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Toll-like receptor 7-adapter complex modulates interferon-α production in HIV-stimulated plasmacytoid dendritic cells.

Patamawenu AA, Wright NE, Shofner T, Evans S, Manion MM, Doria-Rose N, Migueles SA, Mendoza D, Peterson B, Wilhelm C, Rood J, Berkley A, Cogliano NA, Liang CJ, Tesselaar K, Miedema F, Bess J Jr, Lifson J, Connors M.

PLoS One. 2019 Dec 12;14(12):e0225806. doi: 10.1371/journal.pone.0225806. eCollection 2019.


Characterization of the phenotype of human eosinophils and their progenitors in the bone marrow of healthy individuals.

Hassani M, van Staveren S, van Grinsven E, Bartels M, Tesselaar K, Leijte G, Kox M, Pickkers P, Vrisekoop N, Koenderman L.

Haematologica. 2020 Jan 31;105(2):e52-e56. doi: 10.3324/haematol.2019.219048. Print 2020. No abstract available.


In vivo deuterium labelling in mice supports a dynamic model for memory T-cell maintenance in the bone marrow.

Baliu-Piqué M, Otto SA, Borghans JAM, Tesselaar K.

Immunol Lett. 2019 Jun;210:29-32. doi: 10.1016/j.imlet.2019.04.004. Epub 2019 Apr 17.


Age-related distribution and dynamics of T-cells in blood and lymphoid tissues of goats.

Baliu-Piqué M, Kurniawan H, Ravesloot L, Verheij MW, Drylewicz J, Lievaart-Peterson K, Borghans JAM, Koets A, Tesselaar K.

Dev Comp Immunol. 2019 Apr;93:1-10. doi: 10.1016/j.dci.2018.12.004. Epub 2018 Dec 11.


Short Lifespans of Memory T-cells in Bone Marrow, Blood, and Lymph Nodes Suggest That T-cell Memory Is Maintained by Continuous Self-Renewal of Recirculating Cells.

Baliu-Piqué M, Verheij MW, Drylewicz J, Ravesloot L, de Boer RJ, Koets A, Tesselaar K, Borghans JAM.

Front Immunol. 2018 Sep 11;9:2054. doi: 10.3389/fimmu.2018.02054. eCollection 2018.


Current best estimates for the average lifespans of mouse and human leukocytes: reviewing two decades of deuterium-labeling experiments.

Borghans JAM, Tesselaar K, de Boer RJ.

Immunol Rev. 2018 Sep;285(1):233-248. doi: 10.1111/imr.12693. Review.


The effect of switching protease inhibitors to raltegravir on endothelial function, in HIV-infected patients.

Krikke M, Tesselaar K, van den Berk GEL, Otto SA, Freriks LH, van Lelyveld SFL, Visseren FJL, Hoepelman AIM, Arends JE.

HIV Clin Trials. 2018 Apr;19(2):75-83. doi: 10.1080/15284336.2018.1455366.


Impact of Aging, Cytomegalovirus Infection, and Long-Term Treatment for Human Immunodeficiency Virus on CD8+ T-Cell Subsets.

Veel E, Westera L, van Gent R, Bont L, Otto S, Ruijsink B, Rabouw HH, Mudrikova T, Wensing A, Hoepelman AIM, Borghans JAM, Tesselaar K.

Front Immunol. 2018 Mar 21;9:572. doi: 10.3389/fimmu.2018.00572. eCollection 2018.


Dynamics of Recent Thymic Emigrants in Young Adult Mice.

van Hoeven V, Drylewicz J, Westera L, den Braber I, Mugwagwa T, Tesselaar K, Borghans JAM, de Boer RJ.

Front Immunol. 2017 Aug 7;8:933. doi: 10.3389/fimmu.2017.00933. eCollection 2017.


Circulatory and maturation kinetics of human monocyte subsets in vivo.

Tak T, Drylewicz J, Conemans L, de Boer RJ, Koenderman L, Borghans JAM, Tesselaar K.

Blood. 2017 Sep 21;130(12):1474-1477. doi: 10.1182/blood-2017-03-771261. Epub 2017 Jul 25. No abstract available.


