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Items: 18


Uncovering the biosynthetic potential of rare metagenomic DNA using co-occurrence network analysis of targeted sequences.

Libis V, Antonovsky N, Zhang M, Shang Z, Montiel D, Maniko J, Ternei MA, Calle PY, Lemetre C, Owen JG, Brady SF.

Nat Commun. 2019 Aug 26;10(1):3848. doi: 10.1038/s41467-019-11658-z.


Cadasides, Calcium-Dependent Acidic Lipopeptides from the Soil Metagenome That Are Active against Multidrug-Resistant Bacteria.

Wu C, Shang Z, Lemetre C, Ternei MA, Brady SF.

J Am Chem Soc. 2019 Mar 6;141(9):3910-3919. doi: 10.1021/jacs.8b12087. Epub 2019 Feb 20.


Atolypenes, Tricyclic Bacterial Sesterterpenes Discovered Using a Multiplexed In Vitro Cas9-TAR Gene Cluster Refactoring Approach.

Kim SH, Lu W, Ahmadi MK, Montiel D, Ternei MA, Brady SF.

ACS Synth Biol. 2019 Jan 18;8(1):109-118. doi: 10.1021/acssynbio.8b00361. Epub 2018 Dec 21.


Rifamycin congeners kanglemycins are active against rifampicin-resistant bacteria via a distinct mechanism.

Peek J, Lilic M, Montiel D, Milshteyn A, Woodworth I, Biggins JB, Ternei MA, Calle PY, Danziger M, Warrier T, Saito K, Braffman N, Fay A, Glickman MS, Darst SA, Campbell EA, Brady SF.

Nat Commun. 2018 Oct 8;9(1):4147. doi: 10.1038/s41467-018-06587-2.


Culture-independent discovery of the malacidins as calcium-dependent antibiotics with activity against multidrug-resistant Gram-positive pathogens.

Hover BM, Kim SH, Katz M, Charlop-Powers Z, Owen JG, Ternei MA, Maniko J, Estrela AB, Molina H, Park S, Perlin DS, Brady SF.

Nat Microbiol. 2018 Apr;3(4):415-422. doi: 10.1038/s41564-018-0110-1. Epub 2018 Feb 12.


An Optimized Synthetic-Bioinformatic Natural Product Antibiotic Sterilizes Multidrug-Resistant Acinetobacter baumannii-Infected Wounds.

Vila-Farres X, Chu J, Ternei MA, Lemetre C, Park S, Perlin DS, Brady SF.

mSphere. 2018 Jan 24;3(1). pii: e00528-17. doi: 10.1128/mSphere.00528-17. eCollection 2018 Jan-Feb.


Identification of biosynthetic gene clusters from metagenomic libraries using PPTase complementation in a Streptomyces host.

Bitok JK, Lemetre C, Ternei MA, Brady SF.

FEMS Microbiol Lett. 2017 Sep 1;364(16). doi: 10.1093/femsle/fnx155.


Antimicrobials Inspired by Nonribosomal Peptide Synthetase Gene Clusters.

Vila-Farres X, Chu J, Inoyama D, Ternei MA, Lemetre C, Cohen LJ, Cho W, Reddy BV, Zebroski HA, Freundlich JS, Perlin DS, Brady SF.

J Am Chem Soc. 2017 Feb 1;139(4):1404-1407. doi: 10.1021/jacs.6b11861. Epub 2017 Jan 23.


Urban park soil microbiomes are a rich reservoir of natural product biosynthetic diversity.

Charlop-Powers Z, Pregitzer CC, Lemetre C, Ternei MA, Maniko J, Hover BM, Calle PY, McGuire KL, Garbarino J, Forgione HM, Charlop-Powers S, Brady SF.

Proc Natl Acad Sci U S A. 2016 Dec 20;113(51):14811-14816. doi: 10.1073/pnas.1615581113. Epub 2016 Nov 28.


Functional metagenomic discovery of bacterial effectors in the human microbiome and isolation of commendamide, a GPCR G2A/132 agonist.

Cohen LJ, Kang HS, Chu J, Huang YH, Gordon EA, Reddy BV, Ternei MA, Craig JW, Brady SF.

Proc Natl Acad Sci U S A. 2015 Sep 1;112(35):E4825-34. doi: 10.1073/pnas.1508737112. Epub 2015 Aug 17.


Targeted metagenomics: finding rare tryptophan dimer natural products in the environment.

Chang FY, Ternei MA, Calle PY, Brady SF.

J Am Chem Soc. 2015 May 13;137(18):6044-52. doi: 10.1021/jacs.5b01968. Epub 2015 May 4.


Multiplexed metagenome mining using short DNA sequence tags facilitates targeted discovery of epoxyketone proteasome inhibitors.

Owen JG, Charlop-Powers Z, Smith AG, Ternei MA, Calle PY, Reddy BV, Montiel D, Brady SF.

Proc Natl Acad Sci U S A. 2015 Apr 7;112(14):4221-6. doi: 10.1073/pnas.1501124112. Epub 2015 Mar 23.


Global biogeographic sampling of bacterial secondary metabolism.

Charlop-Powers Z, Owen JG, Reddy BV, Ternei MA, GuimarĂ£es DO, de Frias UA, Pupo MT, Seepe P, Feng Z, Brady SF.

Elife. 2015 Jan 19;4:e05048. doi: 10.7554/eLife.05048.


The chemical arsenal of Burkholderia pseudomallei is essential for pathogenicity.

Biggins JB, Kang HS, Ternei MA, DeShazer D, Brady SF.

J Am Chem Soc. 2014 Jul 2;136(26):9484-90. doi: 10.1021/ja504617n. Epub 2014 Jun 24.


Chemical-biogeographic survey of secondary metabolism in soil.

Charlop-Powers Z, Owen JG, Reddy BV, Ternei MA, Brady SF.

Proc Natl Acad Sci U S A. 2014 Mar 11;111(10):3757-62. doi: 10.1073/pnas.1318021111. Epub 2014 Feb 18.


Discovery and synthetic refactoring of tryptophan dimer gene clusters from the environment.

Chang FY, Ternei MA, Calle PY, Brady SF.

J Am Chem Soc. 2013 Nov 27;135(47):17906-12. doi: 10.1021/ja408683p. Epub 2013 Nov 14.


Mapping gene clusters within arrayed metagenomic libraries to expand the structural diversity of biomedically relevant natural products.

Owen JG, Reddy BV, Ternei MA, Charlop-Powers Z, Calle PY, Kim JH, Brady SF.

Proc Natl Acad Sci U S A. 2013 Jul 16;110(29):11797-802. doi: 10.1073/pnas.1222159110. Epub 2013 Jul 3.


Malleilactone, a polyketide synthase-derived virulence factor encoded by the cryptic secondary metabolome of Burkholderia pseudomallei group pathogens.

Biggins JB, Ternei MA, Brady SF.

J Am Chem Soc. 2012 Aug 15;134(32):13192-5. doi: 10.1021/ja3052156. Epub 2012 Aug 1.

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