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Implementation of genomics in medical practice to deliver precision medicine for an Asian population.

Bylstra Y, Davila S, Lim WK, Wu R, Teo JX, Kam S, Lysaght T, Rozen S, Teh BT, Yeo KK, Cook SA, Tan P, Jamuar SS.

NPJ Genom Med. 2019 Jun 7;4:12. doi: 10.1038/s41525-019-0085-8. eCollection 2019. Review.


Preoperative Predictors Including the Role of Inflammatory Indices in Predicting Early Recurrence After Re-resection for Recurrent Hepatocellular Carcinoma.

Guo Y, Chua DW, Koh YX, Lee SY, Cheow PC, Kam JH, Teo JY, Chow PK, Chung AY, Ooi LL, Chan CY, Goh BKP.

World J Surg. 2019 Jun 20. doi: 10.1007/s00268-019-05051-6. [Epub ahead of print]


Vitamin E analogues differentially inhibit human cytochrome P450 3A (CYP3A)-mediated oxidative metabolism of lithocholic acid: Impact of δ-tocotrienol on lithocholic acid cytotoxicity.

Wong SY, Teo JSM, Chai SF, Yeap SL, Lau AJ.

Toxicology. 2019 May 15;423:62-74. doi: 10.1016/j.tox.2019.05.005. [Epub ahead of print]


Challenge of drug resistance in Pseudomonas aeruginosa: clonal spread of NDM-1-positive ST-308 within a tertiary hospital.

Chew KL, Octavia S, Ng OT, Marimuthu K, Venkatachalam I, Cheng B, Lin RTP, Teo JWP.

J Antimicrob Chemother. 2019 May 12. pii: dkz169. doi: 10.1093/jac/dkz169. [Epub ahead of print]


Impact of spontaneous rupture on the survival outcomes after liver resection for hepatocellular carcinoma: A propensity matched analysis comparing ruptured versus non-ruptured tumors.

Chua DW, Koh YX, Allen JC, Chan CY, Lee SY, Cheow PC, Jeyaraj P, Teo JY, Chow PK, Chung AY, Ooi LL, Goh BKP.

Eur J Surg Oncol. 2019 Apr 9. pii: S0748-7983(19)30389-0. doi: 10.1016/j.ejso.2019.03.044. [Epub ahead of print]


In vivo development of amoxicillin and ceftriaxone resistance in Salmonella enterica serovar Typhi.

Tan GSE, Octavia S, Teo JWP, Ang MLT, La MV, Lin RTP, Choudhury S, Ang BSP.

Clin Microbiol Infect. 2019 Mar 23. pii: S1198-743X(19)30117-X. doi: 10.1016/j.cmi.2019.03.015. [Epub ahead of print] No abstract available.


External validation of the Japanese difficulty scoring system for minimally-invasive distal pancreatectomies.

Goh BKP, Kabir T, Koh YX, Teo JY, Lee SY, Kam JH, Cheow PC, Jeyaraj PR, Chow PKH, Ooi LLPJ, Chung AYF, Chan CY.

Am J Surg. 2019 Mar 15. pii: S0002-9610(19)30194-1. doi: 10.1016/j.amjsurg.2019.03.012. [Epub ahead of print]


An Artificial Tissue Homeostasis Circuit Designed via Analog Circuit Techniques.

Teo JJY, Weiss R, Sarpeshkar R.

IEEE Trans Biomed Circuits Syst. 2019 Jun;13(3):540-553. doi: 10.1109/TBCAS.2019.2907074. Epub 2019 Mar 25.


Initial single institution experience with robotic biliary surgery and bilio-enteric anastomosis in southeast Asia.

Goh BKP, Low TY, Teo JY, Lee SY, Chan CY, Chung AYF, Ooi LLPJ.

ANZ J Surg. 2019 Apr;89(4):E142-E146. doi: 10.1111/ans.15135. Epub 2019 Mar 18.


Risk factors and outcomes associated with the isolation of polymyxin B and carbapenem-resistant Enterobacteriaceae spp.: A case-control study.

Teo JQ, Chang CW, Leck H, Tang CY, Lee SJ, Cai Y, Ong RT, Koh TH, Tan TT, Kwa AL.

