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Items: 1 to 50 of 292

1.

CAV1 - GLUT3 signaling is important for cellular energy and can be targeted by Atorvastatin in Non-Small Cell Lung Cancer.

Ali A, Levantini E, Fhu CW, Teo JT, Clohessy JG, Goggi JL, Wu CS, Chen L, Chin TM, Tenen DG.

Theranostics. 2019 Aug 14;9(21):6157-6174. doi: 10.7150/thno.35805. eCollection 2019.

2.

New High-throughput Screen Identifies Compounds That Reduce Viability Specifically In Liver Cancer Cells That Express High Levels of SALL4 by Inhibiting Oxidative Phosphorylation.

Tan JL, Li F, Yeo JZ, Yong KJ, Bassal MA, Ng GH, Lee MY, Leong CY, Tan HK, Wu CS, Liu BH, Chan TH, Tan ZH, Chan YS, Wang S, Lim ZH, Toh TB, Hooi L, Low KN, Ma S, Kong NR, Stein AJ, Wu Y, Thangavelu MT, Suzuki A, Periyasamy G, Asara JM, Dan YY, Bonney GK, Chow EK, Lu GD, Ng HH, Kanagasundaram Y, Ng SB, Tam WL, Tenen DG, Chai L.

Gastroenterology. 2019 Aug 22. pii: S0016-5085(19)41242-0. doi: 10.1053/j.gastro.2019.08.022. [Epub ahead of print]

PMID:
31446059
3.

Mapping Distinct Bone Marrow Niche Populations and Their Differentiation Paths.

Wolock SL, Krishnan I, Tenen DE, Matkins V, Camacho V, Patel S, Agarwal P, Bhatia R, Tenen DG, Klein AM, Welner RS.

Cell Rep. 2019 Jul 9;28(2):302-311.e5. doi: 10.1016/j.celrep.2019.06.031.

4.

Styryl quinazolinones and its ethynyl derivatives induce myeloid differentiation.

Radhakrishnan S, Syed R, Takei H, Kobayashi IS, Nakamura E, Sultana F, Kamal A, Tenen DG, Kobayashi SS.

Bioorg Med Chem Lett. 2019 Aug 15;29(16):2286-2289. doi: 10.1016/j.bmcl.2019.06.024. Epub 2019 Jun 20.

PMID:
31278031
5.

Maintenance and enhancement of human peripheral blood mobilized stem/progenitor cell engraftment after ex vivo culture via an HDACi/SALL4 axis (3465).

Tatetsu H, Armant M, Wang F, Gao C, Ueno S, Tian X, Federation A, Qi J, Bradner J, Tenen DG, Chai L.

Exp Hematol. 2019 Jul;75:53-63.e11. doi: 10.1016/j.exphem.2019.06.473. Epub 2019 Jun 28.

PMID:
31260717
6.

DNMT3B shapes the mCA landscape and regulates mCG for promoter bivalency in human embryonic stem cells.

Tan HK, Wu CS, Li J, Tan ZH, Hoffman JR, Fry CJ, Yang H, Di Ruscio A, Tenen DG.

Nucleic Acids Res. 2019 Aug 22;47(14):7460-7475. doi: 10.1093/nar/gkz520.

7.

Hlf marks the developmental pathway for hematopoietic stem cells but not for erythro-myeloid progenitors.

Yokomizo T, Watanabe N, Umemoto T, Matsuo J, Harai R, Kihara Y, Nakamura E, Tada N, Sato T, Takaku T, Shimono A, Takizawa H, Nakagata N, Mori S, Kurokawa M, Tenen DG, Osato M, Suda T, Komatsu N.

J Exp Med. 2019 Jul 1;216(7):1599-1614. doi: 10.1084/jem.20181399. Epub 2019 May 10.

PMID:
31076455
8.

The enhancer RNA ARIEL activates the oncogenic transcriptional program in T-cell acute lymphoblastic leukemia.

Tan SH, Leong WZ, Ngoc PCT, Tan TK, Bertulfo FC, Lim MC, An O, Li Z, Yeoh AEJ, Fullwood MJ, Tenen DG, Sanda T.

