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Items: 1 to 50 of 68

1.

Metabolic tracing reveals novel adaptations to skeletal muscle cell energy production pathways in response to NAD + depletion.

Oakey LA, Fletcher RS, Elhassan YS, Cartwright DM, Doig CL, Garten A, Thakker A, Maddocks ODK, Zhang T, Tennant DA, Ludwig C, Lavery GG.

Version 2. Wellcome Open Res. 2019 Sep 17 [revised 2019 Jan 1];3:147. doi: 10.12688/wellcomeopenres.14898.2. eCollection 2018.

2.

Nicotinamide Riboside Augments the Aged Human Skeletal Muscle NAD+ Metabolome and Induces Transcriptomic and Anti-inflammatory Signatures.

Elhassan YS, Kluckova K, Fletcher RS, Schmidt MS, Garten A, Doig CL, Cartwright DM, Oakey L, Burley CV, Jenkinson N, Wilson M, Lucas SJE, Akerman I, Seabright A, Lai YC, Tennant DA, Nightingale P, Wallis GA, Manolopoulos KN, Brenner C, Philp A, Lavery GG.

Cell Rep. 2019 Aug 13;28(7):1717-1728.e6. doi: 10.1016/j.celrep.2019.07.043.

3.

Ex vivo metabolite profiling of paediatric central nervous system tumours reveals prognostic markers.

Bennett CD, Gill SK, Kohe SE, Wilson MP, Davies NP, Arvanitis TN, Tennant DA, Peet AC.

Sci Rep. 2019 Jul 19;9(1):10473. doi: 10.1038/s41598-019-45900-x.

4.

Development and Validation of a Combined Hypoxia and Immune Prognostic Classifier for Head and Neck Cancer.

Brooks JM, Menezes AN, Ibrahim M, Archer L, Lal N, Bagnall CJ, von Zeidler SV, Valentine HR, Spruce RJ, Batis N, Bryant JL, Hartley M, Kaul B, Ryan GB, Bao R, Khattri A, Lee SP, Ogbureke KUE, Middleton G, Tennant DA, Beggs AD, Deeks J, West CML, Cazier JB, Willcox BE, Seiwert TY, Mehanna H.

Clin Cancer Res. 2019 Sep 1;25(17):5315-5328. doi: 10.1158/1078-0432.CCR-18-3314. Epub 2019 Jun 10.

PMID:
31182433
5.

Electrochemical properties of the interaction between cytochrome c and a hematite nanowire array electrode.

Wang H, Johs A, Browning JF, Tennant DA, Liang L.

Bioelectrochemistry. 2019 Oct;129:162-169. doi: 10.1016/j.bioelechem.2019.05.012. Epub 2019 May 23.

PMID:
31176253
6.

Tomonaga-Luttinger liquid behavior and spinon confinement in YbAlO3.

Wu LS, Nikitin SE, Wang Z, Zhu W, Batista CD, Tsvelik AM, Samarakoon AM, Tennant DA, Brando M, Vasylechko L, Frontzek M, Savici AT, Sala G, Ehlers G, Christianson AD, Lumsden MD, Podlesnyak A.

Nat Commun. 2019 Feb 11;10(1):698. doi: 10.1038/s41467-019-08485-7.

7.

Verteporfin selectively kills hypoxic glioma cells through iron-binding and increased production of reactive oxygen species.

Eales KL, Wilkinson EA, Cruickshank G, Tucker JHR, Tennant DA.

Sci Rep. 2018 Sep 25;8(1):14358. doi: 10.1038/s41598-018-32727-1.

8.

Tissue metabolite profiles for the characterisation of paediatric cerebellar tumours.

Bennett CD, Kohe SE, Gill SK, Davies NP, Wilson M, Storer LCD, Ritzmann T, Paine SML, Scott IS, Nicklaus-Wollenteit I, Tennant DA, Grundy RG, Peet AC.

Sci Rep. 2018 Aug 10;8(1):11992. doi: 10.1038/s41598-018-30342-8.

9.

Oncogenic IDH1 Mutations Promote Enhanced Proline Synthesis through PYCR1 to Support the Maintenance of Mitochondrial Redox Homeostasis.