Human neonatal thymectomy induces altered B-cell responses and autoreactivity.

van den Broek T, Madi A, Delemarre EM, Schadenberg AWL, Tesselaar K, Borghans JAM, Nierkens S, Redegeld FA, Otten HG, Rossetti M, Albani S, Sorek R, Cohen IR, Jansen NJG, van Wijk F.

Eur J Immunol. 2017 Nov;47(11):1970-1981. doi: 10.1002/eji.201746971. Epub 2017 Sep 6.


Osteoporosis and osteopenia are not associated with T-cell activation in older cART-treated HIV-infected patients.

Krikke M, Klomberg RCW, van der Veer E, Tesselaar K, Verhaar HJJ, Hoepelman AIM, Arends JE.

Neth J Med. 2017 May;75(4):138-144.


Human CD62Ldim neutrophils identified as a separate subset by proteome profiling and in vivo pulse-chase labeling.

Tak T, Wijten P, Heeres M, Pickkers P, Scholten A, Heck AJR, Vrisekoop N, Leenen LP, Borghans JAM, Tesselaar K, Koenderman L.

Blood. 2017 Jun 29;129(26):3476-3485. doi: 10.1182/blood-2016-07-727669. Epub 2017 May 17.


HIV and risk of cardiovascular disease in sub-Saharan Africa: Rationale and design of the Ndlovu Cohort Study.

Vos A, Tempelman H, Devillé W, Barth R, Wensing A, Kretzschmar M, Klipstein-Grobusch K, Hoepelman A, Tesselaar K, Aitken S, Madzivhandila M, Uiterwaal C, Venter F, Coutinho R, Grobbee DE.

Eur J Prev Cardiol. 2017 Jul;24(10):1043-1050. doi: 10.1177/2047487317702039. Epub 2017 Apr 5.


Maraviroc Intensification Improves Endothelial Function in Abacavir-Treated Patients, an Open-Label Randomized Cross-Over Pilot Study.

Krikke M, Tesselaar K, Arends JE, Drylewicz J, Otto SA, van Lelyveld SF, Visseren FJ, Hoepelman AI.

Infect Dis Ther. 2016 Sep;5(3):389-404. doi: 10.1007/s40121-016-0115-0. Epub 2016 Jun 14.


Reconciling Longitudinal Naive T-Cell and TREC Dynamics during HIV-1 Infection.

Drylewicz J, Vrisekoop N, Mugwagwa T, de Boer AB, Otto SA, Hazenberg MD, Tesselaar K, de Boer RJ, Borghans JA.

PLoS One. 2016 Mar 24;11(3):e0152513. doi: 10.1371/journal.pone.0152513. eCollection 2016.


Neonatal thymectomy reveals differentiation and plasticity within human naive T cells.

van den Broek T, Delemarre EM, Janssen WJ, Nievelstein RA, Broen JC, Tesselaar K, Borghans JA, Nieuwenhuis EE, Prakken BJ, Mokry M, Jansen NJ, van Wijk F.

J Clin Invest. 2016 Mar 1;126(3):1126-36. doi: 10.1172/JCI84997. Epub 2016 Feb 22.


Reconciling Estimates of Cell Proliferation from Stable Isotope Labeling Experiments.

Ahmed R, Westera L, Drylewicz J, Elemans M, Zhang Y, Kelly E, Reljic R, Tesselaar K, de Boer RJ, Macallan DC, Borghans JA, Asquith B.

PLoS Comput Biol. 2015 Oct 5;11(10):e1004355. doi: 10.1371/journal.pcbi.1004355. eCollection 2015 Oct.


Quantification of naive and memory T-cell turnover during HIV-1 infection.

Vrisekoop N, Drylewicz J, Van Gent R, Mugwagwa T, Van Lelyveld SF, Veel E, Otto SA, Ackermans MT, Vermeulen JN, Huidekoper HH, Prins JM, Miedema F, de Boer RJ, Tesselaar K, Borghans JA.

AIDS. 2015 Oct 23;29(16):2071-80. doi: 10.1097/QAD.0000000000000822.


Maraviroc Intensification of cART in Patients with Suboptimal Immunological Recovery: A 48-Week, Placebo-Controlled Randomized Trial.

van Lelyveld SF, Drylewicz J, Krikke M, Veel EM, Otto SA, Richter C, Soetekouw R, Prins JM, Brinkman K, Mulder JW, Kroon F, Middel A, Symons J, Wensing AM, Nijhuis M, Borghans JA, Tesselaar K, Hoepelman AI; MIRS study group.