Blood. 2019 Jul 18;134(3):239-251. doi: 10.1182/blood.2018874503. Epub 2019 May 10.

PMID:
31076442
9.

Single-Cell Transcriptomics of Human and Mouse Lung Cancers Reveals Conserved Myeloid Populations across Individuals and Species.

Zilionis R, Engblom C, Pfirschke C, Savova V, Zemmour D, Saatcioglu HD, Krishnan I, Maroni G, Meyerovitz CV, Kerwin CM, Choi S, Richards WG, De Rienzo A, Tenen DG, Bueno R, Levantini E, Pittet MJ, Klein AM.

Immunity. 2019 May 21;50(5):1317-1334.e10. doi: 10.1016/j.immuni.2019.03.009. Epub 2019 Apr 9.

PMID:
30979687
10.

Monitoring structural modulation of redox-sensitive proteins in cells with MS-CETSA.

Sun W, Dai L, Yu H, Puspita B, Zhao T, Li F, Tan JL, Lim YT, Chen MW, Sobota RM, Tenen DG, Prabhu N, Nordlund P.

Redox Biol. 2019 Jun;24:101168. doi: 10.1016/j.redox.2019.101168. Epub 2019 Mar 14.

11.

C/EBPβ is a critical mediator of IFN-α-induced exhaustion of chronic myeloid leukemia stem cells.

Yokota A, Hirai H, Sato R, Adachi H, Sato F, Hayashi Y, Sato A, Kamio N, Miura Y, Nakano M, Tenen DG, Kimura S, Tashiro K, Maekawa T.

Blood Adv. 2019 Feb 12;3(3):476-488. doi: 10.1182/bloodadvances.2018020503.

12.

CARM1 Is Essential for Myeloid Leukemogenesis but Dispensable for Normal Hematopoiesis.

Greenblatt SM, Man N, Hamard PJ, Asai T, Karl D, Martinez C, Bilbao D, Stathias V, Jermakowicz AM, Duffort S, Tadi M, Blumenthal E, Newman S, Vu L, Xu Y, Liu F, Schurer SC, McCabe MT, Kruger RG, Xu M, Yang FC, Tenen DG, Watts J, Vega F, Nimer SD.

Cancer Cell. 2019 Jan 14;35(1):156. doi: 10.1016/j.ccell.2018.12.008. No abstract available.

PMID:
30645972
13.

Styryl Quinazolinones as Potential Inducers of Myeloid Differentiation via Upregulation of C/EBPα.

Sridhar R, Takei H, Syed R, Kobayashi IS, Hui LB, Kamal A, Tenen DG, Kobayashi SS.

Molecules. 2018 Aug 3;23(8). pii: E1938. doi: 10.3390/molecules23081938.

14.

Correction to: EVI2B is a C/EBPα target gene required for granulocytic differentiation and functionality of hematopoietic progenitors.

Zjablovskaja P, Kardosova M, Danek P, Angelisova P, Benoukraf T, Wurm AA, Kalina T, Sian S, Balastik M, Delwel R, Brdicka T, Tenen DG, Behre G, Fiore F, Malissen B, Horejsi V, Alberich-Jorda M.

Cell Death Differ. 2019 Jan;26(1):198. doi: 10.1038/s41418-018-0146-z.

15.

Targeting cancer addiction for SALL4 by shifting its transcriptome with a pharmacologic peptide.

Liu BH, Jobichen C, Chia CSB, Chan THM, Tang JP, Chung TXY, Li J, Poulsen A, Hung AW, Koh-Stenta X, Tan YS, Verma CS, Tan HK, Wu CS, Li F, Hill J, Joy J, Yang H, Chai L, Sivaraman J, Tenen DG.

Proc Natl Acad Sci U S A. 2018 Jul 24;115(30):E7119-E7128. doi: 10.1073/pnas.1801253115. Epub 2018 Jul 5.

16.

CARM1 Is Essential for Myeloid Leukemogenesis but Dispensable for Normal Hematopoiesis.

