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Items: 1 to 50 of 191

1.

Hybridization of Fluoro-amodiaquine (FAQ) with Pyrimidines: Synthesis and Antimalarial Efficacy of FAQ-Pyrimidines.

Tripathi M, Taylor D, Khan SI, Tekwani BL, Ponnan P, Das US, Velpandian T, Rawat DS.

ACS Med Chem Lett. 2019 Mar 13;10(5):714-719. doi: 10.1021/acsmedchemlett.8b00496. eCollection 2019 May 9.

PMID:
31097988
2.

Tetraazamacrocyclic derivatives and their metal complexes as antileishmanial leads.

Hubin TJ, Walker AN, Davilla DJ, Freeman TNC, Epley BM, Hasley TR, Amoyaw PNA, Jain S, Archibald SJ, Prior TJ, Krause JA, Oliver AG, Tekwani BL, Khan MOF.

Polyhedron. 2019 May 1;163:42-53. doi: 10.1016/j.poly.2019.02.027. Epub 2019 Feb 23.

PMID:
30976133
3.

Selective Inhibition of Human Monoamine Oxidase B by Acacetin 7-Methyl Ether Isolated from Turnera diffusa (Damiana).

Chaurasiya ND, Zhao J, Pandey P, Doerksen RJ, Muhammad I, Tekwani BL.

Molecules. 2019 Feb 23;24(4). pii: E810. doi: 10.3390/molecules24040810.

4.

Antiplasmodial and Cytotoxic Cytochalasins from an Endophytic Fungus, Nemania sp. UM10M, Isolated from a Diseased Torreya taxifolia Leaf.

Kumarihamy M, Ferreira D, Croom EM Jr, Sahu R, Tekwani BL, Duke SO, Khan S, Techen N, Nanayakkara NPD.

Molecules. 2019 Feb 21;24(4). pii: E777. doi: 10.3390/molecules24040777.

5.

Formation primaquine-5,6-orthoquinone, the putative active and toxic metabolite of primaquine via direct oxidation in human erythrocytes.

Fasinu PS, Nanayakkara NPD, Wang YH, Chaurasiya ND, Herath HMB, McChesney JD, Avula B, Khan I, Tekwani BL, Walker LA.

Malar J. 2019 Jan 30;18(1):30. doi: 10.1186/s12936-019-2658-5.

6.

Evaluation of Triazole and Isoxazole Derivatives as Potential Anti-infective Agents.

Tarawneh AH, Al-Momani LAA, León F, Jain SK, Gadetskaya AV, Abu-Orabi ST, Tekwani BL, Cutler SJ.

Med Chem Res. 2018 Apr;27(4):1269-1275. doi: 10.1007/s00044-018-2146-4. Epub 2018 Feb 27.

7.

Metabolism of primaquine in normal human volunteers: investigation of phase I and phase II metabolites from plasma and urine using ultra-high performance liquid chromatography-quadrupole time-of-flight mass spectrometry.

Avula B, Tekwani BL, Chaurasiya ND, Fasinu P, Dhammika Nanayakkara NP, Bhandara Herath HMT, Wang YH, Bae JY, Khan SI, Elsohly MA, McChesney JD, Zimmerman PA, Khan IA, Walker LA.

Malar J. 2018 Aug 13;17(1):294. doi: 10.1186/s12936-018-2433-z.

8.

Synthesis and Biological Evaluation of 8-Quinolinamines and Their Amino Acid Conjugates as Broad-Spectrum Anti-infectives.

Jain M, Reddy CVRP, Halder M, Singh S, Kumar R, Wasudeo SG, Singh PP, Khan SI, Jacob MR, Tekwani BL, Jain R.

ACS Omega. 2018 Mar 31;3(3):3060-3075. doi: 10.1021/acsomega.7b02047. Epub 2018 Mar 14.

9.

Interactions of endocannabinoid virodhamine and related analogs with human monoamine oxidase-A and -B.

Pandey P, Chaurasiya ND, Tekwani BL, Doerksen RJ.

Biochem Pharmacol. 2018 Sep;155:82-91. doi: 10.1016/j.bcp.2018.06.024. Epub 2018 Jun 26.

PMID:
29958841
10.

Isoform selectivity of harmine-conjugated 1,2,3-triazoles against human monoamine oxidase.

