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Items: 1 to 50 of 83

1.

ASK1 inhibitor treatment suppresses p38/JNK signalling with reduced kidney inflammation and fibrosis in rat crescentic glomerulonephritis.

Amos LA, Ma FY, Tesch GH, Liles JT, Breckenridge DG, Nikolic-Paterson DJ, Han Y.

J Cell Mol Med. 2018 Sep;22(9):4522-4533. doi: 10.1111/jcmm.13705. Epub 2018 Jul 11.

2.

Proximal tubular epithelial cells preferentially endocytose covalently-modified albumin compared to native albumin.

Ly ND, Tesch GH, Nikolic-Paterson DJ, Poronnik P.

Nephrology (Carlton). 2019 Jan;24(1):121-126. doi: 10.1111/nep.13211.

PMID:
29240283
3.

Cyclophilin D promotes tubular cell damage and the development of interstitial fibrosis in the obstructed kidney.

Hou W, Leong KG, Ozols E, Tesch GH, Nikolic-Paterson DJ, Ma FY.

Clin Exp Pharmacol Physiol. 2018 Mar;45(3):250-260. doi: 10.1111/1440-1681.12881. Epub 2017 Dec 12.

PMID:
29230844
4.

Reduced tubular degradation of glomerular filtered plasma albumin is a common feature in acute and chronic kidney disease.

Han Y, Ly NDK, Tesch GH, Poronnik P, Nikolic-Paterson DJ.

Clin Exp Pharmacol Physiol. 2018 Mar;45(3):241-249. doi: 10.1111/1440-1681.12878. Epub 2017 Nov 28.

PMID:
29124787
5.

Diabetic nephropathy - is this an immune disorder?

Tesch GH.

Clin Sci (Lond). 2017 Jul 31;131(16):2183-2199. doi: 10.1042/CS20160636. Print 2017 Aug 15. Review.

PMID:
28760771
6.

Mineralocorticoid Receptor Signaling as a Therapeutic Target for Renal and Cardiac Fibrosis.

Tesch GH, Young MJ.

Front Pharmacol. 2017 May 29;8:313. doi: 10.3389/fphar.2017.00313. eCollection 2017. Review.

7.

Inhibition of Spleen Tyrosine Kinase Reduces Renal Allograft Injury in a Rat Model of Acute Antibody-Mediated Rejection in Sensitized Recipients.

Ramessur Chandran S, Han Y, Tesch GH, Di Paolo J, Mulley WR, Kanellis J, Ma FY, Nikolic-Paterson DJ.

Transplantation. 2017 Aug;101(8):e240-e248. doi: 10.1097/TP.0000000000001826.

PMID:
28594748
8.

miR-378 reduces mesangial hypertrophy and kidney tubular fibrosis via MAPK signalling.

Wang B, Yao K, Wise AF, Lau R, Shen HH, Tesch GH, Ricardo SD.

Clin Sci (Lond). 2017 Mar 1;131(5):411-423. doi: 10.1042/CS20160571. Epub 2017 Jan 4.

PMID:
28053239
9.

Matrix metalloproteinase-12 deficiency attenuates experimental crescentic anti-glomerular basement membrane glomerulonephritis.

Abraham AP, Ma FY, Mulley WR, Nikolic-Paterson DJ, Tesch GH.

Nephrology (Carlton). 2018 Feb;23(2):183-189. doi: 10.1111/nep.12964.

PMID:
27862656
10.

Cardiac Tissue Injury and Remodeling Is Dependent Upon MR Regulation of Activation Pathways in Cardiac Tissue Macrophages.

Shen JZ, Morgan J, Tesch GH, Rickard AJ, Chrissobolis S, Drummond GR, Fuller PJ, Young MJ.

Endocrinology. 2016 Aug;157(8):3213-23. doi: 10.1210/en.2016-1040. Epub 2016 Jun 2.

PMID:
27253999
11.

ASK1: a new therapeutic target for kidney disease.

Tesch GH, Ma FY, Nikolic-Paterson DJ.

Am J Physiol Renal Physiol. 2016 Aug 1;311(2):F373-81. doi: 10.1152/ajprenal.00208.2016. Epub 2016 May 25. Review.

12.

Suppression of Rapidly Progressive Mouse Glomerulonephritis with the Non-Steroidal Mineralocorticoid Receptor Antagonist BR-4628.

Ma FY, Han Y, Nikolic-Paterson DJ, Kolkhof P, Tesch GH.

