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Chronic obstructive pulmonary disease mortality, a competing risk analysis.

Abukhalaf J, Davidson R, Villalobos N, Meek P, Petersen H, Sood A, Tesfaigzi Y, Vazquez Guillamet R.

Clin Respir J. 2018 Sep 26. doi: 10.1111/crj.12963. [Epub ahead of print]


Does the BCL-2 family member BIK control lung carcinogenesis?

Mebratu YA, Tesfaigzi Y.

Mol Cell Oncol. 2018 May 16;5(4):e1435182. doi: 10.1080/23723556.2018.1435182. eCollection 2018.


The Course of Lung Function in Middle-Aged Heavy Smokers: Incidence and Time to Early Onset of COPD.

Petersen H, Sood A, Polverino F, Owen CA, Pinto-Plata V, Celli BR, Tesfaigzi Y.

Am J Respir Crit Care Med. 2018 Aug 16. doi: 10.1164/rccm.201805-0861LE. [Epub ahead of print] No abstract available.


A Disintegrin and A Metalloproteinase Domain-8 (ADAM8): A Novel Protective Proteinase in COPD.

Polverino F, Rojas-Quintero J, Wang X, Petersen H, Zhang L, Gai X, Higham A, Zhang D, Gupta K, Rout A, Yambayev I, Pinto-Plata V, Sholl LM, Cunoosamy D, Celli BR, Goldring J, Singh D, Tesfaigzi Y, Wedzicha J, Olsson H, Owen CA.

Am J Respir Crit Care Med. 2018 May 11. doi: 10.1164/rccm.201707-1331OC. [Epub ahead of print]


Grading Severity of Productive Cough Based on Symptoms and Airflow Obstruction.

Vazquez Guillamet R, Petersen H, Meek P, Sood A, Tesfaigzi Y.

COPD. 2018 Apr;15(2):206-213. doi: 10.1080/15412555.2018.1458218. Epub 2018 Apr 26.


Early Endotyping: A Chance for Intervention in Chronic Obstructive Pulmonary Disease.

Petersen H, Vazquez Guillamet R, Meek P, Sood A, Tesfaigzi Y.

Am J Respir Cell Mol Biol. 2018 Jul;59(1):13-17. doi: 10.1165/rcmb.2018-0002PS.


Noxa/HSP27 complex delays degradation of ubiquitylated IkBα in airway epithelial cells to reduce pulmonary inflammation.

Zhang C, Jones JT, Chand HS, Wathelet MG, Evans CM, Dickey B, Xiang J, Mebratu YA, Tesfaigzi Y.

Mucosal Immunol. 2018 May;11(3):741-751. doi: 10.1038/mi.2017.117. Epub 2018 Jan 24.


Differences in Respiratory Symptoms and Lung Structure Between Hispanic and Non-Hispanic White Smokers: A Comparative Study.

Diaz AA, Rahaghi FN, Doyle TJ, Young TP, Maclean ES, Martinez CH, San José Estépar R, Guerra S, Tesfaigzi Y, Rosas IO, Washko GR, Wilson DO.

Chronic Obstr Pulm Dis. 2017 Sep 5;4(4):297-304. doi: 10.15326/jcopdf.4.4.2017.0150.


IL-13 in LPS-Induced Inflammation Causes Bcl-2 Expression to Sustain Hyperplastic Mucous cells.

Chand HS, Harris JF, Tesfaigzi Y.

Sci Rep. 2018 Jan 11;8(1):436. doi: 10.1038/s41598-017-18884-9.


IL-17 Plays a Role in Respiratory Syncytial Virus-induced Lung Inflammation and Emphysema in Elastase and LPS-injured Mice.

Mebratu YA, Tesfaigzi Y.

Am J Respir Cell Mol Biol. 2018 Jun;58(6):717-726. doi: 10.1165/rcmb.2017-0265OC.


ERS/ATS workshop report on respiratory health effects of household air pollution.

Sood A, Assad NA, Barnes PJ, Churg A, Gordon SB, Harrod KS, Irshad H, Kurmi OP, Martin WJ 2nd, Meek P, Mortimer K, Noonan CW, Perez-Padilla R, Smith KR, Tesfaigzi Y, Ward T, Balmes J.

Eur Respir J. 2018 Jan 4;51(1). pii: 1700698. doi: 10.1183/13993003.00698-2017. Print 2018 Jan.


