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Inhibition of mitochondrial respiration prevents BRAF-mutant melanoma brain metastasis.

Sundstrøm T, Prestegarden L, Azuaje F, Aasen SN, Røsland GV, Varughese JK, Bahador M, Bernatz S, Braun Y, Harter PN, Skaftnesmo KO, Ingham ES, Mahakian LM, Tam S, Tepper CG, Petersen K, Ferrara KW, Tronstad KJ, Lund-Johansen M, Beschorner R, Bjerkvig R, Thorsen F.

Acta Neuropathol Commun. 2019 Apr 10;7(1):55. doi: 10.1186/s40478-019-0712-8.


A Syngeneic ErbB2 Mammary Cancer Model for Preclinical Immunotherapy Trials.

Pénzváltó Z, Chen JQ, Tepper CG, Davis RR, Silvestrini MT, Umeh-Garcia M, Sweeney C, Borowsky AD.

J Mammary Gland Biol Neoplasia. 2019 Jun;24(2):149-162. doi: 10.1007/s10911-019-09425-3. Epub 2019 Feb 27.


Proteostasis by STUB1/HSP70 complex controls sensitivity to androgen receptor targeted therapy in advanced prostate cancer.

Liu C, Lou W, Yang JC, Liu L, Armstrong CM, Lombard AP, Zhao R, Noel ODV, Tepper CG, Chen HW, Dall'Era M, Evans CP, Gao AC.

Nat Commun. 2018 Nov 16;9(1):4700. doi: 10.1038/s41467-018-07178-x.


KDM8/JMJD5 as a dual coactivator of AR and PKM2 integrates AR/EZH2 network and tumor metabolism in CRPC.

Wang HJ, Pochampalli M, Wang LY, Zou JX, Li PS, Hsu SC, Wang BJ, Huang SH, Yang P, Yang JC, Chu CY, Hsieh CL, Sung SY, Li CF, Tepper CG, Ann DK, Gao AC, Evans CP, Izumiya Y, Chuu CP, Wang WC, Chen HW, Kung HJ.

Oncogene. 2019 Jan;38(1):17-32. doi: 10.1038/s41388-018-0414-x. Epub 2018 Aug 2.


Identification of integrin drug targets for 17 solid tumor types.

Arun AS, Tepper CG, Lam KS.

Oncotarget. 2018 Jul 10;9(53):30146-30162. doi: 10.18632/oncotarget.25731. eCollection 2018 Jul 10.


Distinct immune signatures in directly treated and distant tumors result from TLR adjuvants and focal ablation.

Chavez M, Silvestrini MT, Ingham ES, Fite BZ, Mahakian LM, Tam SM, Ilovitsh A, Monjazeb AM, Murphy WJ, Hubbard NE, Davis RR, Tepper CG, Borowsky AD, Ferrara KW.

Theranostics. 2018 Jun 7;8(13):3611-3628. doi: 10.7150/thno.25613. eCollection 2018.


High frequency of the PNPLA3 rs738409 [G] single-nucleotide polymorphism in Hmong individuals as a potential basis for a predisposition to chronic liver disease.

Tepper CG, Dang JHT, Stewart SL, Fang DM, Wong KA, Liu SY, Davis RR, Dao DY, Gregg JP, Török NJ, Chen MS Jr.

Cancer. 2018 Apr 1;124 Suppl 7:1583-1589. doi: 10.1002/cncr.31122.


KSHV episomes reveal dynamic chromatin loop formation with domain-specific gene regulation.

Campbell M, Watanabe T, Nakano K, Davis RR, Lyu Y, Tepper CG, Durbin-Johnson B, Fujimuro M, Izumiya Y.

Nat Commun. 2018 Jan 4;9(1):49. doi: 10.1038/s41467-017-02089-9.


Oncolytic Reactivation of KSHV as a Therapeutic Approach for Primary Effusion Lymphoma.

Zhou F, Shimoda M, Olney L, Lyu Y, Tran K, Jiang G, Nakano K, Davis RR, Tepper CG, Maverakis E, Campbell M, Li Y, Dandekar S, Izumiya Y.