PLoS One. 2015 Jul 24;10(7):e0132430. doi: 10.1371/journal.pone.0132430. eCollection 2015.


Similar activation state of neutrophils in sputum of asthma patients irrespective of sputum eosinophilia.

Tak T, Hilvering B, Tesselaar K, Koenderman L.

Clin Exp Immunol. 2015 Nov;182(2):204-12. doi: 10.1111/cei.12676. Epub 2015 Sep 16.


Clinical and immunologic effects of maraviroc in progressive multifocal leukoencephalopathy.

Middel A, Arends JE, van Lelyveld SF, Otto S, Schuurman R, Frijns CJ, Tesselaar K, Hoepelman AI.

Neurology. 2015 Jul 7;85(1):104-6. doi: 10.1212/WNL.0000000000001713. Epub 2015 Jun 3. No abstract available.


Novel mutations in TNFRSF7/CD27: Clinical, immunologic, and genetic characterization of human CD27 deficiency.

Alkhairy OK, Perez-Becker R, Driessen GJ, Abolhassani H, van Montfrans J, Borte S, Choo S, Wang N, Tesselaar K, Fang M, Bienemann K, Boztug K, Daneva A, Mechinaud F, Wiesel T, Becker C, Dückers G, Siepermann K, van Zelm MC, Rezaei N, van der Burg M, Aghamohammadi A, Seidel MG, Niehues T, Hammarström L.

J Allergy Clin Immunol. 2015 Sep;136(3):703-712.e10. doi: 10.1016/j.jaci.2015.02.022. Epub 2015 Apr 3.


Lymphocyte maintenance during healthy aging requires no substantial alterations in cellular turnover.

Westera L, van Hoeven V, Drylewicz J, Spierenburg G, van Velzen JF, de Boer RJ, Tesselaar K, Borghans JA.

Aging Cell. 2015 Apr;14(2):219-27. doi: 10.1111/acel.12311. Epub 2015 Jan 28.


Residual viremia is preceding viral blips and persistent low-level viremia in treated HIV-1 patients.

Hofstra LM, Mudrikova T, Stam AJ, Otto S, Tesselaar K, Nijhuis M, Wensing AM.

PLoS One. 2014 Oct 29;9(10):e110749. doi: 10.1371/journal.pone.0110749. eCollection 2014.


The role of T cells in the development of cardiovascular disease in HIV-infected patients.

Krikke M, van Lelyveld SF, Tesselaar K, Arends JE, Hoepelman IM, Visseren FL.

Atherosclerosis. 2014 Nov;237(1):92-8. doi: 10.1016/j.atherosclerosis.2014.08.054. Epub 2014 Sep 6. Review.


Proteome-wide analysis and CXCL4 in systemic sclerosis.

van Roon JA, Tesselaar K, Radstake TR.

N Engl J Med. 2014 Apr 17;370(16):1563-4. doi: 10.1056/NEJMc1402401. No abstract available.


Immune activation and collateral damage in AIDS pathogenesis.

Miedema F, Hazenberg MD, Tesselaar K, van Baarle D, de Boer RJ, Borghans JA.

Front Immunol. 2013 Sep 26;4:298. doi: 10.3389/fimmu.2013.00298. Review.


Closing the gap between T-cell life span estimates from stable isotope-labeling studies in mice and humans.

Westera L, Drylewicz J, den Braber I, Mugwagwa T, van der Maas I, Kwast L, Volman T, van de Weg-Schrijver EH, Bartha I, Spierenburg G, Gaiser K, Ackermans MT, Asquith B, de Boer RJ, Tesselaar K, Borghans JA.

Blood. 2013 Sep 26;122(13):2205-12. doi: 10.1182/blood-2013-03-488411. Epub 2013 Aug 14.


Defects in neutrophil granule mobilization and bactericidal activity in familial hemophagocytic lymphohistiocytosis type 5 (FHL-5) syndrome caused by STXBP2/Munc18-2 mutations.

Zhao XW, Gazendam RP, Drewniak A, van Houdt M, Tool AT, van Hamme JL, Kustiawan I, Meijer AB, Janssen H, Russell DG, van de Corput L, Tesselaar K, Boelens JJ, Kuhnle I, Van Der Werff Ten Bosch J, Kuijpers TW, van den Berg TK.