Dietary nutrients associated with preservation of lung function in Hispanic and non-Hispanic white smokers from New Mexico.

Leng S, Picchi MA, Tesfaigzi Y, Wu G, Gauderman WJ, Xu F, Gilliland FD, Belinsky SA.

Int J Chron Obstruct Pulmon Dis. 2017 Oct 30;12:3171-3181. doi: 10.2147/COPD.S142237. eCollection 2017.


Normalization of FEV1/FVC Ratio to Greater Than 0.7 Does Not Equal Resolution of Disease.

Vazquez Guillamet R, Petersen H, Meek PM, Tesfaigzi Y, Sood A.

Am J Respir Crit Care Med. 2018 Mar 15;197(6):834-835. doi: 10.1164/rccm.201708-1693LE. No abstract available.


Bik reduces hyperplastic cells by increasing Bak and activating DAPk1 to juxtapose ER and mitochondria.

Mebratu YA, Leyva-Baca I, Wathelet MG, Lacey N, Chand HS, Choi AMK, Tesfaigzi Y.

Nat Commun. 2017 Oct 6;8(1):803. doi: 10.1038/s41467-017-00975-w.


Wildfire smoke exposure and human health: Significant gaps in research for a growing public health issue.

Black C, Tesfaigzi Y, Bassein JA, Miller LA.

Environ Toxicol Pharmacol. 2017 Oct;55:186-195. doi: 10.1016/j.etap.2017.08.022. Epub 2017 Aug 30. Review.


Blocking Bcl-2 resolves IL-13-mediated mucous cell hyperplasia in a Bik-dependent manner.

Chand HS, Mebratu YA, Kuehl PJ, Tesfaigzi Y.

J Allergy Clin Immunol. 2017 Nov;140(5):1456-1459.e9. doi: 10.1016/j.jaci.2017.05.038. Epub 2017 Aug 4. No abstract available.


Do COPD subtypes really exist? COPD heterogeneity and clustering in 10 independent cohorts.

Castaldi PJ, Benet M, Petersen H, Rafaels N, Finigan J, Paoletti M, Marike Boezen H, Vonk JM, Bowler R, Pistolesi M, Puhan MA, Anto J, Wauters E, Lambrechts D, Janssens W, Bigazzi F, Camiciottoli G, Cho MH, Hersh CP, Barnes K, Rennard S, Boorgula MP, Dy J, Hansel NN, Crapo JD, Tesfaigzi Y, Agusti A, Silverman EK, Garcia-Aymerich J.

Thorax. 2017 Nov;72(11):998-1006. doi: 10.1136/thoraxjnl-2016-209846. Epub 2017 Jun 21.


Extent of allergic inflammation depends on intermittent versus continuous sensitization to house dust mite.

Jones JT, Tassew DD, Herrera LK, Walton-Filipczak SR, Montera MA, Chand HS, Delgado M, Mebratu YA, Tesfaigzi Y.

Inhal Toxicol. 2017 Feb;29(3):106-112. doi: 10.1080/08958378.2017.1311389. Epub 2017 Apr 16.


Genetic loci associated with chronic obstructive pulmonary disease overlap with loci for lung function and pulmonary fibrosis.

Hobbs BD, de Jong K, Lamontagne M, Bossé Y, Shrine N, Artigas MS, Wain LV, Hall IP, Jackson VE, Wyss AB, London SJ, North KE, Franceschini N, Strachan DP, Beaty TH, Hokanson JE, Crapo JD, Castaldi PJ, Chase RP, Bartz TM, Heckbert SR, Psaty BM, Gharib SA, Zanen P, Lammers JW, Oudkerk M, Groen HJ, Locantore N, Tal-Singer R, Rennard SI, Vestbo J, Timens W, Paré PD, Latourelle JC, Dupuis J, O'Connor GT, Wilk JB, Kim WJ, Lee MK, Oh YM, Vonk JM, de Koning HJ, Leng S, Belinsky SA, Tesfaigzi Y, Manichaikul A, Wang XQ, Rich SS, Barr RG, Sparrow D, Litonjua AA, Bakke P, Gulsvik A, Lahousse L, Brusselle GG, Stricker BH, Uitterlinden AG, Ampleford EJ, Bleecker ER, Woodruff PG, Meyers DA, Qiao D, Lomas DA, Yim JJ, Kim DK, Hawrylkiewicz I, Sliwinski P, Hardin M, Fingerlin TE, Schwartz DA, Postma DS, MacNee W, Tobin MD, Silverman EK, Boezen HM, Cho MH; COPDGene Investigators; ECLIPSE Investigators; LifeLines Investigators; SPIROMICS Research Group; International COPD Genetics Network Investigators; UK BiLEVE Investigators; International COPD Genetics Consortium.

