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Items: 50

1.

Aggregated Tau activates NLRP3-ASC inflammasome exacerbating exogenously seeded and non-exogenously seeded Tau pathology in vivo.

Stancu IC, Cremers N, Vanrusselt H, Couturier J, Vanoosthuyse A, Kessels S, Lodder C, Brône B, Huaux F, Octave JN, Terwel D, Dewachter I.

Acta Neuropathol. 2019 Apr;137(4):599-617. doi: 10.1007/s00401-018-01957-y. Epub 2019 Feb 5.

2.

Long-Term Treatment with Liraglutide, a Glucagon-Like Peptide-1 (GLP-1) Receptor Agonist, Has No Effect on β-Amyloid Plaque Load in Two Transgenic APP/PS1 Mouse Models of Alzheimer's Disease.

Hansen HH, Fabricius K, Barkholt P, Kongsbak-Wismann P, Schlumberger C, Jelsing J, Terwel D, Termont A, Pyke C, Knudsen LB, Vrang N.

PLoS One. 2016 Jul 15;11(7):e0158205. doi: 10.1371/journal.pone.0158205. eCollection 2016.

3.

The GLP-1 receptor agonist liraglutide reduces pathology-specific tau phosphorylation and improves motor function in a transgenic hTauP301L mouse model of tauopathy.

Hansen HH, Barkholt P, Fabricius K, Jelsing J, Terwel D, Pyke C, Knudsen LB, Vrang N.

Brain Res. 2016 Mar 1;1634:158-170. doi: 10.1016/j.brainres.2015.12.052. Epub 2015 Dec 31.

PMID:
26746341
4.

Templated misfolding of Tau by prion-like seeding along neuronal connections impairs neuronal network function and associated behavioral outcomes in Tau transgenic mice.

Stancu IC, Vasconcelos B, Ris L, Wang P, Villers A, Peeraer E, Buist A, Terwel D, Baatsen P, Oyelami T, Pierrot N, Casteels C, Bormans G, Kienlen-Campard P, Octave JN, Moechars D, Dewachter I.

Acta Neuropathol. 2015 Jun;129(6):875-94. doi: 10.1007/s00401-015-1413-4. Epub 2015 Apr 11.

5.

CXCR3 promotes plaque formation and behavioral deficits in an Alzheimer's disease model.

Krauthausen M, Kummer MP, Zimmermann J, Reyes-Irisarri E, Terwel D, Bulic B, Heneka MT, Müller M.

J Clin Invest. 2015 Jan;125(1):365-78. doi: 10.1172/JCI66771. Epub 2014 Dec 15.

6.

Models of β-amyloid induced Tau-pathology: the long and "folded" road to understand the mechanism.

Stancu IC, Vasconcelos B, Terwel D, Dewachter I.

Mol Neurodegener. 2014 Nov 18;9:51. doi: 10.1186/1750-1326-9-51. Review.

7.

Combined treatment with a BACE inhibitor and anti-Aβ antibody gantenerumab enhances amyloid reduction in APPLondon mice.

Jacobsen H, Ozmen L, Caruso A, Narquizian R, Hilpert H, Jacobsen B, Terwel D, Tanghe A, Bohrmann B.

J Neurosci. 2014 Aug 27;34(35):11621-30. doi: 10.1523/JNEUROSCI.1405-14.2014.

8.

Ear2 deletion causes early memory and learning deficits in APP/PS1 mice.

Kummer MP, Hammerschmidt T, Martinez A, Terwel D, Eichele G, Witten A, Figura S, Stoll M, Schwartz S, Pape HC, Schultze JL, Weinshenker D, Heneka MT, Urban I.

J Neurosci. 2014 Jun 25;34(26):8845-54. doi: 10.1523/JNEUROSCI.4027-13.2014. Erratum in: J Neurosci. 2015 Feb 4;35(5):2321. Urban, Inga [Added].

9.

Effects of sub-chronic donepezil on brain Abeta and cognition in a mouse model of Alzheimer's disease.

Easton A, Sankaranarayanan S, Tanghe A, Terwel D, Lin AX, Hoque N, Bourin C, Gu H, Ahlijanian M, Bristow L.

Psychopharmacology (Berl). 2013 Nov;230(2):279-89. doi: 10.1007/s00213-013-3152-3. Epub 2013 Jun 20.

PMID:
23783773
10.

Selective loss of noradrenaline exacerbates early cognitive dysfunction and synaptic deficits in APP/PS1 mice.

Hammerschmidt T, Kummer MP, Terwel D, Martinez A, Gorji A, Pape HC, Rommelfanger KS, Schroeder JP, Stoll M, Schultze J, Weinshenker D, Heneka MT.

