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Expression of Concern: Inhibition of TPO-induced MEK or mTOR activity induces opposite effects on the ploidy of human differentiating megakaryocytes (doi:10.1242/jcs.02784).

Guerriero R, Parolini I, Testa U, Samoggia P, Petrucci E, Sargiacomo M, Chelucci C, Gabbianelli M, Peschle C.

J Cell Sci. 2019 May 31;132(11). pii: jcs233684. doi: 10.1242/jcs.233684. No abstract available.


Correction: Inhibition of TPO-induced MEK or mTOR activity induces opposite effects on the ploidy of human differentiating megakaryocytes (doi:10.1242/jcs.02784).

Guerriero R, Parolini I, Testa U, Samoggia P, Petrucci E, Sargiacomo M, Chelucci C, Gabbianelli M, Peschle C.

J Cell Sci. 2019 May 31;132(11). pii: jcs233676. doi: 10.1242/jcs.233676. No abstract available.


Emerging Therapies for Acute Myelogenus Leukemia Patients Targeting Apoptosis and Mitochondrial Metabolism.

Castelli G, Pelosi E, Testa U.

Cancers (Basel). 2019 Feb 22;11(2). pii: E260. doi: 10.3390/cancers11020260. Review.


The small-molecule compound AC-73 targeting CD147 inhibits leukemic cell proliferation, induces autophagy and increases the chemotherapeutic sensitivity of acute myeloid leukemia cells.

Spinello I, Saulle E, Quaranta MT, Pasquini L, Pelosi E, Castelli G, Ottone T, Voso MT, Testa U, Labbaye C.

Haematologica. 2019 May;104(5):973-985. doi: 10.3324/haematol.2018.199661. Epub 2018 Nov 22.


Genetic Abnormalities, Clonal Evolution, and Cancer Stem Cells of Brain Tumors.

Testa U, Castelli G, Pelosi E.

Med Sci (Basel). 2018 Oct 2;6(4). pii: E85. doi: 10.3390/medsci6040085. Review.


Lung Cancers: Molecular Characterization, Clonal Heterogeneity and Evolution, and Cancer Stem Cells.

Testa U, Castelli G, Pelosi E.

Cancers (Basel). 2018 Jul 27;10(8). pii: E248. doi: 10.3390/cancers10080248. Review.


miR-146 and miR-155: Two Key Modulators of Immune Response and Tumor Development.

Testa U, Pelosi E, Castelli G, Labbaye C.

Noncoding RNA. 2017 Jun 26;3(3). pii: E22. doi: 10.3390/ncrna3030022. Review.


Colorectal cancer: genetic abnormalities, tumor progression, tumor heterogeneity, clonal evolution and tumor-initiating cells.

Testa U, Pelosi E, Castelli G.

Med Sci (Basel). 2018 Apr 13;6(2). pii: E31. doi: 10.3390/medsci6020031. Review.


Pulmonary vascular endothelium: the orchestra conductor in respiratory diseases: Highlights from basic research to therapy.

Huertas A, Guignabert C, Barberà JA, Bärtsch P, Bhattacharya J, Bhattacharya S, Bonsignore MR, Dewachter L, Dinh-Xuan AT, Dorfmüller P, Gladwin MT, Humbert M, Kotsimbos T, Vassilakopoulos T, Sanchez O, Savale L, Testa U, Wilkins MR.

Eur Respir J. 2018 Apr 4;51(4). pii: 1700745. doi: 10.1183/13993003.00745-2017. Print 2018 Apr. Review.


Ovarian Cancers: Genetic Abnormalities, Tumor Heterogeneity and Progression, Clonal Evolution and Cancer Stem Cells.

Testa U, Petrucci E, Pasquini L, Castelli G, Pelosi E.

Medicines (Basel). 2018 Feb 1;5(1). pii: E16. doi: 10.3390/medicines5010016. Review.


Targeting histone methyltransferase and demethylase in acute myeloid leukemia therapy.

Castelli G, Pelosi E, Testa U.

Onco Targets Ther. 2017 Dec 28;11:131-155. doi: 10.2147/OTT.S145971. eCollection 2018. Review.


Melanoma: Genetic Abnormalities, Tumor Progression, Clonal Evolution and Tumor Initiating Cells.

Testa U, Castelli G, Pelosi E.

Med Sci (Basel). 2017 Nov 20;5(4). pii: E28. doi: 10.3390/medsci5040028. Review.


Pancreatic Cancer: Molecular Characterization, Clonal Evolution and Cancer Stem Cells.

