027739
23.

p70 S6 kinase activation is not required for insulin-like growth factor-induced differentiation of rat, mouse, or human skeletal muscle cells.

Canicio J, Gallardo E, Illa I, Testar X, Palacín M, Zorzano A, Kaliman P.

Endocrinology. 1998 Dec;139(12):5042-9.

PMID:
9832443
24.

The amino acid transport system y+L/4F2hc is a heteromultimeric complex.

Estévez R, Camps M, Rojas AM, Testar X, Devés R, Hediger MA, Zorzano A, Palacín M.

FASEB J. 1998 Oct;12(13):1319-29.

PMID:
9761775
25.

Tyramine and vanadate synergistically stimulate glucose transport in rat adipocytes by amine oxidase-dependent generation of hydrogen peroxide.

Marti L, Morin N, Enrique-Tarancon G, Prevot D, Lafontan M, Testar X, Zorzano A, Carpéné C.

J Pharmacol Exp Ther. 1998 Apr;285(1):342-9.

PMID:
9536030
26.

Role of semicarbazide-sensitive amine oxidase on glucose transport and GLUT4 recruitment to the cell surface in adipose cells.

Enrique-Tarancón G, Marti L, Morin N, Lizcano JM, Unzeta M, Sevilla L, Camps M, Palacín M, Testar X, Carpéné C, Zorzano A.

J Biol Chem. 1998 Apr 3;273(14):8025-32.

27.

Insulin-like growth factors require phosphatidylinositol 3-kinase to signal myogenesis: dominant negative p85 expression blocks differentiation of L6E9 muscle cells.

Kaliman P, Canicio J, Shepherd PR, Beeton CA, Testar X, Palacín M, Zorzano A.

Mol Endocrinol. 1998 Jan;12(1):66-77.

PMID:
9440811
28.

Regulation of glucose transport, and glucose transporters expression and trafficking in the heart: studies in cardiac myocytes.

Zorzano A, Sevilla L, Camps M, Becker C, Meyer J, Kammermeier H, Muñoz P, Gumà A, Testar X, Palacín M, Blasi J, Fischer Y.

Am J Cardiol. 1997 Aug 4;80(3A):65A-76A. Review.

PMID:
9293957
29.

Characterization of two distinct intracellular GLUT4 membrane populations in muscle fiber. Differential protein composition and sensitivity to insulin.

Sevilla L, Tomàs E, Muñoz P, Gumá A, Fischer Y, Thomas J, Ruiz-Montasell B, Testar X, Palacín M, Blasi J, Zorzano A.

Endocrinology. 1997 Jul;138(7):3006-15.

30.

Chronic high-fat feeding and middle-aging reduce in an additive fashion Glut4 expression in skeletal muscle and adipose tissue.

Sevilla L, Gumà A, Enrique-Tarancón G, Mora S, Muñoz P, Palacín M, Testar X, Zorzano A.

Biochem Biophys Res Commun. 1997 Jun 9;235(1):89-93.

PMID:
9196041
31.

Effect of cations on the tyrosine kinase activity of the insulin receptor: inhibition by fluoride is magnesium dependent.

Viñals F, Camps M, Testar X, Palacín M, Zorzano A.

Mol Cell Biochem. 1997 Jun;171(1-2):69-73.

PMID:
9201698
32.
33.

Myogenesis and MyoD down-regulate Sp1. A mechanism for the repression of GLUT1 during muscle cell differentiation.

Viñals F, Fandos C, Santalucia T, Ferré J, Testar X, Palacín M, Zorzano A.

J Biol Chem. 1997 May 16;272(20):12913-21.

34.

An intracellular trafficking defect in type I cystinuria rBAT mutants M467T and M467K.

Chillarón J, Estévez R, Samarzija I, Waldegger S, Testar X, Lang F, Zorzano A, Busch A, Palacín M.

J Biol Chem. 1997 Apr 4;272(14):9543-9.

35.

Insulin-induced recruitment of glucose transporter 4 (GLUT4) and GLUT1 in isolated rat cardiac myocytes. Evidence of the existence of different intracellular GLUT4 vesicle populations.

Fischer Y, Thomas J, Sevilla L, Muñoz P, Becker C, Holman G, Kozka IJ, Palacín M, Testar X, Kammermeier H, Zorzano A.

J Biol Chem. 1997 Mar 14;272(11):7085-92.

36.

Localization, by linkage analysis, of the cystinuria type III gene to chromosome 19q13.1.

Bisceglia L, Calonge MJ, Totaro A, Feliubadaló L, Melchionda S, García J, Testar X, Gallucci M, Ponzone A, Zelante L, Zorzano A, Estivill X, Gasparini P, Nunes V, Palacín M.

