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Items: 1 to 50 of 71

1.

Cyclic AMP links glucose stimulation to somatostatin secretion in δ-cells.

Tengholm A.

J Gen Physiol. 2019 Sep 2;151(9):1062-1065. doi: 10.1085/jgp.201912417. Epub 2019 Aug 14. No abstract available.

PMID:
31413066
2.

Fusion pore regulation by cAMP/Epac2 controls cargo release during insulin exocytosis.

Guček A, Gandasi NR, Omar-Hmeadi M, Bakke M, Døskeland SO, Tengholm A, Barg S.

Elife. 2019 May 20;8. pii: e41711. doi: 10.7554/eLife.41711.

3.

Glucose controls glucagon secretion by directly modulating cAMP in alpha cells.

Yu Q, Shuai H, Ahooghalandari P, Gylfe E, Tengholm A.

Diabetologia. 2019 Jul;62(7):1212-1224. doi: 10.1007/s00125-019-4857-6. Epub 2019 Apr 5.

4.

Endoplasmic Reticulum Chaperone Glucose-Regulated Protein 94 Is Essential for Proinsulin Handling.

Ghiasi SM, Dahlby T, Hede Andersen C, Haataja L, Petersen S, Omar-Hmeadi M, Yang M, Pihl C, Bresson SE, Khilji MS, Klindt K, Cheta O, Perone MJ, Tyrberg B, Prats C, Barg S, Tengholm A, Arvan P, Mandrup-Poulsen T, Marzec MT.

Diabetes. 2019 Apr;68(4):747-760. doi: 10.2337/db18-0671. Epub 2019 Jan 22.

PMID:
30670477
5.

ZBED6 negatively regulates insulin production, neuronal differentiation, and cell aggregation in MIN6 cells.

Wang X, Jiang L, Wallerman O, Younis S, Yu Q, Klaesson A, Tengholm A, Welsh N, Andersson L.

FASEB J. 2019 Jan;33(1):88-100. doi: 10.1096/fj.201600835R. Epub 2018 Jun 29.

PMID:
29957057
6.

Functional Characterization of Native, High-Affinity GABAA Receptors in Human Pancreatic β Cells.

Korol SV, Jin Z, Jin Y, Bhandage AK, Tengholm A, Gandasi NR, Barg S, Espes D, Carlsson PO, Laver D, Birnir B.

EBioMedicine. 2018 Apr;30:273-282. doi: 10.1016/j.ebiom.2018.03.014. Epub 2018 Mar 22.

7.

Recruitment of Epac2A to Insulin Granule Docking Sites Regulates Priming for Exocytosis.

Alenkvist I, Gandasi NR, Barg S, Tengholm A.

Diabetes. 2017 Oct;66(10):2610-2622. doi: 10.2337/db17-0050. Epub 2017 Jul 5.

8.

cAMP signalling in insulin and glucagon secretion.

Tengholm A, Gylfe E.

Diabetes Obes Metab. 2017 Sep;19 Suppl 1:42-53. doi: 10.1111/dom.12993. Review.

PMID:
28466587
9.

Fluorescent protein vectors for pancreatic islet cell identification in live-cell imaging.

Shuai H, Xu Y, Yu Q, Gylfe E, Tengholm A.

Pflugers Arch. 2016 Oct;468(10):1765-77. doi: 10.1007/s00424-016-1864-z. Epub 2016 Aug 18.

10.

CART is overexpressed in human type 2 diabetic islets and inhibits glucagon secretion and increases insulin secretion.

Abels M, Riva M, Bennet H, Ahlqvist E, Dyachok O, Nagaraj V, Shcherbina L, Fred RG, Poon W, Sörhede-Winzell M, Fadista J, Lindqvist A, Kask L, Sathanoori R, Dekker-Nitert M, Kuhar MJ, Ahrén B, Wollheim CB, Hansson O, Tengholm A, Fex M, Renström E, Groop L, Lyssenko V, Wierup N.

Diabetologia. 2016 Sep;59(9):1928-37. doi: 10.1007/s00125-016-4020-6. Epub 2016 Jun 23.

PMID:
27338624
11.

Autocrine Signaling Underlies Fast Repetitive Plasma Membrane Translocation of Conventional and Novel Protein Kinase C Isoforms in β Cells.

Wuttke A, Yu Q, Tengholm A.

J Biol Chem. 2016 Jul 15;291(29):14986-95. doi: 10.1074/jbc.M115.698456. Epub 2016 May 20.

12.

Increased Melatonin Signaling Is a Risk Factor for Type 2 Diabetes.

