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Items: 1 to 50 of 70

1.

Developing therapeutic strategies to promote myelin repair in multiple sclerosis.

Baldassari LE, Feng J, Clayton BLL, Oh SH, Sakaie K, Tesar PJ, Wang Y, Cohen JA.

Expert Rev Neurother. 2019 Jun 19. doi: 10.1080/14737175.2019.1632192. [Epub ahead of print]

PMID:
31215271
2.

Diverse Chemical Scaffolds Enhance Oligodendrocyte Formation by Inhibiting CYP51, TM7SF2, or EBP.

Allimuthu D, Hubler Z, Najm FJ, Tang H, Bederman I, Seibel W, Tesar PJ, Adams DJ.

Cell Chem Biol. 2019 Apr 18;26(4):593-599.e4. doi: 10.1016/j.chembiol.2019.01.004. Epub 2019 Feb 14.

PMID:
30773481
3.

NG2 expression in NG2 glia is regulated by binding of SoxE and bHLH transcription factors to a Cspg4 intronic enhancer.

Gotoh H, Wood WM, Patel KD, Factor DC, Boshans LL, Nomura T, Tesar PJ, Ono K, Nishiyama A.

Glia. 2018 Dec;66(12):2684-2699. doi: 10.1002/glia.23521. Epub 2018 Oct 10.

PMID:
30306660
4.

Rapid functional genetics of the oligodendrocyte lineage using pluripotent stem cells.

Lager AM, Corradin OG, Cregg JM, Elitt MS, Shick HE, Clayton BLL, Allan KC, Olsen HE, Madhavan M, Tesar PJ.

Nat Commun. 2018 Sep 13;9(1):3708. doi: 10.1038/s41467-018-06102-7.

5.

Chemical Screening Identifies Enhancers of Mutant Oligodendrocyte Survival and Unmasks a Distinct Pathological Phase in Pelizaeus-Merzbacher Disease.

Elitt MS, Shick HE, Madhavan M, Allan KC, Clayton BLL, Weng C, Miller TE, Factor DC, Barbar L, Nawash BS, Nevin ZS, Lager AM, Li Y, Jin F, Adams DJ, Tesar PJ.

Stem Cell Reports. 2018 Sep 11;11(3):711-726. doi: 10.1016/j.stemcr.2018.07.015. Epub 2018 Aug 23.

6.

Accumulation of 8,9-unsaturated sterols drives oligodendrocyte formation and remyelination.

Hubler Z, Allimuthu D, Bederman I, Elitt MS, Madhavan M, Allan KC, Shick HE, Garrison E, T Karl M, Factor DC, Nevin ZS, Sax JL, Thompson MA, Fedorov Y, Jin J, Wilson WK, Giera M, Bracher F, Miller RH, Tesar PJ, Adams DJ.

Nature. 2018 Aug;560(7718):372-376. doi: 10.1038/s41586-018-0360-3. Epub 2018 Jul 25.

7.

Induction of myelinating oligodendrocytes in human cortical spheroids.

Madhavan M, Nevin ZS, Shick HE, Garrison E, Clarkson-Paredes C, Karl M, Clayton BLL, Factor DC, Allan KC, Barbar L, Jain T, Douvaras P, Fossati V, Miller RH, Tesar PJ.

Nat Methods. 2018 Sep;15(9):700-706. doi: 10.1038/s41592-018-0081-4. Epub 2018 Jul 25.

8.

Drug screening for human genetic diseases using iPSC models.

Elitt MS, Barbar L, Tesar PJ.

Hum Mol Genet. 2018 Aug 1;27(R2):R89-R98. doi: 10.1093/hmg/ddy186. Review.

PMID:
29771306
9.

Physiological genomics identifies genetic modifiers of long QT syndrome type 2 severity.

Chai S, Wan X, Ramirez-Navarro A, Tesar PJ, Kaufman ES, Ficker E, George AL Jr, Deschênes I.

J Clin Invest. 2018 Mar 1;128(3):1043-1056. doi: 10.1172/JCI94996. Epub 2018 Feb 12.