Mol Cancer Ther. 2017 Nov;16(11):2627-2638. doi: 10.1158/1535-7163.MCT-17-0041. Epub 2017 Aug 28.


ZIC2 Is Essential for Maintenance of Latency and Is a Target of an Immediate Early Protein during Kaposi's Sarcoma-Associated Herpesvirus Lytic Reactivation.

Lyu Y, Nakano K, Davis RR, Tepper CG, Campbell M, Izumiya Y.

J Virol. 2017 Oct 13;91(21). pii: e00980-17. doi: 10.1128/JVI.00980-17. Print 2017 Nov 1.


The Phosphatidylinositol 3-Kinase Pathway as a Potential Therapeutic Target in Bladder Cancer.

Zeng SX, Zhu Y, Ma AH, Yu W, Zhang H, Lin TY, Shi W, Tepper CG, Henderson PT, Airhart S, Guo JM, Xu CL, deVere White RW, Pan CX.

Clin Cancer Res. 2017 Nov 1;23(21):6580-6591. doi: 10.1158/1078-0432.CCR-17-0033. Epub 2017 Aug 14.


The androgen receptor is a negative regulator of eIF4E phosphorylation at S209: implications for the use of mTOR inhibitors in advanced prostate cancer.

D'Abronzo LS, Bose S, Crapuchettes ME, Beggs RE, Vinall RL, Tepper CG, Siddiqui S, Mudryj M, Melgoza FU, Durbin-Johnson BP, deVere White RW, Ghosh PM.

Oncogene. 2017 Nov 16;36(46):6359-6373. doi: 10.1038/onc.2017.233. Epub 2017 Jul 24.


Human and feline adipose-derived mesenchymal stem cells have comparable phenotype, immunomodulatory functions, and transcriptome.

Clark KC, Fierro FA, Ko EM, Walker NJ, Arzi B, Tepper CG, Dahlenburg H, Cicchetto A, Kol A, Marsh L, Murphy WJ, Fazel N, Borjesson DL.

Stem Cell Res Ther. 2017 Mar 20;8(1):69. doi: 10.1186/s13287-017-0528-z.


Microdose-Induced Drug-DNA Adducts as Biomarkers of Chemotherapy Resistance in Humans and Mice.

Zimmermann M, Wang SS, Zhang H, Lin TY, Malfatti M, Haack K, Ognibene T, Yang H, Airhart S, Turteltaub KW, Cimino GD, Tepper CG, Drakaki A, Chamie K, de Vere White R, Pan CX, Henderson PT.

Mol Cancer Ther. 2017 Feb;16(2):376-387. doi: 10.1158/1535-7163.MCT-16-0381. Epub 2016 Nov 30.


Decreased expression of let-7c is associated with non-response of muscle-invasive bladder cancer patients to neoadjuvant chemotherapy.

Vinall RL, Tepper CG, Ripoll AA, Gandour-Edwards RF, Durbin-Johnson BP, Yap SA, Ghosh PM, deVere White RW.

Genes Cancer. 2016 Mar;7(3-4):86-97. doi: 10.18632/genesandcancer.103.


Reprogramming metabolism by histone methyltransferase NSD2 drives endocrine resistance via coordinated activation of pentose phosphate pathway enzymes.

Wang J, Duan Z, Nugent Z, Zou JX, Borowsky AD, Zhang Y, Tepper CG, Li JJ, Fiehn O, Xu J, Kung HJ, Murphy LC, Chen HW.

Cancer Lett. 2016 Aug 10;378(2):69-79. doi: 10.1016/j.canlet.2016.05.004. Epub 2016 May 6.


miR-124 and Androgen Receptor Signaling Inhibitors Repress Prostate Cancer Growth by Downregulating Androgen Receptor Splice Variants, EZH2, and Src.

Shi XB, Ma AH, Xue L, Li M, Nguyen HG, Yang JC, Tepper CG, Gandour-Edwards R, Evans CP, Kung HJ, deVere White RW.

