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Items: 12

1.

Proximal recolonization by self-renewing microglia re-establishes microglial homeostasis in the adult mouse brain.

Zhan L, Krabbe G, Du F, Jones I, Reichert MC, Telpoukhovskaia M, Kodama L, Wang C, Cho SH, Sayed F, Li Y, Le D, Zhou Y, Shen Y, West B, Gan L.

PLoS Biol. 2019 Feb 8;17(2):e3000134. doi: 10.1371/journal.pbio.3000134. eCollection 2019 Feb.

2.

Differential effects of partial and complete loss of TREM2 on microglial injury response and tauopathy.

Sayed FA, Telpoukhovskaia M, Kodama L, Li Y, Zhou Y, Le D, Hauduc A, Ludwig C, Gao F, Clelland C, Zhan L, Cooper YA, Davalos D, Akassoglou K, Coppola G, Gan L.

Proc Natl Acad Sci U S A. 2018 Oct 2;115(40):10172-10177. doi: 10.1073/pnas.1811411115. Epub 2018 Sep 19.

3.

Endo-lysosomal dysfunction: a converging mechanism in neurodegenerative diseases.

Wang C, Telpoukhovskaia MA, Bahr BA, Chen X, Gan L.

Curr Opin Neurobiol. 2018 Feb;48:52-58. doi: 10.1016/j.conb.2017.09.005. Epub 2017 Oct 10. Review.

PMID:
29028540
4.

Individuals with progranulin haploinsufficiency exhibit features of neuronal ceroid lipofuscinosis.

Ward ME, Chen R, Huang HY, Ludwig C, Telpoukhovskaia M, Taubes A, Boudin H, Minami SS, Reichert M, Albrecht P, Gelfand JM, Cruz-Herranz A, Cordano C, Alavi MV, Leslie S, Seeley WW, Miller BL, Bigio E, Mesulam MM, Bogyo MS, Mackenzie IR, Staropoli JF, Cotman SL, Huang EJ, Gan L, Green AJ.

Sci Transl Med. 2017 Apr 12;9(385). pii: eaah5642. doi: 10.1126/scitranslmed.aah5642.

5.

In silico to in vitro screening of hydroxypyridinones as acetylcholinesterase inhibitors.

Telpoukhovskaia MA, Patrick BO, Rodríguez-Rodríguez C, Orvig C.

Bioorg Med Chem Lett. 2016 Mar 15;26(6):1624-1628. doi: 10.1016/j.bmcl.2016.01.080. Epub 2016 Feb 1.

PMID:
26869193
6.

3-Hydroxy-4-pyridinone derivatives designed for fluorescence studies to determine interaction with amyloid protein as well as cell permeability.

Telpoukhovskaia MA, Cawthray JF, Rodríguez-Rodríguez C, Scott LE, Page BD, Patrick BO, Orvig C.

Bioorg Med Chem Lett. 2015 Sep 1;25(17):3654-7. doi: 10.1016/j.bmcl.2015.06.059. Epub 2015 Jun 23.

PMID:
26141772
7.

Thioflavin-based molecular probes for application in Alzheimer's disease: from in silico to in vitro models.

Rodríguez-Rodríguez C, Telpoukhovskaia MA, Alí-Torres J, Rodríguez-Santiago L, Manso Y, Bailey GA, Hidalgo J, Sodupe M, Orvig C.

Metallomics. 2015 Jan;7(1):83-92. doi: 10.1039/c4mt00167b. Epub 2014 Oct 17.

PMID:
25325557
8.

Synthesis, characterization, and cytotoxicity studies of Cu(II), Zn(II), and Fe(III) complexes of N-derivatized 3-hydroxy-4-pyridiones.

Telpoukhovskaia MA, Rodríguez-Rodríguez C, Scott LE, Page BD, Patrick BO, Orvig C.

J Inorg Biochem. 2014 Mar;132:59-66. doi: 10.1016/j.jinorgbio.2013.12.003. Epub 2013 Dec 22.

PMID:
24393377
9.

3-Hydroxy-4-pyridinone derivatives as metal ion and amyloid binding agents.

Telpoukhovskaia MA, Rodríguez-Rodríguez C, Cawthray JF, Scott LE, Page BD, Alí-Torres J, Sodupe M, Bailey GA, Patrick BO, Orvig C.

Metallomics. 2014 Feb;6(2):249-62. doi: 10.1039/c3mt00135k.

PMID:
23999879
10.

Exploring the multifunctionality of thioflavin- and deferiprone-based molecules as acetylcholinesterase inhibitors for potential application in Alzheimer's disease.

Telpoukhovskaia MA, Patrick BO, Rodríguez-Rodríguez C, Orvig C.

Mol Biosyst. 2013 Apr 5;9(4):792-805. doi: 10.1039/c3mb25600f.

PMID:
23435553
11.

Werner coordination chemistry and neurodegeneration.

Telpoukhovskaia MA, Orvig C.

Chem Soc Rev. 2013 Feb 21;42(4):1836-46. doi: 10.1039/c2cs35236b. Epub 2012 Sep 5. Review.

PMID:
22952002
12.

Discovery of a synthetic dual inhibitor of HIV and HCV infection based on a tetrabutoxy-calix[4]arene scaffold.

Tsou LK, Dutschman GE, Gullen EA, Telpoukhovskaia M, Cheng YC, Hamilton AD.

Bioorg Med Chem Lett. 2010 Apr 1;20(7):2137-9. doi: 10.1016/j.bmcl.2010.02.043. Epub 2010 Feb 13.

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