Blood. 2013 Jul 4;122(1):109-11. doi: 10.1182/blood-2013-03-494039. Epub 2013 May 17.


What's your age again? Determination of human neutrophil half-lives revisited.

Tak T, Tesselaar K, Pillay J, Borghans JA, Koenderman L.

J Leukoc Biol. 2013 Oct;94(4):595-601. doi: 10.1189/jlb.1112571. Epub 2013 Apr 26. Review.


Quantitating lymphocyte homeostasis in vivo in humans using stable isotope tracers.

Westera L, Zhang Y, Tesselaar K, Borghans JA, Macallan DC.

Methods Mol Biol. 2013;979:107-31. doi: 10.1007/978-1-62703-290-2_10.


A generalized mathematical model to estimate T- and B-cell receptor diversities using AmpliCot.

Baltcheva I, Veel E, Volman T, Koning D, Brouwer A, Le Boudec JY, Tesselaar K, de Boer RJ, Borghans JA.

Biophys J. 2012 Sep 5;103(5):999-1010.


First analysis of human herpesvirus 6T-cell responses: specific boosting after HHV6 reactivation in stem cell transplantation recipients.

de Pagter AP, Boelens JJ, Scherrenburg J, Vroom-de Blank T, Tesselaar K, Nanlohy N, Sanders EA, Schuurman R, van Baarle D.

Clin Immunol. 2012 Sep;144(3):179-89. doi: 10.1016/j.clim.2012.06.006. Epub 2012 Jun 30.


Maintenance of peripheral naive T cells is sustained by thymus output in mice but not humans.

den Braber I, Mugwagwa T, Vrisekoop N, Westera L, Mögling R, de Boer AB, Willems N, Schrijver EH, Spierenburg G, Gaiser K, Mul E, Otto SA, Ruiter AF, Ackermans MT, Miedema F, Borghans JA, de Boer RJ, Tesselaar K.

Immunity. 2012 Feb 24;36(2):288-97. doi: 10.1016/j.immuni.2012.02.006.


CD27 deficiency is associated with combined immunodeficiency and persistent symptomatic EBV viremia.

van Montfrans JM, Hoepelman AI, Otto S, van Gijn M, van de Corput L, de Weger RA, Monaco-Shawver L, Banerjee PP, Sanders EA, Jol-van der Zijde CM, Betts MR, Orange JS, Bloem AC, Tesselaar K.

J Allergy Clin Immunol. 2012 Mar;129(3):787-793.e6. doi: 10.1016/j.jaci.2011.11.013. Epub 2011 Dec 24.


A novel Dutch mutation in UNC13D reveals an essential role of the C2B domain in munc13-4 function.

Elstak ED, te Loo M, Tesselaar K, van Kerkhof P, Loeffen J, Grivas D, Hennekam E, Boelens JJ, Hoogerbrugge PM, van der Sluijs P, van Gijn ME, van de Corput L.

Pediatr Blood Cancer. 2012 Apr;58(4):598-605. doi: 10.1002/pbc.23253. Epub 2011 Jul 13.


Long-term restoration of the human T-cell compartment after thymectomy during infancy: a role for thymic regeneration?

van Gent R, Schadenberg AW, Otto SA, Nievelstein RA, Sieswerda GT, Haas F, Miedema F, Tesselaar K, Jansen NJ, Borghans JA.

Blood. 2011 Jul 21;118(3):627-34. doi: 10.1182/blood-2011-03-341396. Epub 2011 May 31.


Decreased thymic output accounts for decreased naive T cell numbers in children with Down syndrome.

Bloemers BL, Bont L, de Weger RA, Otto SA, Borghans JA, Tesselaar K.

J Immunol. 2011 Apr 1;186(7):4500-7. doi: 10.4049/jimmunol.1001700. Epub 2011 Feb 23.


Immune reconstitution in children following chemotherapy for haematological malignancies: a long-term follow-up.

van Tilburg CM, van Gent R, Bierings MB, Otto SA, Sanders EA, Nibbelke EE, Gaiser JF, Janssens-Korpela PL, Wolfs TF, Bloem AC, Borghans JA, Tesselaar K.

Br J Haematol. 2011 Jan;152(2):201-10. doi: 10.1111/j.1365-2141.2010.08478.x. Epub 2010 Nov 28.