Pelosi E, Castelli G, Testa U.

Biomedicines. 2017 Nov 18;5(4). pii: E65. doi: 10.3390/biomedicines5040065. Review.


The forkhead box C1 (FOXC1) transcription factor is downregulated in acute promyelocytic leukemia.

Fabiani E, Falconi G, Noguera NI, Saulle E, Cicconi L, Divona M, Banella C, Picardi A, Cerio AM, Boe L, Sanchez M, Pelosi E, Testa U, Lo-Coco F, Voso MT.

Oncotarget. 2017 Sep 20;8(48):84074-84085. doi: 10.18632/oncotarget.21101. eCollection 2017 Oct 13.


Mechanisms of anti-cancer effects of ascorbate: Cytotoxic activity and epigenetic modulation.

Mastrangelo D, Pelosi E, Castelli G, Lo-Coco F, Testa U.

Blood Cells Mol Dis. 2018 Mar;69:57-64. doi: 10.1016/j.bcmd.2017.09.005. Epub 2017 Sep 21. Review.


Esophageal Cancer: Genomic and Molecular Characterization, Stem Cell Compartment and Clonal Evolution.

Testa U, Castelli G, Pelosi E.

Medicines (Basel). 2017 Sep 14;4(3). pii: E67. doi: 10.3390/medicines4030067. Review.


Liver Cancer: Molecular Characterization, Clonal Evolution and Cancer Stem Cells.

Castelli G, Pelosi E, Testa U.

Cancers (Basel). 2017 Sep 20;9(9). pii: E127. doi: 10.3390/cancers9090127. Review.


High-dose ascorbate and arsenic trioxide selectively kill acute myeloid leukemia and acute promyelocytic leukemia blasts in vitro.

Noguera NI, Pelosi E, Angelini DF, Piredda ML, Guerrera G, Piras E, Battistini L, Massai L, Berardi A, Catalano G, Cicconi L, Castelli G, D'Angiò A, Pasquini L, Graziani G, Fioritoni G, Voso MT, Mastrangelo D, Testa U, Lo-Coco F.

Oncotarget. 2017 May 16;8(20):32550-32565. doi: 10.18632/oncotarget.15925.


Targeted therapies in the treatment of adult acute myeloid leukemias: current status and future perspectives.

Castelli G, Pelosi E, Testa U.

Int J Hematol Oncol. 2016 Dec;5(4):143-164. doi: 10.2217/ijh-2016-0011. Epub 2017 Feb 7. Review.


Conditioned medium from human umbilical vein endothelial cells markedly improves the proliferation and differentiation of circulating endothelial progenitors.

Castelli G, Parolini I, Cerio AM, D'Angiò A, Pasquini L, Carollo M, Sargiacomo M, Testa U, Pelosi E.

Blood Cells Mol Dis. 2016 Oct;61:58-65. doi: 10.1016/j.bcmd.2016.07.007. Epub 2016 Aug 18.


Endothelial progenitor cells in hematologic malignancies.

Testa U, Saulle E, Castelli G, Pelosi E.

Stem Cell Investig. 2016 Jul 1;3:26. doi: 10.21037/sci.2016.06.07. eCollection 2016. Review.


Oxidative stress and hypoxia in normal and leukemic stem cells.

Testa U, Labbaye C, Castelli G, Pelosi E.

Exp Hematol. 2016 Jul;44(7):540-60. doi: 10.1016/j.exphem.2016.04.012. Epub 2016 May 12. Review.


PML-RAR alpha induces the downmodulation of HHEX: a key event responsible for the induction of an angiogenetic response.

Saulle E, Petronelli A, Pelosi E, Coppotelli E, Pasquini L, Ilari R, Lo-Coco F, Testa U.

J Hematol Oncol. 2016 Apr 7;9:33. doi: 10.1186/s13045-016-0262-5.


Prognostic factors in acute promyelocytic leukemia: strategies to define high-risk patients.

Testa U, Lo-Coco F.

Ann Hematol. 2016 Apr;95(5):673-80. doi: 10.1007/s00277-016-2622-1. Epub 2016 Feb 26. Review.


Targeting LSCs through membrane antigens selectively or preferentially expressed on these cells.

Pelosi E, Castelli G, Testa U.

Blood Cells Mol Dis. 2015 Dec;55(4):336-46. doi: 10.1016/j.bcmd.2015.07.015. Epub 2015 Jul 26. Review.


Experimental and investigational therapies for chemotherapy-induced anemia.

Testa U, Castelli G, Elvira P.

