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Items: 1 to 50 of 279

1.

Styryl Quinazolinones as Potential Inducers of Myeloid Differentiation via Upregulation of C/EBPα.

Sridhar R, Takei H, Syed R, Kobayashi IS, Hui LB, Kamal A, Tenen DG, Kobayashi SS.

Molecules. 2018 Aug 3;23(8). pii: E1938. doi: 10.3390/molecules23081938.

2.

Correction to: EVI2B is a C/EBPα target gene required for granulocytic differentiation and functionality of hematopoietic progenitors.

Zjablovskaja P, Kardosova M, Danek P, Angelisova P, Benoukraf T, Wurm AA, Kalina T, Sian S, Balastik M, Delwel R, Brdicka T, Tenen DG, Behre G, Fiore F, Malissen B, Horejsi V, Alberich-Jorda M.

Cell Death Differ. 2018 Jul 10. doi: 10.1038/s41418-018-0146-z. [Epub ahead of print]

PMID:
29991745
3.

Targeting cancer addiction for SALL4 by shifting its transcriptome with a pharmacologic peptide.

Liu BH, Jobichen C, Chia CSB, Chan THM, Tang JP, Chung TXY, Li J, Poulsen A, Hung AW, Koh-Stenta X, Tan YS, Verma CS, Tan HK, Wu CS, Li F, Hill J, Joy J, Yang H, Chai L, Sivaraman J, Tenen DG.

Proc Natl Acad Sci U S A. 2018 Jul 24;115(30):E7119-E7128. doi: 10.1073/pnas.1801253115. Epub 2018 Jul 5.

PMID:
29976840
4.

Bidirectional regulation of adenosine-to-inosine (A-to-I) RNA editing by DEAH box helicase 9 (DHX9) in cancer.

Hong H, An O, Chan THM, Ng VHE, Kwok HS, Lin JS, Qi L, Han J, Tay DJT, Tang SJ, Yang H, Song Y, Bellido Molias F, Tenen DG, Chen L.

Nucleic Acids Res. 2018 Sep 6;46(15):7953-7969. doi: 10.1093/nar/gky396.

5.

The basic helix-loop-helix transcription factor SHARP1 is an oncogenic driver in MLL-AF6 acute myelogenous leukemia.

Numata A, Kwok HS, Kawasaki A, Li J, Zhou QL, Kerry J, Benoukraf T, Bararia D, Li F, Ballabio E, Tapia M, Deshpande AJ, Welner RS, Delwel R, Yang H, Milne TA, Taneja R, Tenen DG.

Nat Commun. 2018 Apr 24;9(1):1622. doi: 10.1038/s41467-018-03854-0.

6.

Identification of novel lncRNAs regulated by the TAL1 complex in T-cell acute lymphoblastic leukemia.

Ngoc PCT, Tan SH, Tan TK, Chan MM, Li Z, Yeoh AEJ, Tenen DG, Sanda T.

Leukemia. 2018 Mar 26. doi: 10.1038/s41375-018-0110-4. [Epub ahead of print]

PMID:
29654272
7.

C/EBPγ is dispensable for steady-state and emergency granulopoiesis.

Kardosova M, Zjablovskaja P, Danek P, Angelisova P, de Figueiredo-Pontes LL, Welner RS, Brdicka T, Lee S, Tenen DG, Alberich-Jorda M.

Haematologica. 2018 Aug;103(8):e331-e335. doi: 10.3324/haematol.2017.173781. Epub 2018 Mar 22. No abstract available.

8.

LSD1 inhibition exerts its antileukemic effect by recommissioning PU.1- and C/EBPα-dependent enhancers in AML.

Cusan M, Cai SF, Mohammad HP, Krivtsov A, Chramiec A, Loizou E, Witkin MD, Smitheman KN, Tenen DG, Ye M, Will B, Steidl U, Kruger RG, Levine RL, Rienhoff HY Jr, Koche RP, Armstrong SA.