PLoS One. 2015 Dec 23;10(12):e0145666. doi: 10.1371/journal.pone.0145666. eCollection 2015.

13.

Myeloid cell-mediated renal injury in rapidly progressive glomerulonephritis depends upon spleen tyrosine kinase.

Ryan J, Ma FY, Han Y, Ozols E, Kanellis J, Tesch GH, Nikolic-Paterson DJ.

J Pathol. 2016 Jan;238(1):10-20. doi: 10.1002/path.4598. Epub 2015 Sep 22.

PMID:
26251216
14.

ASK1 Inhibitor Halts Progression of Diabetic Nephropathy in Nos3-Deficient Mice.

Tesch GH, Ma FY, Han Y, Liles JT, Breckenridge DG, Nikolic-Paterson DJ.

Diabetes. 2015 Nov;64(11):3903-13. doi: 10.2337/db15-0384. Epub 2015 Jul 15.

15.

Earlier onset of diabesity-Induced adverse cardiac remodeling in female compared to male mice.

Bowden MA, Tesch GH, Julius TL, Rosli S, Love JE, Ritchie RH.

Obesity (Silver Spring). 2015 Jun;23(6):1166-77. doi: 10.1002/oby.21072. Epub 2015 May 9.

16.

Spleen tyrosine kinase contributes to acute renal allograft rejection in the rat.

Ramessur Chandran S, Tesch GH, Han Y, Woodman N, Mulley WR, Kanellis J, Blease K, Ma FY, Nikolic-Paterson DJ.

Int J Exp Pathol. 2015 Feb;96(1):54-62. doi: 10.1111/iep.12110. Epub 2014 Dec 22.

17.

ASK1/p38 signaling in renal tubular epithelial cells promotes renal fibrosis in the mouse obstructed kidney.

Ma FY, Tesch GH, Nikolic-Paterson DJ.

Am J Physiol Renal Physiol. 2014 Dec 1;307(11):F1263-73. doi: 10.1152/ajprenal.00211.2014. Epub 2014 Oct 8.

18.

Myeloid mineralocorticoid receptor activation contributes to progressive kidney disease.

Huang LL, Nikolic-Paterson DJ, Han Y, Ozols E, Ma FY, Young MJ, Tesch GH.

J Am Soc Nephrol. 2014 Oct;25(10):2231-40. doi: 10.1681/ASN.2012111094. Epub 2014 Apr 3.

19.

CCL2-dependent macrophage recruitment is critical for mineralocorticoid receptor-mediated cardiac fibrosis, inflammation, and blood pressure responses in male mice.

Shen JZ, Morgan J, Tesch GH, Fuller PJ, Young MJ.

Endocrinology. 2014 Mar;155(3):1057-66. doi: 10.1210/en.2013-1772. Epub 2014 Jan 15.

PMID:
24428529
20.

Design and pharmacology of a highly specific dual FMS and KIT kinase inhibitor.

Zhang C, Ibrahim PN, Zhang J, Burton EA, Habets G, Zhang Y, Powell B, West BL, Matusow B, Tsang G, Shellooe R, Carias H, Nguyen H, Marimuthu A, Zhang KY, Oh A, Bremer R, Hurt CR, Artis DR, Wu G, Nespi M, Spevak W, Lin P, Nolop K, Hirth P, Tesch GH, Bollag G.

Proc Natl Acad Sci U S A. 2013 Apr 2;110(14):5689-94. doi: 10.1073/pnas.1219457110. Epub 2013 Mar 14.

21.

Role of macrophages in the fibrotic phase of rat crescentic glomerulonephritis.

Han Y, Ma FY, Tesch GH, Manthey CL, Nikolic-Paterson DJ.

Am J Physiol Renal Physiol. 2013 Apr 15;304(8):F1043-53. doi: 10.1152/ajprenal.00389.2012. Epub 2013 Feb 13.

22.

Inflammation in diabetic nephropathy.

Lim AK, Tesch GH.

Mediators Inflamm. 2012;2012:146154. doi: 10.1155/2012/146154. Epub 2012 Aug 21. Review.

23.

Aldosterone induces kidney fibroblast proliferation via activation of growth factor receptors and PI3K/MAPK signalling.

Huang LL, Nikolic-Paterson DJ, Ma FY, Tesch GH.

Nephron Exp Nephrol. 2012;120(4):e115-22. doi: 10.1159/000339500. Epub 2012 Jul 18.

