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Complement Nomenclature-Deconvoluted.

Bohlson SS, Garred P, Kemper C, Tenner AJ.

Front Immunol. 2019 Jun 7;10:1308. doi: 10.3389/fimmu.2019.01308. eCollection 2019.


Preface to the Special issue for the 27th International complement workshop.

Tenner AJ, Atkinson JP, Holers VM.

Mol Immunol. 2018 Oct;102:1-2. doi: 10.1016/j.molimm.2018.07.010. Epub 2018 Jul 27. No abstract available.


New tricks for an ancient system: Physiological and pathological roles of complement in the CNS.

Tenner AJ, Stevens B, Woodruff TM.

Mol Immunol. 2018 Oct;102:3-13. doi: 10.1016/j.molimm.2018.06.264. Epub 2018 Jun 27. Review.


Peripheral complement interactions with amyloid β peptide in Alzheimer's disease: Polymorphisms, structure, and function of complement receptor 1.

Johansson JU, Brubaker WD, Javitz H, Bergen AW, Nishita D, Trigunaite A, Crane A, Ceballos J, Mastroeni D, Tenner AJ, Sabbagh M, Rogers J.

Alzheimers Dement. 2018 Nov;14(11):1438-1449. doi: 10.1016/j.jalz.2018.04.003. Epub 2018 May 21.


Incorporation of a Ligand Peptide for Immune Inhibitory Receptor LAIR-1 on Biomaterial Surfaces Inhibits Macrophage Inflammatory Responses.

Kim YK, Chu SH, Hsieh JY, Kamoku CM, Tenner AJ, Liu WF, Wang SW.

Adv Healthc Mater. 2017 Dec;6(24). doi: 10.1002/adhm.201700707. Epub 2017 Oct 30.


Prevention of C5aR1 signaling delays microglial inflammatory polarization, favors clearance pathways and suppresses cognitive loss.

Hernandez MX, Jiang S, Cole TA, Chu SH, Fonseca MI, Fang MJ, Hohsfield LA, Torres MD, Green KN, Wetsel RA, Mortazavi A, Tenner AJ.

Mol Neurodegener. 2017 Sep 18;12(1):66. doi: 10.1186/s13024-017-0210-z.


Peripheral complement interactions with amyloid β peptide in Alzheimer's disease: 2. Relationship to amyloid β immunotherapy.

Crane A, Brubaker WD, Johansson JU, Trigunaite A, Ceballos J, Bradt B, Glavis-Bloom C, Wallace TL, Tenner AJ, Rogers J.

Alzheimers Dement. 2018 Feb;14(2):243-252. doi: 10.1016/j.jalz.2017.04.015. Epub 2017 Jul 26.


CD200 modulates macrophage cytokine secretion and phagocytosis in response to poly(lactic co-glycolic acid) microparticles and films.

Chen EY, Chu S, Gov L, Kim YK, Lodoen MB, Tenner AJ, Liu WF.

J Mater Chem B. 2017 Feb 28;5(8):1574-1584. doi: 10.1039/C6TB02269C. Epub 2017 Jan 10.


C1q: A fresh look upon an old molecule.

Thielens NM, Tedesco F, Bohlson SS, Gaboriaud C, Tenner AJ.

Mol Immunol. 2017 Sep;89:73-83. doi: 10.1016/j.molimm.2017.05.025. Epub 2017 Jun 7. Review.


Peripheral complement interactions with amyloid β peptide: Erythrocyte clearance mechanisms.

Brubaker WD, Crane A, Johansson JU, Yen K, Garfinkel K, Mastroeni D, Asok P, Bradt B, Sabbagh M, Wallace TL, Glavis-Bloom C, Tenner AJ, Rogers J.

Alzheimers Dement. 2017 Dec;13(12):1397-1409. doi: 10.1016/j.jalz.2017.03.010. Epub 2017 May 2.


Cell-specific deletion of C1qa identifies microglia as the dominant source of C1q in mouse brain.

Fonseca MI, Chu SH, Hernandez MX, Fang MJ, Modarresi L, Selvan P, MacGregor GR, Tenner AJ.

J Neuroinflammation. 2017 Mar 6;14(1):48. doi: 10.1186/s12974-017-0814-9.


C5a Increases the Injury to Primary Neurons Elicited by Fibrillar Amyloid Beta.

Hernandez MX, Namiranian P, Nguyen E, Fonseca MI, Tenner AJ.

ASN Neuro. 2017 Feb;9(1):1759091416687871. doi: 10.1177/1759091416687871.


Preface to the Special Issue for the XXVI International Complement Workshop.

Fujita T, Wakamiya N, Tenner AJ.

Immunobiology. 2016 Oct;221(10):1035-6. doi: 10.1016/j.imbio.2016.06.225. Epub 2016 Jul 4. No abstract available.


Analysis of the Putative Role of CR1 in Alzheimer's Disease: Genetic Association, Expression and Function.

Fonseca MI, Chu S, Pierce AL, Brubaker WD, Hauhart RE, Mastroeni D, Clarke EV, Rogers J, Atkinson JP, Tenner AJ.

