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Items: 1 to 50 of 121

1.

When alpha meets beta, mast cells get hyper.

Ong MS, Tergaonkar V.

J Exp Med. 2019 Jul 30. pii: jem.20191169. doi: 10.1084/jem.20191169. [Epub ahead of print]

PMID:
31362981
2.

Leptin signaling impairs macrophage defenses against Salmonella Typhimurium.

Fischer J, Gutièrrez S, Ganesan R, Calabrese C, Ranjan R, Cildir G, Judith Hos N, Rybniker J, Wolke M, Fries JWU, Tergaonkar V, Plum G, Antebi A, Robinson N.

Proc Natl Acad Sci U S A. 2019 Aug 13;116(33):16551-16560. doi: 10.1073/pnas.1904885116. Epub 2019 Jul 26.

3.

A Role of Agrin in Maintaining the Stability of Vascular Endothelial Growth Factor Receptor-2 during Tumor Angiogenesis.

Njah K, Chakraborty S, Qiu B, Arumugam S, Raju A, Pobbati AV, Lakshmanan M, Tergaonkar V, Thibault G, Wang X, Hong W.

Cell Rep. 2019 Jul 23;28(4):949-965.e7. doi: 10.1016/j.celrep.2019.06.036.

4.

PIP4K2A as a negative regulator of PI3K in PTEN-deficient glioblastoma.

Shin YJ, Sa JK, Lee Y, Kim D, Chang N, Cho HJ, Son M, Oh MYT, Shin K, Lee JK, Park J, Jo YK, Kim M, Paddison PJ, Tergaonkar V, Lee J, Nam DH.

J Exp Med. 2019 May 6;216(5):1120-1134. doi: 10.1084/jem.20172170. Epub 2019 Mar 21.

5.

Hypoxia Induced ER Stress Response as an Adaptive Mechanism in Cancer.

Chipurupalli S, Kannan E, Tergaonkar V, D'Andrea R, Robinson N.

Int J Mol Sci. 2019 Feb 11;20(3). pii: E749. doi: 10.3390/ijms20030749. Review.

6.

The expanding roles of long non-coding RNAs in the regulation of cancer stem cells.

Ma Z, Wang YY, Xin HW, Wang L, Arfuso F, Dharmarajan A, Kumar AP, Wang H, Tang FR, Warrier S, Tergaonkar V, Sethi G.

Int J Biochem Cell Biol. 2019 Mar;108:17-20. doi: 10.1016/j.biocel.2019.01.003. Epub 2019 Jan 7.

PMID:
30630112
7.

Accumulation of JAK activation loop phosphorylation is linked to type I JAK inhibitor withdrawal syndrome in myelofibrosis.

Tvorogov D, Thomas D, Liau NPD, Dottore M, Barry EF, Lathi M, Kan WL, Hercus TR, Stomski F, Hughes TP, Tergaonkar V, Parker MW, Ross DM, Majeti R, Babon JJ, Lopez AF.

Sci Adv. 2018 Nov 28;4(11):eaat3834. doi: 10.1126/sciadv.aat3834. eCollection 2018 Nov.

8.

Indian Hedgehog links obesity to development of hepatocellular carcinoma.

Chong YC, Lim TE, Fu Y, Shin EM, Tergaonkar V, Han W.

Oncogene. 2019 Mar;38(12):2206-2222. doi: 10.1038/s41388-018-0585-5. Epub 2018 Nov 23.

PMID:
30470823
9.

Mitochondrial uncoupling reveals a novel therapeutic opportunity for p53-defective cancers.

Kumar R, Coronel L, Somalanka B, Raju A, Aning OA, An O, Ho YS, Chen S, Mak SY, Hor PY, Yang H, Lakshmanan M, Itoh H, Tan SY, Lim YK, Wong APC, Chew SH, Huynh TH, Goh BC, Lim CY, Tergaonkar V, Cheok CF.

Nat Commun. 2018 Sep 26;9(1):3931. doi: 10.1038/s41467-018-05805-1.

10.

Structural basis for reactivating the mutant TERT promoter by cooperative binding of p52 and ETS1.

Xu X, Li Y, Bharath SR, Ozturk MB, Bowler MW, Loo BZL, Tergaonkar V, Song H.

