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Items: 1 to 50 of 264

1.

A Large Panel of Isogenic APP and PSEN1 Mutant Human iPSC Neurons Reveals Shared Endosomal Abnormalities Mediated by APP β-CTFs, Not Aβ.

Kwart D, Gregg A, Scheckel C, Murphy E, Paquet D, Duffield M, Fak J, Olsen O, Darnell R, Tessier-Lavigne M.

Neuron. 2019 Aug 12. pii: S0896-6273(19)30636-1. doi: 10.1016/j.neuron.2019.07.010. [Epub ahead of print]

PMID:
31416668
2.

Transcriptomic Profiling of the Developing Cardiac Conduction System at Single-Cell Resolution.

Goodyer WR, Beyersdorf BM, Paik DT, Tian L, Li G, Buikema JW, Chirikian O, Choi S, Venkatraman S, Adams EL, Tessier-Lavigne M, Wu JC, Wu SM.

Circ Res. 2019 Aug 2;125(4):379-397. doi: 10.1161/CIRCRESAHA.118.314578. Epub 2019 Jul 9.

PMID:
31284824
3.

Neuronally Enriched RUFY3 Is Required for Caspase-Mediated Axon Degeneration.

Hertz NT, Adams EL, Weber RA, Shen RJ, O'Rourke MK, Simon DJ, Zebroski H, Olsen O, Morgan CW, Mileur TR, Hitchcock AM, Sinnott Armstrong NA, Wainberg M, Bassik MC, Molina H, Wells JA, Tessier-Lavigne M.

Neuron. 2019 Aug 7;103(3):412-422.e4. doi: 10.1016/j.neuron.2019.05.030. Epub 2019 Jun 17.

PMID:
31221560
4.

Diverse spinal commissural neuron populations revealed by fate mapping and molecular profiling using a novel Robo3Cre mouse.

Tulloch AJ, Teo S, Carvajal BV, Tessier-Lavigne M, Jaworski A.

J Comp Neurol. 2019 Dec 15;527(18):2948-2972. doi: 10.1002/cne.24720. Epub 2019 Jun 14.

PMID:
31152445
5.

Structural plasticity of actin-spectrin membrane skeleton and functional role of actin and spectrin in axon degeneration.

Wang G, Simon DJ, Wu Z, Belsky DM, Heller E, O'Rourke MK, Hertz NT, Molina H, Zhong G, Tessier-Lavigne M, Zhuang X.

Elife. 2019 May 1;8. pii: e38730. doi: 10.7554/eLife.38730.

6.

Temporal evolution of cortical ensembles promoting remote memory retrieval.

DeNardo LA, Liu CD, Allen WE, Adams EL, Friedmann D, Fu L, Guenthner CJ, Tessier-Lavigne M, Luo L.

Nat Neurosci. 2019 Mar;22(3):460-469. doi: 10.1038/s41593-018-0318-7. Epub 2019 Jan 28.

7.

Long-Range Guidance of Spinal Commissural Axons by Netrin1 and Sonic Hedgehog from Midline Floor Plate Cells.

Wu Z, Makihara S, Yam PT, Teo S, Renier N, Balekoglu N, Moreno-Bravo JA, Olsen O, Chédotal A, Charron F, Tessier-Lavigne M.

Neuron. 2019 Feb 20;101(4):635-647.e4. doi: 10.1016/j.neuron.2018.12.025. Epub 2019 Jan 17.

PMID:
30661738
8.

Spatiotemporal Control of CNS Myelination by Oligodendrocyte Programmed Cell Death through the TFEB-PUMA Axis.

Sun LO, Mulinyawe SB, Collins HY, Ibrahim A, Li Q, Simon DJ, Tessier-Lavigne M, Barres BA.

Cell. 2018 Dec 13;175(7):1811-1826.e21. doi: 10.1016/j.cell.2018.10.044. Epub 2018 Nov 29.

PMID:
30503207
9.

Evolution of Cortical Neurogenesis in Amniotes Controlled by Robo Signaling Levels.

Cárdenas A, Villalba A, de Juan Romero C, Picó E, Kyrousi C, Tzika AC, Tessier-Lavigne M, Ma L, Drukker M, Cappello S, Borrell V.

Cell. 2018 Jul 26;174(3):590-606.e21. doi: 10.1016/j.cell.2018.06.007. Epub 2018 Jun 28.

10.