10.

iPSC Reprogramming Is Not Just an Open and Shut Case.

Scacheri PC, Tesar PJ.

Cell Stem Cell. 2017 Dec 7;21(6):711-712. doi: 10.1016/j.stem.2017.11.017.

11.

Clemastine fumarate for promotion of optic nerve remyelination.

Cohen JA, Tesar PJ.

Lancet. 2017 Dec 2;390(10111):2421-2422. doi: 10.1016/S0140-6736(17)32639-9. Epub 2017 Oct 10. No abstract available.

PMID:
29029894
12.

Human iPSC Glial Mouse Chimeras Reveal Glial Contributions to Schizophrenia.

Windrem MS, Osipovitch M, Liu Z, Bates J, Chandler-Militello D, Zou L, Munir J, Schanz S, McCoy K, Miller RH, Wang S, Nedergaard M, Findling RL, Tesar PJ, Goldman SA.

Cell Stem Cell. 2017 Aug 3;21(2):195-208.e6. doi: 10.1016/j.stem.2017.06.012. Epub 2017 Jul 20.

13.

Transcription elongation factors represent in vivo cancer dependencies in glioblastoma.

Miller TE, Liau BB, Wallace LC, Morton AR, Xie Q, Dixit D, Factor DC, Kim LJY, Morrow JJ, Wu Q, Mack SC, Hubert CG, Gillespie SM, Flavahan WA, Hoffmann T, Thummalapalli R, Hemann MT, Paddison PJ, Horbinski CM, Zuber J, Scacheri PC, Bernstein BE, Tesar PJ, Rich JN.

Nature. 2017 Jul 20;547(7663):355-359. doi: 10.1038/nature23000. Epub 2017 Jul 5.

14.

Modeling the Mutational and Phenotypic Landscapes of Pelizaeus-Merzbacher Disease with Human iPSC-Derived Oligodendrocytes.

Nevin ZS, Factor DC, Karl RT, Douvaras P, Laukka J, Windrem MS, Goldman SA, Fossati V, Hobson GM, Tesar PJ.

Am J Hum Genet. 2017 Apr 6;100(4):617-634. doi: 10.1016/j.ajhg.2017.03.005. Epub 2017 Mar 30.

15.

Snapshots of Pluripotency.

Tesar PJ.

Stem Cell Reports. 2016 Feb 9;6(2):163-7. doi: 10.1016/j.stemcr.2015.12.011. Epub 2016 Jan 28.

16.

Depletion of Olig2 in oligodendrocyte progenitor cells infected by Theiler's murine encephalomyelitis virus.

Benner B, Martorell AJ, Mahadevan P, Najm FJ, Tesar PJ, Freundt EC.

J Neurovirol. 2016 Jun;22(3):336-48. doi: 10.1007/s13365-015-0402-7. Epub 2015 Dec 2.

PMID:
26631080
17.

Preferential Iron Trafficking Characterizes Glioblastoma Stem-like Cells.

Schonberg DL, Miller TE, Wu Q, Flavahan WA, Das NK, Hale JS, Hubert CG, Mack SC, Jarrar AM, Karl RT, Rosager AM, Nixon AM, Tesar PJ, Hamerlik P, Kristensen BW, Horbinski C, Connor JR, Fox PL, Lathia JD, Rich JN.

Cancer Cell. 2015 Oct 12;28(4):441-455. doi: 10.1016/j.ccell.2015.09.002.

18.

Drug-based modulation of endogenous stem cells promotes functional remyelination in vivo.

Najm FJ, Madhavan M, Zaremba A, Shick E, Karl RT, Factor DC, Miller TE, Nevin ZS, Kantor C, Sargent A, Quick KL, Schlatzer DM, Tang H, Papoian R, Brimacombe KR, Shen M, Boxer MB, Jadhav A, Robinson AP, Podojil JR, Miller SD, Miller RH, Tesar PJ.

Nature. 2015 Jun 11;522(7555):216-20. doi: 10.1038/nature14335. Epub 2015 Apr 20.

19.

Lgr5 Marks Post-Mitotic, Lineage Restricted Cerebellar Granule Neurons during Postnatal Development.