Cancer Res. 2015 Dec 15;75(24):5309-17. doi: 10.1158/0008-5472.CAN-14-0795. Epub 2015 Nov 16.


Development and Characterization of Bladder Cancer Patient-Derived Xenografts for Molecularly Guided Targeted Therapy.

Pan CX, Zhang H, Tepper CG, Lin TY, Davis RR, Keck J, Ghosh PM, Gill P, Airhart S, Bult C, Gandara DR, Liu E, de Vere White RW.

PLoS One. 2015 Aug 13;10(8):e0134346. doi: 10.1371/journal.pone.0134346. eCollection 2015.


Abnormal Mammary Development in 129:STAT1-Null Mice is Stroma-Dependent.

Chen JQ, Mori H, Cardiff RD, Trott JF, Hovey RC, Hubbard NE, Engelberg JA, Tepper CG, Willis BJ, Khan IH, Ravindran RK, Chan SR, Schreiber RD, Borowsky AD.

PLoS One. 2015 Jun 15;10(6):e0129895. doi: 10.1371/journal.pone.0129895. eCollection 2015.


The chromatin modification by SUMO-2/3 but not SUMO-1 prevents the epigenetic activation of key immune-related genes during Kaposi's sarcoma associated herpesvirus reactivation.

Chang PC, Cheng CY, Campbell M, Yang YC, Hsu HW, Chang TY, Chu CH, Lee YW, Hung CL, Lai SM, Tepper CG, Hsieh WP, Wang HW, Tang CY, Wang WC, Kung HJ.

BMC Genomics. 2013 Nov 23;14:824. doi: 10.1186/1471-2164-14-824.


On the origins of the androgen receptor low molecular weight species.

Mudryj M, Tepper CG.

Horm Cancer. 2013 Oct;4(5):259-69. doi: 10.1007/s12672-013-0152-z. Epub 2013 Jul 17. Review.


Modeling truncated AR expression in a natural androgen responsive environment and identification of RHOB as a direct transcriptional target.

Tsai HC, Boucher DL, Martinez A, Tepper CG, Kung HJ.

PLoS One. 2012;7(11):e49887. doi: 10.1371/journal.pone.0049887. Epub 2012 Nov 29.


Tumor suppressive miR-124 targets androgen receptor and inhibits proliferation of prostate cancer cells.

Shi XB, Xue L, Ma AH, Tepper CG, Gandour-Edwards R, Kung HJ, deVere White RW.

Oncogene. 2013 Aug 29;32(35):4130-8. doi: 10.1038/onc.2012.425. Epub 2012 Oct 15.


Enhancing the effectiveness of androgen deprivation in prostate cancer by inducing Filamin A nuclear localization.

Mooso BA, Vinall RL, Tepper CG, Savoy RM, Cheung JP, Singh S, Siddiqui S, Wang Y, Bedolla RG, Martinez A, Mudryj M, Kung HJ, Devere White RW, Ghosh PM.

Endocr Relat Cancer. 2012 Nov 9;19(6):759-77. doi: 10.1530/ERC-12-0171. Print 2012 Dec.


Histone methyltransferase NSD2/MMSET mediates constitutive NF-κB signaling for cancer cell proliferation, survival, and tumor growth via a feed-forward loop.

Yang P, Guo L, Duan ZJ, Tepper CG, Xue L, Chen X, Kung HJ, Gao AC, Zou JX, Chen HW.

Mol Cell Biol. 2012 Aug;32(15):3121-31. doi: 10.1128/MCB.00204-12. Epub 2012 May 29.


Protein arginine methyltransferase 1-directed methylation of Kaposi sarcoma-associated herpesvirus latency-associated nuclear antigen.

Campbell M, Chang PC, Huerta S, Izumiya C, Davis R, Tepper CG, Kim KY, Shevchenko B, Wang DH, Jung JU, Luciw PA, Kung HJ, Izumiya Y.

J Biol Chem. 2012 Feb 17;287(8):5806-18. doi: 10.1074/jbc.M111.289496. Epub 2011 Dec 16.


