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Items: 1 to 50 of 84

1.

Simultaneous measurement of excitation-contraction coupling parameters identifies mechanisms underlying contractile responses of hiPSC-derived cardiomyocytes.

van Meer BJ, Krotenberg A, Sala L, Davis RP, Eschenhagen T, Denning C, Tertoolen LGJ, Mummery CL.

Nat Commun. 2019 Sep 20;10(1):4325. doi: 10.1038/s41467-019-12354-8.

2.

Quantification of Muscle Contraction In Vitro and In Vivo Using MUSCLEMOTION Software: From Stem Cell-Derived Cardiomyocytes to Zebrafish and Human Hearts.

van Meer BJ, Sala L, Tertoolen LGJ, Smith GL, Burton FL, Mummery CL.

Curr Protoc Hum Genet. 2018 Oct;99(1):e67. doi: 10.1002/cphg.67. Epub 2018 Sep 25.

PMID:
30253059
3.

MUSCLEMOTION: A Versatile Open Software Tool to Quantify Cardiomyocyte and Cardiac Muscle Contraction In Vitro and In Vivo.

Sala L, van Meer BJ, Tertoolen LGJ, Bakkers J, Bellin M, Davis RP, Denning C, Dieben MAE, Eschenhagen T, Giacomelli E, Grandela C, Hansen A, Holman ER, Jongbloed MRM, Kamel SM, Koopman CD, Lachaud Q, Mannhardt I, Mol MPH, Mosqueira D, Orlova VV, Passier R, Ribeiro MC, Saleem U, Smith GL, Burton FL, Mummery CL.

Circ Res. 2018 Feb 2;122(3):e5-e16. doi: 10.1161/CIRCRESAHA.117.312067. Epub 2017 Dec 27. Review.

4.

RHOA-ROCK signalling is necessary for lateralization and differentiation of the developing sinoatrial node.

Vicente-Steijn R, Kelder TP, Tertoolen LG, Wisse LJ, Pijnappels DA, Poelmann RE, Schalij MJ, deRuiter MC, Gittenberger-de Groot AC, Jongbloed MRM.

Cardiovasc Res. 2017 Aug 1;113(10):1186-1197. doi: 10.1093/cvr/cvx104.

PMID:
28899000
5.

Electrophysiological Analysis of human Pluripotent Stem Cell-derived Cardiomyocytes (hPSC-CMs) Using Multi-electrode Arrays (MEAs).

Sala L, Ward-van Oostwaard D, Tertoolen LGJ, Mummery CL, Bellin M.

J Vis Exp. 2017 May 12;(123). doi: 10.3791/55587.

6.

Three-dimensional cardiac microtissues composed of cardiomyocytes and endothelial cells co-differentiated from human pluripotent stem cells.

Giacomelli E, Bellin M, Sala L, van Meer BJ, Tertoolen LG, Orlova VV, Mummery CL.

Development. 2017 Mar 15;144(6):1008-1017. doi: 10.1242/dev.143438.

7.

Interpretation of field potentials measured on a multi electrode array in pharmacological toxicity screening on primary and human pluripotent stem cell-derived cardiomyocytes.

Tertoolen LGJ, Braam SR, van Meer BJ, Passier R, Mummery CL.

Biochem Biophys Res Commun. 2018 Mar 18;497(4):1135-1141. doi: 10.1016/j.bbrc.2017.01.151. Epub 2017 Jan 30.

8.

Small molecule absorption by PDMS in the context of drug response bioassays.

van Meer BJ, de Vries H, Firth KSA, van Weerd J, Tertoolen LGJ, Karperien HBJ, Jonkheijm P, Denning C, IJzerman AP, Mummery CL.

Biochem Biophys Res Commun. 2017 Jan 8;482(2):323-328. doi: 10.1016/j.bbrc.2016.11.062. Epub 2016 Nov 14.

9.

Concise Review: Measuring Physiological Responses of Human Pluripotent Stem Cell Derived Cardiomyocytes to Drugs and Disease.

van Meer BJ, Tertoolen LG, Mummery CL.

Stem Cells. 2016 Aug;34(8):2008-15. doi: 10.1002/stem.2403. Epub 2016 Jun 30. Review.

10.

Altered calcium handling and increased contraction force in human embryonic stem cell derived cardiomyocytes following short term dexamethasone exposure.