Nat Genet. 2017 Mar;49(3):426-432. doi: 10.1038/ng.3752. Epub 2017 Feb 6.


A Pilot Study Linking Endothelial Injury in Lungs and Kidneys in Chronic Obstructive Pulmonary Disease.

Polverino F, Laucho-Contreras ME, Petersen H, Bijol V, Sholl LM, Choi ME, Divo M, Pinto-Plata V, Chetta A, Tesfaigzi Y, Celli BR, Owen CA.

Am J Respir Crit Care Med. 2017 Jun 1;195(11):1464-1476. doi: 10.1164/rccm.201609-1765OC.


Connective Tissue Growth Factor Promotes Pulmonary Epithelial Cell Senescence and Is Associated with COPD Severity.

Jang JH, Chand HS, Bruse S, Doyle-Eisele M, Royer C, McDonald J, Qualls C, Klingelhutz AJ, Lin Y, Mallampalli R, Tesfaigzi Y, Nyunoya T.

COPD. 2017 Apr;14(2):228-237. doi: 10.1080/15412555.2016.1262340. Epub 2016 Dec 27.


Spirometric variability in smokers: transitions in COPD diagnosis in a five-year longitudinal study.

Sood A, Petersen H, Qualls C, Meek PM, Vazquez-Guillamet R, Celli BR, Tesfaigzi Y.

Respir Res. 2016 Nov 10;17(1):147.


T cells suppress memory-dependent rapid mucous cell metaplasia in mouse airways.

Chand HS, Mebratu YA, Montera M, Tesfaigzi Y.

Respir Res. 2016 Oct 20;17(1):132.


Inflammation and emphysema in cigarette smoke-exposed mice when instilled with poly (I:C) or infected with influenza A or respiratory syncytial viruses.

Mebratu YA, Smith KR, Agga GE, Tesfaigzi Y.

Respir Res. 2016 Jul 1;17(1):75. doi: 10.1186/s12931-016-0392-x.


Differences in Health-Related Quality of Life Between New Mexican Hispanic and Non-Hispanic White Smokers.

Diaz AA, Petersen H, Meek P, Sood A, Celli B, Tesfaigzi Y.

Chest. 2016 Oct;150(4):869-876. doi: 10.1016/j.chest.2016.06.011. Epub 2016 Jun 16.


Assessment of in vitro COPD models for tobacco regulatory science: Workshop proceedings, conclusions and paths forward for in vitro model use.

Behrsing H, Raabe H, Manuppello J, Bombick B, Curren R, Sullivan K, Sethi S, Phipps R, Tesfaigzi Y, Yan S, D'Ruiz C, Tarran R, Constant S, Phillips G, Gaça M, Hayden P, Cao X, Mathis C, Hoeng J, Braun A, Hill E.

Altern Lab Anim. 2016 May;44(2):129-66.


Club Cell Protein 16 (CC16) Augmentation: A Potential Disease-modifying Approach for Chronic Obstructive Pulmonary Disease (COPD).

Laucho-Contreras ME, Polverino F, Tesfaigzi Y, Pilon A, Celli BR, Owen CA.

Expert Opin Ther Targets. 2016 Jul;20(7):869-83. doi: 10.1517/14728222.2016.1139084. Epub 2016 Feb 11. Review.


Bik Mediates Caspase-Dependent Cleavage of Viral Proteins to Promote Influenza A Virus Infection.

Mebratu YA, Tipper J, Chand HS, Walton S, Harrod KS, Tesfaigzi Y.

Am J Respir Cell Mol Biol. 2016 May;54(5):664-73. doi: 10.1165/rcmb.2015-0133OC.


HIF-1α Plays a Critical Role in the Gestational Sidestream Smoke-Induced Bronchopulmonary Dysplasia in Mice.

Singh SP, Chand HS, Gundavarapu S, Saeed AI, Langley RJ, Tesfaigzi Y, Mishra NC, Sopori ML.

PLoS One. 2015 Sep 11;10(9):e0137757. doi: 10.1371/journal.pone.0137757. eCollection 2015.


Epigenetic Repression of CCDC37 and MAP1B Links Chronic Obstructive Pulmonary Disease to Lung Cancer.

