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Items: 46


Selective blockade of the lyso-PS lipase ABHD12 stimulates immune responses in vivo.

Ogasawara D, Ichu TA, Vartabedian VF, Benthuysen J, Jing H, Reed A, Ulanovskaya OA, Hulce JJ, Roberts A, Brown S, Rosen H, Teijaro JR, Cravatt BF.

Nat Chem Biol. 2018 Dec;14(12):1099-1108. doi: 10.1038/s41589-018-0155-8. Epub 2018 Nov 12.


The probacterial effect of type I interferon signaling requires its own negative regulator USP18.

Shaabani N, Honke N, Nguyen N, Huang Z, Arimoto KI, Lazar D, Loe TK, Lang KS, Prinz M, Knobeloch KP, Zhang DE, Teijaro JR.

Sci Immunol. 2018 Sep 28;3(27). pii: eaau2125. doi: 10.1126/sciimmunol.aau2125.


Taking down defenses to improve vaccines.

Teijaro JR, Burton DR.

Science. 2018 Jan 19;359(6373):277-278. doi: 10.1126/science.aar5421. No abstract available.


Influenza NS1 directly modulates Hedgehog signaling during infection.

Smelkinson MG, Guichard A, Teijaro JR, Malur M, Loureiro ME, Jain P, Ganesan S, Zúñiga EI, Krug RM, Oldstone MB, Bier E.

PLoS Pathog. 2017 Aug 24;13(8):e1006588. doi: 10.1371/journal.ppat.1006588. eCollection 2017 Aug.


Cytokine storms in infectious diseases.

Teijaro JR.

Semin Immunopathol. 2017 Jul;39(5):501-503. doi: 10.1007/s00281-017-0640-2. Epub 2017 Jul 3. No abstract available.


Presentation of Autoantigen in Peripheral Lymph Nodes Is Sufficient for Priming Autoreactive CD8+ T Cells.

Honke N, Shaabani N, Teijaro JR, Christen U, Hardt C, Bezgovsek J, Lang PA, Lang KS.

Front Immunol. 2017 Feb 10;8:113. doi: 10.3389/fimmu.2017.00113. eCollection 2017.


PTPN22 contributes to exhaustion of T lymphocytes during chronic viral infection.

Maine CJ, Teijaro JR, Marquardt K, Sherman LA.

Proc Natl Acad Sci U S A. 2016 Nov 15;113(46):E7231-E7239. Epub 2016 Oct 31.


Pleiotropic Roles of Type 1 Interferons in Antiviral Immune Responses.

Teijaro JR.

Adv Immunol. 2016;132:135-158. doi: 10.1016/ Epub 2016 Sep 20. Review.


Chemical proteomic map of dimethyl fumarate-sensitive cysteines in primary human T cells.

Blewett MM, Xie J, Zaro BW, Backus KM, Altman A, Teijaro JR, Cravatt BF.

Sci Signal. 2016 Sep 13;9(445):rs10. doi: 10.1126/scisignal.aaf7694.


Cutting Edge: B Cell-Intrinsic T-bet Expression Is Required To Control Chronic Viral Infection.

Barnett BE, Staupe RP, Odorizzi PM, Palko O, Tomov VT, Mahan AE, Gunn B, Chen D, Paley MA, Alter G, Reiner SL, Lauer GM, Teijaro JR, Wherry EJ.

J Immunol. 2016 Aug 15;197(4):1017-22. doi: 10.4049/jimmunol.1500368. Epub 2016 Jul 18.


Proteome-wide covalent ligand discovery in native biological systems.

Backus KM, Correia BE, Lum KM, Forli S, Horning BD, González-Páez GE, Chatterjee S, Lanning BR, Teijaro JR, Olson AJ, Wolan DW, Cravatt BF.

Nature. 2016 Jun 23;534(7608):570-4. doi: 10.1038/nature18002. Epub 2016 Jun 15.


Type I interferons in viral control and immune regulation.

Teijaro JR.

Curr Opin Virol. 2016 Feb;16:31-40. doi: 10.1016/j.coviro.2016.01.001. Epub 2016 Jan 24. Review.


S1PR1-mediated IFNAR1 degradation modulates plasmacytoid dendritic cell interferon-α autoamplification.

Teijaro JR, Studer S, Leaf N, Kiosses WB, Nguyen N, Matsuki K, Negishi H, Taniguchi T, Oldstone MB, Rosen H.

Proc Natl Acad Sci U S A. 2016 Feb 2;113(5):1351-6. doi: 10.1073/pnas.1525356113. Epub 2016 Jan 19.


General Molecular Strategy for Development of Arenavirus Live-Attenuated Vaccines.

Iwasaki M, Ngo N, Cubitt B, Teijaro JR, de la Torre JC.

J Virol. 2015 Dec;89(23):12166-77. doi: 10.1128/JVI.02075-15. Epub 2015 Sep 23.


Blockade of interferon Beta, but not interferon alpha, signaling controls persistent viral infection.