Miller TE, Wang J, Sukhdeo K, Horbinski C, Tesar PJ, Wechsler-Reya RJ, Rich JN.

PLoS One. 2014 Dec 10;9(12):e114433. doi: 10.1371/journal.pone.0114433. eCollection 2014.

20.

Epigenomic comparison reveals activation of "seed" enhancers during transition from naive to primed pluripotency.

Factor DC, Corradin O, Zentner GE, Saiakhova A, Song L, Chenoweth JG, McKay RD, Crawford GE, Scacheri PC, Tesar PJ.

Cell Stem Cell. 2014 Jun 5;14(6):854-63. doi: 10.1016/j.stem.2014.05.005.

21.

Long-term outcomes following Medtronic Open Pivot valved conduit.

Naidoo R, Pearse B, Tesar PJ, Yap SA, Barnett AG, Fayers T.

J Heart Valve Dis. 2014 Jan;23(1):105-11.

PMID:
24779336
22.

The silent and apparent neurological injury in transcatheter aortic valve implantation study (SANITY): concept, design and rationale.

Fanning JP, Wesley AJ, Platts DG, Walters DL, Eeles EM, Seco M, Tronstad O, Strugnell W, Barnett AG, Clarke AJ, Bellapart J, Vallely MP, Tesar PJ, Fraser JF.

BMC Cardiovasc Disord. 2014 Apr 5;14:45. doi: 10.1186/1471-2261-14-45.

23.

Derivation of naive human embryonic stem cells.

Ware CB, Nelson AM, Mecham B, Hesson J, Zhou W, Jonlin EC, Jimenez-Caliani AJ, Deng X, Cavanaugh C, Cook S, Tesar PJ, Okada J, Margaretha L, Sperber H, Choi M, Blau CA, Treuting PM, Hawkins RD, Cirulli V, Ruohola-Baker H.

Proc Natl Acad Sci U S A. 2014 Mar 25;111(12):4484-9. doi: 10.1073/pnas.1319738111. Epub 2014 Mar 12.

24.

NPTX1 regulates neural lineage specification from human pluripotent stem cells.

Boles NC, Hirsch SE, Le S, Corneo B, Najm F, Minotti AP, Wang Q, Lotz S, Tesar PJ, Fasano CA.

Cell Rep. 2014 Feb 27;6(4):724-36. doi: 10.1016/j.celrep.2014.01.026. Epub 2014 Feb 13.

25.

Retinal pigmented epithelial cells obtained from human induced pluripotent stem cells possess functional visual cycle enzymes in vitro and in vivo.

Maeda T, Lee MJ, Palczewska G, Marsili S, Tesar PJ, Palczewski K, Takahashi M, Maeda A.

J Biol Chem. 2013 Nov 29;288(48):34484-93. doi: 10.1074/jbc.M113.518571. Epub 2013 Oct 15.

26.

Long-term clinical outcomes after aortic valve replacement using cryopreserved aortic allograft.

Fukushima S, Tesar PJ, Pearse B, Jalali H, Sparks L, Fraser JF, Pohlner PG.

J Thorac Cardiovasc Surg. 2014 Jul;148(1):65-72.e2. doi: 10.1016/j.jtcvs.2013.07.038. Epub 2013 Sep 8.

27.

Generation and characterization of epiblast stem cells from blastocyst-stage mouse embryos.

Factor DC, Najm FJ, Tesar PJ.

Methods Mol Biol. 2013;1074:1-13. doi: 10.1007/978-1-62703-628-3_1.

PMID:
23975801
28.

Contrasting effects of Deadend1 (Dnd1) gain and loss of function mutations on allelic inheritance, testicular cancer, and intestinal polyposis.

Zechel JL, Doerner SK, Lager A, Tesar PJ, Heaney JD, Nadeau JH.

BMC Genet. 2013 Jun 17;14:54. doi: 10.1186/1471-2156-14-54.

29.

Transcription factor-mediated reprogramming of fibroblasts to expandable, myelinogenic oligodendrocyte progenitor cells.