Am J Hum Genet. 1997 Mar;60(3):611-6.

37.

Evidence for posttranscriptional regulation of GLUT4 expression in muscle and adipose tissue from streptozotocin-induced diabetic and benfluorex-treated rats.

Muñoz P, Chillarón J, Camps M, Castelló A, Furriols M, Testar X, Palacín M, Zorzano A.

Biochem Pharmacol. 1996 Dec 13;52(11):1665-73.

PMID:
8986128
38.

Genomic structure and organization of the human rBAT gene (SLC3A1).

Purroy J, Bisceglia L, Calonge MJ, Zelante L, Testar X, Zorzano A, Estivill X, Palacín M, Nunes V, Gasparini P.

Genomics. 1996 Oct 15;37(2):249-52.

PMID:
8921402
39.

Molecular analysis of the cystinuria disease gene: identification of four new mutations, one large deletion, and one polymorphism.

Bisceglia L, Calonge MJ, Dello Strologo L, Rizzoni G, de Sanctis L, Gallucci M, Beccia E, Testar X, Zorzano A, Estivill X, Zelante L, Palacin M, Gasparini P, Nunes V.

Hum Genet. 1996 Oct;98(4):447-51.

PMID:
8792820
40.

Phosphatidylinositol 3-kinase inhibitors block differentiation of skeletal muscle cells.

Kaliman P, Viñals F, Testar X, Palacín M, Zorzano A.

J Biol Chem. 1996 Aug 9;271(32):19146-51.

41.

Obligatory amino acid exchange via systems bo,+-like and y+L-like. A tertiary active transport mechanism for renal reabsorption of cystine and dibasic amino acids.

Chillarón J, Estévez R, Mora C, Wagner CA, Suessbrich H, Lang F, Gelpí JL, Testar X, Busch AE, Zorzano A, Palacín M.

J Biol Chem. 1996 Jul 26;271(30):17761-70.

42.

The molecular basis of cystinuria: the role of the rBAT gene.

Palacín M, Mora C, Chillarón J, Calonge MJ, Estévez R, Torrents D, Testar X, Zorzano A, Nunes V, Purroy J, Estivill X, Gasparini P, Bisceglia L, Zelante L.

Amino Acids. 1996 Jun;11(2):225-46. doi: 10.1007/BF00813862.

PMID:
24178689
43.

The rBAT gene is responsible for L-cystine uptake via the b0,(+)-like amino acid transport system in a "renal proximal tubular" cell line (OK cells).

Mora C, Chillarón J, Calonge MJ, Forgo J, Testar X, Nunes V, Murer H, Zorzano A, Palacín M.

J Biol Chem. 1996 May 3;271(18):10569-76.

44.

Expression and insulin-regulated distribution of caveolin in skeletal muscle. Caveolin does not colocalize with GLUT4 in intracellular membranes.

Muñoz P, Mora S, Sevilla L, Kaliman P, Tomàs E, Gumà A, Testar X, Palacín M, Zorzano A.

J Biol Chem. 1996 Apr 5;271(14):8133-9.

45.

Insulin-induced redistribution of GLUT4 glucose carriers in the muscle fiber. In search of GLUT4 trafficking pathways.

Zorzano A, Muñoz P, Camps M, Mora C, Testar X, Palacín M.

Diabetes. 1996 Jan;45 Suppl 1:S70-81. Review.

46.
47.

The T-tubule is a cell-surface target for insulin-regulated recycling of membrane proteins in skeletal muscle.

Muñoz P, Rosemblatt M, Testar X, Palacín M, Thoidis G, Pilch PF, Zorzano A.

Biochem J. 1995 Dec 1;312 ( Pt 2):393-400.

48.

Genetic heterogeneity in cystinuria: the SLC3A1 gene is linked to type I but not to type III cystinuria.

Calonge MJ, Volpini V, Bisceglia L, Rousaud F, de Sanctis L, Beccia E, Zelante L, Testar X, Zorzano A, Estivill X, et al.

Proc Natl Acad Sci U S A. 1995 Oct 10;92(21):9667-71.

49.

Insulin and insulin-like growth factor I (IGF-I) stimulate GLUT4 glucose transporter translocation in Xenopus oocytes.

Mora S, Kaliman P, Chillarón J, Testar X, Palacín M, Zorzano A.

Biochem J. 1995 Oct 1;311 ( Pt 1):59-65.

50.

Molecular genetics of cystinuria: identification of four new mutations and seven polymorphisms, and evidence for genetic heterogeneity.

Gasparini P, Calonge MJ, Bisceglia L, Purroy J, Dianzani I, Notarangelo A, Rousaud F, Gallucci M, Testar X, Ponzone A, et al.

Am J Hum Genet. 1995 Oct;57(4):781-8.

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