Biol Psychiatry. 2013 Mar 1;73(5):454-63. doi: 10.1016/j.biopsych.2012.06.013. Epub 2012 Aug 9.

11.

Nitration of tyrosine 10 critically enhances amyloid β aggregation and plaque formation.

Kummer MP, Hermes M, Delekarte A, Hammerschmidt T, Kumar S, Terwel D, Walter J, Pape HC, König S, Roeber S, Jessen F, Klockgether T, Korte M, Heneka MT.

Neuron. 2011 Sep 8;71(5):833-44. doi: 10.1016/j.neuron.2011.07.001.

12.

Critical role of astroglial apolipoprotein E and liver X receptor-α expression for microglial Aβ phagocytosis.

Terwel D, Steffensen KR, Verghese PB, Kummer MP, Gustafsson JÅ, Holtzman DM, Heneka MT.

J Neurosci. 2011 May 11;31(19):7049-59. doi: 10.1523/JNEUROSCI.6546-10.2011.

13.

Extracellular phosphorylation of the amyloid β-peptide promotes formation of toxic aggregates during the pathogenesis of Alzheimer's disease.

Kumar S, Rezaei-Ghaleh N, Terwel D, Thal DR, Richard M, Hoch M, Mc Donald JM, Wüllner U, Glebov K, Heneka MT, Walsh DM, Zweckstetter M, Walter J.

EMBO J. 2011 Jun 1;30(11):2255-65. doi: 10.1038/emboj.2011.138. Epub 2011 Apr 28.

14.

Neuroinflammatory and behavioural changes in the Atp7B mutant mouse model of Wilson's disease.

Terwel D, Löschmann YN, Schmidt HH, Schöler HR, Cantz T, Heneka MT.

J Neurochem. 2011 Jul;118(1):105-12. doi: 10.1111/j.1471-4159.2011.07278.x. Epub 2011 May 19.

15.

Distinct adrenergic system changes and neuroinflammation in response to induced locus ceruleus degeneration in APP/PS1 transgenic mice.

Jardanhazi-Kurutz D, Kummer MP, Terwel D, Vogel K, Thiele A, Heneka MT.

Neuroscience. 2011 Mar 10;176:396-407. doi: 10.1016/j.neuroscience.2010.11.052. Epub 2010 Dec 1.

PMID:
21129451
16.

Locus coeruleus degeneration exacerbates olfactory deficits in APP/PS1 transgenic mice.

Rey NL, Jardanhazi-Kurutz D, Terwel D, Kummer MP, Jourdan F, Didier A, Heneka MT.

Neurobiol Aging. 2012 Feb;33(2):426.e1-11. doi: 10.1016/j.neurobiolaging.2010.10.009. Epub 2010 Nov 24.

PMID:
21109328
17.

Restraint stress increases neuroinflammation independently of amyloid β levels in amyloid precursor protein/PS1 transgenic mice.

Perez Nievas BG, Hammerschmidt T, Kummer MP, Terwel D, Leza JC, Heneka MT.

J Neurochem. 2011 Jan;116(1):43-52. doi: 10.1111/j.1471-4159.2010.07083.x. Epub 2010 Dec 2.

18.

Serine-409 phosphorylation and oxidative damage define aggregation of human protein tau in yeast.

Vanhelmont T, Vandebroek T, De Vos A, Terwel D, Lemaire K, Anandhakumar J, Franssens V, Swinnen E, Van Leuven F, Winderickx J.

FEMS Yeast Res. 2010 Dec;10(8):992-1005. doi: 10.1111/j.1567-1364.2010.00662.x.

19.

Neuroinflammatory processes in Alzheimer's disease.

Heneka MT, O'Banion MK, Terwel D, Kummer MP.

J Neural Transm (Vienna). 2010 Aug;117(8):919-47. doi: 10.1007/s00702-010-0438-z. Epub 2010 Jul 15. Review.

PMID:
20632195
20.

Locus ceruleus controls Alzheimer's disease pathology by modulating microglial functions through norepinephrine.

Heneka MT, Nadrigny F, Regen T, Martinez-Hernandez A, Dumitrescu-Ozimek L, Terwel D, Jardanhazi-Kurutz D, Walter J, Kirchhoff F, Hanisch UK, Kummer MP.

Proc Natl Acad Sci U S A. 2010 Mar 30;107(13):6058-63. doi: 10.1073/pnas.0909586107. Epub 2010 Mar 15.

21.

Induced LC degeneration in APP/PS1 transgenic mice accelerates early cerebral amyloidosis and cognitive deficits.