Kosmidis G, Bellin M, Ribeiro MC, van Meer B, Ward-van Oostwaard D, Passier R, Tertoolen LG, Mummery CL, Casini S.

Biochem Biophys Res Commun. 2015 Nov 27;467(4):998-1005. doi: 10.1016/j.bbrc.2015.10.026. Epub 2015 Oct 9.

PMID:
26456652
11.

Transcriptome of human foetal heart compared with cardiomyocytes from pluripotent stem cells.

van den Berg CW, Okawa S, Chuva de Sousa Lopes SM, van Iperen L, Passier R, Braam SR, Tertoolen LG, del Sol A, Davis RP, Mummery CL.

Development. 2015 Sep 15;142(18):3231-8. doi: 10.1242/dev.123810. Epub 2015 Jul 24.

12.

Functional maturation of human pluripotent stem cell derived cardiomyocytes in vitro--correlation between contraction force and electrophysiology.

Ribeiro MC, Tertoolen LG, Guadix JA, Bellin M, Kosmidis G, D'Aniello C, Monshouwer-Kloots J, Goumans MJ, Wang YL, Feinberg AW, Mummery CL, Passier R.

Biomaterials. 2015 May;51:138-150. doi: 10.1016/j.biomaterials.2015.01.067. Epub 2015 Feb 18.

PMID:
25771005
13.

Serum supplemented culture medium masks hypertrophic phenotypes in human pluripotent stem cell derived cardiomyocytes.

Dambrot C, Braam SR, Tertoolen LG, Birket M, Atsma DE, Mummery CL.

J Cell Mol Med. 2014 Aug;18(8):1509-18. doi: 10.1111/jcmm.12356. Epub 2014 Jul 1.

14.

Isogenic human pluripotent stem cell pairs reveal the role of a KCNH2 mutation in long-QT syndrome.

Bellin M, Casini S, Davis RP, D'Aniello C, Haas J, Ward-van Oostwaard D, Tertoolen LG, Jung CB, Elliott DA, Welling A, Laugwitz KL, Moretti A, Mummery CL.

EMBO J. 2013 Dec 11;32(24):3161-75. doi: 10.1038/emboj.2013.240. Epub 2013 Nov 8.

15.

Human embryonic stem cell-derived cardiomyocytes survive and mature in the mouse heart and transiently improve function after myocardial infarction.

van Laake LW, Passier R, Monshouwer-Kloots J, Verkleij AJ, Lips DJ, Freund C, den Ouden K, Ward-van Oostwaard D, Korving J, Tertoolen LG, van Echteld CJ, Doevendans PA, Mummery CL.

Stem Cell Res. 2007 Oct;1(1):9-24. doi: 10.1016/j.scr.2007.06.001. Epub 2007 Aug 17.

16.

Direct interaction between estrogen receptor alpha and NF-kappaB in the nucleus of living cells.

Quaedackers ME, van den Brink CE, van der Saag PT, Tertoolen LG.

Mol Cell Endocrinol. 2007 Jul 15;273(1-2):42-50. Epub 2007 May 16.

PMID:
17590503
17.

FOXO4 is acetylated upon peroxide stress and deacetylated by the longevity protein hSir2(SIRT1).

van der Horst A, Tertoolen LG, de Vries-Smits LM, Frye RA, Medema RH, Burgering BM.

J Biol Chem. 2004 Jul 9;279(28):28873-9. Epub 2004 May 4.

18.

A P19Cl6 GFP reporter line to quantify cardiomyocyte differentiation of stem cells.

Moore JC, Spijker R, Martens AC, de Boer T, Rook MB, van der Heyden MA, Tertoolen LG, Mummery CL.

Int J Dev Biol. 2004 Feb;48(1):47-55.

19.

Receptor protein-tyrosine phosphatase dimerization.

den Hertog J, van der Wijk T, Tertoolen LG, Blanchetot C.

Methods Enzymol. 2003;366:224-40. No abstract available.

PMID:
14674252
20.

Intra- and intermolecular interactions between intracellular domains of receptor protein-tyrosine phosphatases.

Blanchetot C, Tertoolen LG, Overvoorde J, den Hertog J.

J Biol Chem. 2002 Dec 6;277(49):47263-9. Epub 2002 Oct 9.

21.

Regulation of receptor protein-tyrosine phosphatase alpha by oxidative stress.

Blanchetot C, Tertoolen LG, den Hertog J.

EMBO J. 2002 Feb 15;21(4):493-503.