Haider S, Alhusban M, Chaurasiya ND, Tekwani BL, Chittiboyina AG, Khan IA.

Future Med Chem. 2018 Jun 1;10(12):1435-1448. doi: 10.4155/fmc-2018-0006. Epub 2018 May 23.

11.

Isolation and Biological Evaluation of Prenylated Flavonoids from Maclura pomifera.

Orazbekov Y, Ibrahim MA, Mombekov S, Srivedavyasasri R, Datkhayev U, Makhatov B, Chaurasiya ND, Tekwani BL, Ross SA.

Evid Based Complement Alternat Med. 2018 Jan 14;2018:1370368. doi: 10.1155/2018/1370368. eCollection 2018.

12.

Inhibition of human monoamine oxidase A and B by flavonoids isolated from two Algerian medicinal plants.

Larit F, Elokely KM, Chaurasiya ND, Benyahia S, Nael MA, León F, Abu-Darwish MS, Efferth T, Wang YH, Belouahem-Abed D, Benayache S, Tekwani BL, Cutler SJ.

Phytomedicine. 2018 Feb 1;40:27-36. doi: 10.1016/j.phymed.2017.12.032. Epub 2017 Dec 27.

13.

Design, Synthesis and Biological Evaluation of 7-arylbenzo[c]acridine-5,6- diones as Potential Anti-Leishmanial and anti-trypanosomal Agents.

Mahajan S, Khan SI, Tekwani BL, Khan IA, Singh IP.

Med Chem. 2018;14(6):563-572. doi: 10.2174/1573406414666180226163222.

PMID:
29485004
14.

A minimalistic approach to develop new anti-apicomplexa polyamines analogs.

Panozzo-Zénere EA, Porta EOJ, Arrizabalaga G, Fargnoli L, Khan SI, Tekwani BL, Labadie GR.

Eur J Med Chem. 2018 Jan 1;143:866-880. doi: 10.1016/j.ejmech.2017.11.069. Epub 2017 Dec 2.

15.

Monoamine oxidases inhibitors from Colvillea racemosa: Isolation, biological evaluation, and computational study.

Mohamed EI, Zaki MA, Chaurasiya ND, Owis AI, AbouZid S, Wang YH, Avula B, Seida AA, Tekwani BL, Ross SA.

Fitoterapia. 2018 Jan;124:217-223. doi: 10.1016/j.fitote.2017.11.009. Epub 2017 Nov 14.

16.

Interactions of Desmethoxyyangonin, a Secondary Metabolite from Renealmia alpinia, with Human Monoamine Oxidase-A and Oxidase-B.

Chaurasiya ND, León F, Ding Y, Gómez-Betancur I, Benjumea D, Walker LA, Cutler SJ, Tekwani BL.

Evid Based Complement Alternat Med. 2017;2017:4018724. doi: 10.1155/2017/4018724. Epub 2017 Aug 24.

17.

Synthesis and Antimicrobial Evaluation of Fire Ant Venom Alkaloid Based 2-Methyl-6-alkyl-Δ1,6-piperideines.

Yan Y, An Y, Wang X, Chen Y, Jacob MR, Tekwani BL, Dai L, Li XC.

J Nat Prod. 2017 Oct 27;80(10):2795-2798. doi: 10.1021/acs.jnatprod.7b00625. Epub 2017 Oct 12.

PMID:
29023124
18.

Antitrypanosomal and antileishmanial activity of prenyl-1,2,3-triazoles.

Porta EOJ, Jäger SN, Nocito I, Lepesheva GI, Serra EC, Tekwani BL, Labadie GR.

Medchemcomm. 2017 May 1;8(5):1015-1021. doi: 10.1039/C7MD00008A. Epub 2017 Mar 10.

19.

Antimalarial and Antileishmanial Activities of Phytophenolics and Their Synthetic Analogues.

Morimoto M, Cantrell CL, Khan S, Tekwani BL, Duke SO.

Chem Biodivers. 2017 Dec;14(12). doi: 10.1002/cbdv.201700324. Epub 2017 Dec 5.

PMID:
28990331
20.

Inhibitors of ubiquitin E3 ligase as potential new antimalarial drug leads.

Jain J, Jain SK, Walker LA, Tekwani BL.

BMC Pharmacol Toxicol. 2017 Jun 2;18(1):40. doi: 10.1186/s40360-017-0147-4.

21.

