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Items: 1 to 50 of 60

1.

Improving Our Understanding of Salmonella enterica Serovar Paratyphi B through the Engineering and Testing of a Live Attenuated Vaccine Strain.

Higginson EE, Ramachandran G, Hazen TH, Kania DA, Rasko DA, Pasetti MF, Levine MM, Tennant SM.

mSphere. 2018 Nov 28;3(6). pii: e00474-18. doi: 10.1128/mSphere.00474-18.

2.

Improved Tolerability of a Salmonella enterica Serovar Typhimurium Live-Attenuated Vaccine Strain Achieved by Balancing Inflammatory Potential with Immunogenicity.

Higginson EE, Ramachandran G, Panda A, Shipley ST, Kriel EH, DeTolla LJ, Lipsky M, Perkins DJ, Salerno-Goncalves R, Sztein MB, Pasetti MF, Levine MM, Tennant SM.

Infect Immun. 2018 Nov 20;86(12). pii: e00440-18. doi: 10.1128/IAI.00440-18. Print 2018 Dec.

PMID:
30249748
3.

Development of a broad spectrum glycoconjugate vaccine to prevent wound and disseminated infections with Klebsiella pneumoniae and Pseudomonas aeruginosa.

Hegerle N, Choi M, Sinclair J, Amin MN, Ollivault-Shiflett M, Curtis B, Laufer RS, Shridhar S, Brammer J, Toapanta FR, Holder IA, Pasetti MF, Lees A, Tennant SM, Cross AS, Simon R.

PLoS One. 2018 Sep 6;13(9):e0203143. doi: 10.1371/journal.pone.0203143. eCollection 2018.

4.

Responses of the Human Gut Escherichia coli Population to Pathogen and Antibiotic Disturbances.

Richter TKS, Michalski JM, Zanetti L, Tennant SM, Chen WH, Rasko DA.

mSystems. 2018 Jul 24;3(4). pii: e00047-18. doi: 10.1128/mSystems.00047-18. eCollection 2018 Jul-Aug.

5.

Deletions in guaBA and htrA but not clpX or rfaL constitute a live-attenuated vaccine strain of Salmonella Newport to protect against serogroup C2-C3 Salmonella in mice.

Fuche FJ, Jones JA, Ramachandran G, Higginson EE, Simon R, Tennant SM.

Hum Vaccin Immunother. 2018 Jun 21:1-9. doi: 10.1080/21645515.2018.1491499. [Epub ahead of print]

PMID:
29927725
6.

Immunogenicity and protective efficacy against Salmonella C2-C3 infection in mice immunized with a glycoconjugate of S. Newport Core-O polysaccharide linked to the homologous serovar FliC protein.

Schuster O, Sears KT, Ramachandran G, Fuche FJ, Curtis B, Tennant SM, Simon R.

Hum Vaccin Immunother. 2018 Jun 6:1-9. doi: 10.1080/21645515.2018.1483808. [Epub ahead of print]

PMID:
29873578
7.

Immunogenicity and efficacy following sequential parenterally-administered doses of Salmonella Enteritidis COPS:FliC glycoconjugates in infant and adult mice.

Baliban SM, Curtis B, Toema D, Tennant SM, Levine MM, Pasetti MF, Simon R.

PLoS Negl Trop Dis. 2018 May 23;12(5):e0006522. doi: 10.1371/journal.pntd.0006522. eCollection 2018 May.

8.

Overexpression of O-polysaccharide chain length regulators in Gram-negative bacteria using the Wzx-/Wzy-dependent pathway enhances production of defined modal length O-polysaccharide polymers for use as haptens in glycoconjugate vaccines.

Hegerle N, Bose J, Ramachandran G, Galen JE, Levine MM, Simon R, Tennant SM.

J Appl Microbiol. 2018 Aug;125(2):575-585. doi: 10.1111/jam.13772. Epub 2018 May 15.

PMID:
29603538
9.

Characterization of Invasive Salmonella Serogroup C1 Infections in Mali.

Fuche FJ, Sen S, Jones JA, Nkeze J, Permala-Booth J, Tapia MD, Sow SO, Tamboura B, Touré A, Onwuchekwa U, Sylla M, Kotloff KL, Tennant SM.