Najm FJ, Lager AM, Zaremba A, Wyatt K, Caprariello AV, Factor DC, Karl RT, Maeda T, Miller RH, Tesar PJ.

Nat Biotechnol. 2013 May;31(5):426-33. doi: 10.1038/nbt.2561. Epub 2013 Apr 14.

30.

Transcription elongation factor Tcea3 regulates the pluripotent differentiation potential of mouse embryonic stem cells via the Lefty1-Nodal-Smad2 pathway.

Park KS, Cha Y, Kim CH, Ahn HJ, Kim D, Ko S, Kim KH, Chang MY, Ko JH, Noh YS, Han YM, Kim J, Song J, Kim JY, Tesar PJ, Lanza R, Lee KA, Kim KS.

Stem Cells. 2013 Feb;31(2):282-92. doi: 10.1002/stem.1284.

31.

StemCellDB: the human pluripotent stem cell database at the National Institutes of Health.

Mallon BS, Chenoweth JG, Johnson KR, Hamilton RS, Tesar PJ, Yavatkar AS, Tyson LJ, Park K, Chen KG, Fann YC, McKay RD.

Stem Cell Res. 2013 Jan;10(1):57-66. doi: 10.1016/j.scr.2012.09.002. Epub 2012 Sep 26.

32.

Transcriptional regulatory networks in epiblast cells and during anterior neural plate development as modeled in epiblast stem cells.

Iwafuchi-Doi M, Matsuda K, Murakami K, Niwa H, Tesar PJ, Aruga J, Matsuo I, Kondoh H.

Development. 2012 Nov;139(21):3926-37. doi: 10.1242/dev.085936. Epub 2012 Sep 19. Erratum in: Development. 2012 Dec;139(24):4675.

33.

Transgenerational epigenetic effects of the Apobec1 cytidine deaminase deficiency on testicular germ cell tumor susceptibility and embryonic viability.

Nelson VR, Heaney JD, Tesar PJ, Davidson NO, Nadeau JH.

Proc Natl Acad Sci U S A. 2012 Oct 9;109(41):E2766-73. doi: 10.1073/pnas.1207169109. Epub 2012 Aug 24.

34.

DNA and chromatin modification networks distinguish stem cell pluripotent ground states.

Song J, Saha S, Gokulrangan G, Tesar PJ, Ewing RM.

Mol Cell Proteomics. 2012 Oct;11(10):1036-47. Epub 2012 Jul 22.

35.

Epigenomic enhancer profiling defines a signature of colon cancer.

Akhtar-Zaidi B, Cowper-Sal-lari R, Corradin O, Saiakhova A, Bartels CF, Balasubramanian D, Myeroff L, Lutterbaugh J, Jarrar A, Kalady MF, Willis J, Moore JH, Tesar PJ, Laframboise T, Markowitz S, Lupien M, Scacheri PC.

Science. 2012 May 11;336(6082):736-9. doi: 10.1126/science.1217277. Epub 2012 Apr 12.

36.

Accessing naïve human pluripotency.

De Los Angeles A, Loh YH, Tesar PJ, Daley GQ.

Curr Opin Genet Dev. 2012 Jun;22(3):272-82. doi: 10.1016/j.gde.2012.03.001. Epub 2012 Mar 29. Review.

37.

Direct and indirect contribution of human embryonic stem cell-derived hepatocyte-like cells to liver repair in mice.

Woo DH, Kim SK, Lim HJ, Heo J, Park HS, Kang GY, Kim SE, You HJ, Hoeppner DJ, Kim Y, Kwon H, Choi TH, Lee JH, Hong SH, Song KW, Ahn EK, Chenoweth JG, Tesar PJ, McKay RD, Kim JH.

Gastroenterology. 2012 Mar;142(3):602-11. doi: 10.1053/j.gastro.2011.11.030. Epub 2011 Dec 2.

PMID:
22138358
38.

Tracking down the human myelinating cell.

Miller RH, Tesar PJ.

Nat Biotechnol. 2011 Oct 13;29(10):881-3. doi: 10.1038/nbt.2004. No abstract available.

PMID:
21997628
39.

