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Phase I/II trial of Nano-camptothecin CRLX101 with Capecitabine and radiotherapy as neoadjuvant treatment for locally advanced rectal Cancer.

Sanoff HK, Moon DH, Moore DT, Boles J, Bui C, Blackstock W, O'Neil BH, Subramaniam S, McRee AJ, Carlson C, Lee MS, Tepper JE, Wang AZ.

Nanomedicine. 2019 Mar 8. pii: S1549-9634(19)30052-8. doi: 10.1016/j.nano.2019.02.021. [Epub ahead of print]


Klein tunnelling and Hartman effect in graphene junctions with proximity exchange field.

Tepper J, Barnas J.

J Phys Condens Matter. 2019 Feb 27. doi: 10.1088/1361-648X/ab0b20. [Epub ahead of print]


p53 Is a Master Regulator of Proteostasis in SMARCB1-Deficient Malignant Rhabdoid Tumors.

Carugo A, Minelli R, Sapio L, Soeung M, Carbone F, Robinson FS, Tepper J, Chen Z, Lovisa S, Svelto M, Amin S, Srinivasan S, Del Poggetto E, Loponte S, Puca F, Dey P, Malouf GG, Su X, Li L, Lopez-Terrada D, Rakheja D, Lazar AJ, Netto GJ, Rao P, Sgambato A, Maitra A, Tripathi DN, Walker CL, Karam JA, Heffernan TP, Viale A, Roberts CWM, Msaouel P, Tannir NM, Draetta GF, Genovese G.

Cancer Cell. 2019 Feb 11;35(2):204-220.e9. doi: 10.1016/j.ccell.2019.01.006.


Inappropriateness of health care in Canada: a systematic review protocol.

Squires JE, Graham ID, Grinspun D, Lavis J, Légaré F, Bell R, Bornstein S, Brien SE, Dobrow M, Greenough M, Estabrooks CA, Hillmer M, Horsley T, Katz A, Krause C, Levinson W, Levy A, Mancuso M, Maybee A, Morgan S, Penno LN, Neuner A, Rader T, Roberts J, Teare G, Tepper J, Vandyk A, Widmeyer D, Wilson M, Grimshaw JM.

Syst Rev. 2019 Feb 11;8(1):50. doi: 10.1186/s13643-019-0948-1.


A retrospective cohort study of fetal assessment following preterm premature rupture of membranes.

Tepper J, Corelli K, Navathe R, Smith S, Baxter JK.

Int J Gynaecol Obstet. 2019 Apr;145(1):83-90. doi: 10.1002/ijgo.12767. Epub 2019 Feb 19.


Mandibular width as a novel anthropometric measure for assessing obstructive sleep apnea risk.

Maresky HS, Klar MM, Tepper J, Gavriel H, Ziv Baran T, Shapiro CM, Tal S.

Medicine (Baltimore). 2019 Jan;98(4):e14040. doi: 10.1097/MD.0000000000014040.


Physician Characteristics Associated With Ordering 4 Low-Value Screening Tests in Primary Care.

Bouck Z, Ferguson J, Ivers NM, Kerr EA, Shojania KG, Kim M, Cram P, Pendrith C, Mecredy GC, Glazier RH, Tepper J, Austin PC, Martin D, Levinson W, Bhatia RS.

JAMA Netw Open. 2018 Oct 5;1(6):e183506. doi: 10.1001/jamanetworkopen.2018.3506.


Heterogeneity and Diversity of Striatal GABAergic Interneurons: Update 2018.

Tepper JM, Koós T, Ibanez-Sandoval O, Tecuapetla F, Faust TW, Assous M.

Front Neuroanat. 2018 Nov 8;12:91. doi: 10.3389/fnana.2018.00091. eCollection 2018.


"Wisest Is He Who Knows What He Does Not Know."

Marks LB, Tepper JE.

Int J Radiat Oncol Biol Phys. 2018 Nov 15;102(4):687-690. doi: 10.1016/j.ijrobp.2018.01.009. Epub 2018 Oct 18. No abstract available.


Frequency and Associations of Prescription Nonsteroidal Anti-inflammatory Drug Use Among Patients With a Musculoskeletal Disorder and Hypertension, Heart Failure, or Chronic Kidney Disease.