Am J Trop Med Hyg. 2018 Feb;98(2):589-594. doi: 10.4269/ajtmh.17-0508. Epub 2017 Dec 21.

10.

A randomized, placebo-controlled, double-blind Phase 2 trial comparing the reactogenicity and immunogenicity of a single ≥2x108 colony forming units [cfu] standard-dose versus a ≥2x109 cfu high-dose of CVD 103-HgR live attenuated oral cholera vaccine, with Shanchol inactivated oral vaccine as an open label immunologic comparator.

Sow SO, Tapia MD, Chen WH, Haidara FC, Kotloff KL, Pasetti MF, Blackwelder WC, Traoré A, Tamboura B, Doumbia M, Diallo F, Coulibaly F, Onwuchekwa U, Kodio M, Tennant SM, Reymann M, Lam DF, Gurwith M, Lock M, Yonker T, Smith J, Simon JK, Levine MM.

Clin Vaccine Immunol. 2017 Oct 11. pii: CVI.00265-17. doi: 10.1128/CVI.00265-17. [Epub ahead of print]

11.

Virulence of invasive Salmonella Typhimurium ST313 in animal models of infection.

Ramachandran G, Panda A, Higginson EE, Ateh E, Lipsky MM, Sen S, Matson CA, Permala-Booth J, DeTolla LJ, Tennant SM.

PLoS Negl Trop Dis. 2017 Aug 4;11(8):e0005697. doi: 10.1371/journal.pntd.0005697. eCollection 2017 Aug.

12.

Bioactive Immune Components of Anti-Diarrheagenic Enterotoxigenic Escherichia coli Hyperimmune Bovine Colostrum Products.

Sears KT, Tennant SM, Reymann MK, Simon R, Konstantopoulos N, Blackwelder WC, Barry EM, Pasetti MF.

Clin Vaccine Immunol. 2017 Aug 4;24(8). pii: e00186-16. doi: 10.1128/CVI.00186-16. Print 2017 Aug.

13.

Development of a glycoconjugate vaccine to prevent invasive Salmonella Typhimurium infections in sub-Saharan Africa.

Baliban SM, Yang M, Ramachandran G, Curtis B, Shridhar S, Laufer RS, Wang JY, Van Druff J, Higginson EE, Hegerle N, Varney KM, Galen JE, Tennant SM, Lees A, MacKerell AD Jr, Levine MM, Simon R.

PLoS Negl Trop Dis. 2017 Apr 7;11(4):e0005493. doi: 10.1371/journal.pntd.0005493. eCollection 2017 Apr.

14.

Erratum: Distinct Salmonella Enteritidis lineages associated with enterocolitis in high-income settings and invasive disease in low-income settings.

Feasey NA, Hadfield J, Keddy KH, Dallman TJ, Jacobs J, Deng X, Wigley P, Barquist L, Langridge GC, Feltwell T, Harris SR, Mather AE, Fookes M, Aslett M, Msefula C, Kariuki S, Maclennan CA, Onsare RS, Weill FX, Le Hello S, Smith AM, McClelland M, Desai P, Parry CM, Cheesbrough J, French N, Campos J, Chabalgoity JA, Betancor L, Hopkins KL, Nair S, Humphrey TJ, Lunguya O, Cogan TA, Tapia MD, Sow SO, Tennant SM, Bornstein K, Levine MM, Lacharme-Lora L, Everett DB, Kingsley RA, Parkhill J, Heyderman RS, Dougan G, Gordon MA, Thomson NR.

Nat Genet. 2017 Mar 30;49(4):651. doi: 10.1038/ng0417-651c. No abstract available.

PMID:
28358127
15.

Modeling the Potential for Vaccination to Diminish the Burden of Invasive Non-typhoidal Salmonella Disease in Young Children in Mali, West Africa.

Bornstein K, Hungerford L, Hartley D, Sorkin JD, Tapia MD, Sow SO, Onwuchekwa U, Simon R, Tennant SM, Levine MM.

PLoS Negl Trop Dis. 2017 Feb 9;11(2):e0005283. doi: 10.1371/journal.pntd.0005283. eCollection 2017 Feb.

16.

Cryptosporidium hominis gene catalog: a resource for the selection of novel Cryptosporidium vaccine candidates.

Ifeonu OO, Simon R, Tennant SM, Sheoran AS, Daly MC, Felix V, Kissinger JC, Widmer G, Levine MM, Tzipori S, Silva JC.