Blood. 2018 Apr 12;131(15):1730-1742. doi: 10.1182/blood-2017-09-807024. Epub 2018 Feb 16.

PMID:
29453291
9.

Fatty acid synthase mediates EGFR palmitoylation in EGFR mutated non-small cell lung cancer.

Ali A, Levantini E, Teo JT, Goggi J, Clohessy JG, Wu CS, Chen L, Yang H, Krishnan I, Kocher O, Zhang J, Soo RA, Bhakoo K, Chin TM, Tenen DG.

EMBO Mol Med. 2018 Mar;10(3). pii: e8313. doi: 10.15252/emmm.201708313.

10.

ARID5B as a critical downstream target of the TAL1 complex that activates the oncogenic transcriptional program and promotes T-cell leukemogenesis.

Leong WZ, Tan SH, Ngoc PCT, Amanda S, Yam AWY, Liau WS, Gong Z, Lawton LN, Tenen DG, Sanda T.

Genes Dev. 2017 Dec 1;31(23-24):2343-2360. doi: 10.1101/gad.302646.117. Epub 2018 Jan 11.

11.

TIP60 represses telomerase expression by inhibiting Sp1 binding to the TERT promoter.

Rajagopalan D, Pandey AK, Xiuzhen MC, Lee KK, Hora S, Zhang Y, Chua BH, Kwok HS, Bhatia SS, Deng LW, Tenen DG, Kappei D, Jha S.

PLoS Pathog. 2017 Oct 18;13(10):e1006681. doi: 10.1371/journal.ppat.1006681. eCollection 2017 Oct.

12.

An RNA editing/dsRNA binding-independent gene regulatory mechanism of ADARs and its clinical implication in cancer.

Qi L, Song Y, Chan THM, Yang H, Lin CH, Tay DJT, Hong H, Tang SJ, Tan KT, Huang XX, Lin JS, Ng VHE, Maury JJP, Tenen DG, Chen L.

Nucleic Acids Res. 2017 Oct 13;45(18):10436-10451. doi: 10.1093/nar/gkx667.

13.

ZNF143 protein is an important regulator of the myeloid transcription factor C/EBPα.

Gonzalez D, Luyten A, Bartholdy B, Zhou Q, Kardosova M, Ebralidze A, Swanson KD, Radomska HS, Zhang P, Kobayashi SS, Welner RS, Levantini E, Steidl U, Chong G, Collombet S, Choi MH, Friedman AD, Scott LM, Alberich-Jorda M, Tenen DG.

J Biol Chem. 2017 Nov 17;292(46):18924-18936. doi: 10.1074/jbc.M117.811109. Epub 2017 Sep 12.

PMID:
28900037
14.

C/EBPβ is required for survival of Ly6C- monocytes.

Tamura A, Hirai H, Yokota A, Kamio N, Sato A, Shoji T, Kashiwagi T, Torikoshi Y, Miura Y, Tenen DG, Maekawa T.

Blood. 2017 Oct 19;130(16):1809-1818. doi: 10.1182/blood-2017-03-772962. Epub 2017 Aug 14.

PMID:
28807982
15.

C/EBPα deregulation as a paradigm for leukemogenesis.

Pulikkan JA, Tenen DG, Behre G.

Leukemia. 2017 Nov;31(11):2279-2285. doi: 10.1038/leu.2017.229. Epub 2017 Jul 19. Review.

PMID:
28720765
16.

Disruption of the C/EBPα-miR-182 balance impairs granulocytic differentiation.

Wurm AA, Zjablovskaja P, Kardosova M, Gerloff D, Bräuer-Hartmann D, Katzerke C, Hartmann JU, Benoukraf T, Fricke S, Hilger N, Müller AM, Bill M, Schwind S, Tenen DG, Niederwieser D, Alberich-Jorda M, Behre G.

Nat Commun. 2017 Jun 29;8(1):46. doi: 10.1038/s41467-017-00032-6.

17.

