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Items: 3

1.

Trypanosoma brucei aquaglyceroporin 2 is a high-affinity transporter for pentamidine and melaminophenyl arsenic drugs and the main genetic determinant of resistance to these drugs.

Munday JC, Eze AA, Baker N, Glover L, Clucas C, Aguinaga Andrés D, Natto MJ, Teka IA, McDonald J, Lee RS, Graf FE, Ludin P, Burchmore RJ, Turner CM, Tait A, MacLeod A, Mäser P, Barrett MP, Horn D, De Koning HP.

J Antimicrob Chemother. 2014 Mar;69(3):651-63. doi: 10.1093/jac/dkt442. Epub 2013 Nov 13.

2.

Synthesis of marine-derived 3-alkylpyridinium alkaloids with potent antiprotozoal activity.

Rodenko B, Al-Salabi MI, Teka IA, Ho W, El-Sabbagh N, Ali JA, Ibrahim HM, Wanner MJ, Koomen GJ, de Koning HP.

ACS Med Chem Lett. 2011 Oct 5;2(12):901-6. doi: 10.1021/ml200160k. eCollection 2011 Dec 8.

3.

The diamidine diminazene aceturate is a substrate for the high-affinity pentamidine transporter: implications for the development of high resistance levels in trypanosomes.

Teka IA, Kazibwe AJ, El-Sabbagh N, Al-Salabi MI, Ward CP, Eze AA, Munday JC, Mäser P, Matovu E, Barrett MP, de Koning HP.

Mol Pharmacol. 2011 Jul;80(1):110-6. doi: 10.1124/mol.111.071555. Epub 2011 Mar 24.

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