Cdc42 Regulates Neuronal Polarity during Cerebellar Axon Formation and Glial-Guided Migration.

Govek EE, Wu Z, Acehan D, Molina H, Rivera K, Zhu X, Fang Y, Tessier-Lavigne M, Hatten ME.

iScience. 2018 Mar 23;1:35-48. doi: 10.1016/j.isci.2018.01.004.

11.

CRISPR-Cas9 screens in human cells and primary neurons identify modifiers of C9ORF72 dipeptide-repeat-protein toxicity.

Kramer NJ, Haney MS, Morgens DW, Jovičić A, Couthouis J, Li A, Ousey J, Ma R, Bieri G, Tsui CK, Shi Y, Hertz NT, Tessier-Lavigne M, Ichida JK, Bassik MC, Gitler AD.

Nat Genet. 2018 Apr;50(4):603-612. doi: 10.1038/s41588-018-0070-7. Epub 2018 Mar 5.

12.

Netrin-1 Confines Rhombic Lip-Derived Neurons to the CNS.

Yung AR, Druckenbrod NR, Cloutier JF, Wu Z, Tessier-Lavigne M, Goodrich LV.

Cell Rep. 2018 Feb 13;22(7):1666-1680. doi: 10.1016/j.celrep.2018.01.068.

13.

Three-Dimensional Adipose Tissue Imaging Reveals Regional Variation in Beige Fat Biogenesis and PRDM16-Dependent Sympathetic Neurite Density.

Chi J, Wu Z, Choi CHJ, Nguyen L, Tegegne S, Ackerman SE, Crane A, Marchildon F, Tessier-Lavigne M, Cohen P.

Cell Metab. 2018 Jan 9;27(1):226-236.e3. doi: 10.1016/j.cmet.2017.12.011.

14.

Identification of a Brainstem Circuit Controlling Feeding.

Nectow AR, Schneeberger M, Zhang H, Field BC, Renier N, Azevedo E, Patel B, Liang Y, Mitra S, Tessier-Lavigne M, Han MH, Friedman JM.

Cell. 2017 Jul 27;170(3):429-442.e11. doi: 10.1016/j.cell.2017.06.045.

15.

Dual leucine zipper kinase-dependent PERK activation contributes to neuronal degeneration following insult.

Larhammar M, Huntwork-Rodriguez S, Jiang Z, Solanoy H, Sengupta Ghosh A, Wang B, Kaminker JS, Huang K, Eastham-Anderson J, Siu M, Modrusan Z, Farley MM, Tessier-Lavigne M, Lewcock JW, Watkins TA.

Elife. 2017 Apr 25;6. pii: e20725. doi: 10.7554/eLife.20725.

16.

Combined small-molecule inhibition accelerates the derivation of functional cortical neurons from human pluripotent stem cells.

Qi Y, Zhang XJ, Renier N, Wu Z, Atkin T, Sun Z, Ozair MZ, Tchieu J, Zimmer B, Fattahi F, Ganat Y, Azevedo R, Zeltner N, Brivanlou AH, Karayiorgou M, Gogos J, Tomishima M, Tessier-Lavigne M, Shi SH, Studer L.

Nat Biotechnol. 2017 Feb;35(2):154-163. doi: 10.1038/nbt.3777. Epub 2017 Jan 23.

17.

Precise and efficient scarless genome editing in stem cells using CORRECT.

Kwart D, Paquet D, Teo S, Tessier-Lavigne M.

Nat Protoc. 2017 Feb;12(2):329-354. doi: 10.1038/nprot.2016.171. Epub 2017 Jan 19.

PMID:
28102837
18.

A neuronal PI(3,4,5)P3-dependent program of oligodendrocyte precursor recruitment and myelination.

Goebbels S, Wieser GL, Pieper A, Spitzer S, Weege B, Yan K, Edgar JM, Yagensky O, Wichert SP, Agarwal A, Karram K, Renier N, Tessier-Lavigne M, Rossner MJ, Káradóttir RT, Nave KA.

Nat Neurosci. 2017 Jan;20(1):10-15. doi: 10.1038/nn.4425. Epub 2016 Oct 24.

PMID:
27775720
19.

An Atypical SCF-like Ubiquitin Ligase Complex Promotes Wallerian Degeneration through Regulation of Axonal Nmnat2.

Yamagishi Y, Tessier-Lavigne M.