Int J Antimicrob Agents. 2019 May;53(5):657-662. doi: 10.1016/j.ijantimicag.2019.03.011. Epub 2019 Mar 14.


Convergence of Canonical and Non-Canonical Wnt Signal: Differential Kat3 Coactivator Usage.

Lai KKY, Nguyen C, Lee KS, Lee A, Lin DP, Teo JL, Kahn M.

Curr Mol Pharmacol. 2019 Mar 4. doi: 10.2174/1874467212666190304121131. [Epub ahead of print]


HEXIM1 Peptide Exhibits Antimicrobial Activity Against Antibiotic Resistant Bacteria Through Guidance of Cell Penetrating Peptide.

Ho PL, Ong HK, Teo J, Ow DS, Chao SH.

Front Microbiol. 2019 Feb 8;10:203. doi: 10.3389/fmicb.2019.00203. eCollection 2019.


Surface tethering of stem cells with H2O2-responsive anti-oxidizing colloidal particles for protection against oxidation-induced death.

Teo JY, Seo Y, Ko E, Leong J, Hong YT, Yang YY, Kong H.

Biomaterials. 2019 May;201:1-15. doi: 10.1016/j.biomaterials.2019.01.039. Epub 2019 Feb 13.


Polymers with distinctive anticancer mechanism that kills MDR cancer cells and inhibits tumor metastasis.

Zhong G, Yang C, Liu S, Zheng Y, Lou W, Teo JY, Bao C, Cheng W, Tan JPK, Gao S, Park N, Venkataraman S, Huang Y, Tan MH, Wang X, Hedrick JL, Fan W, Yang YY.

Biomaterials. 2019 Apr;199:76-87. doi: 10.1016/j.biomaterials.2019.01.036. Epub 2019 Jan 25.


Do antimicrobial stewardship programme interventions reduce the rate of and protect against Clostridium difficile infection?

Chia BY, Teo JQ, Lee W, Liew YX, Ee RP, Chlebicki MP, Oon LL, Kwa AL.

J Glob Antimicrob Resist. 2019 Jun;17:312-315. doi: 10.1016/j.jgar.2019.01.018. Epub 2019 Jan 22.


Molecular mechanisms of azole resistance in Candida bloodstream isolates.

Teo JQ, Lee SJ, Tan AL, Lim RS, Cai Y, Lim TP, Kwa AL.

BMC Infect Dis. 2019 Jan 17;19(1):63. doi: 10.1186/s12879-019-3672-5.


In vitro activity of apramycin against multidrug-, carbapenem- and aminoglycoside-resistant Enterobacteriaceae and Acinetobacter baumannii.

Juhas M, Widlake E, Teo J, Huseby DL, Tyrrell JM, Polikanov YS, Ercan O, Petersson A, Cao S, Aboklaish AF, Rominski A, Crich D, Böttger EC, Walsh TR, Hughes D, Hobbie SN.

J Antimicrob Chemother. 2019 Apr 1;74(4):944-952. doi: 10.1093/jac/dky546.


In response to Ballantyne and Schaefer's 'Consent and the ethical duty to participate in health data research'.

Hepgul N, Sleeman KE, Firth AM, Johnston A, Teo JTH, Bernal W, Dobson RJB, Higginson IJ.

J Med Ethics. 2019 May;45(5):351-352. doi: 10.1136/medethics-2018-105271. Epub 2019 Jan 7.


Delay in effective therapy in anidulafungin-resistant Candida tropicalis fungaemia: Potential for rapid prediction of antifungal resistance with whole-genome-sequencing.

Chew KL, Octavia S, Lin RTP, Yan GZ, Teo JWP.

J Glob Antimicrob Resist. 2019 Mar;16:105-107. doi: 10.1016/j.jgar.2018.12.010. Epub 2018 Dec 21.


In Vitro Immune Organs-on-Chip for Drug Development: A Review.

Shanti A, Teo J, Stefanini C.

Pharmaceutics. 2018 Dec 15;10(4). pii: E278. doi: 10.3390/pharmaceutics10040278. Review.


Deconstructing Immune Microenvironments of Lymphoid Tissues for Reverse Engineering.

Witzel II, Nasser R, Garcia-Sabaté A, Sapudom J, Ma C, Chen W, Teo JCM.

