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Prion disease is accelerated in mice lacking stress-induced heat shock protein 70 (HSP70).

Mays CE, Armijo E, Morales R, Kramm C, Flores A, Tiwari A, Bian J, Telling GC, Pandita TK, Hunt CR, Soto C.

J Biol Chem. 2019 Jul 18. pii: jbc.RA118.006186. doi: 10.1074/jbc.RA118.006186. [Epub ahead of print]


Primary structural differences at residue 226 of deer and elk PrP dictate selection of distinct CWD prion strains in gene-targeted mice.

Bian J, Christiansen JR, Moreno JA, Kane SJ, Khaychuk V, Gallegos J, Kim S, Telling GC.

Proc Natl Acad Sci U S A. 2019 Jun 18;116(25):12478-12487. doi: 10.1073/pnas.1903947116. Epub 2019 May 30.


Application of PMCA to screen for prion infection in a human cell line used to produce biological therapeutics.

Lyon A, Mays CE, Borriello F, Telling GC, Soto C, Pritzkow S.

Sci Rep. 2019 Mar 19;9(1):4847. doi: 10.1038/s41598-019-41055-x.


Chronic wasting disease: an evolving prion disease of cervids.

Benestad SL, Telling GC.

Handb Clin Neurol. 2018;153:135-151. doi: 10.1016/B978-0-444-63945-5.00008-8.


Comparative analysis of prions in nervous and lymphoid tissues of chronic wasting disease-infected cervids.

Davenport KA, Christiansen JR, Bian J, Young M, Gallegos J, Kim S, Balachandran A, Mathiason CK, Hoover EA, Telling GC.

J Gen Virol. 2018 May;99(5):753-758. doi: 10.1099/jgv.0.001053. Epub 2018 Mar 26.


The cellular prion protein promotes olfactory sensory neuron survival and axon targeting during adult neurogenesis.

Parrie LE, Crowell JAE, Telling GC, Bessen RA.

Dev Biol. 2018 Jun 1;438(1):23-32. doi: 10.1016/j.ydbio.2018.03.012. Epub 2018 Mar 22.


Complement Regulatory Protein Factor H Is a Soluble Prion Receptor That Potentiates Peripheral Prion Pathogenesis.

Kane SJ, Farley TK, Gordon EO, Estep J, Bender HR, Moreno JA, Bartz J, Telling GC, Pickering MC, Zabel MD.

J Immunol. 2017 Dec 1;199(11):3821-3827. doi: 10.4049/jimmunol.1701100. Epub 2017 Oct 25.


PrPC expression and prion seeding activity in the alimentary tract and lymphoid tissue of deer.

Davenport KA, Hoover CE, Bian J, Telling GC, Mathiason CK, Hoover EA.

PLoS One. 2017 Sep 7;12(9):e0183927. doi: 10.1371/journal.pone.0183927. eCollection 2017.


Insights into Mechanisms of Transmission and Pathogenesis from Transgenic Mouse Models of Prion Diseases.

Moreno JA, Telling GC.

Methods Mol Biol. 2017;1658:219-252. doi: 10.1007/978-1-4939-7244-9_16. Review.


Chronic wasting disease prion infection of differentiated neurospheres.

Iwamaru Y, Mathiason CK, Telling GC, Hoover EA.

Prion. 2017 Jul 4;11(4):277-283. doi: 10.1080/19336896.2017.1336273. Epub 2017 Aug 1.


Molecular Mechanisms of Chronic Wasting Disease Prion Propagation.

Moreno JA, Telling GC.

Cold Spring Harb Perspect Med. 2018 Jun 1;8(6). pii: a024448. doi: 10.1101/cshperspect.a024448. Review.


Prion replication without host adaptation during interspecies transmissions.

Bian J, Khaychuk V, Angers RC, Fernández-Borges N, Vidal E, Meyerett-Reid C, Kim S, Calvi CL, Bartz JC, Hoover EA, Agrimi U, Richt JA, Castilla J, Telling GC.

Proc Natl Acad Sci U S A. 2017 Jan 31;114(5):1141-1146. doi: 10.1073/pnas.1611891114. Epub 2017 Jan 17.


Clay Components in Soil Dictate Environmental Stability and Bioavailability of Cervid Prions in Mice.

Wyckoff AC, Kane S, Lockwood K, Seligman J, Michel B, Hill D, Ortega A, Mangalea MR, Telling GC, Miller MW, Vercauteren K, Zabel MD.

