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Bivalent Peptide- and Chelator-Containing Bioconjugates as Toolbox Components for Personalized Nanomedicine.

Daeg J, Xu X, Zhao L, Boye S, Janke A, Temme A, Zhao J, Lederer A, Voit B, Shi X, Appelhans D.

Biomacromolecules. 2019 Oct 17. doi: 10.1021/acs.biomac.9b01127. [Epub ahead of print]


Mono- and Polyassociation Processes of Pentavalent Biotinylated PEI Glycopolymers for the Fabrication of Biohybrid Structures with Targeting Properties.

Fingernagel J, Boye S, Kietz A, Höbel S, Wozniak K, Moreno S, Janke A, Lederer A, Aigner A, Temme A, Voit B, Appelhans D.

Biomacromolecules. 2019 Sep 9;20(9):3408-3424. doi: 10.1021/acs.biomac.9b00667. Epub 2019 Aug 7.


Interaction of Discoidin Domain Receptor 1 with a 14-3-3-Beclin-1-Akt1 Complex Modulates Glioblastoma Therapy Sensitivity.

Vehlow A, Klapproth E, Jin S, Hannen R, Hauswald M, Bartsch JW, Nimsky C, Temme A, Leitinger B, Cordes N.

Cell Rep. 2019 Mar 26;26(13):3672-3683.e7. doi: 10.1016/j.celrep.2019.02.096.


Targeted delivery of TLR3 agonist to tumor cells with single chain antibody fragment-conjugated nanoparticles induces type I-interferon response and apoptosis.

Schau I, Michen S, Hagstotz A, Janke A, Schackert G, Appelhans D, Temme A.

Sci Rep. 2019 Mar 1;9(1):3299. doi: 10.1038/s41598-019-40032-8.


Spatial early warning signals for impending regime shifts: A practical framework for application in real-world landscapes.

Nijp JJ, Temme AJAM, van Voorn GAK, Kooistra L, Hengeveld GM, Soons MB, Teuling AJ, Wallinga J.

Glob Chang Biol. 2019 Jun;25(6):1905-1921. doi: 10.1111/gcb.14591. Epub 2019 Apr 1. Review.


RhoGDIβ affects HeLa cell spindle orientation following UVC irradiation.

Doi N, Kunimatsu Y, Fujiura K, Togari H, Minagi K, Nakaoji K, Hamada K, Temme A, Tatsuka M.

J Cell Physiol. 2019 Jan 16. doi: 10.1002/jcp.28154. [Epub ahead of print]


Multiple genomic regions influence root morphology and seedling growth in cultivated sunflower (Helianthus annuus L.) under well-watered and water-limited conditions.

Masalia RR, Temme AA, Torralba NL, Burke JM.

PLoS One. 2018 Sep 20;13(9):e0204279. doi: 10.1371/journal.pone.0204279. eCollection 2018.


Toxicological investigations of "naked" and polymer-entrapped AOT-based gold nanotriangles.

Liebig F, Moreno S, Thünemann AF, Temme A, Appelhans D, Koetz J.

Colloids Surf B Biointerfaces. 2018 Jul 1;167:560-567. doi: 10.1016/j.colsurfb.2018.04.059. Epub 2018 Apr 30.


Immune Monitoring of Cancer Patients Prior to and During CTLA-4 or PD-1/PD-L1 Inhibitor Treatment.

Tunger A, Kießler M, Wehner R, Temme A, Meier F, Bachmann M, Schmitz M.

Biomedicines. 2018 Mar 1;6(1). pii: E26. doi: 10.3390/biomedicines6010026. Review.


AMPA Receptor Antagonist CFM-2 Decreases Survivin Expression in Cancer Cells.

Ruiz DS, Luksch H, Sifringer M, Temme A, Staufner C, Rzeski W, Marzahn J, Grabarska A, Ikonomidou C, Stepulak A.

Anticancer Agents Med Chem. 2018;18(4):591-596. doi: 10.2174/1871520618666180228123406.