Database (Oxford). 2016 Oct 19;2016. pii: baw137. doi: 10.1093/database/baw137. Print 2016.

17.

Live Attenuated Human Salmonella Vaccine Candidates: Tracking the Pathogen in Natural Infection and Stimulation of Host Immunity.

Galen JE, Buskirk AD, Tennant SM, Pasetti MF.

EcoSal Plus. 2016 Nov;7(1). doi: 10.1128/ecosalplus.ESP-0010-2016. Review.

18.

Use of quantitative molecular diagnostic methods to identify causes of diarrhoea in children: a reanalysis of the GEMS case-control study.

Liu J, Platts-Mills JA, Juma J, Kabir F, Nkeze J, Okoi C, Operario DJ, Uddin J, Ahmed S, Alonso PL, Antonio M, Becker SM, Blackwelder WC, Breiman RF, Faruque AS, Fields B, Gratz J, Haque R, Hossain A, Hossain MJ, Jarju S, Qamar F, Iqbal NT, Kwambana B, Mandomando I, McMurry TL, Ochieng C, Ochieng JB, Ochieng M, Onyango C, Panchalingam S, Kalam A, Aziz F, Qureshi S, Ramamurthy T, Roberts JH, Saha D, Sow SO, Stroup SE, Sur D, Tamboura B, Taniuchi M, Tennant SM, Toema D, Wu Y, Zaidi A, Nataro JP, Kotloff KL, Levine MM, Houpt ER.

Lancet. 2016 Sep 24;388(10051):1291-301. doi: 10.1016/S0140-6736(16)31529-X.

19.
20.

Distinct Salmonella Enteritidis lineages associated with enterocolitis in high-income settings and invasive disease in low-income settings.

Feasey NA, Hadfield J, Keddy KH, Dallman TJ, Jacobs J, Deng X, Wigley P, Barquist L, Langridge GC, Feltwell T, Harris SR, Mather AE, Fookes M, Aslett M, Msefula C, Kariuki S, Maclennan CA, Onsare RS, Weill FX, Le Hello S, Smith AM, McClelland M, Desai P, Parry CM, Cheesbrough J, French N, Campos J, Chabalgoity JA, Betancor L, Hopkins KL, Nair S, Humphrey TJ, Lunguya O, Cogan TA, Tapia MD, Sow SO, Tennant SM, Bornstein K, Levine MM, Lacharme-Lora L, Everett DB, Kingsley RA, Parkhill J, Heyderman RS, Dougan G, Gordon MA, Thomson NR.

Nat Genet. 2016 Oct;48(10):1211-1217. doi: 10.1038/ng.3644. Epub 2016 Aug 22. Erratum in: Nat Genet. 2017 Mar 30;49(4):651.

21.

Aeromonas-Associated Diarrhea in Children Under 5 Years: The GEMS Experience.

Qamar FN, Nisar MI, Quadri F, Shakoor S, Sow SO, Nasrin D, Blackwelder WC, Wu Y, Farag T, Panchalingham S, Sur D, Qureshi S, Faruque AS, Saha D, Alonso PL, Breiman RF, Bassat Q, Tamboura B, Ramamurthy T, Kanungo S, Ahmed S, Hossain A, Das SK, Antonio M, Hossain MJ, Mandomando I, Tennant SM, Kotloff KL, Levine MM, Zaidi AK.

Am J Trop Med Hyg. 2016 Oct 5;95(4):774-780. Epub 2016 Aug 15.

22.

Salmonella Serogroup C: Current Status of Vaccines and Why They Are Needed.

Fuche FJ, Sow O, Simon R, Tennant SM.

Clin Vaccine Immunol. 2016 Sep 6;23(9):737-45. doi: 10.1128/CVI.00243-16. Print 2016 Sep. Review.

23.

Animal Models for Salmonellosis: Applications in Vaccine Research.

Higginson EE, Simon R, Tennant SM.

Clin Vaccine Immunol. 2016 Sep 6;23(9):746-56. doi: 10.1128/CVI.00258-16. Print 2016 Sep. Review.

24.

Maternal immunisation with trivalent inactivated influenza vaccine for prevention of influenza in infants in Mali: a prospective, active-controlled, observer-blind, randomised phase 4 trial.