Super-Enhancers and Broad H3K4me3 Domains Form Complex Gene Regulatory Circuits Involving Chromatin Interactions.

Cao F, Fang Y, Tan HK, Goh Y, Choy JYH, Koh BTH, Hao Tan J, Bertin N, Ramadass A, Hunter E, Green J, Salter M, Akoulitchev A, Wang W, Chng WJ, Tenen DG, Fullwood MJ.

Sci Rep. 2017 May 19;7(1):2186. doi: 10.1038/s41598-017-02257-3.

18.

Neutrophil Elastase Regulates Emergency Myelopoiesis Preceding Systemic Inflammation in Diet-induced Obesity.

Huang JY, Zhou QL, Huang CH, Song Y, Sharma AG, Liao Z, Zhu K, Massidda MW, Jamieson RR, Zhang JY, Tenen DG, Jiang ZY.

J Biol Chem. 2017 Mar 24;292(12):4770-4776. doi: 10.1074/jbc.C116.758748. Epub 2017 Feb 15.

19.

EVI2B is a C/EBPα target gene required for granulocytic differentiation and functionality of hematopoietic progenitors.

Zjablovskaja P, Kardosova M, Danek P, Angelisova P, Benoukraf T, Wurm AA, Kalina T, Sian S, Balastik M, Delwel R, Brdicka T, Tenen DG, Behre G, Fiore F, Malissen B, Horejsi V, Alberich-Jorda M.

Cell Death Differ. 2017 Apr;24(4):705-716. doi: 10.1038/cdd.2017.6. Epub 2017 Feb 10. Erratum in: Cell Death Differ. 2018 Jul 10;:.

20.

The Janus-faced Nature of miR-22 in Hematopoiesis: Is It an Oncogenic Tumor Suppressor or Rather a Tumor-Suppressive Oncogene?

Wurm AA, Tenen DG, Behre G.

PLoS Genet. 2017 Jan 12;13(1):e1006505. doi: 10.1371/journal.pgen.1006505. eCollection 2017 Jan. No abstract available.

21.

Targeting SALL4 by entinostat in lung cancer.

Yong KJ, Li A, Ou WB, Hong CK, Zhao W, Wang F, Tatetsu H, Yan B, Qi L, Fletcher JA, Yang H, Soo R, Tenen DG, Chai L.

Oncotarget. 2016 Nov 15;7(46):75425-75440. doi: 10.18632/oncotarget.12251.

22.

Targeted BMI1 inhibition impairs tumor growth in lung adenocarcinomas with low CEBPα expression.

Yong KJ, Basseres DS, Welner RS, Zhang WC, Yang H, Yan B, Alberich-Jorda M, Zhang J, de Figueiredo-Pontes LL, Battelli C, Hetherington CJ, Ye M, Zhang H, Maroni G, O'Brien K, Magli MC, Borczuk AC, Varticovski L, Kocher O, Zhang P, Moon YC, Sydorenko N, Cao L, Davis TW, Thakkar BM, Soo RA, Iwama A, Lim B, Halmos B, Neuberg D, Tenen DG, Levantini E.

Sci Transl Med. 2016 Aug 3;8(350):350ra104. doi: 10.1126/scitranslmed.aad6066.

PMID:
27488898
23.

ADAR-Mediated RNA Editing Predicts Progression and Prognosis of Gastric Cancer.

Chan TH, Qamra A, Tan KT, Guo J, Yang H, Qi L, Lin JS, Ng VH, Song Y, Hong H, Tay ST, Liu Y, Lee J, Rha SY, Zhu F, So JB, Teh BT, Yeoh KG, Rozen S, Tenen DG, Tan P, Chen L.

Gastroenterology. 2016 Oct;151(4):637-650.e10. doi: 10.1053/j.gastro.2016.06.043. Epub 2016 Jul 1.

PMID:
27373511
24.

The second hit of DNA methylation.

Di Ruscio A, Welner RS, Tenen DG, Amabile G.