Hollinshead KER, Munford H, Eales KL, Bardella C, Li C, Escribano-Gonzalez C, Thakker A, Nonnenmacher Y, Kluckova K, Jeeves M, Murren R, Cuozzo F, Ye D, Laurenti G, Zhu W, Hiller K, Hodson DJ, Hua W, Tomlinson IP, Ludwig C, Mao Y, Tennant DA.

Cell Rep. 2018 Mar 20;22(12):3107-3114. doi: 10.1016/j.celrep.2018.02.084.

10.

High-Speed Tracer Analysis of Metabolism (HS-TrAM).

Smith TB, Patel K, Munford H, Peet A, Tennant DA, Jeeves M, Ludwig C.

Wellcome Open Res. 2018 Jan 12;3:5. doi: 10.12688/wellcomeopenres.13387.2. eCollection 2018.

11.

Metabolic implications of hypoxia and pseudohypoxia in pheochromocytoma and paraganglioma.

Kluckova K, Tennant DA.

Cell Tissue Res. 2018 May;372(2):367-378. doi: 10.1007/s00441-018-2801-6. Epub 2018 Feb 15. Review.

12.

Scaling of Memories and Crossover in Glassy Magnets.

Samarakoon AM, Takahashi M, Zhang D, Yang J, Katayama N, Sinclair R, Zhou HD, Diallo SO, Ehlers G, Tennant DA, Wakimoto S, Yamada K, Chern GW, Sato TJ, Lee SH.

Sci Rep. 2017 Sep 21;7(1):12053. doi: 10.1038/s41598-017-12187-9.

13.

A magnetic topological semimetal Sr1-yMn1-zSb2 (y, z < 0.1).

Liu JY, Hu J, Zhang Q, Graf D, Cao HB, Radmanesh SMA, Adams DJ, Zhu YL, Cheng GF, Liu X, Phelan WA, Wei J, Jaime M, Balakirev F, Tennant DA, DiTusa JF, Chiorescu I, Spinu L, Mao ZQ.

Nat Mater. 2017 Sep;16(9):905-910. doi: 10.1038/nmat4953. Epub 2017 Jul 24.

PMID:
28740190
14.

Neutron scattering in the proximate quantum spin liquid α-RuCl3.

Banerjee A, Yan J, Knolle J, Bridges CA, Stone MB, Lumsden MD, Mandrus DG, Tennant DA, Moessner R, Nagler SE.

Science. 2017 Jun 9;356(6342):1055-1059. doi: 10.1126/science.aah6015.

15.

Field induced spontaneous quasiparticle decay and renormalization of quasiparticle dispersion in a quantum antiferromagnet.

Hong T, Qiu Y, Matsumoto M, Tennant DA, Coester K, Schmidt KP, Awwadi FF, Turnbull MM, Agrawal H, Chernyshev AL.

Nat Commun. 2017 May 5;8:15148. doi: 10.1038/ncomms15148.

16.

Combined Analysis of NMR and MS Spectra (CANMS).

Chong M, Jayaraman A, Marin S, Selivanov V, de Atauri Carulla PR, Tennant DA, Cascante M, Günther UL, Ludwig C.

Angew Chem Int Ed Engl. 2017 Apr 3;56(15):4140-4144. doi: 10.1002/anie.201611634. Epub 2017 Mar 8.

PMID:
28272839
17.

Encoding Magnetic States in Monopole-Like Configurations Using Superconducting Dots.

Palau A, Valencia S, Del-Valle N, Navau C, Cialone M, Arora A, Kronast F, Tennant DA, Obradors X, Sanchez A, Puig T.

Adv Sci (Weinh). 2016 Sep 14;3(11):1600207. eCollection 2016 Nov.

18.

Metabolic differences between cold stored and machine perfused porcine kidneys: A 1H NMR based study.

Nath J, Smith TB, Patel K, Ebbs SR, Hollis A, Tennant DA, Ludwig C, Ready AR.

Cryobiology. 2017 Feb;74:115-120. doi: 10.1016/j.cryobiol.2016.11.006. Epub 2016 Dec 3.

PMID:
27919740
19.

Isocitrate dehydrogenase (IDH), succinate dehydrogenase (SDH), fumarate hydratase (FH): three players for one phenotype in cancer?