Greenblatt SM, Man N, Hamard PJ, Asai T, Karl D, Martinez C, Bilbao D, Stathias V, Jermakowicz AM, Duffort S, Tadi M, Blumenthal E, Newman S, Vu L, Xu Y, Liu F, Schurer SC, McCabe MT, Kruger RG, Xu M, Yang FC, Tenen DG, Watts J, Vega F, Nimer SD.

Cancer Cell. 2018 Jun 11;33(6):1111-1127.e5. doi: 10.1016/j.ccell.2018.05.007. Erratum in: Cancer Cell. 2018 Nov 12;34(5):868. Cancer Cell. 2019 Jan 14;35(1):156.

17.

Bidirectional regulation of adenosine-to-inosine (A-to-I) RNA editing by DEAH box helicase 9 (DHX9) in cancer.

Hong H, An O, Chan THM, Ng VHE, Kwok HS, Lin JS, Qi L, Han J, Tay DJT, Tang SJ, Yang H, Song Y, Bellido Molias F, Tenen DG, Chen L.

Nucleic Acids Res. 2018 Sep 6;46(15):7953-7969. doi: 10.1093/nar/gky396.

18.

The basic helix-loop-helix transcription factor SHARP1 is an oncogenic driver in MLL-AF6 acute myelogenous leukemia.

Numata A, Kwok HS, Kawasaki A, Li J, Zhou QL, Kerry J, Benoukraf T, Bararia D, Li F, Ballabio E, Tapia M, Deshpande AJ, Welner RS, Delwel R, Yang H, Milne TA, Taneja R, Tenen DG.

Nat Commun. 2018 Apr 24;9(1):1622. doi: 10.1038/s41467-018-03854-0.

19.

Identification of novel lncRNAs regulated by the TAL1 complex in T-cell acute lymphoblastic leukemia.

Ngoc PCT, Tan SH, Tan TK, Chan MM, Li Z, Yeoh AEJ, Tenen DG, Sanda T.

Leukemia. 2018 Oct;32(10):2138-2151. doi: 10.1038/s41375-018-0110-4. Epub 2018 Mar 26.

PMID:
29654272
20.

C/EBPγ is dispensable for steady-state and emergency granulopoiesis.

Kardosova M, Zjablovskaja P, Danek P, Angelisova P, de Figueiredo-Pontes LL, Welner RS, Brdicka T, Lee S, Tenen DG, Alberich-Jorda M.

Haematologica. 2018 Aug;103(8):e331-e335. doi: 10.3324/haematol.2017.173781. Epub 2018 Mar 22. No abstract available.

21.

LSD1 inhibition exerts its antileukemic effect by recommissioning PU.1- and C/EBPα-dependent enhancers in AML.

Cusan M, Cai SF, Mohammad HP, Krivtsov A, Chramiec A, Loizou E, Witkin MD, Smitheman KN, Tenen DG, Ye M, Will B, Steidl U, Kruger RG, Levine RL, Rienhoff HY Jr, Koche RP, Armstrong SA.

Blood. 2018 Apr 12;131(15):1730-1742. doi: 10.1182/blood-2017-09-807024. Epub 2018 Feb 16.

22.

Fatty acid synthase mediates EGFR palmitoylation in EGFR mutated non-small cell lung cancer.

Ali A, Levantini E, Teo JT, Goggi J, Clohessy JG, Wu CS, Chen L, Yang H, Krishnan I, Kocher O, Zhang J, Soo RA, Bhakoo K, Chin TM, Tenen DG.

EMBO Mol Med. 2018 Mar;10(3). pii: e8313. doi: 10.15252/emmm.201708313.

23.

ARID5B as a critical downstream target of the TAL1 complex that activates the oncogenic transcriptional program and promotes T-cell leukemogenesis.

Leong WZ, Tan SH, Ngoc PCT, Amanda S, Yam AWY, Liau WS, Gong Z, Lawton LN, Tenen DG, Sanda T.

Genes Dev. 2017 Dec 1;31(23-24):2343-2360. doi: 10.1101/gad.302646.117. Epub 2018 Jan 11.

24.

TIP60 represses telomerase expression by inhibiting Sp1 binding to the TERT promoter.