Expert Opin Investig Drugs. 2015;24(11):1433-45. doi: 10.1517/13543784.2015.1085505. Epub 2015 Sep 10. Review.


Cytotoxic effects of high concentrations of sodium ascorbate on human myeloid cell lines.

Mastrangelo D, Massai L, Lo Coco F, Noguera NI, Borgia L, Fioritoni G, Berardi A, Iacone A, Muscettola M, Pelosi E, Castelli G, Testa U, Di Pisa F, Grasso G.

Ann Hematol. 2015 Nov;94(11):1807-16. doi: 10.1007/s00277-015-2464-2. Epub 2015 Aug 12.


Differential hypoxic regulation of the microRNA-146a/CXCR4 pathway in normal and leukemic monocytic cells: impact on response to chemotherapy.

Spinello I, Quaranta MT, Paolillo R, Pelosi E, Cerio AM, Saulle E, Lo Coco F, Testa U, Labbaye C.

Haematologica. 2015 Sep;100(9):1160-71. doi: 10.3324/haematol.2014.120295. Epub 2015 Jun 4.


Human TM9SF4 Is a New Gene Down-Regulated by Hypoxia and Involved in Cell Adhesion of Leukemic Cells.

Paolillo R, Spinello I, Quaranta MT, Pasquini L, Pelosi E, Lo Coco F, Testa U, Labbaye C.

PLoS One. 2015 May 11;10(5):e0126968. doi: 10.1371/journal.pone.0126968. eCollection 2015.


Targeting of leukemia-initiating cells in acute promyelocytic leukemia.

Testa U, Lo-Coco F.

Stem Cell Investig. 2015 Apr 29;2:8. doi: 10.3978/j.issn.2306-9759.2015.04.03. eCollection 2015. Review.


miR-21 is overexpressed in NPM1-mutant acute myeloid leukemias.

Riccioni R, Lulli V, Castelli G, Biffoni M, Tiberio R, Pelosi E, Lo-Coco F, Testa U.

Leuk Res. 2015 Feb;39(2):221-8. doi: 10.1016/j.leukres.2014.11.001. Epub 2014 Nov 18.


A miRNA Signature in Human Cord Blood Stem and Progenitor Cells as Potential Biomarker of Specific Acute Myeloid Leukemia Subtypes.

Cattaneo M, Pelosi E, Castelli G, Cerio AM, D'Angiò A, Porretti L, Rebulla P, Pavesi L, Russo G, Giordano A, Turri J, Cicconi L, Lo-Coco F, Testa U, Biunno I.

J Cell Physiol. 2015 Aug;230(8):1770-80. doi: 10.1002/jcp.24876.


Human cord blood-derived hemogenic endothelium generates mast cells.

Castelli G, D'Angiò A, Grassi G, Costa V, Pasquini L, Tiberio R, Cerio AM, Testa U, Tripodi M, Pelosi E.

Blood Cells Mol Dis. 2015 Feb;54(2):195-7. doi: 10.1016/j.bcmd.2014.11.002. Epub 2014 Nov 15. No abstract available.


SCF-mediated γ-globin gene expression in adult human erythroid cells is associated with KLF1, BCL11A and SOX6 down-regulation.

Lulli V, Romania P, Morsilli O, Ilari R, Gabbianelli M, Testa U, Marziali G.

Blood Cells Mol Dis. 2015 Jan;54(1):1-3. doi: 10.1016/j.bcmd.2014.10.004. Epub 2014 Nov 3. No abstract available.


MicroRNAs expressed in hematopoietic stem/progenitor cells are deregulated in acute myeloid leukemias.

Testa U, Pelosi E.

Leuk Lymphoma. 2015 May;56(5):1466-74. doi: 10.3109/10428194.2014.955019. Epub 2015 Jan 21. Review.


Salinomycin potentiates the cytotoxic effects of TRAIL on glioblastoma cell lines.

Calzolari A, Saulle E, De Angelis ML, Pasquini L, Boe A, Pelacchi F, Ricci-Vitiani L, Baiocchi M, Testa U.

PLoS One. 2014 Apr 16;9(4):e94438. doi: 10.1371/journal.pone.0094438. eCollection 2014.


CD 123 is a membrane biomarker and a therapeutic target in hematologic malignancies.

Testa U, Pelosi E, Frankel A.

Biomark Res. 2014 Feb 10;2(1):4. doi: 10.1186/2050-7771-2-4.


Endothelial progenitors.

Pelosi E, Castelli G, Testa U.

Blood Cells Mol Dis. 2014 Apr;52(4):186-94. doi: 10.1016/j.bcmd.2013.11.004. Epub 2013 Dec 9. Review.