Nat Commun. 2018 Aug 9;9(1):3183. doi: 10.1038/s41467-018-05644-0.

11.

Evidence for the Involvement of the Master Transcription Factor NF-κB in Cancer Initiation and Progression.

Puar YR, Shanmugam MK, Fan L, Arfuso F, Sethi G, Tergaonkar V.

Biomedicines. 2018 Jul 27;6(3). pii: E82. doi: 10.3390/biomedicines6030082. Review.

12.

Rare variants in Fanconi anemia genes are enriched in acute myeloid leukemia.

Maung KZY, Leo PJ, Bassal M, Casolari DA, Gray JX, Bray SC, Pederson S, Singhal D, Samaraweera SE, Nguyen T, Cildir G, Marshall M, Ewing A, Duncan EL, Brown MA, Saal R, Tergaonkar V, To LB, Marlton P, Gill D, Lewis I, Deans AJ, Brown AL, D'Andrea RJ, Gonda TJ.

Blood Cancer J. 2018 Jun 1;8(6):50. doi: 10.1038/s41408-018-0090-7. No abstract available.

13.

Rap1 deficiency-provoked paracrine dysfunction impairs immunosuppressive potency of mesenchymal stem cells in allograft rejection of heart transplantation.

Ding Y, Liang X, Zhang Y, Yi L, Shum HC, Chen Q, Chan BP, Fan H, Liu Z, Tergaonkar V, Qi Z, Tse HF, Lian Q.

Cell Death Dis. 2018 Mar 7;9(3):386. doi: 10.1038/s41419-018-0414-3.

14.

Meeting Report: The 8th Barossa Meeting-Cell Signaling in Cancer Medicine in the Barossa Valley, Australia.

Gomez GA, Woodcock JM, Tergaonkar V, Gregory PA.

Cell Death Dis. 2018 Feb 15;9(3):284. doi: 10.1038/s41419-018-0285-7. No abstract available.

15.

Thermal proximity coaggregation for system-wide profiling of protein complex dynamics in cells.

Tan CSH, Go KD, Bisteau X, Dai L, Yong CH, Prabhu N, Ozturk MB, Lim YT, Sreekumar L, Lengqvist J, Tergaonkar V, Kaldis P, Sobota RM, Nordlund P.

Science. 2018 Mar 9;359(6380):1170-1177. doi: 10.1126/science.aan0346. Epub 2018 Feb 8.

PMID:
29439025
16.

HoxC5 and miR-615-3p target newly evolved genomic regions to repress hTERT and inhibit tumorigenesis.

Yan T, Ooi WF, Qamra A, Cheung A, Ma D, Sundaram GM, Xu C, Xing M, Poon L, Wang J, Loh YP, Ho JHJ, Ng JJQ, Ramlee MK, Aswad L, Rozen SG, Ghosh S, Bard FA, Sampath P, Tergaonkar V, Davies JOJ, Hughes JR, Goh E, Bi X, Fullwood MJ, Tan P, Li S.

Nat Commun. 2018 Jan 8;9(1):100. doi: 10.1038/s41467-017-02601-1.

17.

GNA13 expression promotes drug resistance and tumor-initiating phenotypes in squamous cell cancers.

Rasheed SAK, Leong HS, Lakshmanan M, Raju A, Dadlani D, Chong FT, Shannon NB, Rajarethinam R, Skanthakumar T, Tan EY, Hwang JSG, Lim KH, Tan DS, Ceppi P, Wang M, Tergaonkar V, Casey PJ, Iyer NG.

Oncogene. 2018 Mar;37(10):1340-1353. doi: 10.1038/s41388-017-0038-6. Epub 2017 Dec 19.

18.

Noncoding RNAs: Master Regulators of Inflammatory Signaling.

Chew CL, Conos SA, Unal B, Tergaonkar V.

Trends Mol Med. 2018 Jan;24(1):66-84. doi: 10.1016/j.molmed.2017.11.003. Epub 2017 Dec 12. Review.

PMID:
29246760
19.

The transcriptional program, functional heterogeneity, and clinical targeting of mast cells.

Cildir G, Pant H, Lopez AF, Tergaonkar V.