Adv Healthc Mater. 2019 Feb;8(4):e1801126. doi: 10.1002/adhm.201801126. Epub 2018 Dec 5. Review.


Clinical relevance of screening checklists for detecting cancer predisposition syndromes in Asian childhood tumours.

Chan SH, Chew W, Ishak NDB, Lim WK, Li ST, Tan SH, Teo JX, Shaw T, Chang K, Chen Y, Iyer P, Tan EEK, Seng MS, Chan MY, Tan AM, Low SYY, Soh SY, Loh AHP, Ngeow J.

NPJ Genom Med. 2018 Nov 15;3:30. doi: 10.1038/s41525-018-0070-7. eCollection 2018.


Correction to: Candidemia in a major regional tertiary referral hospital - epidemiology, practice patterns and outcomes.

Teo JQ, Candra SR, Lee SJ, Chia SY, Leck H, Tan AL, Neo HP, Leow KW, Cai Y, Ee PLR, Lim TP, Lee W, Kwa AL.

Antimicrob Resist Infect Control. 2018 Nov 7;7:130. doi: 10.1186/s13756-018-0413-2. eCollection 2018.


Laparoscopic Liver Resection Difficulty Score-a Validation Study.

Lee SY, Goh BKP, Sepideh G, Allen JC, Merkow RP, Teo JY, Chandra D, Koh YX, Tan EK, Kam JH, Cheow PC, Chow PKH, Ooi LLPJ, Chung AYF, D'Angelica MI, Jarnagin WR, Peter Kingham T, Chan CY.

J Gastrointest Surg. 2019 Mar;23(3):545-555. doi: 10.1007/s11605-018-4036-y. Epub 2018 Nov 12.


Perioperative Outcomes of Laparoscopic Repeat Liver Resection for Recurrent HCC: Comparison with Open Repeat Liver Resection for Recurrent HCC and Laparoscopic Resection for Primary HCC.

Goh BKP, Syn N, Teo JY, Guo YX, Lee SY, Cheow PC, Chow PKH, Ooi LLPJ, Chung AYF, Chan CY.

World J Surg. 2019 Mar;43(3):878-885. doi: 10.1007/s00268-018-4828-y.


Near Infrared Fluorophore-Tagged Chloroquine in Plasmodium falciparum Diagnostic Imaging.

Chan LY, Teo JDW, Tan KS, Sou K, Kwan WL, Lee CK.

Molecules. 2018 Oct 14;23(10). pii: E2635. doi: 10.3390/molecules23102635.


Integrated pharmacokinetic-pharmacodynamic modeling to evaluate empiric carbapenem therapy in bloodstream infections.

Lim TP, Wang R, Poh GQ, Koh TH, Tan TY, Lee W, Teo JQ, Cai Y, Tan TT, Ee PLR, Kwa AL.

Infect Drug Resist. 2018 Sep 27;11:1591-1596. doi: 10.2147/IDR.S168191. eCollection 2018.


Slip of fluid molecules on solid surfaces by surface diffusion.

Shu JJ, Teo JBM, Chan WK.

PLoS One. 2018 Oct 11;13(10):e0205443. doi: 10.1371/journal.pone.0205443. eCollection 2018.


Acquisition of resistance to carbapenem and macrolide-mediated quorum sensing inhibition by Pseudomonas aeruginosa via ICETn4371 6385.

Ding Y, Teo JWP, Drautz-Moses DI, Schuster SC, Givskov M, Yang L.

Commun Biol. 2018 May 31;1:57. doi: 10.1038/s42003-018-0064-0. eCollection 2018.


Tedizolid Activity Against Clinical Mycobacterium abscessus Complex Isolates-An in vitro Characterization Study.

Tang YW, Cheng B, Yeoh SF, Lin RTP, Teo JWP.

Front Microbiol. 2018 Sep 7;9:2095. doi: 10.3389/fmicb.2018.02095. eCollection 2018.


A retrospective review of correlative radiological assessment and surgical exploration for hilar cholangiocarcinoma.

Chua D, Low A, Koh Y, Goh B, Cheow PC, Kam JH, Teo JY, Tan EK, Chung A, Ooi LL, Chan CY, Lee SY.

Ann Hepatobiliary Pancreat Surg. 2018 Aug;22(3):216-222. doi: 10.14701/ahbps.2018.22.3.216. Epub 2018 Aug 31.