Tapia MD, Sow SO, Tamboura B, Tégueté I, Pasetti MF, Kodio M, Onwuchekwa U, Tennant SM, Blackwelder WC, Coulibaly F, Traoré A, Keita AM, Haidara FC, Diallo F, Doumbia M, Sanogo D, DeMatt E, Schluterman NH, Buchwald A, Kotloff KL, Chen WH, Orenstein EW, Orenstein LAV, Villanueva J, Bresee J, Treanor J, Levine MM.

Lancet Infect Dis. 2016 Sep;16(9):1026-1035. doi: 10.1016/S1473-3099(16)30054-8. Epub 2016 May 31.

25.

Poor biofilm-forming ability and long-term survival of invasive Salmonella Typhimurium ST313.

Ramachandran G, Aheto K, Shirtliff ME, Tennant SM.

Pathog Dis. 2016 Jul;74(5). pii: ftw049. doi: 10.1093/femspd/ftw049. Epub 2016 May 23.

26.

The Burden of Cryptosporidium Diarrheal Disease among Children < 24 Months of Age in Moderate/High Mortality Regions of Sub-Saharan Africa and South Asia, Utilizing Data from the Global Enteric Multicenter Study (GEMS).

Sow SO, Muhsen K, Nasrin D, Blackwelder WC, Wu Y, Farag TH, Panchalingam S, Sur D, Zaidi AK, Faruque AS, Saha D, Adegbola R, Alonso PL, Breiman RF, Bassat Q, Tamboura B, Sanogo D, Onwuchekwa U, Manna B, Ramamurthy T, Kanungo S, Ahmed S, Qureshi S, Quadri F, Hossain A, Das SK, Antonio M, Hossain MJ, Mandomando I, Nhampossa T, Acácio S, Omore R, Oundo JO, Ochieng JB, Mintz ED, O'Reilly CE, Berkeley LY, Livio S, Tennant SM, Sommerfelt H, Nataro JP, Ziv-Baran T, Robins-Browne RM, Mishcherkin V, Zhang J, Liu J, Houpt ER, Kotloff KL, Levine MM.

PLoS Negl Trop Dis. 2016 May 24;10(5):e0004729. doi: 10.1371/journal.pntd.0004729. eCollection 2016 May.

27.

Status of paratyphoid fever vaccine research and development.

Martin LB, Simon R, MacLennan CA, Tennant SM, Sahastrabuddhe S, Khan MI.

Vaccine. 2016 Jun 3;34(26):2900-2902. doi: 10.1016/j.vaccine.2016.03.106. Epub 2016 Apr 12.

28.

Nontyphoidal salmonella disease: Current status of vaccine research and development.

Tennant SM, MacLennan CA, Simon R, Martin LB, Khan MI.

Vaccine. 2016 Jun 3;34(26):2907-2910. doi: 10.1016/j.vaccine.2016.03.072. Epub 2016 Mar 29.

29.

Opsonophagocytic Assay To Evaluate Immunogenicity of Nontyphoidal Salmonella Vaccines.

Ramachandran G, Boyd MA, MacSwords J, Higginson EE, Simon R, Galen JE, Pasetti MF, Levine MM, Tennant SM.

Clin Vaccine Immunol. 2016 Jun 6;23(6):520-523. doi: 10.1128/CVI.00106-16. Print 2016 Jun.

30.

Functional Activity of Antibodies Directed towards Flagellin Proteins of Non-Typhoidal Salmonella.

Ramachandran G, Tennant SM, Boyd MA, Wang JY, Tulapurkar ME, Pasetti MF, Levine MM, Simon R.

PLoS One. 2016 Mar 21;11(3):e0151875. doi: 10.1371/journal.pone.0151875. eCollection 2016.

31.

Highlights of the 8th International Conference on Vaccines for Enteric Diseases: the Scottish Encounter To Defeat Diarrheal Diseases.

Tennant SM, Steele AD, Pasetti MF.

Clin Vaccine Immunol. 2016 Apr 4;23(4):272-81. doi: 10.1128/CVI.00082-16. Print 2016 Apr.

32.

Invasive Salmonella Infections Among Children From Rural Mozambique, 2001-2014.