Mol Cell Oncol. 2015 Oct 29;3(3):e1093690. doi: 10.1080/23723556.2015.1093690. eCollection 2016 May.

25.

Multiple sclerosis: getting personal with induced pluripotent stem cells.

Di Ruscio A, Patti F, Welner RS, Tenen DG, Amabile G.

Cell Death Dis. 2016 Apr 14;7:e2185. doi: 10.1038/cddis.2016.59. No abstract available.

26.

Acetylation of C/EBPα inhibits its granulopoietic function.

Bararia D, Kwok HS, Welner RS, Numata A, Sárosi MB, Yang H, Wee S, Tschuri S, Ray D, Weigert O, Levantini E, Ebralidze AK, Gunaratne J, Tenen DG.

Nat Commun. 2016 Mar 23;7:10968. doi: 10.1038/ncomms10968.

27.

SALL4, the missing link between stem cells, development and cancer.

Tatetsu H, Kong NR, Chong G, Amabile G, Tenen DG, Chai L.

Gene. 2016 Jun 15;584(2):111-9. doi: 10.1016/j.gene.2016.02.019. Epub 2016 Feb 16. Review.

28.

The DNA Ligase IV Syndrome R278H Mutation Impairs B Lymphopoiesis via Error-Prone Nonhomologous End-Joining.

Park J, Welner RS, Chan MY, Troppito L, Staber PB, Tenen DG, Yan CT.

J Immunol. 2016 Jan 1;196(1):244-55. doi: 10.4049/jimmunol.1403099. Epub 2015 Nov 25.

29.

Hematopoietic Differentiation Is Required for Initiation of Acute Myeloid Leukemia.

Ye M, Zhang H, Yang H, Koche R, Staber PB, Cusan M, Levantini E, Welner RS, Bach CS, Zhang J, Krivtsov AV, Armstrong SA, Tenen DG.

Cell Stem Cell. 2015 Nov 5;17(5):611-23. doi: 10.1016/j.stem.2015.08.011. Epub 2015 Sep 24.

30.

Non-canonical NF-κB signalling and ETS1/2 cooperatively drive C250T mutant TERT promoter activation.

Li Y, Zhou QL, Sun W, Chandrasekharan P, Cheng HS, Ying Z, Lakshmanan M, Raju A, Tenen DG, Cheng SY, Chuang KH, Li J, Prabhakar S, Li M, Tergaonkar V.

Nat Cell Biol. 2015 Oct;17(10):1327-38. doi: 10.1038/ncb3240. Epub 2015 Sep 21.

31.

A novel mouse model identifies cooperating mutations and therapeutic targets critical for chronic myeloid leukemia progression.

Giotopoulos G, van der Weyden L, Osaki H, Rust AG, Gallipoli P, Meduri E, Horton SJ, Chan WI, Foster D, Prinjha RK, Pimanda JE, Tenen DG, Vassiliou GS, Koschmieder S, Adams DJ, Huntly BJ.

J Exp Med. 2015 Sep 21;212(10):1551-69. doi: 10.1084/jem.20141661. Epub 2015 Aug 24.

32.

Multiple sclerosis: getting personal with induced pluripotent stem cells.

Di Ruscio A, Patti F, Welner RS, Tenen DG, Amabile G.

Cell Death Dis. 2015 Jul 9;6:e1806. doi: 10.1038/cddis.2015.179. Review. Erratum in: Cell Death Dis. 2016;7:e2185.

33.

Fanconi anemia gene variants in therapy-related myeloid neoplasms.

Voso MT, Fabiani E, Zang Z, Fianchi L, Falconi G, Padella A, Martini M, Li Zhang S, Santangelo R, Larocca LM, Criscuolo M, La Brocca A, Cutcutache I, Rozen S, Simonetti G, Manfrini M, Martinelli G, Hohaus S, Leone G, Tan P, Tenen DG.