Laurenti G, Tennant DA.

Biochem Soc Trans. 2016 Aug 15;44(4):1111-6. doi: 10.1042/BST20160099. Review.

PMID:
27528759
20.

(13)C glucose labelling studies using 2D NMR are a useful tool for determining ex vivo whole organ metabolism during hypothermic machine perfusion of kidneys.

Nath J, Smith T, Hollis A, Ebbs S, Canbilen SW, Tennant DA, Ready AR, Ludwig C.

Transplant Res. 2016 Aug 5;5:7. doi: 10.1186/s13737-016-0037-0. eCollection 2016.

21.

Citrullination of histone H3 drives IL-6 production by bone marrow mesenchymal stem cells in MGUS and multiple myeloma.

McNee G, Eales KL, Wei W, Williams DS, Barkhuizen A, Bartlett DB, Essex S, Anandram S, Filer A, Moss PA, Pratt G, Basu S, Davies CC, Tennant DA.

Leukemia. 2017 Feb;31(2):373-381. doi: 10.1038/leu.2016.187. Epub 2016 Jul 11.

22.

Probing Cancer Cell Metabolism Using NMR Spectroscopy.

Hollinshead KE, Williams DS, Tennant DA, Ludwig C.

Adv Exp Med Biol. 2016;899:89-111. doi: 10.1007/978-3-319-26666-4_6. Review.

PMID:
27325263
23.

Mitochondrial metabolic remodeling in response to genetic and environmental perturbations.

Hollinshead KE, Tennant DA.

Wiley Interdiscip Rev Syst Biol Med. 2016 Jul;8(4):272-85. doi: 10.1002/wsbm.1334. Epub 2016 May 19. Review.

24.

Proximate Kitaev quantum spin liquid behaviour in a honeycomb magnet.

Banerjee A, Bridges CA, Yan JQ, Aczel AA, Li L, Stone MB, Granroth GE, Lumsden MD, Yiu Y, Knolle J, Bhattacharjee S, Kovrizhin DL, Moessner R, Tennant DA, Mandrus DG, Nagler SE.

Nat Mater. 2016 Jul;15(7):733-40. doi: 10.1038/nmat4604. Epub 2016 Apr 4.

25.

Hypoxia and metabolic adaptation of cancer cells.

Eales KL, Hollinshead KE, Tennant DA.

Oncogenesis. 2016 Jan 25;5:e190. doi: 10.1038/oncsis.2015.50. Review.

26.

Loss of succinate dehydrogenase activity results in dependency on pyruvate carboxylation for cellular anabolism.

Lussey-Lepoutre C, Hollinshead KE, Ludwig C, Menara M, Morin A, Castro-Vega LJ, Parker SJ, Janin M, Martinelli C, Ottolenghi C, Metallo C, Gimenez-Roqueplo AP, Favier J, Tennant DA.

Nat Commun. 2015 Nov 2;6:8784. doi: 10.1038/ncomms9784.

27.

Alterations in bone marrow metabolism are an early and consistent feature during the development of MGUS and multiple myeloma.

Ludwig C, Williams DS, Bartlett DB, Essex SJ, McNee G, Allwood JW, Jewell E, Barkhuisen A, Parry H, Anandram S, Nicolson P, Gardener C, Seymour F, Basu S, Dunn WB, Moss PA, Pratt G, Tennant DA.

Blood Cancer J. 2015 Oct 16;5:e359. doi: 10.1038/bcj.2015.85. No abstract available.

28.

Investigations of the effect of nonmagnetic Ca substitution for magnetic Dy on spin-freezing in Dy₂Ti₂O₇.

Anand VK, Tennant DA, Lake B.

J Phys Condens Matter. 2015 Nov 4;27(43):436001. doi: 10.1088/0953-8984/27/43/436001. Epub 2015 Oct 7.

PMID:
26443921
29.

A roadmap for interpreting (13)C metabolite labeling patterns from cells.