Mandomando I, Bassat Q, Sigaúque B, Massora S, Quintó L, Ácacio S, Nhampossa T, Vubil D, Garrine M, Macete E, Aide P, Sacoor C, Herrera-León S, Ruiz J, Tennant SM, Menéndez C, Alonso PL.

Clin Infect Dis. 2015 Nov 1;61 Suppl 4:S339-45. doi: 10.1093/cid/civ712.

PMID:
26449950
33.

Invasive Nontyphoidal Salmonella Infections Among Children in Mali, 2002-2014: Microbiological and Epidemiologic Features Guide Vaccine Development.

Tapia MD, Tennant SM, Bornstein K, Onwuchekwa U, Tamboura B, Maiga A, Sylla MB, Sissoko S, Kourouma N, Toure A, Malle D, Livio S, Sow SO, Levine MM.

Clin Infect Dis. 2015 Nov 1;61 Suppl 4:S332-8. doi: 10.1093/cid/civ729. Review.

34.

Detection of Typhoidal and Paratyphoidal Salmonella in Blood by Real-time Polymerase Chain Reaction.

Tennant SM, Toema D, Qamar F, Iqbal N, Boyd MA, Marshall JM, Blackwelder WC, Wu Y, Quadri F, Khan A, Aziz F, Ahmad K, Kalam A, Asif E, Qureshi S, Khan E, Zaidi AK, Levine MM.

Clin Infect Dis. 2015 Nov 1;61 Suppl 4:S241-50. doi: 10.1093/cid/civ726.

PMID:
26449938
35.

Refined live attenuated Salmonella enterica serovar Typhimurium and Enteritidis vaccines mediate homologous and heterologous serogroup protection in mice.

Tennant SM, Schmidlein P, Simon R, Pasetti MF, Galen JE, Levine MM.

Infect Immun. 2015 Dec;83(12):4504-12. doi: 10.1128/IAI.00924-15. Epub 2015 Sep 8.

36.

Salmonella Typhimurium Co-Opts the Host Type I IFN System To Restrict Macrophage Innate Immune Transcriptional Responses Selectively.

Perkins DJ, Rajaiah R, Tennant SM, Ramachandran G, Higginson EE, Dyson TN, Vogel SN.

J Immunol. 2015 Sep 1;195(5):2461-71. doi: 10.4049/jimmunol.1500105. Epub 2015 Jul 22.

37.

Live attenuated vaccines for invasive Salmonella infections.

Tennant SM, Levine MM.

Vaccine. 2015 Jun 19;33 Suppl 3:C36-41. doi: 10.1016/j.vaccine.2015.04.029. Epub 2015 Apr 19. Review.

38.

Adaptation of red blood cell lysis represents a fundamental breakthrough that improves the sensitivity of Salmonella detection in blood.

Boyd MA, Tennant SM, Melendez JH, Toema D, Galen JE, Geddes CD, Levine MM.

J Appl Microbiol. 2015 May;118(5):1199-209. doi: 10.1111/jam.12769. Epub 2015 Mar 12.

39.

Invasive Salmonella Typhimurium ST313 with naturally attenuated flagellin elicits reduced inflammation and replicates within macrophages.

Ramachandran G, Perkins DJ, Schmidlein PJ, Tulapurkar ME, Tennant SM.

PLoS Negl Trop Dis. 2015 Jan 8;9(1):e3394. doi: 10.1371/journal.pntd.0003394. eCollection 2015 Jan.

40.

A scalable method for biochemical purification of Salmonella flagellin.

Simon R, Curtis B, Deumic V, Nicki J, Tennant SM, Pasetti MF, Lees A, Wills PW, Chacon M, Levine MM.

Protein Expr Purif. 2014 Oct;102:1-7. doi: 10.1016/j.pep.2014.07.005. Epub 2014 Jul 19.

41.

Shigella isolates from the global enteric multicenter study inform vaccine development.

Livio S, Strockbine NA, Panchalingam S, Tennant SM, Barry EM, Marohn ME, Antonio M, Hossain A, Mandomando I, Ochieng JB, Oundo JO, Qureshi S, Ramamurthy T, Tamboura B, Adegbola RA, Hossain MJ, Saha D, Sen S, Faruque AS, Alonso PL, Breiman RF, Zaidi AK, Sur D, Sow SO, Berkeley LY, O'Reilly CE, Mintz ED, Biswas K, Cohen D, Farag TH, Nasrin D, Wu Y, Blackwelder WC, Kotloff KL, Nataro JP, Levine MM.

