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Items: 44

1.

Comprehensive Proteomics Analysis of Stressed Human Islets Identifies GDF15 as a Target for Type 1 Diabetes Intervention.

Nakayasu ES, Syed F, Tersey SA, Gritsenko MA, Mitchell HD, Chan CY, Dirice E, Turatsinze JV, Cui Y, Kulkarni RN, Eizirik DL, Qian WJ, Webb-Robertson BM, Evans-Molina C, Mirmira RG, Metz TO.

Cell Metab. 2020 Jan 8. pii: S1550-4131(19)30670-9. doi: 10.1016/j.cmet.2019.12.005. [Epub ahead of print]

PMID:
31928885
2.

Circulating unmethylated insulin DNA as a biomarker of human beta cell death: a multi-laboratory assay comparison.

Speake C, Ylescupidez A, Neiman D, Shemer R, Glaser B, Tersey SA, Usmani-Brown S, Clark P, Wilhelm JJ, Bellin MD, Herold KC, Mirmira RG, Dor Y, Evans-Molina C.

J Clin Endocrinol Metab. 2020 Jan 8. pii: dgaa008. doi: 10.1210/clinem/dgaa008. [Epub ahead of print]

PMID:
31913467
3.

Hypusine biosynthesis in β cells links polyamine metabolism to facultative cellular proliferation to maintain glucose homeostasis.

Levasseur EM, Yamada K, Piñeros AR, Wu W, Syed F, Orr KS, Anderson-Baucum E, Mastracci TL, Maier B, Mosley AL, Liu Y, Bernal-Mizrachi E, Alonso LC, Scott D, Garcia-Ocaña A, Tersey SA, Mirmira RG.

Sci Signal. 2019 Dec 3;12(610). pii: eaax0715. doi: 10.1126/scisignal.aax0715.

PMID:
31796630
4.

Comparative analysis of diagnostic platforms for measurement of differentially methylated insulin DNA.

Farr RJ, Wong WKM, Maynard CL, Tersey SA, Mirmira RG, Hardikar AA, Joglekar MV.

J Biol Methods. 2019;6(2). pii: e113. doi: 10.14440/jbm.2019.280. Epub 2019 Jun 3.

5.

A Versatile, Portable Intravital Microscopy Platform for Studying Beta-cell Biology In Vivo.

Reissaus CA, Piñeros AR, Twigg AN, Orr KS, Conteh AM, Martinez MM, Kamocka MM, Day RN, Tersey SA, Mirmira RG, Dunn KW, Linnemann AK.

Sci Rep. 2019 Jun 11;9(1):8449. doi: 10.1038/s41598-019-44777-0.

6.

Platelet-type 12-lipoxygenase deletion provokes a compensatory 12/15-lipoxygenase increase that exacerbates oxidative stress in mouse islet β cells.

Conteh AM, Reissaus CA, Hernandez-Perez M, Nakshatri S, Anderson RM, Mirmira RG, Tersey SA, Linnemann AK.

J Biol Chem. 2019 Apr 19;294(16):6612-6620. doi: 10.1074/jbc.RA118.007102. Epub 2019 Feb 21.

PMID:
30792307
7.

Combined Analysis of GAD65, miR-375, and Unmethylated Insulin DNA Following Islet Transplantation in Patients With T1D.

Roels S, Costa OR, Tersey SA, Stangé G, De Smet D, Balti EV, Gillard P, Keymeulen B, Ling Z, Pipeleers DG, Gorus FK, Mirmira RG, Martens GA.

J Clin Endocrinol Metab. 2019 Feb 1;104(2):451-460. doi: 10.1210/jc.2017-02520.

8.

Biomarkers of islet beta cell stress and death in type 1 diabetes.

Sims EK, Evans-Molina C, Tersey SA, Eizirik DL, Mirmira RG.

Diabetologia. 2018 Nov;61(11):2259-2265. doi: 10.1007/s00125-018-4712-1. Epub 2018 Aug 15. Review.

9.

Persistent elevations in circulating INS DNA among subjects with longstanding type 1 diabetes.

Neyman A, Nelson J, Tersey SA, Mirmira RG, Evans-Molina C, Sims EK.

Diabetes Obes Metab. 2019 Jan;21(1):95-102. doi: 10.1111/dom.13489. Epub 2018 Aug 24.

10.

1,25-Dihydroxyvitamin D3 enhances glucose-stimulated insulin secretion in mouse and human islets: a role for transcriptional regulation of voltage-gated calcium channels by the vitamin D receptor.

Kjalarsdottir L, Tersey SA, Vishwanath M, Chuang JC, Posner BA, Mirmira RG, Repa JJ.