Rapid and robust generation of functional oligodendrocyte progenitor cells from epiblast stem cells.

Najm FJ, Zaremba A, Caprariello AV, Nayak S, Freundt EC, Scacheri PC, Miller RH, Tesar PJ.

Nat Methods. 2011 Sep 25;8(11):957-62. doi: 10.1038/nmeth.1712.

40.

Risk factors and survival in patients with respiratory failure after cardiac operations.

Bailey ML, Richter SM, Mullany DV, Tesar PJ, Fraser JF.

Ann Thorac Surg. 2011 Nov;92(5):1573-9. doi: 10.1016/j.athoracsur.2011.04.019. Epub 2011 Oct 31.

PMID:
21855851
41.

Epigenetic signatures distinguish multiple classes of enhancers with distinct cellular functions.

Zentner GE, Tesar PJ, Scacheri PC.

Genome Res. 2011 Aug;21(8):1273-83. doi: 10.1101/gr.122382.111. Epub 2011 Jun 1.

42.

Isolation of epiblast stem cells from preimplantation mouse embryos.

Najm FJ, Chenoweth JG, Anderson PD, Nadeau JH, Redline RW, McKay RD, Tesar PJ.

Cell Stem Cell. 2011 Mar 4;8(3):318-25. doi: 10.1016/j.stem.2011.01.016.

43.

CHD7 functions in the nucleolus as a positive regulator of ribosomal RNA biogenesis.

Zentner GE, Hurd EA, Schnetz MP, Handoko L, Wang C, Wang Z, Wei C, Tesar PJ, Hatzoglou M, Martin DM, Scacheri PC.

Hum Mol Genet. 2010 Sep 15;19(18):3491-501. doi: 10.1093/hmg/ddq265. Epub 2010 Jun 29.

44.

Isolation and maintenance of mouse epiblast stem cells.

Chenoweth JG, Tesar PJ.

Methods Mol Biol. 2010;636:25-44. doi: 10.1007/978-1-60761-691-7_2.

PMID:
20336514
45.

Epiblast stem cells contribute new insight into pluripotency and gastrulation.

Chenoweth JG, McKay RD, Tesar PJ.

Dev Growth Differ. 2010 Apr;52(3):293-301. doi: 10.1111/j.1440-169X.2010.01171.x. Epub 2010 Mar 7. Review.

PMID:
20298258
46.

Genetic factors on mouse chromosome 18 affecting susceptibility to testicular germ cell tumors and permissiveness to embryonic stem cell derivation.

Anderson PD, Nelson VR, Tesar PJ, Nadeau JH.

Cancer Res. 2009 Dec 1;69(23):9112-7. doi: 10.1158/0008-5472.CAN-09-3342. Epub 2009 Nov 24.

47.

Determinants of in-hospital and long-term surgical outcomes after repair of postinfarction ventricular septal rupture.

Fukushima S, Tesar PJ, Jalali H, Clarke AJ, Sharma H, Choudhary J, Bartlett H, Pohlner PG.

J Thorac Cardiovasc Surg. 2010 Jul;140(1):59-65. doi: 10.1016/j.jtcvs.2009.09.018. Epub 2009 Nov 17.

48.

Re-do aortic root replacement after an allograft aortic root replacement.

Vrtik M, Tesar PJ.

Ann Thorac Surg. 2009 Oct;88(4):1365-6. doi: 10.1016/j.athoracsur.2008.12.100.

PMID:
19766851
49.

Vascular obstruction related to mediastinal fibrosis: an interesting clinical entity.

Saxena P, Tesar PJ.

J Thorac Cardiovasc Surg. 2007 Nov;134(5):1379; author reply 1379-80. No abstract available.

50.

Identification and characterization of cell type-specific and ubiquitous chromatin regulatory structures in the human genome.

Xi H, Shulha HP, Lin JM, Vales TR, Fu Y, Bodine DM, McKay RD, Chenoweth JG, Tesar PJ, Furey TS, Ren B, Weng Z, Crawford GE.

PLoS Genet. 2007 Aug;3(8):e136. Epub 2007 Jul 2.

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