In vivo labeling with 2H2O reveals a human neutrophil lifespan of 5.4 days.

Pillay J, den Braber I, Vrisekoop N, Kwast LM, de Boer RJ, Borghans JA, Tesselaar K, Koenderman L.

Blood. 2010 Jul 29;116(4):625-7. doi: 10.1182/blood-2010-01-259028. Epub 2010 Apr 21.


Lymphocyte characteristics in children with common variable immunodeficiency.

van de Ven AA, van de Corput L, van Tilburg CM, Tesselaar K, van Gent R, Sanders EA, Boes M, Bloem AC, van Montfrans JM.

Clin Immunol. 2010 Apr;135(1):63-71. doi: 10.1016/j.clim.2009.11.010. Epub 2009 Dec 16.


The cytotoxic protease granzyme M is expressed by lymphocytes of both the innate and adaptive immune system.

de Koning PJ, Tesselaar K, Bovenschen N, Colak S, Quadir R, Volman TJ, Kummer JA.

Mol Immunol. 2010 Jan;47(4):903-11. doi: 10.1016/j.molimm.2009.10.001. Epub 2009 Nov 5.


Lack of CD200 enhances pathological T cell responses during influenza infection.

Rygiel TP, Rijkers ES, de Ruiter T, Stolte EH, van der Valk M, Rimmelzwaan GF, Boon L, van Loon AM, Coenjaerts FE, Hoek RM, Tesselaar K, Meyaard L.

J Immunol. 2009 Aug 1;183(3):1990-6. doi: 10.4049/jimmunol.0900252. Epub 2009 Jul 8.


Refined characterization and reference values of the pediatric T- and B-cell compartments.

van Gent R, van Tilburg CM, Nibbelke EE, Otto SA, Gaiser JF, Janssens-Korpela PL, Sanders EA, Borghans JA, Wulffraat NM, Bierings MB, Bloem AC, Tesselaar K.

Clin Immunol. 2009 Oct;133(1):95-107. doi: 10.1016/j.clim.2009.05.020. Epub 2009 Jul 7. Erratum in: Clin Immunol. 2010 Aug;136(2):307-8.


Be fruitful, multiply, and replenish.

Borghans JA, Tesselaar K.

Blood. 2009 May 28;113(22):5369-70. doi: 10.1182/blood-2009-03-207266. No abstract available.


Life-threatening human herpes virus-6 infection in early childhood: presenting symptom of a primary immunodeficiency?

Hennus MP, van Montfrans JM, van Vught AJ, Tesselaar K, Boelens JJ, Jansen NJ.

Pediatr Crit Care Med. 2009 Mar;10(2):e16-8. doi: 10.1097/PCC.0b013e31819bb956.


In vivo dynamics of stable chronic lymphocytic leukemia inversely correlate with somatic hypermutation levels and suggest no major leukemic turnover in bone marrow.

van Gent R, Kater AP, Otto SA, Jaspers A, Borghans JA, Vrisekoop N, Ackermans MA, Ruiter AF, Wittebol S, Eldering E, van Oers MH, Tesselaar K, Kersten MJ, Miedema F.

Cancer Res. 2008 Dec 15;68(24):10137-44. doi: 10.1158/0008-5472.CAN-08-2325.


Restoration of the CD4 T cell compartment after long-term highly active antiretroviral therapy without phenotypical signs of accelerated immunological aging.

Vrisekoop N, van Gent R, de Boer AB, Otto SA, Borleffs JC, Steingrover R, Prins JM, Kuijpers TW, Wolfs TF, Geelen SP, Vulto I, Lansdorp P, Tesselaar K, Borghans JA, Miedema F.

J Immunol. 2008 Jul 15;181(2):1573-81.


Sparse production but preferential incorporation of recently produced naive T cells in the human peripheral pool.

Vrisekoop N, den Braber I, de Boer AB, Ruiter AF, Ackermans MT, van der Crabben SN, Schrijver EH, Spierenburg G, Sauerwein HP, Hazenberg MD, de Boer RJ, Miedema F, Borghans JA, Tesselaar K.

Proc Natl Acad Sci U S A. 2008 Apr 22;105(16):6115-20. doi: 10.1073/pnas.0709713105. Epub 2008 Apr 17.

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