PLoS One. 2016 Feb 25;11(2):e0149792. doi: 10.1371/journal.pone.0149792. eCollection 2016.


Sialylation of neurites inhibits complement-mediated macrophage removal in a human macrophage-neuron Co-Culture System.

Linnartz-Gerlach B, Schuy C, Shahraz A, Tenner AJ, Neumann H.

Glia. 2016 Jan;64(1):35-47. doi: 10.1002/glia.22901. Epub 2015 Aug 10.


Elimination of Microglia Improves Functional Outcomes Following Extensive Neuronal Loss in the Hippocampus.

Rice RA, Spangenberg EE, Yamate-Morgan H, Lee RJ, Arora RP, Hernandez MX, Tenner AJ, West BL, Green KN.

J Neurosci. 2015 Jul 8;35(27):9977-89. doi: 10.1523/JNEUROSCI.0336-15.2015.


Complement protein C1q bound to apoptotic cells suppresses human macrophage and dendritic cell-mediated Th17 and Th1 T cell subset proliferation.

Clarke EV, Weist BM, Walsh CM, Tenner AJ.

J Leukoc Biol. 2015 Jan;97(1):147-60. doi: 10.1189/jlb.3A0614-278R. Epub 2014 Nov 7.


Complement modulation of T cell immune responses during homeostasis and disease.

Clarke EV, Tenner AJ.

J Leukoc Biol. 2014 Nov;96(5):745-56. doi: 10.1189/jlb.3MR0214-109R. Epub 2014 Sep 10. Review.


Real-time imaging of Toxoplasma-infected human monocytes under fluidic shear stress reveals rapid translocation of intracellular parasites across endothelial barriers.

Ueno N, Harker KS, Clarke EV, McWhorter FY, Liu WF, Tenner AJ, Lodoen MB.

Cell Microbiol. 2014 Apr;16(4):580-95. doi: 10.1111/cmi.12239. Epub 2013 Dec 4.


C1q Binding to and Uptake of Apoptotic Lymphocytes by Human Monocyte-derived Macrophages.

Benoit ME, Clarke EV, Tenner AJ.

Bio Protoc. 2013 Sep 5;3(17). pii: e877.


A dramatic increase of C1q protein in the CNS during normal aging.

Stephan AH, Madison DV, Mateos JM, Fraser DA, Lovelett EA, Coutellier L, Kim L, Tsai HH, Huang EJ, Rowitch DH, Berns DS, Tenner AJ, Shamloo M, Barres BA.

J Neurosci. 2013 Aug 14;33(33):13460-74. doi: 10.1523/JNEUROSCI.1333-13.2013.


Complement activation fragment C5a receptors, CD88 and C5L2, are associated with neurofibrillary pathology.

Fonseca MI, McGuire SO, Counts SE, Tenner AJ.

J Neuroinflammation. 2013 Feb 8;10:25. doi: 10.1186/1742-2094-10-25.


C1q-induced LRP1B and GPR6 proteins expressed early in Alzheimer disease mouse models, are essential for the C1q-mediated protection against amyloid-β neurotoxicity.

Benoit ME, Hernandez MX, Dinh ML, Benavente F, Vasquez O, Tenner AJ.

J Biol Chem. 2013 Jan 4;288(1):654-65. doi: 10.1074/jbc.M112.400168. Epub 2012 Nov 13.


Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study.

Cribbs DH, Berchtold NC, Perreau V, Coleman PD, Rogers J, Tenner AJ, Cotman CW.

J Neuroinflammation. 2012 Jul 23;9:179. doi: 10.1186/1742-2094-9-179.


Complement protein C1q directs macrophage polarization and limits inflammasome activity during the uptake of apoptotic cells.

Benoit ME, Clarke EV, Morgado P, Fraser DA, Tenner AJ.

J Immunol. 2012 Jun 1;188(11):5682-93. doi: 10.4049/jimmunol.1103760. Epub 2012 Apr 20.


Sialic acid on the neuronal glycocalyx prevents complement C1 binding and complement receptor-3-mediated removal by microglia.

Linnartz B, Kopatz J, Tenner AJ, Neumann H.

J Neurosci. 2012 Jan 18;32(3):946-52. doi: 10.1523/JNEUROSCI.3830-11.2012.


Complement in the brain.

Veerhuis R, Nielsen HM, Tenner AJ.

Mol Immunol. 2011 Aug;48(14):1592-603. doi: 10.1016/j.molimm.2011.04.003. Epub 2011 May 4. Review.


Complement protein C1q-mediated neuroprotection is correlated with regulation of neuronal gene and microRNA expression.

Benoit ME, Tenner AJ.

J Neurosci. 2011 Mar 2;31(9):3459-69. doi: 10.1523/JNEUROSCI.3932-10.2011.


Contribution of complement activation pathways to neuropathology differs among mouse models of Alzheimer's disease.

Fonseca MI, Chu SH, Berci AM, Benoit ME, Peters DG, Kimura Y, Tenner AJ.

J Neuroinflammation. 2011 Jan 15;8(1):4. doi: 10.1186/1742-2094-8-4.