PMID:
22814207
24.

Macrophage mineralocorticoid receptor signaling plays a key role in aldosterone-independent cardiac fibrosis.

Bienvenu LA, Morgan J, Rickard AJ, Tesch GH, Cranston GA, Fletcher EK, Delbridge LM, Young MJ.

Endocrinology. 2012 Jul;153(7):3416-25. doi: 10.1210/en.2011-2098. Epub 2012 May 31.

PMID:
22653557
25.

Evaluation of JNK blockade as an early intervention treatment for type 1 diabetic nephropathy in hypertensive rats.

Lim AK, Ma FY, Nikolic-Paterson DJ, Ozols E, Young MJ, Bennett BL, Friedman GC, Tesch GH.

Am J Nephrol. 2011;34(4):337-46. doi: 10.1159/000331058. Epub 2011 Aug 26.

PMID:
21876346
26.

c-fms blockade reverses glomerular macrophage infiltration and halts development of crescentic anti-GBM glomerulonephritis in the rat.

Han Y, Ma FY, Tesch GH, Manthey CL, Nikolic-Paterson DJ.

Lab Invest. 2011 Jul;91(7):978-91. doi: 10.1038/labinvest.2011.61. Epub 2011 Apr 25.

27.

TGF-β1-activated kinase-1 regulates inflammation and fibrosis in the obstructed kidney.

Ma FY, Tesch GH, Ozols E, Xie M, Schneider MD, Nikolic-Paterson DJ.

Am J Physiol Renal Physiol. 2011 Jun;300(6):F1410-21. doi: 10.1152/ajprenal.00018.2011. Epub 2011 Mar 2.

28.

Recent insights into diabetic renal injury from the db/db mouse model of type 2 diabetic nephropathy.

Tesch GH, Lim AK.

Am J Physiol Renal Physiol. 2011 Feb;300(2):F301-10. doi: 10.1152/ajprenal.00607.2010. Epub 2010 Dec 8. Review.

29.

Review: Serum and urine biomarkers of kidney disease: A pathophysiological perspective.

Tesch GH.

Nephrology (Carlton). 2010 Sep;15(6):609-16. doi: 10.1111/j.1440-1797.2010.01361.x. Review.

PMID:
20883281
30.

Macrophages and diabetic nephropathy.

Tesch GH.

Semin Nephrol. 2010 May;30(3):290-301. doi: 10.1016/j.semnephrol.2010.03.007. Review.

PMID:
20620673
31.

Lymphocytes promote albuminuria, but not renal dysfunction or histological damage in a mouse model of diabetic renal injury.

Lim AK, Ma FY, Nikolic-Paterson DJ, Kitching AR, Thomas MC, Tesch GH.

Diabetologia. 2010 Aug;53(8):1772-82. doi: 10.1007/s00125-010-1757-1. Epub 2010 Apr 27.

PMID:
20422398
32.

Lefty antagonises TGF-beta1 induced epithelial-mesenchymal transition in tubular epithelial cells.

Mariasegaram M, Tesch GH, Verhardt S, Hurst L, Lan HY, Nikolic-Paterson DJ.

Biochem Biophys Res Commun. 2010 Mar 19;393(4):855-9. doi: 10.1016/j.bbrc.2010.02.098. Epub 2010 Feb 18.

PMID:
20171171
33.

Antibody blockade of c-fms suppresses the progression of inflammation and injury in early diabetic nephropathy in obese db/db mice.

Lim AK, Ma FY, Nikolic-Paterson DJ, Thomas MC, Hurst LA, Tesch GH.

Diabetologia. 2009 Aug;52(8):1669-79. doi: 10.1007/s00125-009-1399-3. Epub 2009 May 23.

PMID:
19466391
34.

Blockade of the c-Jun amino terminal kinase prevents crescent formation and halts established anti-GBM glomerulonephritis in the rat.

Ma FY, Flanc RS, Tesch GH, Bennett BL, Friedman GC, Nikolic-Paterson DJ.

Lab Invest. 2009 Apr;89(4):470-84. doi: 10.1038/labinvest.2009.2. Epub 2009 Feb 2.

35.

Role of MKK3-p38 MAPK signalling in the development of type 2 diabetes and renal injury in obese db/db mice.

Lim AK, Nikolic-Paterson DJ, Ma FY, Ozols E, Thomas MC, Flavell RA, Davis RJ, Tesch GH.