Cell Rep. 2016 Oct 11;17(3):774-782. doi: 10.1016/j.celrep.2016.09.043.

20.

Three-Dimensional Study of Alzheimer's Disease Hallmarks Using the iDISCO Clearing Method.

Liebmann T, Renier N, Bettayeb K, Greengard P, Tessier-Lavigne M, Flajolet M.

Cell Rep. 2016 Jul 26;16(4):1138-1152. doi: 10.1016/j.celrep.2016.06.060. Epub 2016 Jul 14.

21.

Physiological role for amyloid precursor protein in adult experience-dependent plasticity.

Marik SA, Olsen O, Tessier-Lavigne M, Gilbert CD.

Proc Natl Acad Sci U S A. 2016 Jul 12;113(28):7912-7. doi: 10.1073/pnas.1604299113. Epub 2016 Jun 27.

22.

Mapping of Brain Activity by Automated Volume Analysis of Immediate Early Genes.

Renier N, Adams EL, Kirst C, Wu Z, Azevedo R, Kohl J, Autry AE, Kadiri L, Umadevi Venkataraju K, Zhou Y, Wang VX, Tang CY, Olsen O, Dulac C, Osten P, Tessier-Lavigne M.

Cell. 2016 Jun 16;165(7):1789-1802. doi: 10.1016/j.cell.2016.05.007. Epub 2016 May 26.

23.

NOVA regulates Dcc alternative splicing during neuronal migration and axon guidance in the spinal cord.

Leggere JC, Saito Y, Darnell RB, Tessier-Lavigne M, Junge HJ, Chen Z.

Elife. 2016 May 25;5. pii: e14264. doi: 10.7554/eLife.14264.

24.

Prevalent presence of periodic actin-spectrin-based membrane skeleton in a broad range of neuronal cell types and animal species.

He J, Zhou R, Wu Z, Carrasco MA, Kurshan PT, Farley JE, Simon DJ, Wang G, Han B, Hao J, Heller E, Freeman MR, Shen K, Maniatis T, Tessier-Lavigne M, Zhuang X.

Proc Natl Acad Sci U S A. 2016 May 24;113(21):6029-34. doi: 10.1073/pnas.1605707113. Epub 2016 May 9.

25.

Efficient introduction of specific homozygous and heterozygous mutations using CRISPR/Cas9.

Paquet D, Kwart D, Chen A, Sproul A, Jacob S, Teo S, Olsen KM, Gregg A, Noggle S, Tessier-Lavigne M.

Nature. 2016 May 5;533(7601):125-9. doi: 10.1038/nature17664. Epub 2016 Apr 27.

PMID:
27120160
26.

Axon Degeneration Gated by Retrograde Activation of Somatic Pro-apoptotic Signaling.

Simon DJ, Pitts J, Hertz NT, Yang J, Yamagishi Y, Olsen O, Tešić Mark M, Molina H, Tessier-Lavigne M.

Cell. 2016 Feb 25;164(5):1031-45. doi: 10.1016/j.cell.2016.01.032. Epub 2016 Feb 18.

27.

Floor plate-derived neuropilin-2 functions as a secreted semaphorin sink to facilitate commissural axon midline crossing.

Hernandez-Enriquez B, Wu Z, Martinez E, Olsen O, Kaprielian Z, Maness PF, Yoshida Y, Tessier-Lavigne M, Tran TS.

Genes Dev. 2015 Dec 15;29(24):2617-32. doi: 10.1101/gad.268086.115.

28.

Operational redundancy in axon guidance through the multifunctional receptor Robo3 and its ligand NELL2.

Jaworski A, Tom I, Tong RK, Gildea HK, Koch AW, Gonzalez LC, Tessier-Lavigne M.

Science. 2015 Nov 20;350(6263):961-5. doi: 10.1126/science.aad2615.

29.

Live Imaging of Calcium Dynamics during Axon Degeneration Reveals Two Functionally Distinct Phases of Calcium Influx.

Vargas ME, Yamagishi Y, Tessier-Lavigne M, Sagasti A.

J Neurosci. 2015 Nov 11;35(45):15026-38. doi: 10.1523/JNEUROSCI.2484-15.2015.

30.

The crystal structure of DR6 in complex with the amyloid precursor protein provides insight into death receptor activation.

Xu K, Olsen O, Tzvetkova-Robev D, Tessier-Lavigne M, Nikolov DB.