Evaluation of a Pretargeting Strategy for Molecular Imaging of the Prostate Stem Cell Antigen with a Single Chain Antibody.

Tienken L, Drude N, Schau I, Winz OH, Temme A, Weinhold E, Mottaghy FM, Morgenroth A.

Sci Rep. 2018 Feb 28;8(1):3755. doi: 10.1038/s41598-018-22179-y.


Chromosomal instability induced by increased BIRC5/Survivin levels affects tumorigenicity of glioma cells.

Conde M, Michen S, Wiedemuth R, Klink B, Schröck E, Schackert G, Temme A.

BMC Cancer. 2017 Dec 28;17(1):889. doi: 10.1186/s12885-017-3932-y.


Optical Analysis of Glioma: Fourier-Transform Infrared Spectroscopy Reveals the IDH1 Mutation Status.

Uckermann O, Juratli TA, Galli R, Conde M, Wiedemuth R, Krex D, Geiger K, Temme A, Schackert G, Koch E, Steiner G, Kirsch M.

Clin Cancer Res. 2018 Jun 1;24(11):2530-2538. doi: 10.1158/1078-0432.CCR-17-1795. Epub 2017 Dec 19.


An orthotopic xenograft model for high-risk non-muscle invasive bladder cancer in mice: influence of mouse strain, tumor cell count, dwell time and bladder pretreatment.

Huebner D, Rieger C, Bergmann R, Ullrich M, Meister S, Toma M, Wiedemuth R, Temme A, Novotny V, Wirth MP, Bachmann M, Pietzsch J, Fuessel S.

BMC Cancer. 2017 Nov 23;17(1):790. doi: 10.1186/s12885-017-3778-3.


Arginine Deprivation Therapy: Putative Strategy to Eradicate Glioblastoma Cells by Radiosensitization.

Hinrichs CN, Ingargiola M, Käubler T, Löck S, Temme A, Köhn-Luque A, Deutsch A, Vovk O, Stasyk O, Kunz-Schughart LA.

Mol Cancer Ther. 2018 Feb;17(2):393-406. doi: 10.1158/1535-7163.MCT-16-0807. Epub 2017 Aug 22.


A Poly(Propyleneimine) Dendrimer-Based Polyplex-System for Single-Chain Antibody-Mediated Targeted Delivery and Cellular Uptake of SiRNA.

Tietze S, Schau I, Michen S, Ennen F, Janke A, Schackert G, Aigner A, Appelhans D, Temme A.

Small. 2017 Jul;13(27). doi: 10.1002/smll.201700072. Epub 2017 May 22.


Adhesion- and stress-related adaptation of glioma radiochemoresistance is circumvented by β1 integrin/JNK co-targeting.

Vehlow A, Klapproth E, Storch K, Dickreuter E, Seifert M, Dietrich A, Bütof R, Temme A, Cordes N.

Oncotarget. 2017 Jul 25;8(30):49224-49237. doi: 10.18632/oncotarget.17480.


Intranasal Adeno-Associated Virus Mediated Gene Delivery and Expression of Human Iduronidase in the Central Nervous System: A Noninvasive and Effective Approach for Prevention of Neurologic Disease in Mucopolysaccharidosis Type I.

Belur LR, Temme A, Podetz-Pedersen KM, Riedl M, Vulchanova L, Robinson N, Hanson LR, Kozarsky KF, Orchard PJ, Frey WH 2nd, Low WC, McIvor RS.

Hum Gene Ther. 2017 Jul;28(7):576-587. doi: 10.1089/hum.2017.187. Epub 2017 Apr 20.


Comprehensive molecular characterization of multifocal glioblastoma proves its monoclonal origin and reveals novel insights into clonal evolution and heterogeneity of glioblastomas.

Abou-El-Ardat K, Seifert M, Becker K, Eisenreich S, Lehmann M, Hackmann K, Rump A, Meijer G, Carvalho B, Temme A, Schackert G, Schröck E, Krex D, Klink B.