22.

Dimerization of receptor protein-tyrosine phosphatase alpha in living cells.

Tertoolen LG, Blanchetot C, Jiang G, Overvoorde J, Gadella TW Jr, Hunter T, den Hertog J.

BMC Cell Biol. 2001;2:8. Epub 2001 Jun 1.

23.

Identification of p130cas as an in vivo substrate of receptor protein-tyrosine phosphatase alpha.

Buist A, Blanchetot C, Tertoolen LG, den Hertog J.

J Biol Chem. 2000 Jul 7;275(27):20754-61.

24.

Receptor protein-tyrosine phosphatase signalling in development.

den Hertog J, Blanchetot C, Buist A, Overvoorde J, van der Sar A, Tertoolen LG.

Int J Dev Biol. 1999;43(7):723-33. Review.

25.

Growth factor signalling.

de Laat SW, Boonstra J, Defize LH, Kruijer W, van der Saag PT, Tertoolen LG, van Zoelen EJ, den Hertog J.

Int J Dev Biol. 1999;43(7):681-91. Review.

26.

Study of calcium signaling in non-excitable cells.

Van Den Brink GR, Bloemers SM, Van Den Blink B, Tertoolen LG, Van Deventer SJ, Peppelenbosch MP.

Microsc Res Tech. 1999 Sep 15;46(6):418-33. Review.

PMID:
10504218
27.

Retinoic acid hydroxylase (CYP26) is a key enzyme in neuronal differentiation of embryonal carcinoma cells.

Sonneveld E, van den Brink CE, Tertoolen LG, van der Burg B, van der Saag PT.

Dev Biol. 1999 Sep 15;213(2):390-404.

28.

Potentiation of G-protein-coupled receptor-induced MAP kinase activation by exogenous EGF receptors in SK-N-MC neuroepithelioma cells.

Buist A, Tertoolen LG, den Hertog J.

Biochem Biophys Res Commun. 1998 Oct 9;251(1):6-10.

PMID:
9790898
29.

Sensitization of the histamine H1 receptor by increased ligand affinity.

Bloemers SM, Verheule S, Peppelenbosch MP, Smit MJ, Tertoolen LG, de Laat S.

J Biol Chem. 1998 Jan 23;273(4):2249-55.

30.

Lateral mobility of integrin alpha IIb beta 3 (glycoprotein IIb/IIIa) in the plasma membrane of a human megakaryocyte.

Schootemeijer A, van Willigen G, van der Vuurst H, Tertoolen LG, De Laat SW, Akkerman JW.

Thromb Haemost. 1997 Jan;77(1):143-9.

PMID:
9031465
31.

Activin and basic fibroblast growth factor regulate neurogenesis of murine embryonal carcinoma cells.

Ameerun RF, de Winter JP, van den Eijnden-van Raaij AJ, den Hertog J, de Laat SW, Tertoolen LG.

Cell Growth Differ. 1996 Dec;7(12):1679-88.

32.

Activation of the osmo-sensitive chloride conductance involves P21rho and is accompanied by a transient reorganization of the F-actin cytoskeleton.

Tilly BC, Edixhoven MJ, Tertoolen LG, Morii N, Saitoh Y, Narumiya S, de Jonge HR.

Mol Biol Cell. 1996 Sep;7(9):1419-27.

33.

Neuronal differentiation of embryonic stem cells.

van Inzen WG, Peppelenbosch MP, van den Brand MW, Tertoolen LG, de Laat SW.

Biochim Biophys Acta. 1996 Jun 5;1312(1):21-6.

34.

Rac-dependent and -independent pathways mediate growth factor-induced Ca2+ influx.

Peppelenbosch MP, Tertoolen LG, de Vries-Smits AM, Qiu RG, M'Rabet L, Symons MH, de Laat SW, Bos JL.

J Biol Chem. 1996 Apr 5;271(14):7883-6.

35.

The role of receptor protein tyrosine phosphatase alpha in neuronal differentiation of embryonic stem cells.

van Inzen WG, Peppelenbosch MP, van den Brand MW, Tertoolen LG, de Laat S.

Brain Res Dev Brain Res. 1996 Feb 26;91(2):304-7.

PMID:
8852383
36.

Maximal epidermal growth-factor-induced cytosolic phospholipase A2 activation in vivo requires phosphorylation followed by an increased intracellular calcium concentration.

