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Items: 1 to 50 of 97

1.

Simultaneous measurement of excitation-contraction coupling parameters identifies mechanisms underlying contractile responses of hiPSC-derived cardiomyocytes.

van Meer BJ, Krotenberg A, Sala L, Davis RP, Eschenhagen T, Denning C, Tertoolen LGJ, Mummery CL.

Nat Commun. 2019 Sep 20;10(1):4325. doi: 10.1038/s41467-019-12354-8.

2.

Correction for Muncan et al., "Rapid Loss of Intestinal Crypts upon Conditional Deletion of the Wnt/Tcf-4 Target Gene c-Myc".

Muncan V, Sansom OJ, Tertoolen L, Phesse TJ, Begthel H, Sancho E, Cole AM, Gregorieff A, Moreno de Alboran I, Clevers H, Clarke AR.

Mol Cell Biol. 2018 Nov 28;38(24). pii: e00482-18. doi: 10.1128/MCB.00482-18. Print 2018 Dec 15. No abstract available.

3.

Quantification of Muscle Contraction In Vitro and In Vivo Using MUSCLEMOTION Software: From Stem Cell-Derived Cardiomyocytes to Zebrafish and Human Hearts.

van Meer BJ, Sala L, Tertoolen LGJ, Smith GL, Burton FL, Mummery CL.

Curr Protoc Hum Genet. 2018 Oct;99(1):e67. doi: 10.1002/cphg.67. Epub 2018 Sep 25.

PMID:
30253059
4.

MUSCLEMOTION: A Versatile Open Software Tool to Quantify Cardiomyocyte and Cardiac Muscle Contraction In Vitro and In Vivo.

Sala L, van Meer BJ, Tertoolen LGJ, Bakkers J, Bellin M, Davis RP, Denning C, Dieben MAE, Eschenhagen T, Giacomelli E, Grandela C, Hansen A, Holman ER, Jongbloed MRM, Kamel SM, Koopman CD, Lachaud Q, Mannhardt I, Mol MPH, Mosqueira D, Orlova VV, Passier R, Ribeiro MC, Saleem U, Smith GL, Burton FL, Mummery CL.

Circ Res. 2018 Feb 2;122(3):e5-e16. doi: 10.1161/CIRCRESAHA.117.312067. Epub 2017 Dec 27. Review.

5.

RHOA-ROCK signalling is necessary for lateralization and differentiation of the developing sinoatrial node.

Vicente-Steijn R, Kelder TP, Tertoolen LG, Wisse LJ, Pijnappels DA, Poelmann RE, Schalij MJ, deRuiter MC, Gittenberger-de Groot AC, Jongbloed MRM.

Cardiovasc Res. 2017 Aug 1;113(10):1186-1197. doi: 10.1093/cvr/cvx104.

PMID:
28899000
6.

Electrophysiological Analysis of human Pluripotent Stem Cell-derived Cardiomyocytes (hPSC-CMs) Using Multi-electrode Arrays (MEAs).

Sala L, Ward-van Oostwaard D, Tertoolen LGJ, Mummery CL, Bellin M.

J Vis Exp. 2017 May 12;(123). doi: 10.3791/55587.

7.

Three-dimensional cardiac microtissues composed of cardiomyocytes and endothelial cells co-differentiated from human pluripotent stem cells.

Giacomelli E, Bellin M, Sala L, van Meer BJ, Tertoolen LG, Orlova VV, Mummery CL.

Development. 2017 Mar 15;144(6):1008-1017. doi: 10.1242/dev.143438.

8.

Interpretation of field potentials measured on a multi electrode array in pharmacological toxicity screening on primary and human pluripotent stem cell-derived cardiomyocytes.

Tertoolen LGJ, Braam SR, van Meer BJ, Passier R, Mummery CL.

Biochem Biophys Res Commun. 2018 Mar 18;497(4):1135-1141. doi: 10.1016/j.bbrc.2017.01.151. Epub 2017 Jan 30.

9.

Small molecule absorption by PDMS in the context of drug response bioassays.

van Meer BJ, de Vries H, Firth KSA, van Weerd J, Tertoolen LGJ, Karperien HBJ, Jonkheijm P, Denning C, IJzerman AP, Mummery CL.

Biochem Biophys Res Commun. 2017 Jan 8;482(2):323-328. doi: 10.1016/j.bbrc.2016.11.062. Epub 2016 Nov 14.

10.

Concise Review: Measuring Physiological Responses of Human Pluripotent Stem Cell Derived Cardiomyocytes to Drugs and Disease.

van Meer BJ, Tertoolen LG, Mummery CL.