Innate immune proteins C1q and mannan-binding lectin enhance clearance of atherogenic lipoproteins by human monocytes and macrophages.

Fraser DA, Tenner AJ.

J Immunol. 2010 Oct 1;185(7):3932-9. doi: 10.4049/jimmunol.1002080. Epub 2010 Sep 10.


A novel CD93 polymorphism in non-obese diabetic (NOD) and NZB/W F1 mice is linked to a CD4+ iNKT cell deficient state.

Zekavat G, Mozaffari R, Arias VJ, Rostami SY, Badkerhanian A, Tenner AJ, Nichols KE, Naji A, Noorchashm H.

Immunogenetics. 2010 Jun;62(6):397-407. doi: 10.1007/s00251-010-0442-3. Epub 2010 Apr 13.


Microglial C5aR (CD88) expression correlates with amyloid-beta deposition in murine models of Alzheimer's disease.

Ager RR, Fonseca MI, Chu SH, Sanderson SD, Taylor SM, Woodruff TM, Tenner AJ.

J Neurochem. 2010 Apr;113(2):389-401. doi: 10.1111/j.1471-4159.2010.06595.x. Epub 2010 Feb 2.


C1q enhances microglial clearance of apoptotic neurons and neuronal blebs, and modulates subsequent inflammatory cytokine production.

Fraser DA, Pisalyaput K, Tenner AJ.

J Neurochem. 2010 Feb;112(3):733-43. doi: 10.1111/j.1471-4159.2009.06494.x. Epub 2009 Nov 16.


C1q differentially modulates phagocytosis and cytokine responses during ingestion of apoptotic cells by human monocytes, macrophages, and dendritic cells.

Fraser DA, Laust AK, Nelson EL, Tenner AJ.

J Immunol. 2009 Nov 15;183(10):6175-85. doi: 10.4049/jimmunol.0902232. Epub 2009 Oct 28.


The role of the complement system and the activation fragment C5a in the central nervous system.

Woodruff TM, Ager RR, Tenner AJ, Noakes PG, Taylor SM.

Neuromolecular Med. 2010 Jun;12(2):179-92. doi: 10.1007/s12017-009-8085-y. Epub 2009 Sep 11.


Treatment with a C5aR antagonist decreases pathology and enhances behavioral performance in murine models of Alzheimer's disease.

Fonseca MI, Ager RR, Chu SH, Yazan O, Sanderson SD, LaFerla FM, Taylor SM, Woodruff TM, Tenner AJ.

J Immunol. 2009 Jul 15;183(2):1375-83. doi: 10.4049/jimmunol.0901005. Epub 2009 Jun 26.


The role of the anaphylatoxins in health and disease.

Klos A, Tenner AJ, Johswich KO, Ager RR, Reis ES, Köhl J.

Mol Immunol. 2009 Sep;46(14):2753-66. doi: 10.1016/j.molimm.2009.04.027. Epub 2009 May 28. Review.


The complement cascade: Yin-Yang in neuroinflammation--neuro-protection and -degeneration.

Alexander JJ, Anderson AJ, Barnum SR, Stevens B, Tenner AJ.

J Neurochem. 2008 Dec;107(5):1169-87. doi: 10.1111/j.1471-4159.2008.05668.x. Epub 2008 Oct 24. Review.


Complement C3 and C4 expression in C1q sufficient and deficient mouse models of Alzheimer's disease.

Zhou J, Fonseca MI, Pisalyaput K, Tenner AJ.

J Neurochem. 2008 Sep;106(5):2080-92. doi: 10.1111/j.1471-4159.2008.05558.x. Epub 2008 Jul 9.


Development of a humanized C1q A chain knock-in mouse: assessment of antibody independent beta-amyloid induced complement activation.

Li M, Ager RR, Fraser DA, Tjokro NO, Tenner AJ.

Mol Immunol. 2008 Jun;45(11):3244-52. doi: 10.1016/j.molimm.2008.02.022. Epub 2008 Apr 8.


Complement proteins C1q and MBL are pattern recognition molecules that signal immediate and long-term protective immune functions.

Bohlson SS, Fraser DA, Tenner AJ.

Mol Immunol. 2007 Jan;44(1-3):33-43. Epub 2006 Aug 14. Review.


The double-edged flower: roles of complement protein C1q in neurodegenerative diseases.

Tenner AJ, Fonseca MI.

Adv Exp Med Biol. 2006;586:153-76. Review.


ERK1/2 activation mediates Abeta oligomer-induced neurotoxicity via caspase-3 activation and tau cleavage in rat organotypic hippocampal slice cultures.

Chong YH, Shin YJ, Lee EO, Kayed R, Glabe CG, Tenner AJ.

J Biol Chem. 2006 Jul 21;281(29):20315-25. Epub 2006 May 18.


C1q and MBL, components of the innate immune system, influence monocyte cytokine expression.

Fraser DA, Bohlson SS, Jasinskiene N, Rawal N, Palmarini G, Ruiz S, Rochford R, Tenner AJ.

J Leukoc Biol. 2006 Jul;80(1):107-16. Epub 2006 Apr 14.


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