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Items: 42


Objective Liver Fibrosis Estimation from Shear Wave Elastography.

Brattain LJ, Telfer BA, Dhyani M, Grajo JR, Samir AE.

Conf Proc IEEE Eng Med Biol Soc. 2018 Jul;2018:1-5. doi: 10.1109/EMBC.2018.8513011.


Statin-induced metabolic reprogramming in head and neck cancer: a biomarker for targeting monocarboxylate transporters.

Mehibel M, Ortiz-Martinez F, Voelxen N, Boyers A, Chadwick A, Telfer BA, Mueller-Klieser W, West CM, Critchlow SE, Williams KJ, Stratford IJ.

Sci Rep. 2018 Nov 14;8(1):16804. doi: 10.1038/s41598-018-35103-1.


High content screening of patient-derived cell lines highlights the potential of non-standard chemotherapeutic agents for the treatment of glioblastoma.

Yu KK, Taylor JT, Pathmanaban ON, Youshani AS, Beyit D, Dutko-Gwozdz J, Benson R, Griffiths G, Peers I, Cueppens P, Telfer BA, Williams KJ, McBain C, Kamaly-Asl ID, Bigger BW.

PLoS One. 2018 Mar 2;13(3):e0193694. doi: 10.1371/journal.pone.0193694. eCollection 2018.


Machine learning for medical ultrasound: status, methods, and future opportunities.

Brattain LJ, Telfer BA, Dhyani M, Grajo JR, Samir AE.

Abdom Radiol (NY). 2018 Apr;43(4):786-799. doi: 10.1007/s00261-018-1517-0. Review.


Akt inhibition improves long-term tumour control following radiotherapy by altering the microenvironment.

Searle EJ, Telfer BA, Mukherjee D, Forster DM, Davies BR, Williams KJ, Stratford IJ, Illidge TM.

EMBO Mol Med. 2017 Dec;9(12):1646-1659. doi: 10.15252/emmm.201707767.


Novel carbonic anhydrase IX-targeted therapy enhances the anti-tumour effects of cisplatin in small cell lung cancer.

Bryant JL, Gieling RG, Meredith SL, Allen TJ, Walker L, Telfer BA, Supuran CT, Williams KJ, White A.

Int J Cancer. 2018 Jan 1;142(1):191-201. doi: 10.1002/ijc.31042. Epub 2017 Oct 3.


N-tert-Prenylation of the indole ring improves the cytotoxicity of a short antagonist G analogue against small cell lung cancer.

Offerman SC, Kadirvel M, Abusara OH, Bryant JL, Telfer BA, Brown G, Freeman S, White A, Williams KJ, Aojula HS.

Medchemcomm. 2017 Feb 17;8(3):551-558. doi: 10.1039/c6md00691d. eCollection 2017 Mar 1.


Phosphatidylinositide 3-kinase (PI3K) and PI3K-related kinase (PIKK) activity contributes to radioresistance in thyroid carcinomas.

Burrows N, Williams J, Telfer BA, Resch J, Valentine HR, Fitzmaurice RJ, Eustace A, Irlam J, Rowling EJ, Hoang-Vu C, West CM, Brabant G, Williams KJ.

Oncotarget. 2016 Sep 27;7(39):63106-63123. doi: 10.18632/oncotarget.11056.


The Sulfamate Small Molecule CAIX Inhibitor S4 Modulates Doxorubicin Efficacy.

van Kuijk SJ, Gieling RG, Niemans R, Lieuwes NG, Biemans R, Telfer BA, Haenen GR, Yaromina A, Lambin P, Dubois LJ, Williams KJ.

PLoS One. 2016 Aug 11;11(8):e0161040. doi: 10.1371/journal.pone.0161040. eCollection 2016.


Dissemination via the lymphatic or angiogenic route impacts the pathology, microenvironment and hypoxia-related drug response of lung metastases.

Gieling RG, Fitzmaurice RJ, Telfer BA, Babur M, Williams KJ.

Clin Exp Metastasis. 2015 Aug;32(6):567-77. doi: 10.1007/s10585-015-9728-z. Epub 2015 Jun 26.


Vasoactivity of rucaparib, a PARP-1 inhibitor, is a complex process that involves myosin light chain kinase, P2 receptors, and PARP itself.

McCrudden CM, O'Rourke MG, Cherry KE, Yuen HF, O'Rourke D, Babur M, Telfer BA, Thomas HD, Keane P, Nambirajan T, Hagan C, O'Sullivan JM, Shaw C, Williams KJ, Curtin NJ, Hirst DG, Robson T.

PLoS One. 2015 Feb 17;10(2):e0118187. doi: 10.1371/journal.pone.0118187. eCollection 2015.


Inhibition of monocarboxylate transporter-1 (MCT1) by AZD3965 enhances radiosensitivity by reducing lactate transport.

Bola BM, Chadwick AL, Michopoulos F, Blount KG, Telfer BA, Williams KJ, Smith PD, Critchlow SE, Stratford IJ.