Blood Cancer J. 2015 Jul 3;5:e323. doi: 10.1038/bcj.2015.44. No abstract available.

34.

A Cell-Based High-Throughput Screening for Inducers of Myeloid Differentiation.

Radomska HS, Jernigan F, Nakayama S, Jorge SE, Sun L, Tenen DG, Kobayashi SS.

J Biomol Screen. 2015 Oct;20(9):1150-9. doi: 10.1177/1087057115592220. Epub 2015 Jun 24.

35.

Wnts are dispensable for differentiation and self-renewal of adult murine hematopoietic stem cells.

Kabiri Z, Numata A, Kawasaki A, Edison, Tenen DG, Virshup DM.

Blood. 2015 Aug 27;126(9):1086-94. doi: 10.1182/blood-2014-09-598540. Epub 2015 Jun 18.

36.

PML/RARα-Regulated miR-181a/b Cluster Targets the Tumor Suppressor RASSF1A in Acute Promyelocytic Leukemia.

Bräuer-Hartmann D, Hartmann JU, Wurm AA, Gerloff D, Katzerke C, Verga Falzacappa MV, Pelicci PG, Müller-Tidow C, Tenen DG, Niederwieser D, Behre G.

Cancer Res. 2015 Aug 15;75(16):3411-24. doi: 10.1158/0008-5472.CAN-14-3521. Epub 2015 Jun 3.

37.

Dissecting the role of aberrant DNA methylation in human leukaemia.

Amabile G, Di Ruscio A, Müller F, Welner RS, Yang H, Ebralidze AK, Zhang H, Levantini E, Qi L, Martinelli G, Brummelkamp T, Le Beau MM, Figueroa ME, Bock C, Tenen DG.

Nat Commun. 2015 May 22;6:7091. doi: 10.1038/ncomms8091.

38.

Treatment of chronic myelogenous leukemia by blocking cytokine alterations found in normal stem and progenitor cells.

Welner RS, Amabile G, Bararia D, Czibere A, Yang H, Zhang H, Pontes LL, Ye M, Levantini E, Di Ruscio A, Martinelli G, Tenen DG.

Cancer Cell. 2015 May 11;27(5):671-81. doi: 10.1016/j.ccell.2015.04.004.

39.

Essential role of PU.1 in maintenance of mixed lineage leukemia-associated leukemic stem cells.

Aikawa Y, Yamagata K, Katsumoto T, Shima Y, Shino M, Stanley ER, Cleary ML, Akashi K, Tenen DG, Kitabayashi I.

Cancer Sci. 2015 Mar;106(3):227-36. doi: 10.1111/cas.12593. Epub 2015 Feb 12.

40.

Histone acetylation mediated by Brd1 is crucial for Cd8 gene activation during early thymocyte development.

Mishima Y, Wang C, Miyagi S, Saraya A, Hosokawa H, Mochizuki-Kashio M, Nakajima-Takagi Y, Koide S, Negishi M, Sashida G, Naito T, Ishikura T, Onodera A, Nakayama T, Tenen DG, Yamaguchi N, Koseki H, Taniuchi I, Iwama A.

Nat Commun. 2014 Dec 18;5:5872. doi: 10.1038/ncomms6872.

41.

Myeloid differentiation and the leukemia-initiating cell.

Tenen DG.

Leuk Suppl. 2014 Dec;3(Suppl 1):S25-6. doi: 10.1038/leusup.2014.14. Epub 2014 Dec 17. No abstract available.

42.

Identification of a dynamic core transcriptional network in t(8;21) AML that regulates differentiation block and self-renewal.

Ptasinska A, Assi SA, Martinez-Soria N, Imperato MR, Piper J, Cauchy P, Pickin A, James SR, Hoogenkamp M, Williamson D, Wu M, Tenen DG, Ott S, Westhead DR, Cockerill PN, Heidenreich O, Bonifer C.

Cell Rep. 2014 Sep 25;8(6):1974-1988. doi: 10.1016/j.celrep.2014.08.024. Epub 2014 Sep 18.