Predictors of post-hepatectomy liver failure in patients undergoing extensive liver resections for hepatocellular carcinoma.

Chin KM, Allen JC, Teo JY, Kam JH, Tan EK, Koh Y, Goh KPB, Cheow PC, Raj P, Chow KHP, Chung YFA, Ooi LL, Chan CY, Lee SY.

Ann Hepatobiliary Pancreat Surg. 2018 Aug;22(3):185-196. doi: 10.14701/ahbps.2018.22.3.185. Epub 2018 Aug 31.


A Synthetic Microbial Operational Amplifier.

Zeng J, Teo J, Banerjee A, Chapman TW, Kim J, Sarpeshkar R.

ACS Synth Biol. 2018 Sep 21;7(9):2007-2013. doi: 10.1021/acssynbio.8b00138. Epub 2018 Aug 30.


A selective inhibitor of ceramide synthase 1 reveals a novel role in fat metabolism.

Turner N, Lim XY, Toop HD, Osborne B, Brandon AE, Taylor EN, Fiveash CE, Govindaraju H, Teo JD, McEwen HP, Couttas TA, Butler SM, Das A, Kowalski GM, Bruce CR, Hoehn KL, Fath T, Schmitz-Peiffer C, Cooney GJ, Montgomery MK, Morris JC, Don AS.

Nat Commun. 2018 Aug 21;9(1):3165. doi: 10.1038/s41467-018-05613-7.


Disseminated Volvariella volvacea infections in patients with haematological malignancies: a case series.

Chew KL, Ng DHL, Teo JWP, Tan KB, Poon LM, Tambyah PA, Ong CWM.

Clin Microbiol Infect. 2019 Jan;25(1):117-119. doi: 10.1016/j.cmi.2018.07.032. Epub 2018 Aug 9. No abstract available.


Correction: Population genomics in South East Asia captures unexpectedly high carrier frequency for treatable inherited disorders.

Bylstra Y, Kuan JL, Lim WK, Bhalshankar JD, Teo JX, Davila S, Teh BT, Rozen S, Tan EC, Liew WKM, Yeo KK, Tan P; SinGapore Incidental Finding (SGIF) study group, Saw SM, Cheng CY, Cook S, Foo R, Jamuar SS.

Genet Med. 2018 Dec;20(12):1692. doi: 10.1038/s41436-018-0142-1.


Homozygous OB-fold variants in telomere protein TPP1 are associated with dyskeratosis congenita-like phenotypes.

Tummala H, Collopy LC, Walne AJ, Ellison A, Cardoso S, Aksu T, Yarali N, Aslan D, Fikret Akata R, Teo J, Songyang Z, Pontikos N, Fitzgibbon J, Tomita K, Vulliamy T, Dokal I.

Blood. 2018 Sep 20;132(12):1349-1353. doi: 10.1182/blood-2018-03-837799. Epub 2018 Jul 31. No abstract available.


Perioperative Outcomes of Laparoscopic Minor Hepatectomy for Hepatocellular Carcinoma in the Elderly.

Goh BKP, Chua D, Syn N, Teo JY, Chan CY, Lee SY, Jeyaraj PR, Cheow PC, Chow PKH, Ooi LLPJ, Chung AYF.

World J Surg. 2018 Dec;42(12):4063-4069. doi: 10.1007/s00268-018-4741-4.


Changing trends and outcomes associated with the adoption of minimally invasive hepatectomy: a contemporary single-institution experience with 400 consecutive resections.

Goh BKP, Lee SY, Teo JY, Kam JH, Jeyaraj PR, Cheow PC, Chow PKH, Ooi LLPJ, Chung AYF, Chan CY.

Surg Endosc. 2018 Nov;32(11):4658-4665. doi: 10.1007/s00464-018-6310-1. Epub 2018 Jul 2.


Rapid Antibiotic Combination Testing for Carbapenem-Resistant Gram-Negative Bacteria within Six Hours Using ATP Bioluminescence.

Cai Y, Seah CL, Leck H, Lim TP, Teo JQ, Lee W, Tan TT, Koh TH, Ee PLR, Kwa AL.