Bouck Z, Mecredy GC, Ivers NM, Barua M, Martin D, Austin PC, Tepper J, Bhatia RS.

JAMA Intern Med. 2018 Nov 1;178(11):1516-1525. doi: 10.1001/jamainternmed.2018.4273.


Organ-specific metastases obtained by culturing colorectal cancer cells on tissue-specific decellularized scaffolds.

Tian X, Werner ME, Roche KC, Hanson AD, Foote HP, Yu SK, Warner SB, Copp JA, Lara H, Wauthier EL, Caster JM, Herring LE, Zhang L, Tepper JE, Hsu DS, Zhang T, Reid LM, Wang AZ.

Nat Biomed Eng. 2018;2:443-452. Epub 2018 Apr 23.


Improving the quality of health care in Canada.

Dhalla IA, Tepper J.

CMAJ. 2018 Oct 1;190(39):E1162-E1167. doi: 10.1503/cmaj.171045. No abstract available.


Routine use of chest x-ray for low-risk patients undergoing a periodic health examination: a retrospective cohort study.

Bouck Z, Mecredy G, Ivers NM, Pendrith C, Fine B, Martin D, Glazier RH, Tepper J, Levinson W, Bhatia RS.

CMAJ Open. 2018 Aug 13;6(3):E322-E329. doi: 10.9778/cmajo.20170138. Print 2018 Jul-Sep.


Identification and Characterization of a Novel Spontaneously Active Bursty GABAergic Interneuron in the Mouse Striatum.

Assous M, Faust TW, Assini R, Shah F, Sidibe Y, Tepper JM.

J Neurosci. 2018 Jun 20;38(25):5688-5699. doi: 10.1523/JNEUROSCI.3354-17.2018. Epub 2018 May 22.


Measuring situation awareness in medical education objective structured clinical examination guides.

Frere M, Tepper J, Fischer M, Kennedy K, Kropmans T.

Educ Health (Abingdon). 2017 Sep-Dec;30(3):193-197. doi: 10.4103/efh.EfH_306_16.


Advancing Primary Care Through Alternative Payment Models: Lessons from the United States & Canada.

Bazemore A, Phillips RL Jr, Glazier R, Tepper J.

J Am Board Fam Med. 2018 May-Jun;31(3):322-327. doi: 10.3122/jabfm.2018.03.170297.


Bridging Hospital and Community Care for Homeless Adults with Mental Health Needs: Outcomes of a Brief Interdisciplinary Intervention.

Stergiopoulos V, Gozdzik A, Nisenbaum R, Durbin J, Hwang SW, O'Campo P, Tepper J, Wasylenki D.

Can J Psychiatry. 2018 Nov;63(11):774-784. doi: 10.1177/0706743718772539. Epub 2018 May 1.


Workshop Report for Cancer Research: Defining the Shades of Gy: Utilizing the Biological Consequences of Radiotherapy in the Development of New Treatment Approaches-Meeting Viewpoint.

Ahmed MM, Coleman CN, Mendonca M, Bentzen S, Vikram B, Seltzer SM, Goodhead D, Obcemea C, Mohan R, Prise KM, Capala J, Citrin D, Kao G, Aryankalayil M, Eke I, Buchsbaum JC, Prasanna PGS, Liu FF, Le QT, Teicher B, Kirsch DG, Smart D, Tepper J, Formenti S, Haas-Kogan D, Raben D, Mitchell J.

Cancer Res. 2018 May 1;78(9):2166-2170. doi: 10.1158/0008-5472.CAN-17-3760. Epub 2018 Apr 23. No abstract available.


Mature results of a prospective study of deintensified chemoradiotherapy for low-risk human papillomavirus-associated oropharyngeal squamous cell carcinoma.

Chera BS, Amdur RJ, Tepper JE, Tan X, Weiss J, Grilley-Olson JE, Hayes DN, Zanation A, Hackman TG, Patel S, Sheets N, Weissler MC, Mendenhall WM.

Cancer. 2018 Jun 1;124(11):2347-2354. doi: 10.1002/cncr.31338. Epub 2018 Mar 26.