J Steroid Biochem Mol Biol. 2019 Jan;185:17-26. doi: 10.1016/j.jsbmb.2018.07.004. Epub 2018 Jul 30.

PMID:
30071248
11.

In situ type I oligomeric collagen macroencapsulation promotes islet longevity and function in vitro and in vivo.

Stephens CH, Orr KS, Acton AJ, Tersey SA, Mirmira RG, Considine RV, Voytik-Harbin SL.

Am J Physiol Endocrinol Metab. 2018 Oct 1;315(4):E650-E661. doi: 10.1152/ajpendo.00073.2018. Epub 2018 Jun 12.

12.

Episodic β-cell death and dedifferentiation during diet-induced obesity and dysglycemia in male mice.

Tersey SA, Levasseur EM, Syed F, Farb TB, Orr KS, Nelson JB, Shaw JL, Bokvist K, Mather KJ, Mirmira RG.

FASEB J. 2018 May 29:fj201800150RR. doi: 10.1096/fj.201800150RR. [Epub ahead of print]

13.

An In Vivo Zebrafish Model for Interrogating ROS-Mediated Pancreatic β-Cell Injury, Response, and Prevention.

Kulkarni AA, Conteh AM, Sorrell CA, Mirmira A, Tersey SA, Mirmira RG, Linnemann AK, Anderson RM.

Oxid Med Cell Longev. 2018 Mar 28;2018:1324739. doi: 10.1155/2018/1324739. eCollection 2018.

14.

Hypoglycemia in a Patient With a Polyhormonal Pancreatic Neuroendocrine Tumor With Evidence of Endocrine Progenitors.

Simons ZB, Morgan RC, Rose L, Nelson JB, Tersey SA, Mirmira RG.

J Endocr Soc. 2018 Jan 16;2(2):172-177. doi: 10.1210/js.2017-00409. eCollection 2018 Feb 1.

15.

Elevated unmethylated and methylated insulin DNA are unique markers of A+β+ ketosis prone diabetes.

Mulukutla SN, Tersey SA, Hampe CS, Mirmira RG, Balasubramanyam A.

J Diabetes Complications. 2018 Feb;32(2):193-195. doi: 10.1016/j.jdiacomp.2017.10.013. Epub 2017 Oct 31.

16.

A system for detecting high impact-low frequency mutations in primary tumors and metastases.

Anjanappa M, Hao Y, Simpson ER, Bhat-Nakshatri P, Nelson JB, Tersey SA, Mirmira RG, Cohen-Gadol AA, Saadatzadeh MR, Li L, Fang F, Nephew KP, Miller KD, Liu Y, Nakshatri H.

Oncogene. 2018 Jan 11;37(2):185-196. doi: 10.1038/onc.2017.322. Epub 2017 Sep 11.

17.

Molecular mechanisms of nonalcoholic fatty liver disease: Potential role for 12-lipoxygenase.

Samala N, Tersey SA, Chalasani N, Anderson RM, Mirmira RG.

J Diabetes Complications. 2017 Nov;31(11):1630-1637. doi: 10.1016/j.jdiacomp.2017.07.014. Epub 2017 Jul 31. Review.

18.

Inhibition of 12/15-Lipoxygenase Protects Against β-Cell Oxidative Stress and Glycemic Deterioration in Mouse Models of Type 1 Diabetes.

Hernandez-Perez M, Chopra G, Fine J, Conteh AM, Anderson RM, Linnemann AK, Benjamin C, Nelson JB, Benninger KS, Nadler JL, Maloney DJ, Tersey SA, Mirmira RG.

Diabetes. 2017 Nov;66(11):2875-2887. doi: 10.2337/db17-0215. Epub 2017 Aug 25.

19.

Chronic high fat feeding restricts islet mRNA translation initiation independently of ER stress via DNA damage and p53 activation.

Hatanaka M, Anderson-Baucum E, Lakhter A, Kono T, Maier B, Tersey SA, Tanizawa Y, Evans-Molina C, Mirmira RG, Sims EK.

Sci Rep. 2017 Jun 19;7(1):3758. doi: 10.1038/s41598-017-03869-5.

20.

Measurement of Differentially Methylated INS DNA Species in Human Serum Samples as a Biomarker of Islet β Cell Death.

Tersey SA, Nelson JB, Fisher MM, Mirmira RG.

J Vis Exp. 2016 Dec 21;(118). doi: 10.3791/54838.

21.

Peroxisome Proliferator-activated Receptor-γ Activation Augments the β-Cell Unfolded Protein Response and Rescues Early Glycemic Deterioration and β Cell Death in Non-obese Diabetic Mice.