Stem Cells. 2016 Aug;34(8):2008-15. doi: 10.1002/stem.2403. Epub 2016 Jun 30. Review.

11.

Altered calcium handling and increased contraction force in human embryonic stem cell derived cardiomyocytes following short term dexamethasone exposure.

Kosmidis G, Bellin M, Ribeiro MC, van Meer B, Ward-van Oostwaard D, Passier R, Tertoolen LG, Mummery CL, Casini S.

Biochem Biophys Res Commun. 2015 Nov 27;467(4):998-1005. doi: 10.1016/j.bbrc.2015.10.026. Epub 2015 Oct 9.

PMID:
26456652
12.

Transcriptome of human foetal heart compared with cardiomyocytes from pluripotent stem cells.

van den Berg CW, Okawa S, Chuva de Sousa Lopes SM, van Iperen L, Passier R, Braam SR, Tertoolen LG, del Sol A, Davis RP, Mummery CL.

Development. 2015 Sep 15;142(18):3231-8. doi: 10.1242/dev.123810. Epub 2015 Jul 24.

13.

Functional maturation of human pluripotent stem cell derived cardiomyocytes in vitro--correlation between contraction force and electrophysiology.

Ribeiro MC, Tertoolen LG, Guadix JA, Bellin M, Kosmidis G, D'Aniello C, Monshouwer-Kloots J, Goumans MJ, Wang YL, Feinberg AW, Mummery CL, Passier R.

Biomaterials. 2015 May;51:138-150. doi: 10.1016/j.biomaterials.2015.01.067. Epub 2015 Feb 18.

PMID:
25771005
14.

Serum supplemented culture medium masks hypertrophic phenotypes in human pluripotent stem cell derived cardiomyocytes.

Dambrot C, Braam SR, Tertoolen LG, Birket M, Atsma DE, Mummery CL.

J Cell Mol Med. 2014 Aug;18(8):1509-18. doi: 10.1111/jcmm.12356. Epub 2014 Jul 1.

15.

Isogenic human pluripotent stem cell pairs reveal the role of a KCNH2 mutation in long-QT syndrome.

Bellin M, Casini S, Davis RP, D'Aniello C, Haas J, Ward-van Oostwaard D, Tertoolen LG, Jung CB, Elliott DA, Welling A, Laugwitz KL, Moretti A, Mummery CL.

EMBO J. 2013 Dec 11;32(24):3161-75. doi: 10.1038/emboj.2013.240. Epub 2013 Nov 8.

16.

Repolarization reserve determines drug responses in human pluripotent stem cell derived cardiomyocytes.

Braam SR, Tertoolen L, Casini S, Matsa E, Lu HR, Teisman A, Passier R, Denning C, Gallacher DJ, Towart R, Mummery CL.

Stem Cell Res. 2013 Jan;10(1):48-56. doi: 10.1016/j.scr.2012.08.007. Epub 2012 Sep 7.

17.

A novel mutant allele of Ncx1: a single amino acid substitution leads to cardiac dysfunction.

Wansleeben C, Feitsma H, Tertoolen L, Kroon C, Guryev V, Cuppen E, Meijlink F.

Int J Dev Biol. 2010;54(10):1465-71. doi: 10.1387/ijdb.093051cw.

18.

Prediction of drug-induced cardiotoxicity using human embryonic stem cell-derived cardiomyocytes.

Braam SR, Tertoolen L, van de Stolpe A, Meyer T, Passier R, Mummery CL.

Stem Cell Res. 2010 Mar;4(2):107-16. doi: 10.1016/j.scr.2009.11.004. Epub 2009 Dec 3.

19.

Human embryonic stem cell-derived cardiomyocytes survive and mature in the mouse heart and transiently improve function after myocardial infarction.

van Laake LW, Passier R, Monshouwer-Kloots J, Verkleij AJ, Lips DJ, Freund C, den Ouden K, Ward-van Oostwaard D, Korving J, Tertoolen LG, van Echteld CJ, Doevendans PA, Mummery CL.

Stem Cell Res. 2007 Oct;1(1):9-24. doi: 10.1016/j.scr.2007.06.001. Epub 2007 Aug 17.

20.

Direct interaction between estrogen receptor alpha and NF-kappaB in the nucleus of living cells.

Quaedackers ME, van den Brink CE, van der Saag PT, Tertoolen LG.

Mol Cell Endocrinol. 2007 Jul 15;273(1-2):42-50. Epub 2007 May 16.

PMID:
17590503
21.

Rapid loss of intestinal crypts upon conditional deletion of the Wnt/Tcf-4 target gene c-Myc.

Muncan V, Sansom OJ, Tertoolen L, Phesse TJ, Begthel H, Sancho E, Cole AM, Gregorieff A, de Alboran IM, Clevers H, Clarke AR.