Multivalent Binding and Biomimetic Cell Rolling Improves the Sensitivity and Specificity of Circulating Tumor Cell Capture.

Myung JH, Eblan MJ, Caster JM, Park SJ, Poellmann MJ, Wang K, Tam KA, Miller SM, Shen C, Chen RC, Zhang T, Tepper JE, Chera BS, Wang AZ, Hong S.

Clin Cancer Res. 2018 Jun 1;24(11):2539-2547. doi: 10.1158/1078-0432.CCR-17-3078. Epub 2018 Mar 15.


Excitatory extrinsic afferents to striatal interneurons and interactions with striatal microcircuitry.

Assous M, Tepper JM.

Eur J Neurosci. 2018 Feb 26. doi: 10.1111/ejn.13881. [Epub ahead of print] Review.


A prospective study of the safety and efficacy of liver stereotactic body radiotherapy in patients with and without prior liver-directed therapy.

Moon DH, Wang AZ, Tepper JE.

Radiother Oncol. 2018 Mar;126(3):527-533. doi: 10.1016/j.radonc.2018.01.004. Epub 2018 Jan 30.


Toxicology Evaluation of Drugs Administered via Uncommon Routes: Intranasal, Intraocular, Intrathecal/Intraspinal, and Intra-Articular.

Emami A, Tepper J, Short B, Yaksh TL, Bendele AM, Ramani T, Cisternas AF, Chang JH, Mellon RD.

Int J Toxicol. 2018 Jan/Feb;37(1):4-27. doi: 10.1177/1091581817741840. Epub 2017 Dec 21.


Ultrafast laser inscription in ZBLAN integrated optics chips for mid-IR beam combination in astronomical interferometry.

Tepper J, Labadie L, Gross S, Arriola A, Minardi S, Diener R, Withford MJ.

Opt Express. 2017 Aug 21;25(17):20642-20653. doi: 10.1364/OE.25.020642.


Towards 3D-photonic, multi-telescope beam combiners for mid-infrared astrointerferometry.

Diener R, Tepper J, Labadie L, Pertsch T, Nolte S, Minardi S.

Opt Express. 2017 Aug 7;25(16):19262-19274. doi: 10.1364/OE.25.019262.


Adjuvant Chemoradiotherapy With Epirubicin, Cisplatin, and Fluorouracil Compared With Adjuvant Chemoradiotherapy With Fluorouracil and Leucovorin After Curative Resection of Gastric Cancer: Results From CALGB 80101 (Alliance).

Fuchs CS, Niedzwiecki D, Mamon HJ, Tepper JE, Ye X, Swanson RS, Enzinger PC, Haller DG, Dragovich T, Alberts SR, Bjarnason GA, Willett CG, Gunderson LL, Goldberg RM, Venook AP, Ilson D, O'Reilly E, Ciombor K, Berg DJ, Meyerhardt J, Mayer RJ.

J Clin Oncol. 2017 Nov 10;35(32):3671-3677. doi: 10.1200/JCO.2017.74.2130. Epub 2017 Oct 4.


Oncologist, cancer patient, oncologist.

Tepper JE.

Pract Radiat Oncol. 2018 Sep - Oct;8(5):295-296. doi: 10.1016/j.prro.2017.08.007. Epub 2017 Aug 31. No abstract available.


Defining Health Profession Regulators' Roles in the Canadian Healthcare System.

Tepper J, Ahmed H, Brown AD.

Healthc Pap. 2017;16(4):4-7.


Ethics in Clinical Care.

Tepper JE.

Int J Radiat Oncol Biol Phys. 2017 Oct 1;99(2):250-254. doi: 10.1016/j.ijrobp.2017.03.036. Epub 2017 Mar 29. No abstract available.


Electrocardiograms in Low-Risk Patients Undergoing an Annual Health Examination.

Bhatia RS, Bouck Z, Ivers NM, Mecredy G, Singh J, Pendrith C, Ko DT, Martin D, Wijeysundera HC, Tu JV, Wilson L, Wintemute K, Dorian P, Tepper J, Austin PC, Glazier RH, Levinson W.

