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Items: 30

1.

R-spondin 2 Drives Liver Tumor Development in a Yes-Associated Protein-Dependent Manner.

Conboy CB, VĂ©lez-Reyes GL, Tschida BR, Hu H, Kaufmann G, Koes N, Keller B, Alsinet C, CornellĂ  H, Pinyol R, Abrahante JE, Temiz NA, Linden MA, Amin K, Kuka TP, Keng VW, Llovet JM, Starr TK, Largaespada DA.

Hepatol Commun. 2019 Sep 3;3(11):1496-1509. doi: 10.1002/hep4.1422. eCollection 2019 Nov.

2.

Evaluating the landscape of gene cooperativity with receptor tyrosine kinases in liver tumorigenesis using transposon-mediated mutagenesis.

Fan Y, Bazai SK, Daian F, Arechederra M, Richelme S, Temiz NA, Yim A, Habermann BH, Dono R, Largaespada DA, Maina F.

J Hepatol. 2019 Mar;70(3):470-482. doi: 10.1016/j.jhep.2018.11.027. Epub 2018 Dec 6.

PMID:
30529386
3.

Insulin Receptor Substrate Suppression by the Tyrphostin NT157 Inhibits Responses to Insulin-Like Growth Factor-I and Insulin in Breast Cancer Cells.

Yang Y, Chan JY, Temiz NA, Yee D.

Horm Cancer. 2018 Dec;9(6):371-382. doi: 10.1007/s12672-018-0343-8. Epub 2018 Sep 18.

4.

Mutation Signatures Including APOBEC in Cancer Cell Lines.

Jarvis MC, Ebrahimi D, Temiz NA, Harris RS.

JNCI Cancer Spectr. 2018 Jan;2(1). pii: pky002. doi: 10.1093/jncics/pky002. Epub 2018 Mar 17.

5.

Cancer Stem Cell Phenotypes in ER+ Breast Cancer Models Are Promoted by PELP1/AIB1 Complexes.

Truong TH, Hu H, Temiz NA, Hagen KM, Girard BJ, Brady NJ, Schwertfeger KL, Lange CA, Ostrander JH.

Mol Cancer Res. 2018 Apr;16(4):707-719. doi: 10.1158/1541-7786.MCR-17-0598. Epub 2018 Jan 18.

6.

Comparative Transcriptome Analysis Quantifies Immune Cell Transcript Levels, Metastatic Progression, and Survival in Osteosarcoma.

Scott MC, Temiz NA, Sarver AE, LaRue RS, Rathe SK, Varshney J, Wolf NK, Moriarity BS, O'Brien TD, Spector LG, Largaespada DA, Modiano JF, Subramanian S, Sarver AL.

Cancer Res. 2018 Jan 15;78(2):326-337. doi: 10.1158/0008-5472.CAN-17-0576. Epub 2017 Oct 24.

7.

Sleeping Beauty Insertional Mutagenesis in Mice Identifies Drivers of Steatosis-Associated Hepatic Tumors.

Tschida BR, Temiz NA, Kuka TP, Lee LA, Riordan JD, Tierrablanca CA, Hullsiek R, Wagner S, Hudson WA, Linden MA, Amin K, Beckmann PJ, Heuer RA, Sarver AL, Yang JD, Roberts LR, Nadeau JH, Dupuy AJ, Keng VW, Largaespada DA.

Cancer Res. 2017 Dec 1;77(23):6576-6588. doi: 10.1158/0008-5472.CAN-17-2281. Epub 2017 Oct 9.

8.

Ras oncogene-independent activation of RALB signaling is a targetable mechanism of escape from NRAS(V12) oncogene addiction in acute myeloid leukemia.

Pomeroy EJ, Lee LA, Lee RDW, Schirm DK, Temiz NA, Ma J, Gruber TA, Diaz-Flores E, Moriarity BS, Downing JR, Shannon KM, Largaespada DA, Eckfeldt CE.