A Combined In Vitro Assay for Evaluation of Neurotrophic Activity and Cytotoxicity.

Chaurasiya ND, Shukla S, Tekwani BL.

SLAS Discov. 2017 Jul;22(6):667-675. doi: 10.1177/2472555217698677. Epub 2017 Mar 17.

PMID:
28314119
22.

Biological evaluation of phytoconstituents from Polygonum hydropiper.

Xiao H, Rao Ravu R, Tekwani BL, Li W, Liu WB, Jacob MR, Khan SI, Cai X, Peng CY, Khan IA, Li XC, Wang W.

Nat Prod Res. 2017 Sep;31(17):2053-2057. doi: 10.1080/14786419.2016.1269094. Epub 2016 Dec 21.

PMID:
28000515
23.

Mechanism for neurotropic action of vorinostat, a pan histone deacetylase inhibitor.

Shukla S, Shariat-Madar Z, Walker LA, Tekwani BL.

Mol Cell Neurosci. 2016 Dec;77:11-20. doi: 10.1016/j.mcn.2016.09.003. Epub 2016 Sep 24.

PMID:
27678157
24.

Isolation of Acacetin from Calea urticifolia with Inhibitory Properties against Human Monoamine Oxidase-A and -B.

Chaurasiya ND, Gogineni V, Elokely KM, León F, Núñez MJ, Klein ML, Walker LA, Cutler SJ, Tekwani BL.

J Nat Prod. 2016 Oct 28;79(10):2538-2544. Epub 2016 Oct 18.

PMID:
27754693
25.

Pathway-specific inhibition of primaquine metabolism by chloroquine/quinine.

Fasinu PS, Tekwani BL, Avula B, Chaurasiya ND, Nanayakkara NP, Wang YH, Khan IA, Walker LA.

Malar J. 2016 Sep 13;15:466. doi: 10.1186/s12936-016-1509-x.

26.

Single-Dose Primaquine in a Preclinical Model of Glucose-6-Phosphate Dehydrogenase Deficiency: Implications for Use in Malaria Transmission-Blocking Programs.

Wickham KS, Baresel PC, Marcsisin SR, Sousa J, Vuong CT, Reichard GA, Campo B, Tekwani BL, Walker LA, Rochford R.

Antimicrob Agents Chemother. 2016 Sep 23;60(10):5906-13. doi: 10.1128/AAC.00600-16. Print 2016 Oct.

27.

Methemoglobinemia Hemotoxicity of Some Antimalarial 8-Aminoquinoline Analogues and Their Hydroxylated Derivatives: Density Functional Theory Computation of Ionization Potentials.

Ding Y, Liu H, Tekwani BL, Nanayakkara NP, Khan IA, Walker LA, Doerksen RJ.

Chem Res Toxicol. 2016 Jul 18;29(7):1132-41. doi: 10.1021/acs.chemrestox.6b00063. Epub 2016 Jul 1.

PMID:
27223244
28.

Diversity-oriented natural product platform identifies plant constituents targeting Plasmodium falciparum.

Zhang J, Bowling JJ, Smithson D, Clark J, Jacob MR, Khan SI, Tekwani BL, Connelly M, Samoylenko V, Ibrahim MA, Zaki MA, Wang M, Hester JP, Tu Y, Jeffries C, Twarog N, Shelat AA, Walker LA, Muhammad I, Guy RK.

Malar J. 2016 May 10;15(1):270. doi: 10.1186/s12936-016-1313-7.

29.

Differential kinetic profiles and metabolism of primaquine enantiomers by human hepatocytes.

Fasinu PS, Avula B, Tekwani BL, Nanayakkara NP, Wang YH, Bandara Herath HM, McChesney JD, Reichard GA, Marcsisin SR, Elsohly MA, Khan SI, Khan IA, Walker LA.

Malar J. 2016 Apr 19;15:224. doi: 10.1186/s12936-016-1270-1.

30.

Potent antitrypanosomal triterpenoid saponins from Mussaenda luteola.

Mohamed SM, Bachkeet EY, Bayoumi SA, Jain S, Cutler SJ, Tekwani BL, Ross SA.

Fitoterapia. 2015 Dec;107:114-121. doi: 10.1016/j.fitote.2015.10.011. Epub 2015 Oct 30.

31.

Synthesis and biological evaluation of polyalthic acid derivatives for the treatment of neglected diseases.