JAMA Intern Med. 2017 Sep 1;177(9):1326-1333. doi: 10.1001/jamainternmed.2017.2649.


The Ketogenic Diet: A Solution to Ireland's Obesity Epidemic?

Tepper J, Frere M.

Ir Med J. 2017 Mar 10;110(3):526. No abstract available.


Antigen-capturing nanoparticles improve the abscopal effect and cancer immunotherapy.

Min Y, Roche KC, Tian S, Eblan MJ, McKinnon KP, Caster JM, Chai S, Herring LE, Zhang L, Zhang T, DeSimone JM, Tepper JE, Vincent BG, Serody JS, Wang AZ.

Nat Nanotechnol. 2017 Sep;12(9):877-882. doi: 10.1038/nnano.2017.113. Epub 2017 Jun 26.


Differential processing of thalamic information via distinct striatal interneuron circuits.

Assous M, Kaminer J, Shah F, Garg A, Koós T, Tepper JM.

Nat Commun. 2017 Jun 12;8:15860. doi: 10.1038/ncomms15860.



Koong AC, Tepper JE.

Semin Radiat Oncol. 2017 Jul;27(3):189. doi: 10.1016/j.semradonc.2017.03.005. Epub 2017 Mar 18. No abstract available.


Promoting continuity of care for homeless adults with unmet health needs: The role of brief interventions.

Lamanna D, Stergiopoulos V, Durbin J, O'Campo P, Poremski D, Tepper J.

Health Soc Care Community. 2018 Jan;26(1):56-64. doi: 10.1111/hsc.12461. Epub 2017 Jun 1.


Geriatric Assessment as a Predictor of Tolerance, Quality of Life, and Outcomes in Older Patients With Head and Neck Cancers and Lung Cancers Receiving Radiation Therapy.

VanderWalde NA, Deal AM, Comitz E, Stravers L, Muss H, Reeve BB, Basch E, Tepper J, Chera B.

Int J Radiat Oncol Biol Phys. 2017 Jul 15;98(4):850-857. doi: 10.1016/j.ijrobp.2016.11.048. Epub 2016 Dec 2.


Synthetic vulnerabilities of mesenchymal subpopulations in pancreatic cancer.

Genovese G, Carugo A, Tepper J, Robinson FS, Li L, Svelto M, Nezi L, Corti D, Minelli R, Pettazzoni P, Gutschner T, Wu CC, Seth S, Akdemir KC, Leo E, Amin S, Molin MD, Ying H, Kwong LN, Colla S, Takahashi K, Ghosh P, Giuliani V, Muller F, Dey P, Jiang S, Garvey J, Liu CG, Zhang J, Heffernan TP, Toniatti C, Fleming JB, Goggins MG, Wood LD, Sgambato A, Agaimy A, Maitra A, Roberts CW, Wang H, Viale A, DePinho RA, Draetta GF, Chin L.

Nature. 2017 Feb 16;542(7641):362-366. doi: 10.1038/nature21064. Epub 2017 Feb 8.


Ketamine: Future Treatment For Unresponsive Depression?

Frere M, Tepper J.

Ir Med J. 2016 Sep 9;109(8):453.


CRLX101, a Nanoparticle-Drug Conjugate Containing Camptothecin, Improves Rectal Cancer Chemoradiotherapy by Inhibiting DNA Repair and HIF1α.

Tian X, Nguyen M, Foote HP, Caster JM, Roche KC, Peters CG, Wu P, Jayaraman L, Garmey EG, Tepper JE, Eliasof S, Wang AZ.

Cancer Res. 2017 Jan 1;77(1):112-122. doi: 10.1158/0008-5472.CAN-15-2951. Epub 2016 Oct 26. Erratum in: Cancer Res. 2017 Dec 1;77(23 ):6790-6791.


A pragmatic randomized control trial and realist evaluation on the implementation and effectiveness of an internet application to support self-management among individuals seeking specialized mental health care: a study protocol.

Hensel JM, Shaw J, Jeffs L, Ivers NM, Desveaux L, Cohen A, Agarwal P, Wodchis WP, Tepper J, Larsen D, McGahan A, Cram P, Mukerji G, Mamdani M, Yang R, Wong I, Onabajo N, Jamieson T, Bhatia RS.