J Exp Med. 2017 Sep 4;214(9):2491-2506. doi: 10.1084/jem.20170910. Epub 2017 Aug 15. Review.

20.

Ikk2 regulates cytokinesis during vertebrate development.

Shen H, Shin EM, Lee S, Mathavan S, Koh H, Osato M, Choi H, Tergaonkar V, Korzh V.

Sci Rep. 2017 Aug 14;7(1):8094. doi: 10.1038/s41598-017-06904-7.

21.

PRDM15 safeguards naive pluripotency by transcriptionally regulating WNT and MAPK-ERK signaling.

Mzoughi S, Zhang J, Hequet D, Teo SX, Fang H, Xing QR, Bezzi M, Seah MKY, Ong SLM, Shin EM, Wollmann H, Wong ESM, Al-Haddawi M, Stewart CL, Tergaonkar V, Loh YH, Dunn NR, Messerschmidt DM, Guccione E.

Nat Genet. 2017 Sep;49(9):1354-1363. doi: 10.1038/ng.3922. Epub 2017 Jul 24.

PMID:
28740264
22.

Role of the β Common (βc) Family of Cytokines in Health and Disease.

Hercus TR, Kan WLT, Broughton SE, Tvorogov D, Ramshaw HS, Sandow JJ, Nero TL, Dhagat U, Thompson EJ, Shing KSCT, McKenzie DR, Wilson NJ, Owczarek CM, Vairo G, Nash AD, Tergaonkar V, Hughes T, Ekert PG, Samuel MS, Bonder CS, Grimbaldeston MA, Parker MW, Lopez AF.

Cold Spring Harb Perspect Biol. 2018 Jun 1;10(6). pii: a028514. doi: 10.1101/cshperspect.a028514. Review.

PMID:
28716883
23.

A circRNA from SEPALLATA3 regulates splicing of its cognate mRNA through R-loop formation.

Conn VM, Hugouvieux V, Nayak A, Conos SA, Capovilla G, Cildir G, Jourdain A, Tergaonkar V, Schmid M, Zubieta C, Conn SJ.

Nat Plants. 2017 Apr 18;3:17053. doi: 10.1038/nplants.2017.53.

PMID:
28418376
24.

Absence of NUCKS augments paracrine effects of mesenchymal stem cells-mediated cardiac protection.

Zhang Y, Chiu S, Liang X, Chai YH, Qin Y, Wang J, Li X, Qiu B, Tergaonkar V, Tse HF, Lian Q.

Exp Cell Res. 2017 Jul 1;356(1):74-84. doi: 10.1016/j.yexcr.2017.04.012. Epub 2017 Apr 12.

PMID:
28412246
25.

Runx Family Genes in Tissue Stem Cell Dynamics.

Wang CQ, Mok MM, Yokomizo T, Tergaonkar V, Osato M.

Adv Exp Med Biol. 2017;962:117-138. doi: 10.1007/978-981-10-3233-2_9. Review.

PMID:
28299655
26.

Agrin as a Mechanotransduction Signal Regulating YAP through the Hippo Pathway.

Chakraborty S, Njah K, Pobbati AV, Lim YB, Raju A, Lakshmanan M, Tergaonkar V, Lim CT, Hong W.

Cell Rep. 2017 Mar 7;18(10):2464-2479. doi: 10.1016/j.celrep.2017.02.041.

27.

Current Insights to Regulation and Role of Telomerase in Human Diseases.

Ozturk MB, Li Y, Tergaonkar V.

Antioxidants (Basel). 2017 Feb 28;6(1). pii: E17. doi: 10.3390/antiox6010017. Review.

28.

Transcriptional Regulation of Telomerase Reverse Transcriptase (TERT) by MYC.

Khattar E, Tergaonkar V.

Front Cell Dev Biol. 2017 Jan 26;5:1. doi: 10.3389/fcell.2017.00001. eCollection 2017. Review.

29.

Wanted DEAD/H or Alive: Helicases Winding Up in Cancers.

Cai W, Xiong Chen Z, Rane G, Satendra Singh S, Choo Z, Wang C, Yuan Y, Zea Tan T, Arfuso F, Yap CT, Pongor LS, Yang H, Lee MB, Cher Goh B, Sethi G, Benoukraf T, Tergaonkar V, Prem Kumar A.