Schalkwijk CG, van der Heijden MA, Bunt G, Maas R, Tertoolen LG, van Bergen en Henegouwen PM, Verkleij AJ, van den Bosch H, Boonstra J.

Biochem J. 1996 Jan 1;313 ( Pt 1):91-6.

37.

Rac mediates growth factor-induced arachidonic acid release.

Peppelenbosch MP, Qiu RG, de Vries-Smits AM, Tertoolen LG, de Laat SW, McCormick F, Hall A, Symons MH, Bos JL.

Cell. 1995 Jun 16;81(6):849-56.

38.

Intracellular acidification of gastrula ectoderm is important for posterior axial development in Xenopus.

Gutknecht DR, Koster CH, Tertoolen LG, de Laat SW, Durston AJ.

Development. 1995 Jun;121(6):1911-25.

39.

Relation between membrane fluidity and signal transduction in the human megakaryoblastic cell line MEG-01.

Schootemeijer A, Gorter G, Tertoolen LG, De Laat SW, Akkerman JW.

Biochim Biophys Acta. 1995 May 24;1236(1):128-34.

40.

Ionic responses to epidermal growth factor in zebrafish cells.

Peppelenbosch MP, Tertoolen LG, de Laat SW, Zivkovic D.

Exp Cell Res. 1995 May;218(1):183-8.

PMID:
7737359
41.

Evaluation of single-channel gating kinetics produced after amplitude-based separation of unitary currents.

Peppelenbosch MP, Tertoolen LG, Van der Flier A, De Laat SW.

J Neurosci Methods. 1995 May;58(1-2):49-59.

PMID:
7475233
42.

Cytosolic calcium ions regulate lipid mobility in the plasma membrane of the human megakaryoblastic cell line MEG-01.

Schootemeijer A, Van Beekhuizen AE, Tertoolen LG, De Laat SW, Akkerman JW.

Eur J Biochem. 1994 Sep 1;224(2):423-30.

43.

Rapid alterations in lateral mobility of lipids in the plasma membrane of activated human megakaryocytes.

Schootemeijer A, van Beekhuizen AE, Gorter G, Tertoolen LG, de Laat SW, Akkerman JW.

Eur J Biochem. 1994 Apr 1;221(1):353-62.

44.

Epidermal growth factor induces phosphorylation of extracellular signal-regulated kinase 2 via multiple pathways.

Burgering BM, de Vries-Smits AM, Medema RH, van Weeren PC, Tertoolen LG, Bos JL.

Mol Cell Biol. 1993 Dec;13(12):7248-56.

45.

Extracellular ATP elevates cytoplasmatic free Ca2+ in HeLa cells by the interaction with a 5'-nucleotide receptor.

Smit MJ, Leurs R, Bloemers SM, Tertoolen LG, Bast A, De Laat SW, Timmerman H.

Eur J Pharmacol. 1993 Oct 15;247(2):223-6.

PMID:
8282011
46.

Receptor protein tyrosine phosphatase alpha activates pp60c-src and is involved in neuronal differentiation.

den Hertog J, Pals CE, Peppelenbosch MP, Tertoolen LG, de Laat SW, Kruijer W.

EMBO J. 1993 Oct;12(10):3789-98.

47.

Protein tyrosine phosphorylation is involved in osmoregulation of ionic conductances.

Tilly BC, van den Berghe N, Tertoolen LG, Edixhoven MJ, de Jonge HR.

J Biol Chem. 1993 Sep 25;268(27):19919-22.

48.

Epidermal growth factor-induced actin remodeling is regulated by 5-lipoxygenase and cyclooxygenase products.

Peppelenbosch MP, Tertoolen LG, Hage WJ, de Laat SW.

Cell. 1993 Aug 13;74(3):565-75.

PMID:
8348619
49.

Mouse P19 embryonal carcinoma cells express functional histamine H1-receptors.

Bloemers SM, Leurs R, Smit MJ, Verheule S, Tertoolen LG, Timmerman H, de Laat SW.

Biochem Biophys Res Commun. 1993 Feb 26;191(1):118-25.

PMID:
8447817
50.

Short-term desensitization of the histamine H1 receptor in human HeLa cells: involvement of protein kinase C dependent and independent pathways.

Smit MJ, Bloemers SM, Leurs R, Tertoolen LG, Bast A, de Laat SW, Timmerman H.

Br J Pharmacol. 1992 Oct;107(2):448-55.

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