Jardanhazi-Kurutz D, Kummer MP, Terwel D, Vogel K, Dyrks T, Thiele A, Heneka MT.

Neurochem Int. 2010 Nov;57(4):375-82. doi: 10.1016/j.neuint.2010.02.001. Epub 2010 Feb 6.

PMID:
20144675
22.

NOS2 gene deficiency protects from sepsis-induced long-term cognitive deficits.

Weberpals M, Hermes M, Hermann S, Kummer MP, Terwel D, Semmler A, Berger M, Schäfers M, Heneka MT.

J Neurosci. 2009 Nov 11;29(45):14177-84. doi: 10.1523/JNEUROSCI.3238-09.2009.

23.

PPARgamma and RXRgamma ligands act synergistically as potent antineoplastic agents in vitro and in vivo glioma models.

Papi A, Tatenhorst L, Terwel D, Hermes M, Kummer MP, Orlandi M, Heneka MT.

J Neurochem. 2009 Jun;109(6):1779-90. doi: 10.1111/j.1471-4159.2009.06111.x. Epub 2009 May 11.

24.

Amyloid activates GSK-3beta to aggravate neuronal tauopathy in bigenic mice.

Terwel D, Muyllaert D, Dewachter I, Borghgraef P, Croes S, Devijver H, Van Leuven F.

Am J Pathol. 2008 Mar;172(3):786-98. doi: 10.2353/ajpath.2008.070904. Epub 2008 Feb 7.

25.

Neurodegeneration and neuroinflammation in cdk5/p25-inducible mice: a model for hippocampal sclerosis and neocortical degeneration.

Muyllaert D, Terwel D, Kremer A, Sennvik K, Borghgraef P, Devijver H, Dewachter I, Van Leuven F.

Am J Pathol. 2008 Feb;172(2):470-85. doi: 10.2353/ajpath.2008.070693. Epub 2008 Jan 17.

26.

Deregulation of NMDA-receptor function and down-stream signaling in APP[V717I] transgenic mice.

Dewachter I, Filipkowski RK, Priller C, Ris L, Neyton J, Croes S, Terwel D, Gysemans M, Devijver H, Borghgraef P, Godaux E, Kaczmarek L, Herms J, Van Leuven F.

Neurobiol Aging. 2009 Feb;30(2):241-56. Epub 2007 Jul 27.

PMID:
17673336
27.

Tau-4R suppresses proliferation and promotes neuronal differentiation in the hippocampus of tau knockin/knockout mice.

Sennvik K, Boekhoorn K, Lasrado R, Terwel D, Verhaeghe S, Korr H, Schmitz C, Tomiyama T, Mori H, Krugers H, Joels M, Ramakers GJ, Lucassen PJ, Van Leuven F.

FASEB J. 2007 Jul;21(9):2149-61. Epub 2007 Mar 6.

PMID:
17341679
28.

Transgenic mouse models for Alzheimer's disease: the role of GSK-3B in combined amyloid and tau-pathology.

Muyllaert D, Terwel D, Borghgraef P, Devijver H, Dewachter I, Van Leuven F.

Rev Neurol (Paris). 2006 Oct;162(10):903-7.

PMID:
17028556
29.

Microtubule binding and clustering of human Tau-4R and Tau-P301L proteins isolated from yeast deficient in orthologues of glycogen synthase kinase-3beta or cdk5.

Vandebroek T, Terwel D, Vanhelmont T, Gysemans M, Van Haesendonck C, Engelborghs Y, Winderickx J, Van Leuven F.

J Biol Chem. 2006 Sep 1;281(35):25388-97. Epub 2006 Jul 3.

30.

Improved long-term potentiation and memory in young tau-P301L transgenic mice before onset of hyperphosphorylation and tauopathy.

Boekhoorn K, Terwel D, Biemans B, Borghgraef P, Wiegert O, Ramakers GJ, de Vos K, Krugers H, Tomiyama T, Mori H, Joels M, van Leuven F, Lucassen PJ.

J Neurosci. 2006 Mar 29;26(13):3514-23.

31.

Identification and isolation of a hyperphosphorylated, conformationally changed intermediate of human protein tau expressed in yeast.

Vandebroek T, Vanhelmont T, Terwel D, Borghgraef P, Lemaire K, Snauwaert J, Wera S, Van Leuven F, Winderickx J.

Biochemistry. 2005 Aug 30;44(34):11466-75.

PMID:
16114883
32.

Changed conformation of mutant Tau-P301L underlies the moribund tauopathy, absent in progressive, nonlethal axonopathy of Tau-4R/2N transgenic mice.