Front Microbiol. 2016 Nov 23;7:1885. eCollection 2016.


Insights into Chronic Wasting Disease and Bovine Spongiform Encephalopathy Species Barriers by Use of Real-Time Conversion.

Davenport KA, Henderson DM, Bian J, Telling GC, Mathiason CK, Hoover EA.

J Virol. 2015 Sep;89(18):9524-31. doi: 10.1128/JVI.01439-15. Epub 2015 Jul 8.


Grass plants bind, retain, uptake, and transport infectious prions.

Pritzkow S, Morales R, Moda F, Khan U, Telling GC, Hoover E, Soto C.

Cell Rep. 2015 May 26;11(8):1168-75. doi: 10.1016/j.celrep.2015.04.036. Epub 2015 May 14.


Structural effects of PrP polymorphisms on intra- and interspecies prion transmission.

Angers R, Christiansen J, Nalls AV, Kang HE, Hunter N, Hoover E, Mathiason CK, Sheetz M, Telling GC.

Proc Natl Acad Sci U S A. 2014 Jul 29;111(30):11169-74. doi: 10.1073/pnas.1404739111. Epub 2014 Jul 17.


Quinacrine promotes replication and conformational mutation of chronic wasting disease prions.

Bian J, Kang HE, Telling GC.

Proc Natl Acad Sci U S A. 2014 Apr 22;111(16):6028-33. doi: 10.1073/pnas.1322377111. Epub 2014 Apr 7.


Prion disease tempo determined by host-dependent substrate reduction.

Mays CE, Kim C, Haldiman T, van der Merwe J, Lau A, Yang J, Grams J, Di Bari MA, Nonno R, Telling GC, Kong Q, Langeveld J, McKenzie D, Westaway D, Safar JG.

J Clin Invest. 2014 Feb;124(2):847-58. doi: 10.1172/JCI72241. Epub 2014 Jan 16.


Assessing the susceptibility of transgenic mice overexpressing deer prion protein to bovine spongiform encephalopathy.

Vickery CM, Lockey R, Holder TM, Thorne L, Beck KE, Wilson C, Denyer M, Sheehan J, Marsh S, Webb PR, Dexter I, Norman A, Popescu E, Schneider A, Holden P, Griffiths PC, Plater JM, Dagleish MP, Martin S, Telling GC, Simmons MM, Spiropoulos J.

J Virol. 2014 Feb;88(3):1830-3. doi: 10.1128/JVI.02762-13. Epub 2013 Nov 20.


Epigenetic dominance of prion conformers.

Saijo E, Kang HE, Bian J, Bowling KG, Browning S, Kim S, Hunter N, Telling GC.

PLoS Pathog. 2013 Oct;9(10):e1003692. doi: 10.1371/journal.ppat.1003692. Epub 2013 Oct 31.


Complement protein C3 exacerbates prion disease in a mouse model of chronic wasting disease.

Michel B, Ferguson A, Johnson T, Bender H, Meyerett-Reid C, Wyckoff AC, Pulford B, Telling GC, Zabel MD.

Int Immunol. 2013 Dec;25(12):697-702. doi: 10.1093/intimm/dxt034. Epub 2013 Sep 13.


Co-existence of distinct prion types enables conformational evolution of human PrPSc by competitive selection.

Haldiman T, Kim C, Cohen Y, Chen W, Blevins J, Qing L, Cohen ML, Langeveld J, Telling GC, Kong Q, Safar JG.

J Biol Chem. 2013 Oct 11;288(41):29846-61. doi: 10.1074/jbc.M113.500108. Epub 2013 Aug 23.


Intranasal inoculation of white-tailed deer (Odocoileus virginianus) with lyophilized chronic wasting disease prion particulate complexed to montmorillonite clay.

Nichols TA, Spraker TR, Rigg TD, Meyerett-Reid C, Hoover C, Michel B, Bian J, Hoover E, Gidlewski T, Balachandran A, O'Rourke K, Telling GC, Bowen R, Zabel MD, VerCauteren KC.

PLoS One. 2013 May 9;8(5):e62455. doi: 10.1371/journal.pone.0062455. Print 2013.


The importance of prions.

Telling GC.

PLoS Pathog. 2013 Jan;9(1):e1003090. doi: 10.1371/journal.ppat.1003090. Epub 2013 Jan 31. No abstract available.