Genes Dev. 2015 Apr 15;29(8):785-90. doi: 10.1101/gad.257675.114. Epub 2015 Apr 2.

31.

Pathological axonal death through a MAPK cascade that triggers a local energy deficit.

Yang J, Wu Z, Renier N, Simon DJ, Uryu K, Park DS, Greer PA, Tournier C, Davis RJ, Tessier-Lavigne M.

Cell. 2015 Jan 15;160(1-2):161-76. doi: 10.1016/j.cell.2014.11.053.

32.

Gas1 is a receptor for sonic hedgehog to repel enteric axons.

Jin S, Martinelli DC, Zheng X, Tessier-Lavigne M, Fan CM.

Proc Natl Acad Sci U S A. 2015 Jan 6;112(1):E73-80. doi: 10.1073/pnas.1418629112. Epub 2014 Dec 22.

33.

Signaling switch of the axon guidance receptor Robo3 during vertebrate evolution.

Zelina P, Blockus H, Zagar Y, Péres A, Friocourt F, Wu Z, Rama N, Fouquet C, Hohenester E, Tessier-Lavigne M, Schweitzer J, Roest Crollius H, Chédotal A.

Neuron. 2014 Dec 17;84(6):1258-72. doi: 10.1016/j.neuron.2014.11.004. Epub 2014 Nov 26.

34.

A rare mutation in UNC5C predisposes to late-onset Alzheimer's disease and increases neuronal cell death.

Wetzel-Smith MK, Hunkapiller J, Bhangale TR, Srinivasan K, Maloney JA, Atwal JK, Sa SM, Yaylaoglu MB, Foreman O, Ortmann W, Rathore N, Hansen DV, Tessier-Lavigne M; Alzheimer's Disease Genetics Consortium, Mayeux R, Pericak-Vance M, Haines J, Farrer LA, Schellenberg GD, Goate A, Behrens TW, Cruchaga C, Watts RJ, Graham RR.

Nat Med. 2014 Dec;20(12):1452-7. doi: 10.1038/nm.3736. Epub 2014 Nov 24.

35.

iDISCO: a simple, rapid method to immunolabel large tissue samples for volume imaging.

Renier N, Wu Z, Simon DJ, Yang J, Ariel P, Tessier-Lavigne M.

Cell. 2014 Nov 6;159(4):896-910. doi: 10.1016/j.cell.2014.10.010. Epub 2014 Oct 30.

36.

Netrin-1 controls sympathetic arterial innervation.

Brunet I, Gordon E, Han J, Cristofaro B, Broqueres-You D, Liu C, Bouvrée K, Zhang J, del Toro R, Mathivet T, Larrivée B, Jagu J, Pibouin-Fragner L, Pardanaud L, Machado MJ, Kennedy TE, Zhuang Z, Simons M, Levy BI, Tessier-Lavigne M, Grenz A, Eltzschig H, Eichmann A.

J Clin Invest. 2014 Jul;124(7):3230-40. doi: 10.1172/JCI75181. Epub 2014 Jun 17.

37.

ADAM metalloproteases promote a developmental switch in responsiveness to the axonal repellant Sema3A.

Romi E, Gokhman I, Wong E, Antonovsky N, Ludwig A, Sagi I, Saftig P, Tessier-Lavigne M, Yaron A.

Nat Commun. 2014 Jun 5;5:4058. doi: 10.1038/ncomms5058.

PMID:
24898499
38.

Neural migration. Structures of netrin-1 bound to two receptors provide insight into its axon guidance mechanism.

Xu K, Wu Z, Renier N, Antipenko A, Tzvetkova-Robev D, Xu Y, Minchenko M, Nardi-Dei V, Rajashankar KR, Himanen J, Tessier-Lavigne M, Nikolov DB.

Science. 2014 Jun 13;344(6189):1275-9. doi: 10.1126/science.1255149. Epub 2014 May 29.

39.

Genetic analysis reveals that amyloid precursor protein and death receptor 6 function in the same pathway to control axonal pruning independent of β-secretase.

Olsen O, Kallop DY, McLaughlin T, Huntwork-Rodriguez S, Wu Z, Duggan CD, Simon DJ, Lu Y, Easley-Neal C, Takeda K, Hass PE, Jaworski A, O'Leary DD, Weimer RM, Tessier-Lavigne M.

J Neurosci. 2014 May 7;34(19):6438-47. doi: 10.1523/JNEUROSCI.3522-13.2014.