Tessema M, Yingling CM, Picchi MA, Wu G, Liu Y, Weissfeld JL, Siegfried JM, Tesfaigzi Y, Belinsky SA.

J Thorac Oncol. 2015 Aug;10(8):1181-8. doi: 10.1097/JTO.0000000000000592.


Low plasma CC16 levels in smokers are associated with a higher risk for chronic bronchitis.

Petersen H, Leng S, Belinsky SA, Miller BE, Tal-Singer R, Owen CA, Celli B, Tesfaigzi Y.

Eur Respir J. 2015 Nov;46(5):1501-3. doi: 10.1183/13993003.00682-2015. Epub 2015 Jul 9. No abstract available.


Lung-Function Trajectories Leading to Chronic Obstructive Pulmonary Disease.

Lange P, Celli B, Agustí A, Boje Jensen G, Divo M, Faner R, Guerra S, Marott JL, Martinez FD, Martinez-Camblor P, Meek P, Owen CA, Petersen H, Pinto-Plata V, Schnohr P, Sood A, Soriano JB, Tesfaigzi Y, Vestbo J.

N Engl J Med. 2015 Jul 9;373(2):111-22. doi: 10.1056/NEJMoa1411532.


Correlation of Cigarette Smoke-Induced Pulmonary Inflammation and Emphysema in C3H and C57Bl/6 Mice.

Awji EG, Seagrave JC, Tesfaigzi Y.

Toxicol Sci. 2015 Sep;147(1):75-83. doi: 10.1093/toxsci/kfv108. Epub 2015 Jun 1.


Chronic Bronchitis Is Associated With Worse Symptoms and Quality of Life Than Chronic Airflow Obstruction.

Meek PM, Petersen H, Washko GR, Diaz AA, Klm V, Sood A, Tesfaigzi Y.

Chest. 2015 Aug;148(2):408-416. doi: 10.1378/chest.14-2240.


15q12 variants, sputum gene promoter hypermethylation, and lung cancer risk: a GWAS in smokers.

Leng S, Liu Y, Weissfeld JL, Thomas CL, Han Y, Picchi MA, Edlund CK, Willink RP, Gaither Davis AL, Do KC, Nukui T, Zhang X, Burki EA, Van Den Berg D, Romkes M, Gauderman WJ, Crowell RE, Tesfaigzi Y, Stidley CA, Amos CI, Siegfried JM, Gilliland FD, Belinsky SA.

J Natl Cancer Inst. 2015 Feb 23;107(5). pii: djv035. doi: 10.1093/jnci/djv035.


Protective role for club cell secretory protein-16 (CC16) in the development of COPD.

Laucho-Contreras ME, Polverino F, Gupta K, Taylor KL, Kelly E, Pinto-Plata V, Divo M, Ashfaq N, Petersen H, Stripp B, Pilon AL, Tesfaigzi Y, Celli BR, Owen CA.

Eur Respir J. 2015 Jun;45(6):1544-56. doi: 10.1183/09031936.00134214. Epub 2015 Feb 19.


A genome-wide association study of chronic obstructive pulmonary disease in Hispanics.

Chen W, Brehm JM, Manichaikul A, Cho MH, Boutaoui N, Yan Q, Burkart KM, Enright PL, Rotter JI, Petersen H, Leng S, Obeidat M, Bossé Y, Brandsma CA, Hao K, Rich SS, Powell R, Avila L, Soto-Quiros M, Silverman EK, Tesfaigzi Y, Barr RG, Celedón JC.

Ann Am Thorac Soc. 2015 Mar;12(3):340-8. doi: 10.1513/AnnalsATS.201408-380OC.


A novel nonhuman primate model of cigarette smoke-induced airway disease.

Polverino F, Doyle-Eisele M, McDonald J, Wilder JA, Royer C, Laucho-Contreras M, Kelly EM, Divo M, Pinto-Plata V, Mauderly J, Celli BR, Tesfaigzi Y, Owen CA.

Am J Pathol. 2015 Mar;185(3):741-55. doi: 10.1016/j.ajpath.2014.11.006. Epub 2014 Dec 24.


A genetic variant of p53 restricts the mucous secretory phenotype by regulating SPDEF and Bcl-2 expression.

Chand HS, Montano G, Huang X, Randell SH, Mebratu Y, Petersen H, Tesfaigzi Y.

Nat Commun. 2014 Nov 27;5:5567. doi: 10.1038/ncomms6567.