Maganti AV, Tersey SA, Syed F, Nelson JB, Colvin SC, Maier B, Mirmira RG.

J Biol Chem. 2016 Oct 21;291(43):22524-22533. Epub 2016 Sep 9.

22.

Loss of Free Fatty Acid Receptor 2 leads to impaired islet mass and beta cell survival.

Villa SR, Priyadarshini M, Fuller MH, Bhardwaj T, Brodsky MR, Angueira AR, Mosser RE, Carboneau BA, Tersey SA, Mancebo H, Gilchrist A, Mirmira RG, Gannon M, Layden BT.

Sci Rep. 2016 Jun 21;6:28159. doi: 10.1038/srep28159.

23.

Sirtuin 6 regulates glucose-stimulated insulin secretion in mouse pancreatic beta cells.

Xiong X, Wang G, Tao R, Wu P, Kono T, Li K, Ding WX, Tong X, Tersey SA, Harris RA, Mirmira RG, Evans-Molina C, Dong XC.

Diabetologia. 2016 Jan;59(1):151-160. doi: 10.1007/s00125-015-3778-2.

24.

Elevations in Circulating Methylated and Unmethylated Preproinsulin DNA in New-Onset Type 1 Diabetes.

Fisher MM, Watkins RA, Blum J, Evans-Molina C, Chalasani N, DiMeglio LA, Mather KJ, Tersey SA, Mirmira RG.

Diabetes. 2015 Nov;64(11):3867-72. doi: 10.2337/db15-0430. Epub 2015 Jul 27.

25.

Minireview: 12-Lipoxygenase and Islet β-Cell Dysfunction in Diabetes.

Tersey SA, Bolanis E, Holman TR, Maloney DJ, Nadler JL, Mirmira RG.

Mol Endocrinol. 2015 Jun;29(6):791-800. doi: 10.1210/me.2015-1041. Epub 2015 Mar 24. Review.

26.

Transcriptional activity of the islet β cell factor Pdx1 is augmented by lysine methylation catalyzed by the methyltransferase Set7/9.

Maganti AV, Maier B, Tersey SA, Sampley ML, Mosley AL, Özcan S, Pachaiyappan B, Woster PM, Hunter CS, Stein R, Mirmira RG.

J Biol Chem. 2015 Apr 10;290(15):9812-22. doi: 10.1074/jbc.M114.616219. Epub 2015 Feb 24.

27.

Maintenance of Pdx1 mRNA translation in islet β-cells during the unfolded protein response.

Templin AT, Maier B, Tersey SA, Hatanaka M, Mirmira RG.

Mol Endocrinol. 2014 Nov;28(11):1820-30. doi: 10.1210/me.2014-1157. Epub 2014 Sep 24.

28.

12-lipoxygenase promotes obesity-induced oxidative stress in pancreatic islets.

Tersey SA, Maier B, Nishiki Y, Maganti AV, Nadler JL, Mirmira RG.

Mol Cell Biol. 2014 Oct 1;34(19):3735-45. doi: 10.1128/MCB.00157-14. Epub 2014 Jul 28.

29.

Deoxyhypusine synthase promotes differentiation and proliferation of T helper type 1 (Th1) cells in autoimmune diabetes.

Colvin SC, Maier B, Morris DL, Tersey SA, Mirmira RG.

J Biol Chem. 2013 Dec 20;288(51):36226-35. doi: 10.1074/jbc.M113.473942. Epub 2013 Nov 6.

30.

Divergent compensatory responses to high-fat diet between C57BL6/J and C57BLKS/J inbred mouse strains.

Sims EK, Hatanaka M, Morris DL, Tersey SA, Kono T, Chaudry ZZ, Day KH, Moss DR, Stull ND, Mirmira RG, Evans-Molina C.

Am J Physiol Endocrinol Metab. 2013 Dec;305(12):E1495-511. doi: 10.1152/ajpendo.00366.2013. Epub 2013 Oct 29.

31.

Protective effects of polyamine depletion in mouse models of type 1 diabetes: implications for therapy.

Tersey SA, Colvin SC, Maier B, Mirmira RG.

Amino Acids. 2014 Mar;46(3):633-42. doi: 10.1007/s00726-013-1560-7. Epub 2013 Jul 12.

32.

Detection of islet β-cell death in vivo by multiplex PCR analysis of differentially methylated DNA.

Fisher MM, Perez Chumbiauca CN, Mather KJ, Mirmira RG, Tersey SA.

Endocrinology. 2013 Sep;154(9):3476-81. doi: 10.1210/en.2013-1223. Epub 2013 Jul 3.

33.

Effects of combination therapy with dipeptidyl peptidase-IV and histone deacetylase inhibitors in the non-obese diabetic mouse model of type 1 diabetes.