Dual blockade of PKA and NF-κB inhibits H2 relaxin-mediated castrate-resistant growth of prostate cancer sublines and induces apoptosis.

Vinall RL, Mahaffey CM, Davis RR, Luo Z, Gandour-Edwards R, Ghosh PM, Tepper CG, de Vere White RW.

Horm Cancer. 2011 Aug;2(4):224-38. doi: 10.1007/s12672-011-0076-4.


Evaluating rational non-cross-resistant combination therapy in advanced clear cell renal cell carcinoma: combined mTOR and AKT inhibitor therapy.

Holland WS, Tepper CG, Pietri JE, Chinn DC, Gandara DR, Mack PC, Lara PN Jr.

Cancer Chemother Pharmacol. 2012 Jan;69(1):185-94. doi: 10.1007/s00280-011-1684-y. Epub 2011 Jun 5.


Recombinant origin of the retrovirus XMRV.

Paprotka T, Delviks-Frankenberry KA, Cingöz O, Martinez A, Kung HJ, Tepper CG, Hu WS, Fivash MJ Jr, Coffin JM, Pathak VK.

Science. 2011 Jul 1;333(6038):97-101. doi: 10.1126/science.1205292. Epub 2011 May 31.


Histone demethylase JMJD2A regulates Kaposi's sarcoma-associated herpesvirus replication and is targeted by a viral transcriptional factor.

Chang PC, Fitzgerald LD, Hsia DA, Izumiya Y, Wu CY, Hsieh WP, Lin SF, Campbell M, Lam KS, Luciw PA, Tepper CG, Kung HJ.

J Virol. 2011 Apr;85(7):3283-93. doi: 10.1128/JVI.02485-10. Epub 2011 Jan 12.


miR-125b promotes growth of prostate cancer xenograft tumor through targeting pro-apoptotic genes.

Shi XB, Xue L, Ma AH, Tepper CG, Kung HJ, White RW.

Prostate. 2011 Apr;71(5):538-49. doi: 10.1002/pros.21270. Epub 2010 Sep 30.


ANCCA/ATAD2 overexpression identifies breast cancer patients with poor prognosis, acting to drive proliferation and survival of triple-negative cells through control of B-Myb and EZH2.

Kalashnikova EV, Revenko AS, Gemo AT, Andrews NP, Tepper CG, Zou JX, Cardiff RD, Borowsky AD, Chen HW.

Cancer Res. 2010 Nov 15;70(22):9402-12. doi: 10.1158/0008-5472.CAN-10-1199. Epub 2010 Sep 23.


Genome-wide analysis of androgen receptor binding and gene regulation in two CWR22-derived prostate cancer cell lines.

Chen H, Libertini SJ, George M, Dandekar S, Tepper CG, Al-Bataina B, Kung HJ, Ghosh PM, Mudryj M.

Endocr Relat Cancer. 2010 Oct 5;17(4):857-73. doi: 10.1677/ERC-10-0081. Print 2010 Dec.


Nrdp1-mediated regulation of ErbB3 expression by the androgen receptor in androgen-dependent but not castrate-resistant prostate cancer cells.

Chen L, Siddiqui S, Bose S, Mooso B, Asuncion A, Bedolla RG, Vinall R, Tepper CG, Gandour-Edwards R, Shi X, Lu XH, Siddiqui J, Chinnaiyan AM, Mehra R, Devere White RW, Carraway KL 3rd, Ghosh PM.

Cancer Res. 2010 Jul 15;70(14):5994-6003. doi: 10.1158/0008-5472.CAN-09-4440. Epub 2010 Jun 29.


KDM8, a H3K36me2 histone demethylase that acts in the cyclin A1 coding region to regulate cancer cell proliferation.

Hsia DA, Tepper CG, Pochampalli MR, Hsia EY, Izumiya C, Huerta SB, Wright ME, Chen HW, Kung HJ, Izumiya Y.

Proc Natl Acad Sci U S A. 2010 May 25;107(21):9671-6. doi: 10.1073/pnas.1000401107. Epub 2010 May 10.