Tuomi T, Nagorny CLF, Singh P, Bennet H, Yu Q, Alenkvist I, Isomaa B, Östman B, Söderström J, Pesonen AK, Martikainen S, Räikkönen K, Forsén T, Hakaste L, Almgren P, Storm P, Asplund O, Shcherbina L, Fex M, Fadista J, Tengholm A, Wierup N, Groop L, Mulder H.

Cell Metab. 2016 Jun 14;23(6):1067-1077. doi: 10.1016/j.cmet.2016.04.009. Epub 2016 May 12.

13.

Neuropeptide S inhibits gastrointestinal motility and increases mucosal permeability through nitric oxide.

Wan Saudi WS, Halim MA, Rudholm-Feldreich T, Gillberg L, Rosenqvist E, Tengholm A, Sundbom M, Karlbom U, Näslund E, Webb DL, Sjöblom M, Hellström PM.

Am J Physiol Gastrointest Liver Physiol. 2015 Oct 15;309(8):G625-34. doi: 10.1152/ajpgi.00104.2015. Epub 2015 Jul 23.

14.

Submembrane ATP and Ca2+ kinetics in α-cells: unexpected signaling for glucagon secretion.

Li J, Yu Q, Ahooghalandari P, Gribble FM, Reimann F, Tengholm A, Gylfe E.

FASEB J. 2015 Aug;29(8):3379-88. doi: 10.1096/fj.14-265918. Epub 2015 Apr 24.

15.

Imaging sub-plasma membrane cAMP dynamics with fluorescent translocation reporters.

Tengholm A, Idevall-Hagren O.

Methods Mol Biol. 2015;1294:85-101. doi: 10.1007/978-1-4939-2537-7_7.

PMID:
25783879
16.

Impaired cAMP generation contributes to defective glucose-stimulated insulin secretion after long-term exposure to palmitate.

Tian G, Sol ER, Xu Y, Shuai H, Tengholm A.

Diabetes. 2015 Mar;64(3):904-15. doi: 10.2337/db14-1036. Epub 2014 Oct 3.

17.

Purinergic P2Y1 receptors take centre stage in autocrine stimulation of human beta cells.

Tengholm A.

Diabetologia. 2014 Dec;57(12):2436-9. doi: 10.1007/s00125-014-3392-8. Epub 2014 Oct 3.

PMID:
25277952
18.

Absence of Shb impairs insulin secretion by elevated FAK activity in pancreatic islets.

Alenkvist I, Dyachok O, Tian G, Li J, Mehrabanfar S, Jin Y, Birnir B, Tengholm A, Welsh M.

J Endocrinol. 2014 Dec;223(3):267-75. doi: 10.1530/JOE-14-0531. Epub 2014 Oct 1.

PMID:
25274988
19.

Neurotransmitter control of islet hormone pulsatility.

Gylfe E, Tengholm A.

Diabetes Obes Metab. 2014 Sep;16 Suppl 1:102-10. doi: 10.1111/dom.12345. Review.

PMID:
25200303
20.

DNA methylation of alternative promoters directs tissue specific expression of Epac2 isoforms.

Hoivik EA, Witsoe SL, Bergheim IR, Xu Y, Jakobsson I, Tengholm A, Doskeland SO, Bakke M.

PLoS One. 2013 Jul 4;8(7):e67925. doi: 10.1371/journal.pone.0067925. Print 2013.

21.

The role of mechanical force and ROS in integrin-dependent signals.

Zeller KS, Riaz A, Sarve H, Li J, Tengholm A, Johansson S.

PLoS One. 2013 May 30;8(5):e64897. doi: 10.1371/journal.pone.0064897. Print 2013.

22.

Spatial control of Epac2 activity by cAMP and Ca2+-mediated activation of Ras in pancreatic β cells.

Idevall-Hagren O, Jakobsson I, Xu Y, Tengholm A.

Sci Signal. 2013 Apr 30;6(273):ra29.1-11, S1-6. doi: 10.1126/scisignal.2003932.

PMID:
23633676
23.

Functional differences between aggregated and dispersed insulin-producing cells.

Chowdhury A, Dyachok O, Tengholm A, Sandler S, Bergsten P.

Diabetologia. 2013 Jul;56(7):1557-68. doi: 10.1007/s00125-013-2903-3. Epub 2013 Apr 19.

24.

Oscillations of sub-membrane ATP in glucose-stimulated beta cells depend on negative feedback from Ca(2+).

Li J, Shuai HY, Gylfe E, Tengholm A.