Cabrera SM, Colvin SC, Tersey SA, Maier B, Nadler JL, Mirmira RG.

Clin Exp Immunol. 2013 Jun;172(3):375-82. doi: 10.1111/cei.12068.

34.

Deletion of 12/15-lipoxygenase alters macrophage and islet function in NOD-Alox15(null) mice, leading to protection against type 1 diabetes development.

Green-Mitchell SM, Tersey SA, Cole BK, Ma K, Kuhn NS, Cunningham TD, Maybee NA, Chakrabarti SK, McDuffie M, Taylor-Fishwick DA, Mirmira RG, Nadler JL, Morris MA.

PLoS One. 2013;8(2):e56763. doi: 10.1371/journal.pone.0056763. Epub 2013 Feb 21.

35.

Mouse islet of Langerhans isolation using a combination of purified collagenase and neutral protease.

Stull ND, Breite A, McCarthy R, Tersey SA, Mirmira RG.

J Vis Exp. 2012 Sep 7;(67). pii: 4137. doi: 10.3791/4137.

36.

Amelioration of type 1 diabetes following treatment of non-obese diabetic mice with INGAP and lisofylline.

Tersey SA, Carter JD, Rosenberg L, Taylor-Fishwick DA, Mirmira RG, Nadler JL.

J Diabetes Mellitus. 2012 May 1;2(2):251-257.

37.

Islet β-cell endoplasmic reticulum stress precedes the onset of type 1 diabetes in the nonobese diabetic mouse model.

Tersey SA, Nishiki Y, Templin AT, Cabrera SM, Stull ND, Colvin SC, Evans-Molina C, Rickus JL, Maier B, Mirmira RG.

Diabetes. 2012 Apr;61(4):818-27. doi: 10.2337/db11-1293.

38.

Deoxyhypusine synthase haploinsufficiency attenuates acute cytokine signaling.

Templin AT, Maier B, Nishiki Y, Tersey SA, Mirmira RG.

Cell Cycle. 2011 Apr 1;10(7):1043-9. Epub 2011 Apr 1.

39.

Inhibition of deoxyhypusine synthase enhances islet {beta} cell function and survival in the setting of endoplasmic reticulum stress and type 2 diabetes.

Robbins RD, Tersey SA, Ogihara T, Gupta D, Farb TB, Ficorilli J, Bokvist K, Maier B, Mirmira RG.

J Biol Chem. 2010 Dec 17;285(51):39943-52. doi: 10.1074/jbc.M110.170142. Epub 2010 Oct 18.

40.

Hypusine: a new target for therapeutic intervention in diabetic inflammation.

Maier B, Tersey SA, Mirmira RG.

Discov Med. 2010 Jul;10(50):18-23. Review.

41.

The unique hypusine modification of eIF5A promotes islet beta cell inflammation and dysfunction in mice.

Maier B, Ogihara T, Trace AP, Tersey SA, Robbins RD, Chakrabarti SK, Nunemaker CS, Stull ND, Taylor CA, Thompson JE, Dondero RS, Lewis EC, Dinarello CA, Nadler JL, Mirmira RG.

J Clin Invest. 2010 Jun;120(6):2156-70. doi: 10.1172/JCI38924. Epub 2010 May 24.

42.

Peroxisome proliferator-activated receptor gamma activation restores islet function in diabetic mice through reduction of endoplasmic reticulum stress and maintenance of euchromatin structure.

Evans-Molina C, Robbins RD, Kono T, Tersey SA, Vestermark GL, Nunemaker CS, Garmey JC, Deering TG, Keller SR, Maier B, Mirmira RG.

Mol Cell Biol. 2009 Apr;29(8):2053-67. doi: 10.1128/MCB.01179-08. Epub 2009 Feb 23.

43.

Noninvasive assessment of pancreatic beta-cell function in vivo with manganese-enhanced magnetic resonance imaging.

Antkowiak PF, Tersey SA, Carter JD, Vandsburger MH, Nadler JL, Epstein FH, Mirmira RG.

Am J Physiol Endocrinol Metab. 2009 Mar;296(3):E573-8. doi: 10.1152/ajpendo.90336.2008. Epub 2008 Dec 30.

44.

Nonobese diabetic (NOD) mice congenic for a targeted deletion of 12/15-lipoxygenase are protected from autoimmune diabetes.

McDuffie M, Maybee NA, Keller SR, Stevens BK, Garmey JC, Morris MA, Kropf E, Rival C, Ma K, Carter JD, Tersey SA, Nunemaker CS, Nadler JL.

Diabetes. 2008 Jan;57(1):199-208. Epub 2007 Oct 16.

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