BMC Psychiatry. 2016 Oct 18;16(1):350.


Neostriatal GABAergic Interneurons Mediate Cholinergic Inhibition of Spiny Projection Neurons.

Faust TW, Assous M, Tepper JM, Koós T.

J Neurosci. 2016 Sep 7;36(36):9505-11. doi: 10.1523/JNEUROSCI.0466-16.2016.


Segregated cholinergic transmission modulates dopamine neurons integrated in distinct functional circuits.

Dautan D, Souza AS, Huerta-Ocampo I, Valencia M, Assous M, Witten IB, Deisseroth K, Tepper JM, Bolam JP, Gerdjikov TV, Mena-Segovia J.

Nat Neurosci. 2016 Aug;19(8):1025-33. doi: 10.1038/nn.4335. Epub 2016 Jun 27.


In Vivo Functional Platform Targeting Patient-Derived Xenografts Identifies WDR5-Myc Association as a Critical Determinant of Pancreatic Cancer.

Carugo A, Genovese G, Seth S, Nezi L, Rose JL, Bossi D, Cicalese A, Shah PK, Viale A, Pettazzoni PF, Akdemir KC, Bristow CA, Robinson FS, Tepper J, Sanchez N, Gupta S, Estecio MR, Giuliani V, Dellino GI, Riva L, Yao W, Di Francesco ME, Green T, D'Alesio C, Corti D, Kang Y, Jones P, Wang H, Fleming JB, Maitra A, Pelicci PG, Chin L, DePinho RA, Lanfrancone L, Heffernan TP, Draetta GF.

Cell Rep. 2016 Jun 28;16(1):133-147. doi: 10.1016/j.celrep.2016.05.063. Epub 2016 Jun 16.


Considerations for the Characterization and Interpretation of Results Related to Alternative Complement Activation in Monkeys Associated with Oligonucleotide-Based Therapeutics.

Henry SP, Seguin R, Cavagnaro J, Berman C, Tepper J, Kornbrust D.

Nucleic Acid Ther. 2016 Aug;26(4):210-5. doi: 10.1089/nat.2015.0593. Epub 2016 Mar 16. Review.


Patient-Centred Care: The Proving Ground for Continuity and Equity in Our Health System.

Brown A, Tepper J.

Healthc Pap. 2015;14(4):4-6. No abstract available.


Symposium Summary: "Breathe In, Breathe Out, Its Easy: What You Need to Know About Developing Inhaled Drugs".

Tepper JS, Kuehl PJ, Cracknell S, Nikula KJ, Pei L, Blanchard JD.

Int J Toxicol. 2016 Jul;35(4):376-92. doi: 10.1177/1091581815624080. Epub 2016 Feb 7.


Failure Is the New Success.

Tepper J, Martin D.

Healthc Pap. 2015;15(2):4-6. No abstract available.


Preoperative Laboratory Investigations: Rates and Variability Prior to Low-risk Surgical Procedures.

Kirkham KR, Wijeysundera DN, Pendrith C, Ng R, Tu JV, Boozary AS, Tepper J, Schull MJ, Levinson W, Bhatia RS.

Anesthesiology. 2016 Apr;124(4):804-14. doi: 10.1097/ALN.0000000000001013.


Phase 2 Trial of De-intensified Chemoradiation Therapy for Favorable-Risk Human Papillomavirus-Associated Oropharyngeal Squamous Cell Carcinoma.

Chera BS, Amdur RJ, Tepper J, Qaqish B, Green R, Aumer SL, Hayes N, Weiss J, Grilley-Olson J, Zanation A, Hackman T, Funkhouser W, Sheets N, Weissler M, Mendenhall W.

Int J Radiat Oncol Biol Phys. 2015 Dec 1;93(5):976-85. doi: 10.1016/j.ijrobp.2015.08.033. Epub 2015 Aug 22.


Special Series: Advances in GI Cancer.

Meyerhardt JA, Tepper JE, Venook AP.

J Clin Oncol. 2015 Jun 1;33(16):1717-20. doi: 10.1200/JCO.2015.60.8661. Epub 2015 Apr 27. No abstract available.


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