J Natl Cancer Inst. 2017 Jan 25;109(6). doi: 10.1093/jnci/djw278. Print 2017 Jan. Review.

PMID:
28122908
30.

Inhibition of NUCKS Facilitates Corneal Recovery Following Alkali Burn.

Poon MW, Jiang D, Qin P, Zhang Y, Qiu B, Chanda S, Tergaonkar V, Li Q, Wong IY, Yu Z, Tse HF, Wong DS, Lian Q.

Sci Rep. 2017 Jan 20;7:41224. doi: 10.1038/srep41224.

31.

Aberrant activation of the GIMAP enhancer by oncogenic transcription factors in T-cell acute lymphoblastic leukemia.

Liau WS, Tan SH, Ngoc PCT, Wang CQ, Tergaonkar V, Feng H, Gong Z, Osato M, Look AT, Sanda T.

Leukemia. 2017 Aug;31(8):1798-1807. doi: 10.1038/leu.2016.392. Epub 2016 Dec 28.

32.

Activation of mutant TERT promoter by RAS-ERK signaling is a key step in malignant progression of BRAF-mutant human melanomas.

Li Y, Cheng HS, Chng WJ, Tergaonkar V.

Proc Natl Acad Sci U S A. 2016 Dec 13;113(50):14402-14407. Epub 2016 Nov 23.

33.

Long-Range Chromatin Interactions Drive Mutant TERT Promoter Activation.

Akıncılar SC, Khattar E, Boon PL, Unal B, Fullwood MJ, Tergaonkar V.

Cancer Discov. 2016 Nov;6(11):1276-1291. Epub 2016 Sep 20.

34.

Cyclin A2 regulates erythrocyte morphology and numbers.

Jayapal SR, Ang HY, Wang CQ, Bisteau X, Caldez MJ, Xuan GX, Yu W, Tergaonkar V, Osato M, Lim B, Kaldis P.

Cell Cycle. 2016 Nov 16;15(22):3070-3081. Epub 2016 Sep 22.

35.

Telomerase reverse transcriptase promotes cancer cell proliferation by augmenting tRNA expression.

Khattar E, Kumar P, Liu CY, Akıncılar SC, Raju A, Lakshmanan M, Maury JJ, Qiang Y, Li S, Tan EY, Hui KM, Shi M, Loh YH, Tergaonkar V.

J Clin Invest. 2016 Oct 3;126(10):4045-4060. doi: 10.1172/JCI86042. Epub 2016 Sep 19.

36.

RNA helicase DP103 and TAK1: a new connection in cancer.

Shin EM, Osato M, Kumar AP, Tergaonkar V.

Mol Cell Oncol. 2015 Jan 26;2(3):e985911. doi: 10.4161/23723556.2014.985911. eCollection 2015 Jul-Sep. No abstract available.

37.

HIFI-α activation underlies a functional switch in the paradoxical role of Ezh2/PRC2 in breast cancer.

Mahara S, Lee PL, Feng M, Tergaonkar V, Chng WJ, Yu Q.

Proc Natl Acad Sci U S A. 2016 Jun 28;113(26):E3735-44. doi: 10.1073/pnas.1602079113. Epub 2016 Jun 14.

38.

Distinct Responses of Stem Cells to Telomere Uncapping-A Potential Strategy to Improve the Safety of Cell Therapy.

Liu CC, Ma DL, Yan TD, Fan X, Poon Z, Poon LF, Goh SA, Rozen SG, Hwang WY, Tergaonkar V, Tan P, Ghosh S, Virshup DM, Goh EL, Li S.

Stem Cells. 2016 Oct;34(10):2471-2484. doi: 10.1002/stem.2431. Epub 2016 Jun 30.

39.

RNAi Reveals Phase-Specific Global Regulators of Human Somatic Cell Reprogramming.

Toh CX, Chan JW, Chong ZS, Wang HF, Guo HC, Satapathy S, Ma D, Goh GY, Khattar E, Yang L, Tergaonkar V, Chang YT, Collins JJ, Daley GQ, Wee KB, Farran CA, Li H, Lim YP, Bard FA, Loh YH.

Cell Rep. 2016 Jun 21;15(12):2597-607. doi: 10.1016/j.celrep.2016.05.049. Epub 2016 Jun 9.