Antimicrob Agents Chemother. 2018 Aug 27;62(9). pii: e00183-18. doi: 10.1128/AAC.00183-18. Print 2018 Sep.


Population genomics in South East Asia captures unexpectedly high carrier frequency for treatable inherited disorders.

Bylstra Y, Kuan JL, Lim WK, Bhalshankar JD, Teo JX, Davila S, Teh BT, Rozen S, Tan EC, Liew WKM, Yeo KK, Tan P; SinGapore Incidental Finding (SGIF) study group, Saw SM, Cheng CY, Cook S, Foo R, Jamuar SS.

Genet Med. 2019 Jan;21(1):207-212. doi: 10.1038/s41436-018-0008-6. Epub 2018 Jul 2. Erratum in: Genet Med. 2018 Dec;20(12):1692.


A new therapeutic avenue for bronchiectasis: Dry powder inhaler of ciprofloxacin nanoplex exhibits superior ex vivo mucus permeability and antibacterial efficacy to its native ciprofloxacin counterpart.

Tran TT, Vidaillac C, Yu H, Yong VFL, Roizman D, Chandrasekaran R, Lim AYH, Low TB, Tan GL, Abisheganaden JA, Koh MS, Teo J, Chotirmall SH, Hadinoto K.

Int J Pharm. 2018 Aug 25;547(1-2):368-376. doi: 10.1016/j.ijpharm.2018.06.017. Epub 2018 Jun 7.


Teicoplanin - Tigecycline Combination Shows Synergy Against Mycobacterium abscessus.

Aziz DB, Teo JWP, Dartois V, Dick T.

Front Microbiol. 2018 May 11;9:932. doi: 10.3389/fmicb.2018.00932. eCollection 2018.


Aztreonam-Avibactam Combination Restores Susceptibility of Aztreonam in Dual-Carbapenemase-Producing Enterobacteriaceae.

Chew KL, Tay MKL, Cheng B, Lin RTP, Octavia S, Teo JWP.

Antimicrob Agents Chemother. 2018 Jul 27;62(8). pii: e00414-18. doi: 10.1128/AAC.00414-18. Print 2018 Aug. No abstract available.


Differentiation Therapy Targeting the β-Catenin/CBP Interaction in Pancreatic Cancer.

Manegold P, Lai KKY, Wu Y, Teo JL, Lenz HJ, Genyk YS, Pandol SJ, Wu K, Lin DP, Chen Y, Nguyen C, Zhao Y, Kahn M.

Cancers (Basel). 2018 Mar 29;10(4). pii: E95. doi: 10.3390/cancers10040095.


Short-Term Outcomes of Extended Pancreatectomy: A Single-Surgeon Experience.

Low TY, Koh YX, Teo JY, Goh BKP.

Gastrointest Tumors. 2018 Feb;4(3-4):72-83. doi: 10.1159/000484523. Epub 2017 Nov 30.


Structure-activity relationship studies of ultra-short peptides with potent activities against fluconazole-resistant Candida albicans.

Ng SMS, Yap JM, Lau QY, Ng FM, Ong EHQ, Barkham T, Teo JWP, Alfatah M, Kong KW, Hoon S, Arumugam P, Hill J, Brian Chia CS.

Eur J Med Chem. 2018 Apr 25;150:479-490. doi: 10.1016/j.ejmech.2018.03.027. Epub 2018 Mar 9.


Longitudinal monitoring reveals dynamic changes in circulating tumor cells (CTCs) and CTC-associated miRNAs in response to chemotherapy in metastatic colorectal cancer patients.

Tan K, Leong SM, Kee Z, Caramat PV, Teo J, Blanco MVM, Koay ESC, Cheong WK, Soh TI, Yong WP, Pang A.

Cancer Lett. 2018 Jun 1;423:1-8. doi: 10.1016/j.canlet.2018.02.039. Epub 2018 Mar 5.


Systematic review of the clinical utility and validity of the Sendai and Fukuoka Consensus Guidelines for the management of intraductal papillary mucinous neoplasms of the pancreas.

Srinivasan N, Teo JY, Chin YK, Hennedige T, Tan DM, Low AS, Thng CH, Goh BKP.

HPB (Oxford). 2018 Jun;20(6):497-504. doi: 10.1016/j.hpb.2018.01.009. Epub 2018 Feb 24.

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