Buescher JM, Antoniewicz MR, Boros LG, Burgess SC, Brunengraber H, Clish CB, DeBerardinis RJ, Feron O, Frezza C, Ghesquiere B, Gottlieb E, Hiller K, Jones RG, Kamphorst JJ, Kibbey RG, Kimmelman AC, Locasale JW, Lunt SY, Maddocks OD, Malloy C, Metallo CM, Meuillet EJ, Munger J, Nöh K, Rabinowitz JD, Ralser M, Sauer U, Stephanopoulos G, St-Pierre J, Tennant DA, Wittmann C, Vander Heiden MG, Vazquez A, Vousden K, Young JD, Zamboni N, Fendt SM.

Curr Opin Biotechnol. 2015 Aug;34:189-201. doi: 10.1016/j.copbio.2015.02.003. Epub 2015 Feb 28. Review.

30.

Metabolomic perfusate analysis during kidney machine perfusion: the pig provides an appropriate model for human studies.

Nath J, Guy A, Smith TB, Cobbold M, Inston NG, Hodson J, Tennant DA, Ludwig C, Ready AR.

PLoS One. 2014 Dec 12;9(12):e114818. doi: 10.1371/journal.pone.0114818. eCollection 2014.

31.

Metabolomic analysis of perfusate during hypothermic machine perfusion of human cadaveric kidneys.

Guy AJ, Nath J, Cobbold M, Ludwig C, Tennant DA, Inston NG, Ready AR.

Transplantation. 2015 Apr;99(4):754-9. doi: 10.1097/TP.0000000000000398.

PMID:
25222017
32.

Hypoxia inducible factors in liver disease and hepatocellular carcinoma: current understanding and future directions.

Wilson GK, Tennant DA, McKeating JA.

J Hepatol. 2014 Dec;61(6):1397-406. doi: 10.1016/j.jhep.2014.08.025. Epub 2014 Aug 23. Review.

33.

The role of HIFs in ischemia-reperfusion injury.

Howell NJ, Tennant DA.

Hypoxia (Auckl). 2014 Jul 30;2:107-115. eCollection 2014. Review.

34.

DiME: a scalable disease module identification algorithm with application to glioma progression.

Liu Y, Tennant DA, Zhu Z, Heath JK, Yao X, He S.

PLoS One. 2014 Feb 11;9(2):e86693. doi: 10.1371/journal.pone.0086693. eCollection 2014.

35.

Multispinon continua at zero and finite temperature in a near-ideal Heisenberg chain.

Lake B, Tennant DA, Caux JS, Barthel T, Schollwöck U, Nagler SE, Frost CD.

Phys Rev Lett. 2013 Sep 27;111(13):137205. Epub 2013 Sep 26.

PMID:
24116814
36.

Lifetimes of antiferromagnetic magnons in two and three dimensions: experiment, theory, and numerics.

Bayrakci SP, Tennant DA, Leininger P, Keller T, Gibson MC, Wilson SD, Birgeneau RJ, Keimer B.

Phys Rev Lett. 2013 Jul 5;111(1):017204. Epub 2013 Jul 3.

PMID:
23863025
37.

A role for cytosolic fumarate hydratase in urea cycle metabolism and renal neoplasia.

Adam J, Yang M, Bauerschmidt C, Kitagawa M, O'Flaherty L, Maheswaran P, Özkan G, Sahgal N, Baban D, Kato K, Saito K, Iino K, Igarashi K, Stratford M, Pugh C, Tennant DA, Ludwig C, Davies B, Ratcliffe PJ, El-Bahrawy M, Ashrafian H, Soga T, Pollard PJ.

Cell Rep. 2013 May 30;3(5):1440-8. doi: 10.1016/j.celrep.2013.04.006. Epub 2013 May 2.

38.

Glucose utilization via glycogen phosphorylase sustains proliferation and prevents premature senescence in cancer cells.

Favaro E, Bensaad K, Chong MG, Tennant DA, Ferguson DJ, Snell C, Steers G, Turley H, Li JL, Günther UL, Buffa FM, McIntyre A, Harris AL.

Cell Metab. 2012 Dec 5;16(6):751-64. doi: 10.1016/j.cmet.2012.10.017. Epub 2012 Nov 21.

39.

Fumarate is cardioprotective via activation of the Nrf2 antioxidant pathway.