Rajagopalan D, Pandey AK, Xiuzhen MC, Lee KK, Hora S, Zhang Y, Chua BH, Kwok HS, Bhatia SS, Deng LW, Tenen DG, Kappei D, Jha S.

PLoS Pathog. 2017 Oct 18;13(10):e1006681. doi: 10.1371/journal.ppat.1006681. eCollection 2017 Oct.

25.

An RNA editing/dsRNA binding-independent gene regulatory mechanism of ADARs and its clinical implication in cancer.

Qi L, Song Y, Chan THM, Yang H, Lin CH, Tay DJT, Hong H, Tang SJ, Tan KT, Huang XX, Lin JS, Ng VHE, Maury JJP, Tenen DG, Chen L.

Nucleic Acids Res. 2017 Oct 13;45(18):10436-10451. doi: 10.1093/nar/gkx667.

26.

ZNF143 protein is an important regulator of the myeloid transcription factor C/EBPα.

Gonzalez D, Luyten A, Bartholdy B, Zhou Q, Kardosova M, Ebralidze A, Swanson KD, Radomska HS, Zhang P, Kobayashi SS, Welner RS, Levantini E, Steidl U, Chong G, Collombet S, Choi MH, Friedman AD, Scott LM, Alberich-Jorda M, Tenen DG.

J Biol Chem. 2017 Nov 17;292(46):18924-18936. doi: 10.1074/jbc.M117.811109. Epub 2017 Sep 12.

27.

C/EBPβ is required for survival of Ly6C- monocytes.

Tamura A, Hirai H, Yokota A, Kamio N, Sato A, Shoji T, Kashiwagi T, Torikoshi Y, Miura Y, Tenen DG, Maekawa T.

Blood. 2017 Oct 19;130(16):1809-1818. doi: 10.1182/blood-2017-03-772962. Epub 2017 Aug 14.

28.

C/EBPα deregulation as a paradigm for leukemogenesis.

Pulikkan JA, Tenen DG, Behre G.

Leukemia. 2017 Nov;31(11):2279-2285. doi: 10.1038/leu.2017.229. Epub 2017 Jul 19. Review.

PMID:
28720765
29.

Disruption of the C/EBPα-miR-182 balance impairs granulocytic differentiation.

Wurm AA, Zjablovskaja P, Kardosova M, Gerloff D, Bräuer-Hartmann D, Katzerke C, Hartmann JU, Benoukraf T, Fricke S, Hilger N, Müller AM, Bill M, Schwind S, Tenen DG, Niederwieser D, Alberich-Jorda M, Behre G.

Nat Commun. 2017 Jun 29;8(1):46. doi: 10.1038/s41467-017-00032-6.

30.

Super-Enhancers and Broad H3K4me3 Domains Form Complex Gene Regulatory Circuits Involving Chromatin Interactions.

Cao F, Fang Y, Tan HK, Goh Y, Choy JYH, Koh BTH, Hao Tan J, Bertin N, Ramadass A, Hunter E, Green J, Salter M, Akoulitchev A, Wang W, Chng WJ, Tenen DG, Fullwood MJ.

Sci Rep. 2017 May 19;7(1):2186. doi: 10.1038/s41598-017-02257-3.

31.

Neutrophil Elastase Regulates Emergency Myelopoiesis Preceding Systemic Inflammation in Diet-induced Obesity.

Huang JY, Zhou QL, Huang CH, Song Y, Sharma AG, Liao Z, Zhu K, Massidda MW, Jamieson RR, Zhang JY, Tenen DG, Jiang ZY.

J Biol Chem. 2017 Mar 24;292(12):4770-4776. doi: 10.1074/jbc.C116.758748. Epub 2017 Feb 15.

32.

EVI2B is a C/EBPα target gene required for granulocytic differentiation and functionality of hematopoietic progenitors.

Zjablovskaja P, Kardosova M, Danek P, Angelisova P, Benoukraf T, Wurm AA, Kalina T, Sian S, Balastik M, Delwel R, Brdicka T, Tenen DG, Behre G, Fiore F, Malissen B, Horejsi V, Alberich-Jorda M.