Mizuno CS, Souza AB, Tekwani BL, Ambrósio SR, Veneziani RC.

Bioorg Med Chem Lett. 2015 Dec 1;25(23):5529-31. doi: 10.1016/j.bmcl.2015.10.062. Epub 2015 Oct 21.

PMID:
26520665
32.

Antimicrobial and Antileishmanial Activities of Diterpenoids Isolated from the Roots of Salvia deserta.

Búfalo J, Cantrell CL, Jacob MR, Schrader KK, Tekwani BL, Kustova TS, Ali A, Boaro CS.

Planta Med. 2016 Jan;82(1-2):131-7. doi: 10.1055/s-0035-1557875. Epub 2015 Aug 26.

PMID:
26308356
33.

Oleanolic acid acrylate elicits antidepressant-like effect mediated by 5-HT1A receptor.

Fajemiroye JO, Polepally PR, Chaurasiya ND, Tekwani BL, Zjawiony JK, Costa EA.

Sci Rep. 2015 Jul 22;5:11582. doi: 10.1038/srep11582.

34.

Plasmodium falciparum Thioredoxin Reductase (PfTrxR) and Its Role as a Target for New Antimalarial Discovery.

McCarty SE, Schellenberger A, Goodwin DC, Fuanta NR, Tekwani BL, Calderón AI.

Molecules. 2015 Jun 22;20(6):11459-73. doi: 10.3390/molecules200611459. Review.

35.

Differential cytochrome P450 2D metabolism alters tafenoquine pharmacokinetics.

Vuong C, Xie LH, Potter BM, Zhang J, Zhang P, Duan D, Nolan CK, Sciotti RJ, Zottig VE, Nanayakkara NP, Tekwani BL, Walker LA, Smith PL, Paris RM, Read LT, Li Q, Pybus BS, Sousa JC, Reichard GA, Smith B, Marcsisin SR.

Antimicrob Agents Chemother. 2015 Jul;59(7):3864-9. doi: 10.1128/AAC.00343-15. Epub 2015 Apr 13.

36.

Differential CYP 2D6 metabolism alters primaquine pharmacokinetics.

Potter BM, Xie LH, Vuong C, Zhang J, Zhang P, Duan D, Luong TL, Bandara Herath HM, Dhammika Nanayakkara NP, Tekwani BL, Walker LA, Nolan CK, Sciotti RJ, Zottig VE, Smith PL, Paris RM, Read LT, Li Q, Pybus BS, Sousa JC, Reichard GA, Marcsisin SR.

Antimicrob Agents Chemother. 2015 Apr;59(4):2380-7. doi: 10.1128/AAC.00015-15. Epub 2015 Feb 2.

37.

Enantioselective pharmacokinetics of primaquine in healthy human volunteers.

Tekwani BL, Avula B, Sahu R, Chaurasiya ND, Khan SI, Jain S, Fasinu PS, Herath HM, Stanford D, Nanayakkara NP, McChesney JD, Yates TW, ElSohly MA, Khan IA, Walker LA.

Drug Metab Dispos. 2015 Apr;43(4):571-7. doi: 10.1124/dmd.114.061127. Epub 2015 Jan 30.

PMID:
25637634
38.

Enantioselective metabolism of primaquine by human CYP2D6.

Fasinu PS, Tekwani BL, Nanayakkara NP, Avula B, Herath HM, Wang YH, Adelli VR, Elsohly MA, Khan SI, Khan IA, Pybus BS, Marcsisin SR, Reichard GA, McChesney JD, Walker LA.

Malar J. 2014 Dec 17;13:507. doi: 10.1186/1475-2875-13-507.

39.

4-Aminoquinoline-pyrimidine hybrids: synthesis, antimalarial activity, heme binding and docking studies.

Kumar D, Khan SI, Tekwani BL, Ponnan P, Rawat DS.

Eur J Med Chem. 2015 Jan 7;89:490-502. doi: 10.1016/j.ejmech.2014.10.061. Epub 2014 Oct 22.

PMID:
25462261
40.

Monoamine oxidase inhibitory constituents of propolis: kinetics and mechanism of inhibition of recombinant human MAO-A and MAO-B.

Chaurasiya ND, Ibrahim MA, Muhammad I, Walker LA, Tekwani BL.

Molecules. 2014 Nov 18;19(11):18936-52. doi: 10.3390/molecules191118936.