Mol Cell Biol. 2006 Nov;26(22):8418-26. Epub 2006 Sep 5. Erratum in: Mol Cell Biol. 2018 Nov 28;38(24):.

22.

Patterning the heart, a template for human cardiomyocyte development.

Chuva de Sousa Lopes SM, Hassink RJ, Feijen A, van Rooijen MA, Doevendans PA, Tertoolen L, Brutel de la Rivière A, Mummery CL.

Dev Dyn. 2006 Jul;235(7):1994-2002.

23.

Type I collagen limits VEGFR-2 signaling by a SHP2 protein-tyrosine phosphatase-dependent mechanism 1.

Mitola S, Brenchio B, Piccinini M, Tertoolen L, Zammataro L, Breier G, Rinaudo MT, den Hertog J, Arese M, Bussolino F.

Circ Res. 2006 Jan 6;98(1):45-54. Epub 2005 Dec 8.

PMID:
16339483
24.

Human embryonic stem cells: genetic manipulation on the way to cardiac cell therapies.

Moore JC, van Laake LW, Braam SR, Xue T, Tsang SY, Ward D, Passier R, Tertoolen LL, Li RA, Mummery CL.

Reprod Toxicol. 2005 Sep-Oct;20(3):377-91.

PMID:
15967632
25.

Fast fluorescence lifetime imaging of calcium in living cells.

Agronskaia AV, Tertoolen L, Gerritsen HC.

J Biomed Opt. 2004 Nov-Dec;9(6):1230-7.

26.

FOXO4 is acetylated upon peroxide stress and deacetylated by the longevity protein hSir2(SIRT1).

van der Horst A, Tertoolen LG, de Vries-Smits LM, Frye RA, Medema RH, Burgering BM.

J Biol Chem. 2004 Jul 9;279(28):28873-9. Epub 2004 May 4.

27.

A P19Cl6 GFP reporter line to quantify cardiomyocyte differentiation of stem cells.

Moore JC, Spijker R, Martens AC, de Boer T, Rook MB, van der Heyden MA, Tertoolen LG, Mummery CL.

Int J Dev Biol. 2004 Feb;48(1):47-55.

28.

Receptor protein-tyrosine phosphatase dimerization.

den Hertog J, van der Wijk T, Tertoolen LG, Blanchetot C.

Methods Enzymol. 2003;366:224-40. No abstract available.

PMID:
14674252
29.

Differentiation of human embryonic stem cells to cardiomyocytes: role of coculture with visceral endoderm-like cells.

Mummery C, Ward-van Oostwaard D, Doevendans P, Spijker R, van den Brink S, Hassink R, van der Heyden M, Opthof T, Pera M, de la Riviere AB, Passier R, Tertoolen L.

Circulation. 2003 Jun 3;107(21):2733-40. Epub 2003 May 12.

PMID:
12742992
30.

Intra- and intermolecular interactions between intracellular domains of receptor protein-tyrosine phosphatases.

Blanchetot C, Tertoolen LG, Overvoorde J, den Hertog J.

J Biol Chem. 2002 Dec 6;277(49):47263-9. Epub 2002 Oct 9.

31.

Cardiomyocyte differentiation of mouse and human embryonic stem cells.

Mummery C, Ward D, van den Brink CE, Bird SD, Doevendans PA, Opthof T, Brutel de la Riviere A, Tertoolen L, van der Heyden M, Pera M.

J Anat. 2002 Mar;200(Pt 3):233-42.

32.

Regulation of receptor protein-tyrosine phosphatase alpha by oxidative stress.

Blanchetot C, Tertoolen LG, den Hertog J.

EMBO J. 2002 Feb 15;21(4):493-503.

33.

Impairment of MAD2B-PRCC interaction in mitotic checkpoint defective t(X;1)-positive renal cell carcinomas.

Weterman MA, van Groningen JJ, Tertoolen L, van Kessel AG.

Proc Natl Acad Sci U S A. 2001 Nov 20;98(24):13808-13.

34.

Dimerization of receptor protein-tyrosine phosphatase alpha in living cells.

Tertoolen LG, Blanchetot C, Jiang G, Overvoorde J, Gadella TW Jr, Hunter T, den Hertog J.

BMC Cell Biol. 2001;2:8. Epub 2001 Jun 1.

35.

Identification of p130cas as an in vivo substrate of receptor protein-tyrosine phosphatase alpha.

Buist A, Blanchetot C, Tertoolen LG, den Hertog J.

J Biol Chem. 2000 Jul 7;275(27):20754-61.

36.