MicroRNAs and their potential for translation in prostate cancer.

DeVere White RW, Vinall RL, Tepper CG, Shi XB.

Urol Oncol. 2009 May-Jun;27(3):307-11. doi: 10.1016/j.urolonc.2009.01.004.


Androgen-induced coactivator ANCCA mediates specific androgen receptor signaling in prostate cancer.

Zou JX, Guo L, Revenko AS, Tepper CG, Gemo AT, Kung HJ, Chen HW.

Cancer Res. 2009 Apr 15;69(8):3339-46. doi: 10.1158/0008-5472.CAN-08-3440. Epub 2009 Mar 24.


A novel androgen receptor splice variant is up-regulated during prostate cancer progression and promotes androgen depletion-resistant growth.

Guo Z, Yang X, Sun F, Jiang R, Linn DE, Chen H, Chen H, Kong X, Melamed J, Tepper CG, Kung HJ, Brodie AM, Edwards J, Qiu Y.

Cancer Res. 2009 Mar 15;69(6):2305-13. doi: 10.1158/0008-5472.CAN-08-3795. Epub 2009 Feb 24.


The Src inhibitor AZD0530 blocks invasion and may act as a radiosensitizer in lung cancer cells.

Purnell PR, Mack PC, Tepper CG, Evans CP, Green TP, Gumerlock PH, Lara PN, Gandara DR, Kung HJ, Gautschi O.

J Thorac Oncol. 2009 Apr;4(4):448-54. doi: 10.1097/JTO.0b013e31819c78fb.


MicroRNAs and prostate cancer.

Shi XB, Tepper CG, White RW.

J Cell Mol Med. 2008 Sep-Oct;12(5A):1456-65. doi: 10.1111/j.1582-4934.2008.00420.x. Epub 2008 Jul 8. Review.


Cancerous miRNAs and their regulation.

Shi XB, Tepper CG, deVere White RW.

Cell Cycle. 2008 Jun 1;7(11):1529-38. Epub 2008 Mar 20. Review.


Regulation of Id1 expression by SRC: implications for targeting of the bone morphogenetic protein pathway in cancer.

Gautschi O, Tepper CG, Purnell PR, Izumiya Y, Evans CP, Green TP, Desprez PY, Lara PN, Gandara DR, Mack PC, Kung HJ.

Cancer Res. 2008 Apr 1;68(7):2250-8. doi: 10.1158/0008-5472.CAN-07-6403.


An androgen-regulated miRNA suppresses Bak1 expression and induces androgen-independent growth of prostate cancer cells.

Shi XB, Xue L, Yang J, Ma AH, Zhao J, Xu M, Tepper CG, Evans CP, Kung HJ, deVere White RW.

Proc Natl Acad Sci U S A. 2007 Dec 11;104(50):19983-8. Epub 2007 Dec 3.


Evidence for calpain-mediated androgen receptor cleavage as a mechanism for androgen independence.

Libertini SJ, Tepper CG, Rodriguez V, Asmuth DM, Kung HJ, Mudryj M.

Cancer Res. 2007 Oct 1;67(19):9001-5.


The oncogenic potential of a prostate cancer-derived androgen receptor mutant.

Shi XB, Xue L, Tepper CG, Gandour-Edwards R, Ghosh P, Kung HJ, DeVere White RW.

Prostate. 2007 May 1;67(6):591-602.


GCP-mediated growth inhibition and apoptosis of prostate cancer cells via androgen receptor-dependent and -independent mechanisms.

Tepper CG, Vinall RL, Wee CB, Xue L, Shi XB, Burich R, Mack PC, de Vere White RW.

Prostate. 2007 Apr 1;67(5):521-35.


Male germ cell-associated kinase, a male-specific kinase regulated by androgen, is a coactivator of androgen receptor in prostate cancer cells.

Ma AH, Xia L, Desai SJ, Boucher DL, Guan Y, Shih HM, Shi XB, deVere White RW, Chen HW, Tepper CG, Kung HJ.

Cancer Res. 2006 Sep 1;66(17):8439-47.

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