Ashrafian H, Czibik G, Bellahcene M, Aksentijević D, Smith AC, Mitchell SJ, Dodd MS, Kirwan J, Byrne JJ, Ludwig C, Isackson H, Yavari A, Støttrup NB, Contractor H, Cahill TJ, Sahgal N, Ball DR, Birkler RI, Hargreaves I, Tennant DA, Land J, Lygate CA, Johannsen M, Kharbanda RK, Neubauer S, Redwood C, de Cabo R, Ahmet I, Talan M, Günther UL, Robinson AJ, Viant MR, Pollard PJ, Tyler DJ, Watkins H.

Cell Metab. 2012 Mar 7;15(3):361-71. doi: 10.1016/j.cmet.2012.01.017.

40.

From transcriptional profiling to tumor biology in pheochromocytoma and paraganglioma.

Cascón A, Tennant DA.

Endocr Pathol. 2012 Mar;23(1):15-20. doi: 10.1007/s12022-012-9195-x. Review.

PMID:
22323008
41.

Metabolic profiling of hypoxic cells revealed a catabolic signature required for cell survival.

Frezza C, Zheng L, Tennant DA, Papkovsky DB, Hedley BA, Kalna G, Watson DG, Gottlieb E.

PLoS One. 2011;6(9):e24411. doi: 10.1371/journal.pone.0024411. Epub 2011 Sep 2.

42.

PK-M2 Makes Cells Sweeter on HIF1.

Tennant DA.

Cell. 2011 May 27;145(5):647-9. doi: 10.1016/j.cell.2011.05.009.

43.

HIF prolyl hydroxylase-3 mediates alpha-ketoglutarate-induced apoptosis and tumor suppression.

Tennant DA, Gottlieb E.

J Mol Med (Berl). 2010 Aug;88(8):839-49. doi: 10.1007/s00109-010-0627-0. Epub 2010 Apr 11.

PMID:
20383689
44.

Targeting metabolic transformation for cancer therapy.

Tennant DA, Durán RV, Gottlieb E.

Nat Rev Cancer. 2010 Apr;10(4):267-77. doi: 10.1038/nrc2817. Epub 2010 Mar 19. Review.

PMID:
20300106
45.

IDH1 mutations in gliomas: when an enzyme loses its grip.

Frezza C, Tennant DA, Gottlieb E.

Cancer Cell. 2010 Jan 19;17(1):7-9. doi: 10.1016/j.ccr.2009.12.031.

46.

Quantum criticality in an Ising chain: experimental evidence for emergent E8 symmetry.

Coldea R, Tennant DA, Wheeler EM, Wawrzynska E, Prabhakaran D, Telling M, Habicht K, Smeibidl P, Kiefer K.

Science. 2010 Jan 8;327(5962):177-80. doi: 10.1126/science.1180085.

47.

Dirac strings and magnetic monopoles in the spin ice Dy2Ti2O7.

Morris DJ, Tennant DA, Grigera SA, Klemke B, Castelnovo C, Moessner R, Czternasty C, Meissner M, Rule KC, Hoffmann JU, Kiefer K, Gerischer S, Slobinsky D, Perry RS.

Science. 2009 Oct 16;326(5951):411-4. doi: 10.1126/science.1178868. Epub 2009 Sep 3.

48.

Reactivating HIF prolyl hydroxylases under hypoxia results in metabolic catastrophe and cell death.

Tennant DA, Frezza C, MacKenzie ED, Nguyen QD, Zheng L, Selak MA, Roberts DL, Dive C, Watson DG, Aboagye EO, Gottlieb E.

Oncogene. 2009 Nov 12;28(45):4009-21. doi: 10.1038/onc.2009.250. Epub 2009 Aug 31.

PMID:
19718054
49.

Metabolic transformation in cancer.

Tennant DA, Durán RV, Boulahbel H, Gottlieb E.

Carcinogenesis. 2009 Aug;30(8):1269-80. doi: 10.1093/carcin/bgp070. Epub 2009 Mar 25. Review.

PMID:
19321800
50.

Nature of the spin dynamics and 1/3 magnetization plateau in azurite.

Rule KC, Wolter AU, Süllow S, Tennant DA, Brühl A, Köhler S, Wolf B, Lang M, Schreuer J.

Phys Rev Lett. 2008 Mar 21;100(11):117202. Epub 2008 Mar 19.

PMID:
18517818

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