Oncogene. 2017 Jun 8;36(23):3263-3273. doi: 10.1038/onc.2016.471. Epub 2016 Dec 19.

9.

The DNA cytosine deaminase APOBEC3B promotes tamoxifen resistance in ER-positive breast cancer.

Law EK, Sieuwerts AM, LaPara K, Leonard B, Starrett GJ, Molan AM, Temiz NA, Vogel RI, Meijer-van Gelder ME, Sweep FC, Span PN, Foekens JA, Martens JW, Yee D, Harris RS.

Sci Adv. 2016 Oct 7;2(10):e1601737. eCollection 2016 Oct.

10.

The DNA cytosine deaminase APOBEC3H haplotype I likely contributes to breast and lung cancer mutagenesis.

Starrett GJ, Luengas EM, McCann JL, Ebrahimi D, Temiz NA, Love RP, Feng Y, Adolph MB, Chelico L, Law EK, Carpenter MA, Harris RS.

Nat Commun. 2016 Sep 21;7:12918. doi: 10.1038/ncomms12918.

11.

Mutation Processes in 293-Based Clones Overexpressing the DNA Cytosine Deaminase APOBEC3B.

Akre MK, Starrett GJ, Quist JS, Temiz NA, Carpenter MA, Tutt AN, Grigoriadis A, Harris RS.

PLoS One. 2016 May 10;11(5):e0155391. doi: 10.1371/journal.pone.0155391. eCollection 2016.

12.

MYC and PVT1 synergize to regulate RSPO1 levels in breast cancer.

Sarver AL, Murray CD, Temiz NA, Tseng YY, Bagchi A.

Cell Cycle. 2016;15(7):881-5. doi: 10.1080/15384101.2016.1149660.

13.

RNA sequencing of Sleeping Beauty transposon-induced tumors detects transposon-RNA fusions in forward genetic cancer screens.

Temiz NA, Moriarity BS, Wolf NK, Riordan JD, Dupuy AJ, Largaespada DA, Sarver AL.

Genome Res. 2016 Jan;26(1):119-29. doi: 10.1101/gr.188649.114. Epub 2015 Nov 9.

14.

Erratum to: The somatic autosomal mutation matrix in cancer genomes.

Temiz NA, Donohue DE, Bacolla A, Vasquez KM, Cooper DN, Mudunuri U, Ivanic J, Cer RZ, Yi M, Stephens RM, Collins JR, Luke BT.

Hum Genet. 2015 Aug;134(8):865-7. doi: 10.1007/s00439-015-1576-z. No abstract available.

15.

The somatic autosomal mutation matrix in cancer genomes.

Temiz NA, Donohue DE, Bacolla A, Vasquez KM, Cooper DN, Mudunuri U, Ivanic J, Cer RZ, Yi M, Stephens RM, Collins JR, Luke BT.

Hum Genet. 2015 Aug;134(8):851-64. doi: 10.1007/s00439-015-1566-1. Epub 2015 May 23. Erratum in: Hum Genet. 2015 Aug;134(8):865-7.

16.

A Sleeping Beauty forward genetic screen identifies new genes and pathways driving osteosarcoma development and metastasis.

Moriarity BS, Otto GM, Rahrmann EP, Rathe SK, Wolf NK, Weg MT, Manlove LA, LaRue RS, Temiz NA, Molyneux SD, Choi K, Holly KJ, Sarver AL, Scott MC, Forster CL, Modiano JF, Khanna C, Hewitt SM, Khokha R, Yang Y, Gorlick R, Dyer MA, Largaespada DA.

Nat Genet. 2015 Jun;47(6):615-24. doi: 10.1038/ng.3293. Epub 2015 May 11.

17.

Human papillomavirus E6 triggers upregulation of the antiviral and cancer genomic DNA deaminase APOBEC3B.

Vieira VC, Leonard B, White EA, Starrett GJ, Temiz NA, Lorenz LD, Lee D, Soares MA, Lambert PF, Howley PM, Harris RS.

MBio. 2014 Dec 23;5(6). pii: e02234-14. doi: 10.1128/mBio.02234-14.