Diabetologia. 2009 Feb;52(2):347-58. doi: 10.1007/s00125-008-1215-5. Epub 2008 Dec 9.

PMID:
19066844
36.

In vivo visualization of albumin degradation in the proximal tubule.

Slattery C, Lee A, Zhang Y, Kelly DJ, Thorn P, Nikolic-Paterson DJ, Tesch GH, Poronnik P.

Kidney Int. 2008 Dec;74(11):1480-6. doi: 10.1038/ki.2008.463. Epub 2008 Sep 17.

37.

MKK3 signalling plays an essential role in leukocyte-mediated pancreatic injury in the multiple low-dose streptozotocin model.

Fukuda K, Tesch GH, Yap FY, Forbes JM, Flavell RA, Davis RJ, Nikolic-Paterson DJ.

Lab Invest. 2008 Apr;88(4):398-407. doi: 10.1038/labinvest.2008.10. Epub 2008 Feb 18.

38.

MCP-1/CCL2: a new diagnostic marker and therapeutic target for progressive renal injury in diabetic nephropathy.

Tesch GH.

Am J Physiol Renal Physiol. 2008 Apr;294(4):F697-701. doi: 10.1152/ajprenal.00016.2008. Epub 2008 Feb 13. Review.

39.

c-Jun amino terminal kinase 1 deficient mice are protected from streptozotocin-induced islet injury.

Fukuda K, Tesch GH, Nikolic-Paterson DJ.

Biochem Biophys Res Commun. 2008 Feb 15;366(3):710-6. Epub 2007 Dec 17.

PMID:
18082135
40.

Quantification of renal pathology by image analysis.

Rangan GK, Tesch GH.

Nephrology (Carlton). 2007 Dec;12(6):553-8.

PMID:
17995580
41.

Monocyte chemoattractant protein-1 has prosclerotic effects both in a mouse model of experimental diabetes and in vitro in human mesangial cells.

Giunti S, Tesch GH, Pinach S, Burt DJ, Cooper ME, Cavallo-Perin P, Camussi G, Gruden G.

Diabetologia. 2008 Jan;51(1):198-207. Epub 2007 Oct 30.

PMID:
17968528
42.

Role of macrophages in complications of type 2 diabetes.

Tesch GH.

Clin Exp Pharmacol Physiol. 2007 Oct;34(10):1016-9. Review.

PMID:
17714088
43.

MKK3-p38 signaling promotes apoptosis and the early inflammatory response in the obstructed mouse kidney.

Ma FY, Tesch GH, Flavell RA, Davis RJ, Nikolic-Paterson DJ.

Am J Physiol Renal Physiol. 2007 Nov;293(5):F1556-63. Epub 2007 Aug 8.

44.

A pathogenic role for JNK signaling in experimental anti-GBM glomerulonephritis.

Flanc RS, Ma FY, Tesch GH, Han Y, Atkins RC, Bennett BL, Friedman GC, Fan JH, Nikolic-Paterson DJ.

Kidney Int. 2007 Sep;72(6):698-708. Epub 2007 Jun 27.

45.

Rodent models of streptozotocin-induced diabetic nephropathy.

Tesch GH, Allen TJ.

Nephrology (Carlton). 2007 Jun;12(3):261-6. Review.

PMID:
17498121
46.
47.

A pathogenic role for c-Jun amino-terminal kinase signaling in renal fibrosis and tubular cell apoptosis.

Ma FY, Flanc RS, Tesch GH, Han Y, Atkins RC, Bennett BL, Friedman GC, Fan JH, Nikolic-Paterson DJ.

J Am Soc Nephrol. 2007 Feb;18(2):472-84. Epub 2007 Jan 3.

48.

Monocyte chemoattractant protein-1-induced tissue inflammation is critical for the development of renal injury but not type 2 diabetes in obese db/db mice.

Chow FY, Nikolic-Paterson DJ, Ma FY, Ozols E, Rollins BJ, Tesch GH.

Diabetologia. 2007 Feb;50(2):471-80. Epub 2006 Dec 12.

PMID:
17160673
49.

Recent insights into experimental mouse models of diabetic nephropathy.

Tesch GH, Nikolic-Paterson DJ.

Nephron Exp Nephrol. 2006;104(2):e57-62. Epub 2006 Jun 19. Review.

50.

Treatment of tissue sections for in situ hybridization.

Tesch GH, Lan HY, Nikolic-Paterson DJ.

Methods Mol Biol. 2006;326:1-7. Review.

PMID:
16780190

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