Brain injury-induced proteolysis is reduced in a novel calpastatin-overexpressing transgenic mouse.

Schoch KM, von Reyn CR, Bian J, Telling GC, Meaney DF, Saatman KE.

J Neurochem. 2013 Jun;125(6):909-20. doi: 10.1111/jnc.12144. Epub 2013 Feb 3.


Genetic depletion of complement receptors CD21/35 prevents terminal prion disease in a mouse model of chronic wasting disease.

Michel B, Ferguson A, Johnson T, Bender H, Meyerett-Reid C, Pulford B, von Teichman A, Seelig D, Weis JH, Telling GC, Aguzzi A, Zabel MD.

J Immunol. 2012 Nov 1;189(9):4520-7. doi: 10.4049/jimmunol.1201579. Epub 2012 Sep 21.


Characterization of conformation-dependent prion protein epitopes.

Kang HE, Weng CC, Saijo E, Saylor V, Bian J, Kim S, Ramos L, Angers R, Langenfeld K, Khaychuk V, Calvi C, Bartz J, Hunter N, Telling GC.

J Biol Chem. 2012 Oct 26;287(44):37219-32. doi: 10.1074/jbc.M112.395921. Epub 2012 Sep 4.


Small protease sensitive oligomers of PrPSc in distinct human prions determine conversion rate of PrP(C).

Kim C, Haldiman T, Surewicz K, Cohen Y, Chen W, Blevins J, Sy MS, Cohen M, Kong Q, Telling GC, Surewicz WK, Safar JG.

PLoS Pathog. 2012;8(8):e1002835. doi: 10.1371/journal.ppat.1002835. Epub 2012 Aug 2.


Detection of prion protein in the cerebrospinal fluid of elk (Cervus canadensis nelsoni) with chronic wasting disease using protein misfolding cyclic amplification.

Nichols TA, Spraker TR, Gidlewski T, Powers JG, Telling GC, VerCauteren KC, Zabel MD.

J Vet Diagn Invest. 2012 Jul;24(4):746-9. doi: 10.1177/1040638712448060. Epub 2012 May 23.


Detection of PrPCWD in feces from naturally exposed Rocky Mountain elk (Cervus elaphus nelsoni) using protein misfolding cyclic amplification.

Pulford B, Spraker TR, Wyckoff AC, Meyerett C, Bender H, Ferguson A, Wyatt B, Lockwood K, Powers J, Telling GC, Wild MA, Zabel MD.

J Wildl Dis. 2012 Apr;48(2):425-34.


Sensitivity of protein misfolding cyclic amplification versus immunohistochemistry in ante-mortem detection of chronic wasting disease.

Haley NJ, Mathiason CK, Carver S, Telling GC, Zabel MD, Hoover EA.

J Gen Virol. 2012 May;93(Pt 5):1141-50. doi: 10.1099/vir.0.039073-0. Epub 2012 Jan 25.


Chronic wasting disease prion trafficking via the autonomic nervous system.

Seelig DM, Mason GL, Telling GC, Hoover EA.

Am J Pathol. 2011 Sep;179(3):1319-28. doi: 10.1016/j.ajpath.2011.05.057. Epub 2011 Jul 21.


Transgenic mouse models and prion strains.

Telling GC.

Top Curr Chem. 2011;305:79-99. doi: 10.1007/128_2011_166. Review.


Alteration of the chronic wasting disease species barrier by in vitro prion amplification.

Kurt TD, Seelig DM, Schneider JR, Johnson CJ, Telling GC, Heisey DM, Hoover EA.

J Virol. 2011 Sep;85(17):8528-37. doi: 10.1128/JVI.00809-11. Epub 2011 Jun 22.


Unaltered prion protein expression in Alzheimer disease patients.

Saijo E, Scheff SW, Telling GC.

Prion. 2011 Apr-Jun;5(2):109-16. Epub 2011 Apr 1.


Detection of chronic wasting disease prions in salivary, urinary, and intestinal tissues of deer: potential mechanisms of prion shedding and transmission.

Haley NJ, Mathiason CK, Carver S, Zabel M, Telling GC, Hoover EA.

J Virol. 2011 Jul;85(13):6309-18. doi: 10.1128/JVI.00425-11. Epub 2011 Apr 27.


In vitro amplification of misfolded prion protein using lysate of cultured cells.