Cell Death Differ. 2017 Apr;24(4):705-716. doi: 10.1038/cdd.2017.6. Epub 2017 Feb 10. Erratum in: Cell Death Differ. 2019 Jan;26(1):198.

33.

The Janus-faced Nature of miR-22 in Hematopoiesis: Is It an Oncogenic Tumor Suppressor or Rather a Tumor-Suppressive Oncogene?

Wurm AA, Tenen DG, Behre G.

PLoS Genet. 2017 Jan 12;13(1):e1006505. doi: 10.1371/journal.pgen.1006505. eCollection 2017 Jan. No abstract available.

34.

Targeting SALL4 by entinostat in lung cancer.

Yong KJ, Li A, Ou WB, Hong CK, Zhao W, Wang F, Tatetsu H, Yan B, Qi L, Fletcher JA, Yang H, Soo R, Tenen DG, Chai L.

Oncotarget. 2016 Nov 15;7(46):75425-75440. doi: 10.18632/oncotarget.12251.

35.

Targeted BMI1 inhibition impairs tumor growth in lung adenocarcinomas with low CEBPα expression.

Yong KJ, Basseres DS, Welner RS, Zhang WC, Yang H, Yan B, Alberich-Jorda M, Zhang J, de Figueiredo-Pontes LL, Battelli C, Hetherington CJ, Ye M, Zhang H, Maroni G, O'Brien K, Magli MC, Borczuk AC, Varticovski L, Kocher O, Zhang P, Moon YC, Sydorenko N, Cao L, Davis TW, Thakkar BM, Soo RA, Iwama A, Lim B, Halmos B, Neuberg D, Tenen DG, Levantini E.

Sci Transl Med. 2016 Aug 3;8(350):350ra104. doi: 10.1126/scitranslmed.aad6066.

PMID:
27488898
36.

ADAR-Mediated RNA Editing Predicts Progression and Prognosis of Gastric Cancer.

Chan TH, Qamra A, Tan KT, Guo J, Yang H, Qi L, Lin JS, Ng VH, Song Y, Hong H, Tay ST, Liu Y, Lee J, Rha SY, Zhu F, So JB, Teh BT, Yeoh KG, Rozen S, Tenen DG, Tan P, Chen L.

Gastroenterology. 2016 Oct;151(4):637-650.e10. doi: 10.1053/j.gastro.2016.06.043. Epub 2016 Jul 1.

PMID:
27373511
37.

The second hit of DNA methylation.

Di Ruscio A, Welner RS, Tenen DG, Amabile G.

Mol Cell Oncol. 2015 Oct 29;3(3):e1093690. doi: 10.1080/23723556.2015.1093690. eCollection 2016 May.

38.

Multiple sclerosis: getting personal with induced pluripotent stem cells.

Di Ruscio A, Patti F, Welner RS, Tenen DG, Amabile G.

Cell Death Dis. 2016 Apr 14;7:e2185. doi: 10.1038/cddis.2016.59. No abstract available.

39.

Acetylation of C/EBPα inhibits its granulopoietic function.

Bararia D, Kwok HS, Welner RS, Numata A, Sárosi MB, Yang H, Wee S, Tschuri S, Ray D, Weigert O, Levantini E, Ebralidze AK, Gunaratne J, Tenen DG.

Nat Commun. 2016 Mar 23;7:10968. doi: 10.1038/ncomms10968.

40.

SALL4, the missing link between stem cells, development and cancer.

Tatetsu H, Kong NR, Chong G, Amabile G, Tenen DG, Chai L.

Gene. 2016 Jun 15;584(2):111-9. doi: 10.1016/j.gene.2016.02.019. Epub 2016 Feb 16. Review.

41.

The DNA Ligase IV Syndrome R278H Mutation Impairs B Lymphopoiesis via Error-Prone Nonhomologous End-Joining.

Park J, Welner RS, Chan MY, Troppito L, Staber PB, Tenen DG, Yan CT.

J Immunol. 2016 Jan 1;196(1):244-55. doi: 10.4049/jimmunol.1403099. Epub 2015 Nov 25.

42.