Transcriptional fine-tuning of microRNA-223 levels directs lineage choice of human hematopoietic progenitors.

Vian L, Di Carlo M, Pelosi E, Fazi F, Santoro S, Cerio AM, Boe A, Rotilio V, Billi M, Racanicchi S, Testa U, Grignani F, Nervi C.

Cell Death Differ. 2014 Feb;21(2):290-301. doi: 10.1038/cdd.2013.145. Epub 2013 Oct 18.


The Impact of FLT3 Mutations on the Development of Acute Myeloid Leukemias.

Testa U, Pelosi E.

Leuk Res Treatment. 2013;2013:275760. doi: 10.1155/2013/275760. Epub 2013 Jul 9.


MicroRNA-486-3p regulates γ-globin expression in human erythroid cells by directly modulating BCL11A.

Lulli V, Romania P, Morsilli O, Cianciulli P, Gabbianelli M, Testa U, Giuliani A, Marziali G.

PLoS One. 2013 Apr 4;8(4):e60436. doi: 10.1371/journal.pone.0060436. Print 2013.


Human haemato-endothelial precursors: cord blood CD34+ cells produce haemogenic endothelium.

Pelosi E, Castelli G, Martin-Padura I, Bordoni V, Santoro S, Conigliaro A, Cerio AM, De Santis Puzzonia M, Marighetti P, Biffoni M, Alonzi T, Amicone L, Alcalay M, Bertolini F, Testa U, Tripodi M.

PLoS One. 2012;7(12):e51109. doi: 10.1371/journal.pone.0051109. Epub 2012 Dec 4.


miRNA let-7c promotes granulocytic differentiation in acute myeloid leukemia.

Pelosi A, Careccia S, Lulli V, Romania P, Marziali G, Testa U, Lavorgna S, Lo-Coco F, Petti MC, Calabretta B, Levrero M, Piaggio G, Rizzo MG.

Oncogene. 2013 Aug 1;32(31):3648-54. doi: 10.1038/onc.2012.398. Epub 2012 Sep 10.


MicroRNA-146a and AMD3100, two ways to control CXCR4 expression in acute myeloid leukemias.

Spinello I, Quaranta MT, Riccioni R, Riti V, Pasquini L, Boe A, Pelosi E, Vitale A, Foà R, Testa U, Labbaye C.

Blood Cancer J. 2011 Jun;1(6):e26. doi: 10.1038/bcj.2011.24. Epub 2011 Jun 24.


Autocrine role of angiopoietins during megakaryocytic differentiation.

Saulle E, Guerriero R, Petronelli A, Coppotelli E, Gabbianelli M, Morsilli O, Spinello I, Pelosi E, Castelli G, Testa U, Coppola S.

PLoS One. 2012;7(7):e39796. doi: 10.1371/journal.pone.0039796. Epub 2012 Jul 6.


A small molecule SMAC mimic LBW242 potentiates TRAIL- and anticancer drug-mediated cell death of ovarian cancer cells.

Petrucci E, Pasquini L, Bernabei M, Saulle E, Biffoni M, Accarpio F, Sibio S, Di Giorgio A, Di Donato V, Casorelli A, Benedetti-Panici P, Testa U.

PLoS One. 2012;7(4):e35073. doi: 10.1371/journal.pone.0035073. Epub 2012 Apr 25.


The emerging role of MIR-146A in the control of hematopoiesis, immune function and cancer.

Labbaye C, Testa U.

J Hematol Oncol. 2012 Mar 27;5:13. doi: 10.1186/1756-8722-5-13. Review.


Human umbilical cord is a unique and safe source of various types of stem cells suitable for treatment of hematological diseases and for regenerative medicine.

Pelosi E, Castelli G, Testa U.

Blood Cells Mol Dis. 2012 Jun 15;49(1):20-8. doi: 10.1016/j.bcmd.2012.02.007. Epub 2012 Mar 23. Review.


Immunophenotypic features of acute myeloid leukaemia patients exhibiting high FLT3 expression not associated with mutations.

Riccioni R, Pelosi E, Riti V, Castelli G, Lo-Coco F, Testa U.

Br J Haematol. 2011 Apr;153(1):33-42. doi: 10.1111/j.1365-2141.2011.08577.x. Epub 2011 Feb 20.


Leukemia stem cells.

Testa U.

Ann Hematol. 2011 Mar;90(3):245-71. doi: 10.1007/s00277-010-1118-7. Epub 2010 Nov 25. Review.


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