Diabetologia. 2013 Jul;56(7):1577-86. doi: 10.1007/s00125-013-2894-0. Epub 2013 Mar 28.

25.

Imatinib mesilate-induced phosphatidylinositol 3-kinase signalling and improved survival in insulin-producing cells: role of Src homology 2-containing inositol 5'-phosphatase interaction with c-Abl.

Mokhtari D, Al-Amin A, Turpaev K, Li T, Idevall-Hagren O, Li J, Wuttke A, Fred RG, Ravassard P, Scharfmann R, Tengholm A, Welsh N.

Diabetologia. 2013 Jun;56(6):1327-38. doi: 10.1007/s00125-013-2868-2. Epub 2013 Mar 5.

PMID:
23462796
26.

P2Y₁ receptor-dependent diacylglycerol signaling microdomains in β cells promote insulin secretion.

Wuttke A, Idevall-Hagren O, Tengholm A.

FASEB J. 2013 Apr;27(4):1610-20. doi: 10.1096/fj.12-221499. Epub 2013 Jan 8.

PMID:
23299857
27.

Aberrant association between vascular endothelial growth factor receptor-2 and VE-cadherin in response to vascular endothelial growth factor-a in Shb-deficient lung endothelial cells.

Zang G, Christoffersson G, Tian G, Harun-Or-Rashid M, Vågesjö E, Phillipson M, Barg S, Tengholm A, Welsh M.

Cell Signal. 2013 Jan;25(1):85-92. doi: 10.1016/j.cellsig.2012.09.018. Epub 2012 Sep 18.

PMID:
23000345
28.

Cyclic AMP dynamics in the pancreatic β-cell.

Tengholm A.

Ups J Med Sci. 2012 Nov;117(4):355-69. doi: 10.3109/03009734.2012.724732. Epub 2012 Sep 13. Review.

29.

Role of phosphodiesterases in the shaping of sub-plasma-membrane cAMP oscillations and pulsatile insulin secretion.

Tian G, Sågetorp J, Xu Y, Shuai H, Degerman E, Tengholm A.

J Cell Sci. 2012 Nov 1;125(Pt 21):5084-95. doi: 10.1242/jcs.107201. Epub 2012 Sep 3.

30.

Anchored phosphatases modulate glucose homeostasis.

Hinke SA, Navedo MF, Ulman A, Whiting JL, Nygren PJ, Tian G, Jimenez-Caliani AJ, Langeberg LK, Cirulli V, Tengholm A, Dell'Acqua ML, Santana LF, Scott JD.

EMBO J. 2012 Oct 17;31(20):3991-4004. doi: 10.1038/emboj.2012.244. Epub 2012 Aug 31. Erratum in: EMBO J. 2012 Nov 28;31(23):4481.

31.

cAMP induces stromal interaction molecule 1 (STIM1) puncta but neither Orai1 protein clustering nor store-operated Ca2+ entry (SOCE) in islet cells.

Tian G, Tepikin AV, Tengholm A, Gylfe E.

J Biol Chem. 2012 Mar 23;287(13):9862-72. doi: 10.1074/jbc.M111.292854. Epub 2012 Feb 1.

32.

Ghrelin attenuates cAMP-PKA signaling to evoke insulinostatic cascade in islet β-cells.

Dezaki K, Damdindorj B, Sone H, Dyachok O, Tengholm A, Gylfe E, Kurashina T, Yoshida M, Kakei M, Yada T.

Diabetes. 2011 Sep;60(9):2315-24. doi: 10.2337/db11-0368. Epub 2011 Jul 25.

33.

Glucose- and hormone-induced cAMP oscillations in α- and β-cells within intact pancreatic islets.

Tian G, Sandler S, Gylfe E, Tengholm A.

Diabetes. 2011 May;60(5):1535-43. doi: 10.2337/db10-1087. Epub 2011 Mar 28.

34.

Tensin2 reduces intracellular phosphatidylinositol 3,4,5-trisphosphate levels at the plasma membrane.

Hafizi S, Gustafsson A, Oslakovic C, Idevall-Hagren O, Tengholm A, Sperandio O, Villoutreix BO, Dahlbäck B.

Biochem Biophys Res Commun. 2010 Aug 27;399(3):396-401. doi: 10.1016/j.bbrc.2010.07.085. Epub 2010 Aug 3.

PMID:
20678486
35.

PI3-kinase p110α mediates β1 integrin-induced Akt activation and membrane protrusion during cell attachment and initial spreading.