43.

The Runx-PU.1 pathway preserves normal and AML/ETO9a leukemic stem cells.

Staber PB, Zhang P, Ye M, Welner RS, Levantini E, Di Ruscio A, Ebralidze AK, Bach C, Zhang H, Zhang J, Vanura K, Delwel R, Yang H, Huang G, Tenen DG.

Blood. 2014 Oct 9;124(15):2391-9. doi: 10.1182/blood-2014-01-550855. Epub 2014 Sep 3.

44.

NF-κB/STAT5/miR-155 network targets PU.1 in FLT3-ITD-driven acute myeloid leukemia.

Gerloff D, Grundler R, Wurm AA, Bräuer-Hartmann D, Katzerke C, Hartmann JU, Madan V, Müller-Tidow C, Duyster J, Tenen DG, Niederwieser D, Behre G.

Leukemia. 2015 Mar;29(3):535-47. doi: 10.1038/leu.2014.231. Epub 2014 Aug 5.

45.

Induced pluripotent stem cells in hematology: current and future applications.

Focosi D, Amabile G, Di Ruscio A, Quaranta P, Tenen DG, Pistello M.

Blood Cancer J. 2014 May 9;4:e211. doi: 10.1038/bcj.2014.30. Review.

46.

Runx1 exon 6-related alternative splicing isoforms differentially regulate hematopoiesis in mice.

Komeno Y, Yan M, Matsuura S, Lam K, Lo MC, Huang YJ, Tenen DG, Downing JR, Zhang DE.

Blood. 2014 Jun 12;123(24):3760-9. doi: 10.1182/blood-2013-08-521252. Epub 2014 Apr 25.

47.

NOTCH2 and FLT3 gene mis-splicings are common events in patients with acute myeloid leukemia (AML): new potential targets in AML.

Adamia S, Bar-Natan M, Haibe-Kains B, Pilarski PM, Bach C, Pevzner S, Calimeri T, Avet-Loiseau H, Lode L, Verselis S, Fox EA, Galinsky I, Mathews S, Dagogo-Jack I, Wadleigh M, Steensma DP, Motyckova G, Deangelo DJ, Quackenbush J, Tenen DG, Stone RM, Griffin JD.

Blood. 2014 May 1;123(18):2816-25. doi: 10.1182/blood-2013-02-481507. Epub 2014 Feb 26.

48.

RNA editome imbalance in hepatocellular carcinoma.

Qi L, Chan TH, Tenen DG, Chen L.

Cancer Res. 2014 Mar 1;74(5):1301-6. doi: 10.1158/0008-5472.CAN-13-3485. Epub 2014 Feb 20. Review.

49.

Downregulation of RUNX1/CBFβ by MLL fusion proteins enhances hematopoietic stem cell self-renewal.

Zhao X, Chen A, Yan X, Zhang Y, He F, Hayashi Y, Dong Y, Rao Y, Li B, Conway RM, Maiques-Diaz A, Elf SE, Huang N, Zuber J, Xiao Z, Tse W, Tenen DG, Wang Q, Chen W, Mulloy JC, Nimer SD, Huang G.

Blood. 2014 Mar 13;123(11):1729-38. doi: 10.1182/blood-2013-03-489575. Epub 2014 Jan 21.

50.

PU.1 is essential for MLL leukemia partially via crosstalk with the MEIS/HOX pathway.

Zhou J, Wu J, Li B, Liu D, Yu J, Yan X, Zheng S, Wang J, Zhang L, Zhang L, He F, Li Q, Chen A, Zhang Y, Zhao X, Guan Y, Zhao X, Yan J, Ni J, Nobrega MA, Löwenberg B, Delwel R, Valk PJ, Kumar A, Xie L, Tenen DG, Huang G, Wang QF.

Leukemia. 2014 Jul;28(7):1436-48. doi: 10.1038/leu.2013.384. Epub 2013 Dec 26.

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