Mays CE, Yeom J, Kang HE, Bian J, Khaychuk V, Kim Y, Bartz JC, Telling GC, Ryou C.

PLoS One. 2011 Mar 28;6(3):e18047. doi: 10.1371/journal.pone.0018047.


Prion protein expression and functional importance in skeletal muscle.

Smith JD, Moylan JS, Hardin BJ, Chambers MA, Estus S, Telling GC, Reid MB.

Antioxid Redox Signal. 2011 Nov 1;15(9):2465-75. doi: 10.1089/ars.2011.3945. Epub 2011 Jun 8.


Generation of a new form of human PrP(Sc) in vitro by interspecies transmission from cervid prions.

Barria MA, Telling GC, Gambetti P, Mastrianni JA, Soto C.

J Biol Chem. 2011 Mar 4;286(9):7490-5. doi: 10.1074/jbc.M110.198465. Epub 2011 Jan 5.


Minor oral lesions facilitate transmission of chronic wasting disease.

Denkers ND, Telling GC, Hoover EA.

J Virol. 2011 Feb;85(3):1396-9. doi: 10.1128/JVI.01655-10. Epub 2010 Nov 17.


Nucleic acid-free mutation of prion strains.

Telling GC.

Prion. 2010 Oct-Dec;4(4):252-5. Epub 2010 Oct 19. Review.


Prion strain mutation determined by prion protein conformational compatibility and primary structure.

Angers RC, Kang HE, Napier D, Browning S, Seward T, Mathiason C, Balachandran A, McKenzie D, Castilla J, Soto C, Jewell J, Graham C, Hoover EA, Telling GC.

Science. 2010 May 28;328(5982):1154-8. doi: 10.1126/science.1187107. Epub 2010 May 13.


Pathogenesis of chronic wasting disease in cervidized transgenic mice.

Seelig DM, Mason GL, Telling GC, Hoover EA.

Am J Pathol. 2010 Jun;176(6):2785-97. doi: 10.2353/ajpath.2010.090710. Epub 2010 Apr 15.


B cells and platelets harbor prion infectivity in the blood of deer infected with chronic wasting disease.

Mathiason CK, Hayes-Klug J, Hays SA, Powers J, Osborn DA, Dahmes SJ, Miller KV, Warren RJ, Mason GL, Telling GC, Young AJ, Hoover EA.

J Virol. 2010 May;84(10):5097-107. doi: 10.1128/JVI.02169-09. Epub 2010 Mar 10.


Aerosol and nasal transmission of chronic wasting disease in cervidized mice.

Denkers ND, Seelig DM, Telling GC, Hoover EA.

J Gen Virol. 2010 Jun;91(Pt 6):1651-8. doi: 10.1099/vir.0.017335-0. Epub 2010 Feb 17.


Detection of sub-clinical CWD infection in conventional test-negative deer long after oral exposure to urine and feces from CWD+ deer.

Haley NJ, Mathiason CK, Zabel MD, Telling GC, Hoover EA.

PLoS One. 2009 Nov 24;4(11):e7990. doi: 10.1371/journal.pone.0007990.


Detection of protease-resistant cervid prion protein in water from a CWD-endemic area.

Nichols TA, Pulford B, Wyckoff AC, Meyerett C, Michel B, Gertig K, Hoover EA, Jewell JE, Telling GC, Zabel MD.

Prion. 2009 Jul-Sep;3(3):171-83. Epub 2009 Jul 14.


Enhancement of protein misfolding cyclic amplification by using concentrated cellular prion protein source.

Mays CE, Titlow W, Seward T, Telling GC, Ryou C.

Biochem Biophys Res Commun. 2009 Oct 16;388(2):306-10. doi: 10.1016/j.bbrc.2009.07.163. Epub 2009 Aug 5.


Chronic wasting disease prions in elk antler velvet.

Angers RC, Seward TS, Napier D, Green M, Hoover E, Spraker T, O'Rourke K, Balachandran A, Telling GC.

Emerg Infect Dis. 2009 May;15(5):696-703. doi: 10.3201/eid1505.081458.


Detection of CWD prions in urine and saliva of deer by transgenic mouse bioassay.

Haley NJ, Seelig DM, Zabel MD, Telling GC, Hoover EA.

PLoS One. 2009;4(3):e4848. doi: 10.1371/journal.pone.0004848. Epub 2009 Mar 18.

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