18.

APOBEC3B upregulation and genomic mutation patterns in serous ovarian carcinoma.

Leonard B, Hart SN, Burns MB, Carpenter MA, Temiz NA, Rathore A, Vogel RI, Nikas JB, Law EK, Brown WL, Li Y, Zhang Y, Maurer MJ, Oberg AL, Cunningham JM, Shridhar V, Bell DA, April C, Bentley D, Bibikova M, Cheetham RK, Fan JB, Grocock R, Humphray S, Kingsbury Z, Peden J, Chien J, Swisher EM, Hartmann LC, Kalli KR, Goode EL, Sicotte H, Kaufmann SH, Harris RS.

Cancer Res. 2013 Dec 15;73(24):7222-31. doi: 10.1158/0008-5472.CAN-13-1753. Epub 2013 Oct 23.

19.

Guanine holes are prominent targets for mutation in cancer and inherited disease.

Bacolla A, Temiz NA, Yi M, Ivanic J, Cer RZ, Donohue DE, Ball EV, Mudunuri US, Wang G, Jain A, Volfovsky N, Luke BT, Stephens RM, Cooper DN, Collins JR, Vasquez KM.

PLoS Genet. 2013;9(9):e1003816. doi: 10.1371/journal.pgen.1003816. Epub 2013 Sep 26.

20.

Evidence for APOBEC3B mutagenesis in multiple human cancers.

Burns MB, Temiz NA, Harris RS.

Nat Genet. 2013 Sep;45(9):977-83. doi: 10.1038/ng.2701. Epub 2013 Jul 14.

21.

APOBEC3B is an enzymatic source of mutation in breast cancer.

Burns MB, Lackey L, Carpenter MA, Rathore A, Land AM, Leonard B, Refsland EW, Kotandeniya D, Tretyakova N, Nikas JB, Yee D, Temiz NA, Donohue DE, McDougle RM, Brown WL, Law EK, Harris RS.

Nature. 2013 Feb 21;494(7437):366-70. doi: 10.1038/nature11881. Epub 2013 Feb 6. Erratum in: Nature. 2013 Oct 24;502(7472):580.

22.

Non-B DB v2.0: a database of predicted non-B DNA-forming motifs and its associated tools.

Cer RZ, Donohue DE, Mudunuri US, Temiz NA, Loss MA, Starner NJ, Halusa GN, Volfovsky N, Yi M, Luke BT, Bacolla A, Collins JR, Stephens RM.

Nucleic Acids Res. 2013 Jan;41(Database issue):D94-D100. doi: 10.1093/nar/gks955. Epub 2012 Nov 3.

23.

The role of methylation in the intrinsic dynamics of B- and Z-DNA.

Temiz NA, Donohue DE, Bacolla A, Luke BT, Collins JR.

PLoS One. 2012;7(4):e35558. doi: 10.1371/journal.pone.0035558. Epub 2012 Apr 17.

24.

Searching for non-B DNA-forming motifs using nBMST (non-B DNA motif search tool).

Cer RZ, Bruce KH, Donohue DE, Temiz NA, Mudunuri US, Yi M, Volfovsky N, Bacolla A, Luke BT, Collins JR, Stephens RM.

Curr Protoc Hum Genet. 2012 Apr;Chapter 18:Unit 18.7.1-22. doi: 10.1002/0471142905.hg1807s73.

25.

Novel modulation factor quantifies the role of water molecules in protein interactions.

Bueno M, Temiz NA, Camacho CJ.

Proteins. 2010 Nov 15;78(15):3226-34. doi: 10.1002/prot.22805.

PMID:
20665475
26.

Optimization of minimum set of protein-DNA interactions: a quasi exact solution with minimum over-fitting.

Temiz NA, Trapp A, Prokopyev OA, Camacho CJ.

Bioinformatics. 2010 Feb 1;26(3):319-25. doi: 10.1093/bioinformatics/btp664. Epub 2009 Dec 4.

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