Terwel D, Lasrado R, Snauwaert J, Vandeweert E, Van Haesendonck C, Borghgraef P, Van Leuven F.

J Biol Chem. 2005 Feb 4;280(5):3963-73. Epub 2004 Oct 27.

33.

Axonal transport, tau protein, and neurodegeneration in Alzheimer's disease.

Terwel D, Dewachter I, Van Leuven F.

Neuromolecular Med. 2002;2(2):151-65. Review.

PMID:
12428809
34.

Neonatal neuronal overexpression of glycogen synthase kinase-3 beta reduces brain size in transgenic mice.

Spittaels K, Van den Haute C, Van Dorpe J, Terwel D, Vandezande K, Lasrado R, Bruynseels K, Irizarry M, Verhoye M, Van Lint J, Vandenheede JR, Ashton D, Mercken M, Loos R, Hyman B, Van der Linden A, Geerts H, Van Leuven F.

Neuroscience. 2002;113(4):797-808.

PMID:
12182887
35.

Apolipoprotein E protects against neuropathology induced by a high-fat diet and maintains the integrity of the blood-brain barrier during aging.

Mulder M, Blokland A, van den Berg DJ, Schulten H, Bakker AH, Terwel D, Honig W, de Kloet ER, Havekes LM, Steinbusch HW, de Lange EC.

Lab Invest. 2001 Jul;81(7):953-60.

PMID:
11454984
36.

S-nitroso-N-acetylpenicillamine and nitroprusside induce apoptosis in a neuronal cell line by the production of different reactive molecules.

Terwel D, Nieland LJ, Schutte B, Reutelingsperger CP, Ramaekers FC, Steinbusch HW.

Eur J Pharmacol. 2000 Jul 14;400(1):19-33.

PMID:
10913581
37.
38.
39.

Affected enzyme activities in Alzheimer's disease are sensitive to antemortem hypoxia.

Terwel D, Bothmer J, Wolf E, Meng F, Jolles J.

J Neurol Sci. 1998 Nov 26;161(1):47-56.

PMID:
9879681
40.

Brain enzyme activities after intracerebroventricular injection of streptozotocin in rats receiving acetyl-L-carnitine.

Terwel D, Prickaerts J, Meng F, Jolles J.

Eur J Pharmacol. 1995 Dec 4;287(1):65-71.

PMID:
8666027
41.
42.

Properties of aminopeptidase activity involved in the conversion of vasopressin by rat brain membranes.

Burbach JP, De Bree FM, Terwel D, Tan A, Maskova HP, Van der Kleij AA.

Peptides. 1993 Jul-Aug;14(4):807-13. Erratum in: Peptides 1994;15(5):933.

PMID:
7993391
43.

Pitfalls in the measurement of plasma osmolality pertinent to research in vasopressin and water metabolism.

Bohnen N, Terwel D, Markerink M, Ten Haaf JA, Jolles J.

Clin Chem. 1992 Nov;38(11):2278-80.

44.
45.

Comparative structural analysis of the transcriptionally active proopiomelanocortin genes A and B of Xenopus laevis.

Deen PM, Bussemakers MJ, Terwel D, Roubos EW, Martens GJ.

Mol Biol Evol. 1992 May;9(3):483-94.

PMID:
1584015
46.

Changes in plasma vasopressin concentration and plasma osmolality in relation to age and time of day in the male Wistar rat.

Terwel D, ten Haaf JA, Markerink M, Jolles J.

Acta Endocrinol (Copenh). 1992 Apr;126(4):357-62.

PMID:
1595328
47.

Inverse relationship between plasma vasopressin and intracranial pressure.

Bohnen N, Twijnstra A, Terwel D, Jolles J.

Horm Metab Res. 1992 Mar;24(3):141-2. No abstract available.

PMID:
1577405
48.

Structural analysis of the entire proopiomelanocortin gene of Xenopus laevis.

Deen PM, Terwel D, Bussemakers MJ, Roubos EW, Martens GJ.

Eur J Biochem. 1991 Oct 1;201(1):129-37.

49.

Csf arginine-vasopressin decreases during dehydration in a patient with post-traumatic diabetes insipidus.

Bohnen N, Twijnstra A, Terwel D, Jolles J.

Horm Metab Res. 1990 Sep;22(9):508-9. No abstract available.

PMID:
2258140
50.

Measurement and distribution of vasopressin-converting aminopeptidase activity in rat brain.

Burbach JP, Terwel D, Lebouille JL.

Biochem Biophys Res Commun. 1987 Apr 29;144(2):726-31.

PMID:
3579938

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