Clin Infect Dis. 2014 Oct;59(7):933-41. doi: 10.1093/cid/ciu468. Epub 2014 Jun 23.

42.

Serum bactericidal assays to evaluate typhoidal and nontyphoidal Salmonella vaccines.

Boyd MA, Tennant SM, Saague VA, Simon R, Muhsen K, Ramachandran G, Cross AS, Galen JE, Pasetti MF, Levine MM.

Clin Vaccine Immunol. 2014 May;21(5):712-21. doi: 10.1128/CVI.00115-14. Epub 2014 Mar 12.

43.

Safety and tolerability of a live oral Salmonella typhimurium vaccine candidate in SIV-infected nonhuman primates.

Ault A, Tennant SM, Gorres JP, Eckhaus M, Sandler NG, Roque A, Livio S, Bao S, Foulds KE, Kao SF, Roederer M, Schmidlein P, Boyd MA, Pasetti MF, Douek DC, Estes JD, Nabel GJ, Levine MM, Rao SS.

Vaccine. 2013 Dec 2;31(49):5879-88. doi: 10.1016/j.vaccine.2013.09.041. Epub 2013 Oct 5.

PMID:
24099872
44.

Comparing the roles of antibodies to nontyphoidal Salmonella enterica in high- and low-income countries and implications for vaccine development.

MacLennan CA, Tennant SM.

Clin Vaccine Immunol. 2013 Oct;20(10):1487-90. doi: 10.1128/CVI.00465-13. Epub 2013 Jul 31. No abstract available.

45.

Sustained protection in mice immunized with fractional doses of Salmonella Enteritidis core and O polysaccharide-flagellin glycoconjugates.

Simon R, Wang JY, Boyd MA, Tulapurkar ME, Ramachandran G, Tennant SM, Pasetti M, Galen JE, Levine MM.

PLoS One. 2013 May 31;8(5):e64680. doi: 10.1371/journal.pone.0064680. Print 2013.

46.

Intracontinental spread of human invasive Salmonella Typhimurium pathovariants in sub-Saharan Africa.

Okoro CK, Kingsley RA, Connor TR, Harris SR, Parry CM, Al-Mashhadani MN, Kariuki S, Msefula CL, Gordon MA, de Pinna E, Wain J, Heyderman RS, Obaro S, Alonso PL, Mandomando I, MacLennan CA, Tapia MD, Levine MM, Tennant SM, Parkhill J, Dougan G.

Nat Genet. 2012 Nov;44(11):1215-21. doi: 10.1038/ng.2423. Epub 2012 Sep 30.

47.

Engineering and preclinical evaluation of attenuated nontyphoidal Salmonella strains serving as live oral vaccines and as reagent strains.

Tennant SM, Wang JY, Galen JE, Simon R, Pasetti MF, Gat O, Levine MM.

Infect Immun. 2011 Oct;79(10):4175-85. doi: 10.1128/IAI.05278-11. Epub 2011 Aug 1.

48.

Salmonella enterica serovar enteritidis core O polysaccharide conjugated to H:g,m flagellin as a candidate vaccine for protection against invasive infection with S. enteritidis.

Simon R, Tennant SM, Wang JY, Schmidlein PJ, Lees A, Ernst RK, Pasetti MF, Galen JE, Levine MM.

Infect Immun. 2011 Oct;79(10):4240-9. doi: 10.1128/IAI.05484-11. Epub 2011 Aug 1.

49.

Mouse models to assess the efficacy of non-typhoidal Salmonella vaccines: revisiting the role of host innate susceptibility and routes of challenge.

Simon R, Tennant SM, Galen JE, Levine MM.

Vaccine. 2011 Jul 18;29(32):5094-106. doi: 10.1016/j.vaccine.2011.05.022. Epub 2011 May 25. Review.

50.

Ultra-fast and sensitive detection of non-typhoidal Salmonella using microwave-accelerated metal-enhanced fluorescence ("MAMEF").

Tennant SM, Zhang Y, Galen JE, Geddes CD, Levine MM.

PLoS One. 2011 Apr 8;6(4):e18700. doi: 10.1371/journal.pone.0018700.

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