Mol Cancer Ther. 2014 Dec;13(12):2805-16. doi: 10.1158/1535-7163.MCT-13-1091. Epub 2014 Oct 3.


A novel systemically administered Toll-like receptor 7 agonist potentiates the effect of ionizing radiation in murine solid tumor models.

Adlard AL, Dovedi SJ, Telfer BA, Koga-Yamakawa E, Pollard C, Honeychurch J, Illidge TM, Murata M, Robinson DT, Jewsbury PJ, Wilkinson RW, Stratford IJ.

Int J Cancer. 2014 Aug 15;135(4):820-9. doi: 10.1002/ijc.28711. Epub 2014 Jan 17.


Automated B-line scoring on thoracic sonography.

Brattain LJ, Telfer BA, Liteplo AS, Noble VE.

J Ultrasound Med. 2013 Dec;32(12):2185-90. doi: 10.7863/ultra.32.12.2185.


Endothelial heparan sulfate 6-O-sulfation levels regulate angiogenic responses of endothelial cells to fibroblast growth factor 2 and vascular endothelial growth factor.

Ferreras C, Rushton G, Cole CL, Babur M, Telfer BA, van Kuppevelt TH, Gardiner JM, Williams KJ, Jayson GC, Avizienyte E.

J Biol Chem. 2012 Oct 19;287(43):36132-46. doi: 10.1074/jbc.M112.384875. Epub 2012 Aug 27.


Antimetastatic effect of sulfamate carbonic anhydrase IX inhibitors in breast carcinoma xenografts.

Gieling RG, Babur M, Mamnani L, Burrows N, Telfer BA, Carta F, Winum JY, Scozzafava A, Supuran CT, Williams KJ.

J Med Chem. 2012 Jun 14;55(11):5591-600. doi: 10.1021/jm300529u. Epub 2012 Jun 5.


Inhibition of PARP-1 by olaparib (AZD2281) increases the radiosensitivity of a lung tumor xenograft.

Senra JM, Telfer BA, Cherry KE, McCrudden CM, Hirst DG, O'Connor MJ, Wedge SR, Stratford IJ.

Mol Cancer Ther. 2011 Oct;10(10):1949-58. doi: 10.1158/1535-7163.MCT-11-0278. Epub 2011 Aug 8.


The clinically active PARP inhibitor AG014699 ameliorates cardiotoxicity but does not enhance the efficacy of doxorubicin, despite improving tumor perfusion and radiation response in mice.

Ali M, Kamjoo M, Thomas HD, Kyle S, Pavlovska I, Babur M, Telfer BA, Curtin NJ, Williams KJ.

Mol Cancer Ther. 2011 Dec;10(12):2320-9. doi: 10.1158/1535-7163.MCT-11-0356. Epub 2011 Sep 16.


The hypoxia-selective cytotoxin NLCQ-1 (NSC 709257) controls metastatic disease when used as an adjuvant to radiotherapy.

Lunt SJ, Cawthorne C, Ali M, Telfer BA, Babur M, Smigova A, Julyan PJ, Price PM, Stratford IJ, Bloomer WD, Papadopoulou MV, Williams KJ.

Br J Cancer. 2010 Jul 13;103(2):201-8. doi: 10.1038/sj.bjc.6605753. Epub 2010 Jun 29.


Glucocorticoid receptor over-expression promotes human small cell lung cancer apoptosis in vivo and thereby slows tumor growth.

Sommer P, Cowen RL, Berry A, Cookson A, Telfer BA, Williams KJ, Stratford IJ, Kay P, White A, Ray DW.

Endocr Relat Cancer. 2010 Feb 18;17(1):203-13. doi: 10.1677/ERC-09-0241. Print 2010 Mar.


In vivo activation of the hypoxia-targeted cytotoxin AQ4N in human tumor xenografts.

Williams KJ, Albertella MR, Fitzpatrick B, Loadman PM, Shnyder SD, Chinje EC, Telfer BA, Dunk CR, Harris PA, Stratford IJ.

Mol Cancer Ther. 2009 Dec;8(12):3266-75. doi: 10.1158/1535-7163.MCT-09-0396.


The mitogen-activated protein/extracellular signal-regulated kinase kinase 1/2 inhibitor AZD6244 (ARRY-142886) enhances the radiation responsiveness of lung and colorectal tumor xenografts.

Shannon AM, Telfer BA, Smith PD, Babur M, Logie A, Wilkinson RW, Debray C, Stratford IJ, Williams KJ, Wedge SR.

Clin Cancer Res. 2009 Nov 1;15(21):6619-29. doi: 10.1158/1078-0432.CCR-08-2958. Epub 2009 Oct 20.


Vasoactivity of AG014699, a clinically active small molecule inhibitor of poly(ADP-ribose) polymerase: a contributory factor to chemopotentiation in vivo?

Ali M, Telfer BA, McCrudden C, O'Rourke M, Thomas HD, Kamjoo M, Kyle S, Robson T, Shaw C, Hirst DG, Curtin NJ, Williams KJ.

Clin Cancer Res. 2009 Oct 1;15(19):6106-12. doi: 10.1158/1078-0432.CCR-09-0398. Epub 2009 Sep 29.