Zeller KS, Idevall-Hagren O, Stefansson A, Velling T, Jackson SP, Downward J, Tengholm A, Johansson S.

Cell Signal. 2010 Dec;22(12):1838-48. doi: 10.1016/j.cellsig.2010.07.011. Epub 2010 Jul 25. Erratum in: Cell Signal. 2012 Apr;24(4):971-2.

PMID:
20667469
36.

Imaging phosphoinositide dynamics in living cells.

Wuttke A, Idevall-Hagren O, Tengholm A.

Methods Mol Biol. 2010;645:219-35. doi: 10.1007/978-1-60327-175-2_14.

PMID:
20645191
37.

cAMP mediators of pulsatile insulin secretion from glucose-stimulated single beta-cells.

Idevall-Hagren O, Barg S, Gylfe E, Tengholm A.

J Biol Chem. 2010 Jul 23;285(30):23007-18. doi: 10.1074/jbc.M109.095992. Epub 2010 May 24.

38.

Distinct plasma-membrane PtdIns(4)P and PtdIns(4,5)P2 dynamics in secretagogue-stimulated beta-cells.

Wuttke A, Sågetorp J, Tengholm A.

J Cell Sci. 2010 May 1;123(Pt 9):1492-502. doi: 10.1242/jcs.060525. Epub 2010 Apr 7.

39.

Ca2+ and cAMP signaling in human embryonic stem cell-derived dopamine neurons.

Malmersjö S, Liste I, Dyachok O, Tengholm A, Arenas E, Uhlén P.

Stem Cells Dev. 2010 Sep;19(9):1355-64. doi: 10.1089/scd.2009.0436.

PMID:
20043754
40.

Wnt-5a-induced phosphorylation of DARPP-32 inhibits breast cancer cell migration in a CREB-dependent manner.

Hansen C, Howlin J, Tengholm A, Dyachok O, Vogel WF, Nairn AC, Greengard P, Andersson T.

J Biol Chem. 2009 Oct 2;284(40):27533-43. doi: 10.1074/jbc.M109.048884. Epub 2009 Aug 3.

41.

Spatio-temporal dynamics of phosphatidylinositol-3,4,5-trisphosphate signalling.

Tengholm A, Idevall-Hagren O.

Vitam Horm. 2009;80:287-311. doi: 10.1016/S0083-6729(08)00611-0. Review.

PMID:
19251042
42.

Capacitative Ca2+ entry via Orai1 and stromal interacting molecule 1 (STIM1) regulates adenylyl cyclase type 8.

Martin AC, Willoughby D, Ciruela A, Ayling LJ, Pagano M, Wachten S, Tengholm A, Cooper DM.

Mol Pharmacol. 2009 Apr;75(4):830-42. doi: 10.1124/mol.108.051748. Epub 2009 Jan 26. Erratum in: Mol Pharmacol. 2009 May;75(5):1248.

43.

Oscillatory control of insulin secretion.

Tengholm A, Gylfe E.

Mol Cell Endocrinol. 2009 Jan 15;297(1-2):58-72. doi: 10.1016/j.mce.2008.07.009. Epub 2008 Jul 26. Review.

PMID:
18706473
44.

Glucose-induced cyclic AMP oscillations regulate pulsatile insulin secretion.

Dyachok O, Idevall-Hagren O, Sågetorp J, Tian G, Wuttke A, Arrieumerlou C, Akusjärvi G, Gylfe E, Tengholm A.

Cell Metab. 2008 Jul;8(1):26-37. doi: 10.1016/j.cmet.2008.06.003.

46.

Cyclic AMP: swing that message!

Tengholm A.

Cell Mol Life Sci. 2007 Feb;64(4):382-5. No abstract available.

PMID:
17221163
48.

cAMP oscillations restrict protein kinase A redistribution in insulin-secreting cells.

Dyachok O, Sågetorp J, Isakov Y, Tengholm A.

Biochem Soc Trans. 2006 Aug;34(Pt 4):498-501.

PMID:
16856843
49.

Involvement of JAK2 and Src kinase tyrosine phosphorylation in human growth hormone-stimulated increases in cytosolic free Ca2+ and insulin secretion.

Zhang F, Zhang Q, Tengholm A, Sjöholm A.

Am J Physiol Cell Physiol. 2006 Sep;291(3):C466-75. Epub 2006 Apr 5.

50.

Oscillations of cyclic AMP in hormone-stimulated insulin-secreting beta-cells.

Dyachok O, Isakov Y, Sågetorp J, Tengholm A.

Nature. 2006 Jan 19;439(7074):349-52.

PMID:
16421574

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