40.

Erratum: Phosphoprotein network analysis of white adipose tissues unveils deregulated pathways in response to high-fat diet.

Alli Shaik A, Qiu B, Wee S, Choi H, Gunaratne J, Tergaonkar V.

Sci Rep. 2016 Jun 10;6:27230. doi: 10.1038/srep27230. No abstract available.

41.

Phosphoprotein network analysis of white adipose tissues unveils deregulated pathways in response to high-fat diet.

Shaik AA, Qiu B, Wee S, Choi H, Gunaratne J, Tergaonkar V.

Sci Rep. 2016 May 16;6:25844. doi: 10.1038/srep25844. Erratum in: Sci Rep. 2016 Jun 10;6:27230.

42.

Noncanonical NF-κB Signaling in Health and Disease.

Cildir G, Low KC, Tergaonkar V.

Trends Mol Med. 2016 May;22(5):414-429. doi: 10.1016/j.molmed.2016.03.002. Epub 2016 Apr 7. Review.

PMID:
27068135
43.

Repressor and activator protein accelerates hepatic ischemia reperfusion injury by promoting neutrophil inflammatory response.

Li CX, Lo CM, Lian Q, Ng KT, Liu XB, Ma YY, Qi X, Yeung OW, Tergaonkar V, Yang XX, Liu H, Liu J, Shao Y, Man K.

Oncotarget. 2016 May 10;7(19):27711-23. doi: 10.18632/oncotarget.8509.

44.

Cancer prevention and therapy through the modulation of transcription factors by bioactive natural compounds.

Shanmugam MK, Lee JH, Chai EZ, Kanchi MM, Kar S, Arfuso F, Dharmarajan A, Kumar AP, Ramar PS, Looi CY, Mustafa MR, Tergaonkar V, Bishayee A, Ahn KS, Sethi G.

Semin Cancer Biol. 2016 Oct;40-41:35-47. doi: 10.1016/j.semcancer.2016.03.005. Epub 2016 Mar 30. Review.

PMID:
27038646
45.

Telomerase reactivation in cancers: Mechanisms that govern transcriptional activation of the wild-type vs. mutant TERT promoters.

Li Y, Tergaonkar V.

Transcription. 2016 Mar 14;7(2):44-9. doi: 10.1080/21541264.2016.1160173. Epub 2016 Mar 30. Review.

46.

Reactivation of telomerase in cancer.

Akincilar SC, Unal B, Tergaonkar V.

Cell Mol Life Sci. 2016 Apr;73(8):1659-70. doi: 10.1007/s00018-016-2146-9. Epub 2016 Feb 4. Review.

47.

Antisense oligonucleotide-mediated MDM4 exon 6 skipping impairs tumor growth.

Dewaele M, Tabaglio T, Willekens K, Bezzi M, Teo SX, Low DH, Koh CM, Rambow F, Fiers M, Rogiers A, Radaelli E, Al-Haddawi M, Tan SY, Hermans E, Amant F, Yan H, Lakshmanan M, Koumar RC, Lim ST, Derheimer FA, Campbell RM, Bonday Z, Tergaonkar V, Shackleton M, Blattner C, Marine JC, Guccione E.

J Clin Invest. 2016 Jan;126(1):68-84. doi: 10.1172/JCI82534. Epub 2015 Nov 23.

48.

NFκB drives TERT promoter reactivation in cancer.

Tergaonkar V.

Cell Cycle. 2016;15(2):156-7. doi: 10.1080/15384101.2015.1118908. No abstract available.

49.

Rap1 induces cytokine production in pro-inflammatory macrophages through NFκB signaling and is highly expressed in human atherosclerotic lesions.

Cai Y, Sukhova GK, Wong HK, Xu A, Tergaonkar V, Vanhoutte PM, Tang EH.

Cell Cycle. 2015;14(22):3580-92. doi: 10.1080/15384101.2015.1100771.

50.

Paracrine regulation in mesenchymal stem cells: the role of Rap1.

Zhang Y, Zhang Z, Gao F, Tse HF, Tergaonkar V, Lian Q.

Cell Death Dis. 2015 Oct 22;6:e1932. doi: 10.1038/cddis.2015.285. No abstract available.

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