Hematopoietic Differentiation Is Required for Initiation of Acute Myeloid Leukemia.

Ye M, Zhang H, Yang H, Koche R, Staber PB, Cusan M, Levantini E, Welner RS, Bach CS, Zhang J, Krivtsov AV, Armstrong SA, Tenen DG.

Cell Stem Cell. 2015 Nov 5;17(5):611-23. doi: 10.1016/j.stem.2015.08.011. Epub 2015 Sep 24.

43.

Non-canonical NF-κB signalling and ETS1/2 cooperatively drive C250T mutant TERT promoter activation.

Li Y, Zhou QL, Sun W, Chandrasekharan P, Cheng HS, Ying Z, Lakshmanan M, Raju A, Tenen DG, Cheng SY, Chuang KH, Li J, Prabhakar S, Li M, Tergaonkar V.

Nat Cell Biol. 2015 Oct;17(10):1327-38. doi: 10.1038/ncb3240. Epub 2015 Sep 21.

44.

A novel mouse model identifies cooperating mutations and therapeutic targets critical for chronic myeloid leukemia progression.

Giotopoulos G, van der Weyden L, Osaki H, Rust AG, Gallipoli P, Meduri E, Horton SJ, Chan WI, Foster D, Prinjha RK, Pimanda JE, Tenen DG, Vassiliou GS, Koschmieder S, Adams DJ, Huntly BJ.

J Exp Med. 2015 Sep 21;212(10):1551-69. doi: 10.1084/jem.20141661. Epub 2015 Aug 24.

45.

Multiple sclerosis: getting personal with induced pluripotent stem cells.

Di Ruscio A, Patti F, Welner RS, Tenen DG, Amabile G.

Cell Death Dis. 2015 Jul 9;6:e1806. doi: 10.1038/cddis.2015.179. Review. Erratum in: Cell Death Dis. 2016;7:e2185.

46.

Fanconi anemia gene variants in therapy-related myeloid neoplasms.

Voso MT, Fabiani E, Zang Z, Fianchi L, Falconi G, Padella A, Martini M, Li Zhang S, Santangelo R, Larocca LM, Criscuolo M, La Brocca A, Cutcutache I, Rozen S, Simonetti G, Manfrini M, Martinelli G, Hohaus S, Leone G, Tan P, Tenen DG.

Blood Cancer J. 2015 Jul 3;5:e323. doi: 10.1038/bcj.2015.44. No abstract available.

47.

A Cell-Based High-Throughput Screening for Inducers of Myeloid Differentiation.

Radomska HS, Jernigan F, Nakayama S, Jorge SE, Sun L, Tenen DG, Kobayashi SS.

J Biomol Screen. 2015 Oct;20(9):1150-9. doi: 10.1177/1087057115592220. Epub 2015 Jun 24.

48.

Wnts are dispensable for differentiation and self-renewal of adult murine hematopoietic stem cells.

Kabiri Z, Numata A, Kawasaki A, Edison, Tenen DG, Virshup DM.

Blood. 2015 Aug 27;126(9):1086-94. doi: 10.1182/blood-2014-09-598540. Epub 2015 Jun 18.

49.

PML/RARα-Regulated miR-181a/b Cluster Targets the Tumor Suppressor RASSF1A in Acute Promyelocytic Leukemia.

Bräuer-Hartmann D, Hartmann JU, Wurm AA, Gerloff D, Katzerke C, Verga Falzacappa MV, Pelicci PG, Müller-Tidow C, Tenen DG, Niederwieser D, Behre G.

Cancer Res. 2015 Aug 15;75(16):3411-24. doi: 10.1158/0008-5472.CAN-14-3521. Epub 2015 Jun 3.

50.

Dissecting the role of aberrant DNA methylation in human leukaemia.

Amabile G, Di Ruscio A, Müller F, Welner RS, Yang H, Ebralidze AK, Zhang H, Levantini E, Qi L, Martinelli G, Brummelkamp T, Le Beau MM, Figueroa ME, Bock C, Tenen DG.

Nat Commun. 2015 May 22;6:7091. doi: 10.1038/ncomms8091.

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