Inhibition of vascular endothelial growth factor signalling using cediranib (RECENTIN; AZD2171) enhances radiation response and causes substantial physiological changes in lung tumour xenografts.

Williams KJ, Telfer BA, Shannon AM, Babur M, Stratford IJ, Wedge SR.

Br J Radiol. 2008 Oct;81 Spec No 1:S21-7. doi: 10.1259/bjr/59853976.


Hypoxia-targeted over-expression of carboxylesterase as a means of increasing tumour sensitivity to irinotecan (CPT-11).

Matzow T, Cowen RL, Williams KJ, Telfer BA, Flint PJ, Southgate TD, Saunders MP.

J Gene Med. 2007 Apr;9(4):244-52.


Combining radiotherapy with AZD2171, a potent inhibitor of vascular endothelial growth factor signaling: pathophysiologic effects and therapeutic benefit.

Williams KJ, Telfer BA, Shannon AM, Babur M, Stratford IJ, Wedge SR.

Mol Cancer Ther. 2007 Feb;6(2):599-606.


Tirapazamine administered as a neoadjuvant to radiotherapy reduces metastatic dissemination.

Lunt SJ, Telfer BA, Fitzmaurice RJ, Stratford IJ, Williams KJ.

Clin Cancer Res. 2005 Jun 1;11(11):4212-6.


Enhanced response to radiotherapy in tumours deficient in the function of hypoxia-inducible factor-1.

Williams KJ, Telfer BA, Xenaki D, Sheridan MR, Desbaillets I, Peters HJ, Honess D, Harris AL, Dachs GU, van der Kogel A, Stratford IJ.

Radiother Oncol. 2005 Apr;75(1):89-98. Epub 2005 Apr 18.


ZD6474, a potent inhibitor of vascular endothelial growth factor signaling, combined with radiotherapy: schedule-dependent enhancement of antitumor activity.

Williams KJ, Telfer BA, Brave S, Kendrew J, Whittaker L, Stratford IJ, Wedge SR.

Clin Cancer Res. 2004 Dec 15;10(24):8587-93.


Hypoxia targeted gene therapy to increase the efficacy of tirapazamine as an adjuvant to radiotherapy: reversing tumor radioresistance and effecting cure.

Cowen RL, Williams KJ, Chinje EC, Jaffar M, Sheppard FC, Telfer BA, Wind NS, Stratford IJ.

Cancer Res. 2004 Feb 15;64(4):1396-402.


Viral delivery of P450 reductase recapitulates the ability of constitutive overexpression of reductase enzymes to potentiate the activity of mitomycin C in human breast cancer xenografts.

Cowen RL, Patterson AV, Telfer BA, Airley RE, Hobbs S, Phillips RM, Jaffar M, Stratford IJ, Williams KJ.

Mol Cancer Ther. 2003 Sep;2(9):901-9.


Oxygen-sensitive enzyme-prodrug gene therapy for the eradication of radiation-resistant solid tumours.

Patterson AV, Williams KJ, Cowen RL, Jaffar M, Telfer BA, Saunders M, Airley R, Honess D, van der Kogel AJ, Wolf CR, Stratford IJ.

Gene Ther. 2002 Jul;9(14):946-54.


17beta-Oestradiol treatment modulates nitric oxide synthase activity in MDA231 tumour with implications on growth and radiation response.

Chinje EC, Williams KJ, Telfer BA, Wood PJ, van der Kogel AJ, Stratford IJ.

Br J Cancer. 2002 Jan 7;86(1):136-42.


A protective role for HIF-1 in response to redox manipulation and glucose deprivation: implications for tumorigenesis.

Williams KJ, Telfer BA, Airley RE, Peters HP, Sheridan MR, van der Kogel AJ, Harris AL, Stratford IJ.

Oncogene. 2002 Jan 10;21(2):282-90.


Uptake of teicoplanin by isolated rat hepatocytes: comparison with in vivo hepatic distribution.

Reinoso RF, Telfer BA, Brennan BS, Rowland M.

Drug Metab Dispos. 2001 Apr;29(4 Pt 1):453-9.


In vitro studies of teicoplanin binding to rat tissues and erythrocytes.

Reinoso RF, Telfer BA, Rowland M.

Eur J Pharm Sci. 1998 Apr;6(2):145-52.


Tissue water content in rats measured by desiccation.

Reinoso RF, Telfer BA, Rowland M.

J Pharmacol Toxicol Methods. 1997 Oct;38(2):87-92.


Detection of abnormal peripheral blood mononuclear cell cytokine networks in human IgA nephropathy.

de Caestecker MP, Bottomley M, Telfer BA, Hutchinson IV, Vose BM, Ballardie FW.

Kidney Int. 1993 Dec;44(6):1298-308.


Neural network and wavelet transform for scale-invariant data classification.

Szu HH, Yang XY, Telfer BA, Sheng Y.

Phys Rev E Stat Phys Plasmas Fluids Relat Interdiscip Topics. 1993 Aug;48(2):1497-1501. No abstract available.


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