Neuro Oncol. 2017 Apr 1;19(4):546-557. doi: 10.1093/neuonc/now231.


Assessing the efficacy of coherent anti-Stokes Raman scattering microscopy for the detection of infiltrating glioblastoma in fresh brain samples.

Galli R, Uckermann O, Temme A, Leipnitz E, Meinhardt M, Koch E, Schackert G, Steiner G, Kirsch M.

J Biophotonics. 2017 Mar;10(3):404-414. doi: 10.1002/jbio.201500323. Epub 2016 Mar 11.


Liposome-polyethylenimine complexes (DPPC-PEI lipopolyplexes) for therapeutic siRNA delivery in vivo.

Ewe A, Panchal O, Pinnapireddy SR, Bakowsky U, Przybylski S, Temme A, Aigner A.

Nanomedicine. 2017 Jan;13(1):209-218. doi: 10.1016/j.nano.2016.08.005. Epub 2016 Aug 20.


Janus face-like effects of Aurora B inhibition: antitumoral mode of action versus induction of aneuploid progeny.

Wiedemuth R, Klink B, Fujiwara M, Schröck E, Tatsuka M, Schackert G, Temme A.

Carcinogenesis. 2016 Oct;37(10):993-1003. doi: 10.1093/carcin/bgw083. Epub 2016 Aug 11.


Chimeric antigen receptor-engineered primary natural killer cells: a tool to improve adoptive tumor immunotherapy.

Temme A, Schmitz M.

Immunotherapy. 2016 Sep;8(9):983-6. doi: 10.2217/imt-2016-0072. No abstract available.


Radiation-Induced RhoGDIβ Cleavage Leads to Perturbation of Cell Polarity: A Possible Link to Cancer Spreading.

Fujiwara M, Okamoto M, Hori M, Suga H, Jikihara H, Sugihara Y, Shimamoto F, Mori T, Nakaoji K, Hamada K, Ota T, Wiedemuth R, Temme A, Tatsuka M.

J Cell Physiol. 2016 Nov;231(11):2493-505. doi: 10.1002/jcp.25362. Epub 2016 Mar 14.


Genetically Engineered Natural Killer Cells as a Means for Adoptive Tumor Immunotherapy.

Michen S, Temme A.

Crit Rev Immunol. 2016;36(4):329-347. doi: 10.1615/CritRevImmunol.2017019376. Review.


Winners always win: growth of a wide range of plant species from low to future high CO2.

Temme AA, Liu JC, Cornwell WK, Cornelissen JH, Aerts R.

Ecol Evol. 2015 Oct 15;5(21):4949-61. doi: 10.1002/ece3.1687. eCollection 2015 Nov.


ILKAP, ILK and PINCH1 control cell survival of p53-wildtype glioblastoma cells after irradiation.

Hausmann C, Temme A, Cordes N, Eke I.

Oncotarget. 2015 Oct 27;6(33):34592-605. doi: 10.18632/oncotarget.5423.


Time-of-Flight Microwave Camera.

Charvat G, Temme A, Feigin M, Raskar R.

Sci Rep. 2015 Oct 5;5:14709. doi: 10.1038/srep14709.


The nucleoporin ALADIN regulates Aurora A localization to ensure robust mitotic spindle formation.

Carvalhal S, Ribeiro SA, Arocena M, Kasciukovic T, Temme A, Koehler K, Huebner A, Griffis ER.

Mol Biol Cell. 2015 Oct 1;26(19):3424-38. doi: 10.1091/mbc.E15-02-0113. Epub 2015 Aug 5.


Antisense- and siRNA-mediated inhibition of the anti-apoptotic gene Bcl-xL for chemosensitization of bladder cancer cells.

Rieger C, Huebner D, Temme A, Wirth MP, Fuessel S.

Int J Oncol. 2015 Sep;47(3):1121-30. doi: 10.3892/ijo.2015.3096. Epub 2015 Jul 20.