Receptor protein-tyrosine phosphatase signalling in development.

den Hertog J, Blanchetot C, Buist A, Overvoorde J, van der Sar A, Tertoolen LG.

Int J Dev Biol. 1999;43(7):723-33. Review.

37.

Growth factor signalling.

de Laat SW, Boonstra J, Defize LH, Kruijer W, van der Saag PT, Tertoolen LG, van Zoelen EJ, den Hertog J.

Int J Dev Biol. 1999;43(7):681-91. Review.

38.

Study of calcium signaling in non-excitable cells.

Van Den Brink GR, Bloemers SM, Van Den Blink B, Tertoolen LG, Van Deventer SJ, Peppelenbosch MP.

Microsc Res Tech. 1999 Sep 15;46(6):418-33. Review.

PMID:
10504218
39.

Retinoic acid hydroxylase (CYP26) is a key enzyme in neuronal differentiation of embryonal carcinoma cells.

Sonneveld E, van den Brink CE, Tertoolen LG, van der Burg B, van der Saag PT.

Dev Biol. 1999 Sep 15;213(2):390-404.

40.

Potentiation of G-protein-coupled receptor-induced MAP kinase activation by exogenous EGF receptors in SK-N-MC neuroepithelioma cells.

Buist A, Tertoolen LG, den Hertog J.

Biochem Biophys Res Commun. 1998 Oct 9;251(1):6-10.

PMID:
9790898
41.

Sensitization of the histamine H1 receptor by increased ligand affinity.

Bloemers SM, Verheule S, Peppelenbosch MP, Smit MJ, Tertoolen LG, de Laat S.

J Biol Chem. 1998 Jan 23;273(4):2249-55.

42.

Lateral mobility of integrin alpha IIb beta 3 (glycoprotein IIb/IIIa) in the plasma membrane of a human megakaryocyte.

Schootemeijer A, van Willigen G, van der Vuurst H, Tertoolen LG, De Laat SW, Akkerman JW.

Thromb Haemost. 1997 Jan;77(1):143-9.

PMID:
9031465
43.

Activin and basic fibroblast growth factor regulate neurogenesis of murine embryonal carcinoma cells.

Ameerun RF, de Winter JP, van den Eijnden-van Raaij AJ, den Hertog J, de Laat SW, Tertoolen LG.

Cell Growth Differ. 1996 Dec;7(12):1679-88.

44.

Activation of the osmo-sensitive chloride conductance involves P21rho and is accompanied by a transient reorganization of the F-actin cytoskeleton.

Tilly BC, Edixhoven MJ, Tertoolen LG, Morii N, Saitoh Y, Narumiya S, de Jonge HR.

Mol Biol Cell. 1996 Sep;7(9):1419-27.

45.

Neuronal differentiation of embryonic stem cells.

van Inzen WG, Peppelenbosch MP, van den Brand MW, Tertoolen LG, de Laat SW.

Biochim Biophys Acta. 1996 Jun 5;1312(1):21-6.

46.

Rac-dependent and -independent pathways mediate growth factor-induced Ca2+ influx.

Peppelenbosch MP, Tertoolen LG, de Vries-Smits AM, Qiu RG, M'Rabet L, Symons MH, de Laat SW, Bos JL.

J Biol Chem. 1996 Apr 5;271(14):7883-6.

47.

The role of receptor protein tyrosine phosphatase alpha in neuronal differentiation of embryonic stem cells.

van Inzen WG, Peppelenbosch MP, van den Brand MW, Tertoolen LG, de Laat S.

Brain Res Dev Brain Res. 1996 Feb 26;91(2):304-7.

PMID:
8852383
48.

Fibrinogen binding to ICAM-1 on EA.hy 926 endothelial cells is dependent on an intact cytoskeleton.

van de Stolpe A, Jacobs N, Hage WJ, Tertoolen L, van Kooyk Y, Nováková IR, de Witte T.

Thromb Haemost. 1996 Jan;75(1):182-9.

PMID:
8713799
49.

Maximal epidermal growth-factor-induced cytosolic phospholipase A2 activation in vivo requires phosphorylation followed by an increased intracellular calcium concentration.

Schalkwijk CG, van der Heijden MA, Bunt G, Maas R, Tertoolen LG, van Bergen en Henegouwen PM, Verkleij AJ, van den Bosch H, Boonstra J.

Biochem J. 1996 Jan 1;313 ( Pt 1):91-6.

50.

Rac mediates growth factor-induced arachidonic acid release.

Peppelenbosch MP, Qiu RG, de Vries-Smits AM, Tertoolen LG, de Laat SW, McCormick F, Hall A, Symons MH, Bos JL.

Cell. 1995 Jun 16;81(6):849-56.

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