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Items: 25


Two Separation-of-Function Isoforms of Human TPP1 Dictate Telomerase Regulation in Somatic and Germ Cells.

Grill S, Bisht K, Tesmer VM, Shami AN, Hammoud SS, Nandakumar J.

Cell Rep. 2019 Jun 18;27(12):3511-3521.e7. doi: 10.1016/j.celrep.2019.05.073.


The N Terminus of the OB Domain of Telomere Protein TPP1 Is Critical for Telomerase Action.

Grill S, Tesmer VM, Nandakumar J.

Cell Rep. 2018 Jan 30;22(5):1132-1140. doi: 10.1016/j.celrep.2018.01.012.


Dissecting the telomere-inner nuclear membrane interface formed in meiosis.

Pendlebury DF, Fujiwara Y, Tesmer VM, Smith EM, Shibuya H, Watanabe Y, Nandakumar J.

Nat Struct Mol Biol. 2017 Dec;24(12):1064-1072. doi: 10.1038/nsmb.3493. Epub 2017 Oct 30.


Structural and functional consequences of a disease mutation in the telomere protein TPP1.

Bisht K, Smith EM, Tesmer VM, Nandakumar J.

Proc Natl Acad Sci U S A. 2016 Nov 15;113(46):13021-13026. Epub 2016 Nov 2.


Structural and functional analysis of the regulator of G protein signaling 2-gαq complex.

Nance MR, Kreutz B, Tesmer VM, Sterne-Marr R, Kozasa T, Tesmer JJ.

Structure. 2013 Mar 5;21(3):438-48. doi: 10.1016/j.str.2012.12.016. Epub 2013 Feb 21.


Molecular mechanism for inhibition of g protein-coupled receptor kinase 2 by a selective RNA aptamer.

Tesmer VM, Lennarz S, Mayer G, Tesmer JJ.

Structure. 2012 Aug 8;20(8):1300-9. doi: 10.1016/j.str.2012.05.002. Epub 2012 Jun 21.


Heterotrimeric G protein beta1gamma2 subunits change orientation upon complex formation with G protein-coupled receptor kinase 2 (GRK2) on a model membrane.

Boughton AP, Yang P, Tesmer VM, Ding B, Tesmer JJ, Chen Z.

Proc Natl Acad Sci U S A. 2011 Sep 13;108(37):E667-73. doi: 10.1073/pnas.1108236108. Epub 2011 Aug 29.


An autoinhibitory helix in the C-terminal region of phospholipase C-β mediates Gαq activation.

Lyon AM, Tesmer VM, Dhamsania VD, Thal DM, Gutierrez J, Chowdhury S, Suddala KC, Northup JK, Tesmer JJ.

Nat Struct Mol Biol. 2011 Aug 7;18(9):999-1005. doi: 10.1038/nsmb.2095.


Structure of human G protein-coupled receptor kinase 2 in complex with the kinase inhibitor balanol.

Tesmer JJ, Tesmer VM, Lodowski DT, Steinhagen H, Huber J.

J Med Chem. 2010 Feb 25;53(4):1867-70. doi: 10.1021/jm9017515.


Assembly of high order G alpha q-effector complexes with RGS proteins.

Shankaranarayanan A, Thal DM, Tesmer VM, Roman DL, Neubig RR, Kozasa T, Tesmer JJ.

J Biol Chem. 2008 Dec 12;283(50):34923-34. doi: 10.1074/jbc.M805860200. Epub 2008 Oct 20.


The structure of G protein-coupled receptor kinase (GRK)-6 defines a second lineage of GRKs.

Lodowski DT, Tesmer VM, Benovic JL, Tesmer JJ.

J Biol Chem. 2006 Jun 16;281(24):16785-93. Epub 2006 Apr 13.


Snapshot of activated G proteins at the membrane: the Galphaq-GRK2-Gbetagamma complex.

Tesmer VM, Kawano T, Shankaranarayanan A, Kozasa T, Tesmer JJ.

Science. 2005 Dec 9;310(5754):1686-90.


Regulation of HIV-1 transcription by NF-IL6 in activated Jurkat T cells.

Buckner AE, Tesmer VM, Bina M.

Virus Res. 2002 Oct;89(1):53-63.


Regulation of HIV-1 transcription in activated monocyte macrophages.

Yang Y, Tesmer VM, Bina M.

Virology. 2002 Aug 1;299(2):256-265.


Organization of the promoter region of the human NF-IL6 gene.

Yang Y, Pares-Matos EI, Tesmer VM, Dai C, Ashworth S, Huai J, Bina M.

Biochim Biophys Acta. 2002 Aug 19;1577(1):102-8.


Telomere shortening is proportional to the size of the G-rich telomeric 3'-overhang.

Huffman KE, Levene SD, Tesmer VM, Shay JW, Wright WE.

J Biol Chem. 2000 Jun 30;275(26):19719-22.


Normal human telomeres are not late replicating.

Wright WE, Tesmer VM, Liao ML, Shay JW.

Exp Cell Res. 1999 Sep 15;251(2):492-9.


Two inactive fragments of the integral RNA cooperate to assemble active telomerase with the human protein catalytic subunit (hTERT) in vitro.

Tesmer VM, Ford LP, Holt SE, Frank BC, Yi X, Aisner DL, Ouellette M, Shay JW, Wright WE.

Mol Cell Biol. 1999 Sep;19(9):6207-16.


Both transcriptional and posttranscriptional mechanisms regulate human telomerase template RNA levels.

Yi X, Tesmer VM, Savre-Train I, Shay JW, Wright WE.

Mol Cell Biol. 1999 Jun;19(6):3989-97.


Functional requirement of p23 and Hsp90 in telomerase complexes.

Holt SE, Aisner DL, Baur J, Tesmer VM, Dy M, Ouellette M, Trager JB, Morin GB, Toft DO, Shay JW, Wright WE, White MA.

Genes Dev. 1999 Apr 1;13(7):817-26.


Reconstitution of human telomerase with the template RNA component hTR and the catalytic protein subunit hTRT.

Weinrich SL, Pruzan R, Ma L, Ouellette M, Tesmer VM, Holt SE, Bodnar AG, Lichtsteiner S, Kim NW, Trager JB, Taylor RD, Carlos R, Andrews WH, Wright WE, Shay JW, Harley CB, Morin GB.

Nat Genet. 1997 Dec;17(4):498-502.


Normal human chromosomes have long G-rich telomeric overhangs at one end.

Wright WE, Tesmer VM, Huffman KE, Levene SD, Shay JW.

Genes Dev. 1997 Nov 1;11(21):2801-9.


Regulation of HIV-1 gene expression by NF-IL6.

Tesmer VM, Bina M.

J Mol Biol. 1996 Sep 27;262(3):327-35.


NF-IL6-mediated transcriptional activation of the long terminal repeat of the human immunodeficiency virus type 1.

Tesmer VM, Rajadhyaksha A, Babin J, Bina M.

Proc Natl Acad Sci U S A. 1993 Aug 1;90(15):7298-302.


Evidence for leucine zipper motif in lactose repressor protein.

Chakerian AE, Tesmer VM, Manly SP, Brackett JK, Lynch MJ, Hoh JT, Matthews KS.

J Biol Chem. 1991 Jan 25;266(3):1371-4.

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