Engineering NK Cells Modified With an EGFRvIII-specific Chimeric Antigen Receptor to Overexpress CXCR4 Improves Immunotherapy of CXCL12/SDF-1α-secreting Glioblastoma.

Müller N, Michen S, Tietze S, Töpfer K, Schulte A, Lamszus K, Schmitz M, Schackert G, Pastan I, Temme A.

J Immunother. 2015 Jun;38(5):197-210. doi: 10.1097/CJI.0000000000000082.


DAP12-based activating chimeric antigen receptor for NK cell tumor immunotherapy.

Töpfer K, Cartellieri M, Michen S, Wiedemuth R, Müller N, Lindemann D, Bachmann M, Füssel M, Schackert G, Temme A.

J Immunol. 2015 Apr 1;194(7):3201-12. doi: 10.4049/jimmunol.1400330. Epub 2015 Mar 4.


Overcoming concealment effects of targeting moieties in the PEG corona: controlled permeable polymersomes decorated with folate-antennae for selective targeting of tumor cells.

Yassin MA, Appelhans D, Wiedemuth R, Formanek P, Boye S, Lederer A, Temme A, Voit B.

Small. 2015 Apr;11(13):1580-91. doi: 10.1002/smll.201402581. Epub 2014 Oct 31.


tRNA modifying enzymes, NSUN2 and METTL1, determine sensitivity to 5-fluorouracil in HeLa cells.

Okamoto M, Fujiwara M, Hori M, Okada K, Yazama F, Konishi H, Xiao Y, Qi G, Shimamoto F, Ota T, Temme A, Tatsuka M.

PLoS Genet. 2014 Sep 18;10(9):e1004639. doi: 10.1371/journal.pgen.1004639. eCollection 2014 Sep.


Redirection of CD4+ and CD8+ T lymphocytes via a novel antibody-based modular targeting system triggers efficient killing of PSCA+ prostate tumor cells.

Arndt C, Feldmann A, Töpfer K, Koristka S, Cartellieri M, Temme A, Ehninger A, Ehninger G, Bachmann M.

Prostate. 2014 Sep;74(13):1347-58. doi: 10.1002/pros.22851. Epub 2014 Jul 22.


Differential growth inhibition of cerebral metastases by anti-angiogenic compounds.

Martin DK, Uckermann O, Bertram A, Liebner C, Hendruschk S, Sitoci-Ficici KH, Schackert G, Lord EM, Temme A, Kirsch M.

Anticancer Res. 2014 Jul;34(7):3293-302.


Survivin safeguards chromosome numbers and protects from aneuploidy independently from p53.

Wiedemuth R, Klink B, Töpfer K, Schröck E, Schackert G, Tatsuka M, Temme A.

Mol Cancer. 2014 May 9;13:107. doi: 10.1186/1476-4598-13-107.


Cytotoxic response of human regulatory T cells upon T-cell receptor-mediated activation: a matter of purity.

Koristka S, Cartellieri M, Arndt C, Feldmann A, Töpfer K, Michalk I, Temme A, Ehninger G, Bachmann M.

Blood Cancer J. 2014 Apr 11;4:e199. doi: 10.1038/bcj.2014.20. No abstract available.


A novel ex vivo isolation and expansion procedure for chimeric antigen receptor engrafted human T cells.

Cartellieri M, Koristka S, Arndt C, Feldmann A, Stamova S, von Bonin M, Töpfer K, Krüger T, Geib M, Michalk I, Temme A, Bornhäuser M, Lindemann D, Ehninger G, Bachmann MP.

PLoS One. 2014 Apr 3;9(4):e93745. doi: 10.1371/journal.pone.0093745. eCollection 2014.


Storage stability of optimal liposome-polyethylenimine complexes (lipopolyplexes) for DNA or siRNA delivery.

Ewe A, Schaper A, Barnert S, Schubert R, Temme A, Bakowsky U, Aigner A.

Acta Biomater. 2014 Jun;10(6):2663-73. doi: 10.1016/j.actbio.2014.02.037. Epub 2014 Mar 1.