41.

Pharmacological activities of cilantro's aliphatic aldehydes against Leishmania donovani.

Donega MA, Mello SC, Moraes RM, Jain SK, Tekwani BL, Cantrell CL.

Planta Med. 2014 Dec;80(18):1706-11. doi: 10.1055/s-0034-1383183. Epub 2014 Oct 23.

PMID:
25340465
42.

In vitro and in vivo anti-malarial activity of tigecycline, a glycylcycline antibiotic, in combination with chloroquine.

Sahu R, Walker LA, Tekwani BL.

Malar J. 2014 Oct 21;13:414. doi: 10.1186/1475-2875-13-414.

43.

A new enniatin antibiotic from the endophyte Fusarium tricinctum Corda.

Zaher AM, Makboul MA, Moharram AM, Tekwani BL, Calderón AI.

J Antibiot (Tokyo). 2015 Mar;68(3):197-200. doi: 10.1038/ja.2014.129. Epub 2014 Oct 15.

PMID:
25315756
44.

Pharmacokinetics and pharmacodynamics of (+)-primaquine and (-)-primaquine enantiomers in rhesus macaques (Macaca mulatta).

Saunders D, Vanachayangkul P, Imerbsin R, Khemawoot P, Siripokasupkul R, Tekwani BL, Sampath A, Nanayakkara NP, Ohrt C, Lanteri C, Gettyacamin M, Teja-Isavadharm P, Walker L.

Antimicrob Agents Chemother. 2014 Dec;58(12):7283-91. doi: 10.1128/AAC.02576-13. Epub 2014 Sep 29.

45.

The antileishmanial activity of isoforms 6- and 8-selective histone deacetylase inhibitors.

Sodji Q, Patil V, Jain S, Kornacki JR, Mrksich M, Tekwani BL, Oyelere AK.

Bioorg Med Chem Lett. 2014 Oct 15;24(20):4826-30. doi: 10.1016/j.bmcl.2014.08.060. Epub 2014 Sep 4.

46.

Synthesis, antileishmanial and antitrypanosomal activities of N-substituted tetrahydro-β-carbolines.

Manda S, Khan SI, Jain SK, Mohammed S, Tekwani BL, Khan IA, Vishwakarma RA, Bharate SB.

Bioorg Med Chem Lett. 2014 Aug 1;24(15):3247-50. doi: 10.1016/j.bmcl.2014.06.030. Epub 2014 Jun 18.

PMID:
24980054
47.

Hydroxylated derivatives of NPC1161: theoretical insights into their potential toxicity and the feasibility and regioselectivity of their formation.

Ding Y, Liu H, Nanayakkara NP, Khan IA, Tekwani BL, Walker LA, Doerksen RJ.

J Phys Chem A. 2014 Jul 24;118(29):5501-7. doi: 10.1021/jp502612t. Epub 2014 Jul 11.

48.

Scalable preparation and differential pharmacologic and toxicologic profiles of primaquine enantiomers.

Nanayakkara NP, Tekwani BL, Herath HM, Sahu R, Gettayacamin M, Tungtaeng A, van Gessel Y, Baresel P, Wickham KS, Bartlett MS, Fronczek FR, Melendez V, Ohrt C, Reichard GA, McChesney JD, Rochford R, Walker LA.

Antimicrob Agents Chemother. 2014 Aug;58(8):4737-44. doi: 10.1128/AAC.02674-13. Epub 2014 Jun 9.

49.

Synthesis and antimalarial activity of metal complexes of cross-bridged tetraazamacrocyclic ligands.

Hubin TJ, Amoyaw PN, Roewe KD, Simpson NC, Maples RD, Carder Freeman TN, Cain AN, Le JG, Archibald SJ, Khan SI, Tekwani BL, Khan MO.

Bioorg Med Chem. 2014 Jul 1;22(13):3239-44. doi: 10.1016/j.bmc.2014.05.003. Epub 2014 May 11.

50.

Inuloxins A-D and derivatives as antileishmanial agents: structure-activity relationship study.

Avolio F, Rimando AM, Cimmino A, Andolfi A, Jain S, Tekwani BL, Evidente A.

J Antibiot (Tokyo). 2014 Aug;67(8):597-601. doi: 10.1038/ja.2014.47. Epub 2014 Apr 30. No abstract available.

PMID:
24781956

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