40.

A death receptor 6-amyloid precursor protein pathway regulates synapse density in the mature CNS but does not contribute to Alzheimer's disease-related pathophysiology in murine models.

Kallop DY, Meilandt WJ, Gogineni A, Easley-Neal C, Wu T, Jubb AM, Yaylaoglu M, Shamloo M, Tessier-Lavigne M, Scearce-Levie K, Weimer RM.

J Neurosci. 2014 May 7;34(19):6425-37. doi: 10.1523/JNEUROSCI.4963-13.2014.

41.

FLRT3 is a Robo1-interacting protein that determines Netrin-1 attraction in developing axons.

Leyva-Díaz E, del Toro D, Menal MJ, Cambray S, Susín R, Tessier-Lavigne M, Klein R, Egea J, López-Bendito G.

Curr Biol. 2014 Mar 3;24(5):494-508. doi: 10.1016/j.cub.2014.01.042. Epub 2014 Feb 20.

42.

Defining the ligand specificity of the deleted in colorectal cancer (DCC) receptor.

Haddick PC, Tom I, Luis E, Quiñones G, Wranik BJ, Ramani SR, Stephan JP, Tessier-Lavigne M, Gonzalez LC.

PLoS One. 2014 Jan 6;9(1):e84823. doi: 10.1371/journal.pone.0084823. eCollection 2014.

43.

Regulation of axon degeneration after injury and in development by the endogenous calpain inhibitor calpastatin.

Yang J, Weimer RM, Kallop D, Olsen O, Wu Z, Renier N, Uryu K, Tessier-Lavigne M.

Neuron. 2013 Dec 4;80(5):1175-89. doi: 10.1016/j.neuron.2013.08.034. Epub 2013 Nov 7.

44.

Death receptor 6 regulates adult experience-dependent cortical plasticity.

Marik SA, Olsen O, Tessier-Lavigne M, Gilbert CD.

J Neurosci. 2013 Sep 18;33(38):14998-5003. doi: 10.1523/JNEUROSCI.2398-13.2013.

45.

In defense of basic science funding: today's scientific discovery is tomorrow's medical advance.

Tessier-Lavigne M.

Cold Spring Harb Perspect Med. 2013 Jun 1;3(6). pii: a019554. doi: 10.1101/cshperspect.a019554.

46.

DLK initiates a transcriptional program that couples apoptotic and regenerative responses to axonal injury.

Watkins TA, Wang B, Huntwork-Rodriguez S, Yang J, Jiang Z, Eastham-Anderson J, Modrusan Z, Kaminker JS, Tessier-Lavigne M, Lewcock JW.

Proc Natl Acad Sci U S A. 2013 Mar 5;110(10):4039-44. doi: 10.1073/pnas.1211074110. Epub 2013 Feb 19.

47.

Roundabout receptors are critical for foregut separation from the body wall.

Domyan ET, Branchfield K, Gibson DA, Naiche LA, Lewandoski M, Tessier-Lavigne M, Ma L, Sun X.

Dev Cell. 2013 Jan 14;24(1):52-63. doi: 10.1016/j.devcel.2012.11.018.

48.

A caspase cascade regulating developmental axon degeneration.

Simon DJ, Weimer RM, McLaughlin T, Kallop D, Stanger K, Yang J, O'Leary DD, Hannoush RN, Tessier-Lavigne M.

J Neurosci. 2012 Dec 5;32(49):17540-53. doi: 10.1523/JNEUROSCI.3012-12.2012.

49.

14-3-3 proteins regulate a cell-intrinsic switch from sonic hedgehog-mediated commissural axon attraction to repulsion after midline crossing.

Yam PT, Kent CB, Morin S, Farmer WT, Alchini R, Lepelletier L, Colman DR, Tessier-Lavigne M, Fournier AE, Charron F.

Neuron. 2012 Nov 21;76(4):735-49. doi: 10.1016/j.neuron.2012.09.017.

50.

Slit/Robo signaling modulates the proliferation of central nervous system progenitors.

Borrell V, Cárdenas A, Ciceri G, Galcerán J, Flames N, Pla R, Nóbrega-Pereira S, García-Frigola C, Peregrín S, Zhao Z, Ma L, Tessier-Lavigne M, Marín O.

Neuron. 2012 Oct 18;76(2):338-52. doi: 10.1016/j.neuron.2012.08.003. Epub 2012 Oct 17.

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