Meta-analysis reveals profound responses of plant traits to glacial CO2 levels.

Temme AA, Cornwell WK, Cornelissen JH, Aerts R.

Ecol Evol. 2013 Nov;3(13):4525-35. doi: 10.1002/ece3.836. Epub 2013 Oct 18.


The detergent-soluble cytoplasmic pool of survivin suppresses anoikis and its expression is associated with metastatic disease of human colon cancer.

Hori M, Miki T, Okamoto M, Yazama F, Konishi H, Kaneko H, Shimamoto F, Ota T, Temme A, Tatsuka M.

PLoS One. 2013;8(2):e55710. doi: 10.1371/journal.pone.0055710. Epub 2013 Feb 6.


Synthesis of hetero-polymer functionalized nanocarriers by combining surface-initiated ATRP and RAFT polymerization.

Huang X, Hauptmann N, Appelhans D, Formanek P, Frank S, Kaskel S, Temme A, Voit B.

Small. 2012 Dec 7;8(23):3579-83. doi: 10.1002/smll.201201397. Epub 2012 Aug 22.


Three-dimensional invasion of human glioblastoma cells remains unchanged by X-ray and carbon ion irradiation in vitro.

Eke I, Storch K, Kästner I, Vehlow A, Faethe C, Mueller-Klieser W, Taucher-Scholz G, Temme A, Schackert G, Cordes N.

Int J Radiat Oncol Biol Phys. 2012 Nov 15;84(4):e515-23. doi: 10.1016/j.ijrobp.2012.06.012. Epub 2012 Aug 15.


Novel humanized and highly efficient bispecific antibodies mediate killing of prostate stem cell antigen-expressing tumor cells by CD8+ and CD4+ T cells.

Feldmann A, Arndt C, Töpfer K, Stamova S, Krone F, Cartellieri M, Koristka S, Michalk I, Lindemann D, Schmitz M, Temme A, Bornhäuser M, Ehninger G, Bachmann M.

J Immunol. 2012 Sep 15;189(6):3249-59. doi: 10.4049/jimmunol.1200341. Epub 2012 Aug 8.


Tumor evasion from T cell surveillance.

Töpfer K, Kempe S, Müller N, Schmitz M, Bachmann M, Cartellieri M, Schackert G, Temme A.

J Biomed Biotechnol. 2011;2011:918471. doi: 10.1155/2011/918471. Epub 2011 Nov 15. Review.


Retargeting of human regulatory T cells by single-chain bispecific antibodies.

Koristka S, Cartellieri M, Theil A, Feldmann A, Arndt C, Stamova S, Michalk I, Töpfer K, Temme A, Kretschmer K, Bornhäuser M, Ehninger G, Schmitz M, Bachmann M.

J Immunol. 2012 Feb 1;188(3):1551-8. doi: 10.4049/jimmunol.1101760. Epub 2011 Dec 19.


SOX2-RNAi attenuates S-phase entry and induces RhoA-dependent switch to protease-independent amoeboid migration in human glioma cells.

Oppel F, Müller N, Schackert G, Hendruschk S, Martin D, Geiger KD, Temme A.

Mol Cancer. 2011 Nov 9;10:137. doi: 10.1186/1476-4598-10-137.


Silencing of selected glutamate receptor subunits modulates cancer growth.

Luksch H, Uckermann O, Stepulak A, Hendruschk S, Marzahn J, Bastian S, Staufner C, Temme A, Ikonomidou C.

Anticancer Res. 2011 Oct;31(10):3181-92.


RNA interference targeting survivin exerts antitumoral effects in vitro and in established glioma xenografts in vivo.

Hendruschk S, Wiedemuth R, Aigner A, Töpfer K, Cartellieri M, Martin D, Kirsch M, Ikonomidou C, Schackert G, Temme A.

Neuro Oncol. 2011 Oct;13(10):1074-89. doi: 10.1093/neuonc/nor098. Epub 2011 Jul 25.

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