Wood smoke enhances cigarette smoke-induced inflammation by inducing the aryl hydrocarbon receptor repressor in airway epithelial cells.

Awji EG, Chand H, Bruse S, Smith KR, Colby JK, Mebratu Y, Levy BD, Tesfaigzi Y.

Am J Respir Cell Mol Biol. 2015 Mar;52(3):377-86. doi: 10.1165/rcmb.2014-0142OC.


Epigenetic change (GATA-4 gene methylation) is associated with health status in chronic obstructive pulmonary disease.

Meek PM, Sood A, Petersen H, Belinsky SA, Tesfaigzi Y.

Biol Res Nurs. 2015 Mar;17(2):191-8. doi: 10.1177/1099800414538113. Epub 2014 Jun 27.


CCN1 secretion and cleavage regulate the lung epithelial cell functions after cigarette smoke.

Moon HG, Kim SH, Gao J, Quan T, Qin Z, Osorio JC, Rosas IO, Wu M, Tesfaigzi Y, Jin Y.

Am J Physiol Lung Cell Mol Physiol. 2014 Aug 15;307(4):L326-37. doi: 10.1152/ajplung.00102.2014. Epub 2014 Jun 27.


Mononuclear phagocytes and airway epithelial cells: novel sources of matrix metalloproteinase-8 (MMP-8) in patients with idiopathic pulmonary fibrosis.

Craig VJ, Polverino F, Laucho-Contreras ME, Shi Y, Liu Y, Osorio JC, Tesfaigzi Y, Pinto-Plata V, Gochuico BR, Rosas IO, Owen CA.

PLoS One. 2014 May 14;9(5):e97485. doi: 10.1371/journal.pone.0097485. eCollection 2014.


Reply from the authors.

Sood A, Petersen H, Meek P, Tesfaigzi Y.

Am J Respir Crit Care Med. 2014 Apr 1;189(7):871. doi: 10.1164/rccm.201401-0123LE. No abstract available.


Increased methylation of lung cancer-associated genes in sputum DNA of former smokers with chronic mucous hypersecretion.

Bruse S, Petersen H, Weissfeld J, Picchi M, Willink R, Do K, Siegfried J, Belinsky SA, Tesfaigzi Y.

Respir Res. 2014 Jan 9;15:2. doi: 10.1186/1465-9921-15-2.


Aldehyde dehydrogenase 3A1 protects airway epithelial cells from cigarette smoke-induced DNA damage and cytotoxicity.

Jang JH, Bruse S, Liu Y, Duffy V, Zhang C, Oyamada N, Randell S, Matsumoto A, Thompson DC, Lin Y, Vasiliou V, Tesfaigzi Y, Nyunoya T.

Free Radic Biol Med. 2014 Mar;68:80-6. doi: 10.1016/j.freeradbiomed.2013.11.028. Epub 2013 Dec 4.


Native American ancestry, lung function, and COPD in Costa Ricans.

Chen W, Brehm JM, Boutaoui N, Soto-Quiros M, Avila L, Celli BR, Bruse S, Tesfaigzi Y, Celedón JC.

Chest. 2014 Apr;145(4):704-710. doi: 10.1378/chest.13-1308.


Spirometry and health status worsen with weight gain in obese smokers but improve in normal-weight smokers.

Sood A, Petersen H, Meek P, Tesfaigzi Y.

Am J Respir Crit Care Med. 2014 Feb 1;189(3):274-81. doi: 10.1164/rccm.201306-1060OC.


Is BMF central for anoikis and autophagy?

Delgado M, Tesfaigzi Y.

Autophagy. 2014 Jan;10(1):168-9. doi: 10.4161/auto.26759. Epub 2013 Nov 11. No abstract available.


Histone deacetylase 6-mediated selective autophagy regulates COPD-associated cilia dysfunction.

Lam HC, Cloonan SM, Bhashyam AR, Haspel JA, Singh A, Sathirapongsasuti JF, Cervo M, Yao H, Chung AL, Mizumura K, An CH, Shan B, Franks JM, Haley KJ, Owen CA, Tesfaigzi Y, Washko GR, Quackenbush J, Silverman EK, Rahman I, Kim HP, Mahmood A, Biswal SS, Ryter SW, Choi AM.

J Clin Invest. 2013 Dec;123(12):5212-30. doi: 10.1172/JCI69636. Epub 2013 Nov 8.

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