Ng CT, Sullivan BM, Teijaro JR, Lee AM, Welch M, Rice S, Sheehan KC, Schreiber RD, Oldstone MB.

Cell Host Microbe. 2015 May 13;17(5):653-61. doi: 10.1016/j.chom.2015.04.005.


Early virus-host interactions dictate the course of a persistent infection.

Sullivan BM, Teijaro JR, de la Torre JC, Oldstone MB.

PLoS Pathog. 2015 Jan 8;11(1):e1004588. doi: 10.1371/journal.ppat.1004588. eCollection 2015 Jan.


The role of cytokine responses during influenza virus pathogenesis and potential therapeutic options.

Teijaro JR.

Curr Top Microbiol Immunol. 2015;386:3-22. doi: 10.1007/82_2014_411. Review.


Type I interferon is a therapeutic target for virus-induced lethal vascular damage.

Baccala R, Welch MJ, Gonzalez-Quintial R, Walsh KB, Teijaro JR, Nguyen A, Ng CT, Sullivan BM, Zarpellon A, Ruggeri ZM, de la Torre JC, Theofilopoulos AN, Oldstone MB.

Proc Natl Acad Sci U S A. 2014 Jun 17;111(24):8925-30. doi: 10.1073/pnas.1408148111. Epub 2014 Jun 2.


Animal model of respiratory syncytial virus: CD8+ T cells cause a cytokine storm that is chemically tractable by sphingosine-1-phosphate 1 receptor agonist therapy.

Walsh KB, Teijaro JR, Brock LG, Fremgen DM, Collins PL, Rosen H, Oldstone MB.

J Virol. 2014 Jun;88(11):6281-93. doi: 10.1128/JVI.00464-14. Epub 2014 Mar 26.


Protection of ferrets from pulmonary injury due to H1N1 2009 influenza virus infection: immunopathology tractable by sphingosine-1-phosphate 1 receptor agonist therapy.

Teijaro JR, Walsh KB, Long JP, Tordoff KP, Stark GV, Eisfeld AJ, Kawaoka Y, Rosen H, Oldstone MB.

Virology. 2014 Mar;452-453:152-7. doi: 10.1016/j.virol.2014.01.003. Epub 2014 Jan 31.


Mapping the innate signaling cascade essential for cytokine storm during influenza virus infection.

Teijaro JR, Walsh KB, Rice S, Rosen H, Oldstone MB.

Proc Natl Acad Sci U S A. 2014 Mar 11;111(10):3799-804. doi: 10.1073/pnas.1400593111. Epub 2014 Feb 26.


MicroRNAs of the miR-17∼92 family are critical regulators of T(FH) differentiation.

Kang SG, Liu WH, Lu P, Jin HY, Lim HW, Shepherd J, Fremgen D, Verdin E, Oldstone MB, Qi H, Teijaro JR, Xiao C.

Nat Immunol. 2013 Aug;14(8):849-57. doi: 10.1038/ni.2648. Epub 2013 Jun 30.


Persistent LCMV infection is controlled by blockade of type I interferon signaling.

Teijaro JR, Ng C, Lee AM, Sullivan BM, Sheehan KC, Welch M, Schreiber RD, de la Torre JC, Oldstone MB.

Science. 2013 Apr 12;340(6129):207-11. doi: 10.1126/science.1235214.


Three phases of CD8 T cell response in the lung following H1N1 influenza infection and sphingosine 1 phosphate agonist therapy.

Matheu MP, Teijaro JR, Walsh KB, Greenberg ML, Marsolais D, Parker I, Rosen H, Oldstone MB, Cahalan MD.

PLoS One. 2013;8(3):e58033. doi: 10.1371/journal.pone.0058033. Epub 2013 Mar 22.


Dissecting influenza virus pathogenesis uncovers a novel chemical approach to combat the infection.

Oldstone MB, Teijaro JR, Walsh KB, Rosen H.

Virology. 2013 Jan 5;435(1):92-101. doi: 10.1016/j.virol.2012.09.039. Review.


Toll-like receptor 7 is required for effective adaptive immune responses that prevent persistent virus infection.

Walsh KB, Teijaro JR, Zuniga EI, Welch MJ, Fremgen DM, Blackburn SD, von Tiehl KF, Wherry EJ, Flavell RA, Oldstone MB.

Cell Host Microbe. 2012 Jun 14;11(6):643-53. doi: 10.1016/j.chom.2012.04.016.


CD8 T cell defect of TNF-α and IL-2 in DNAM-1 deficient mice delays clearance in vivo of a persistent virus infection.

Welch MJ, Teijaro JR, Lewicki HA, Colonna M, Oldstone MB.

Virology. 2012 Aug 1;429(2):163-70. doi: 10.1016/j.virol.2012.04.006. Epub 2012 May 12.


Cutting edge: Tissue-retentive lung memory CD4 T cells mediate optimal protection to respiratory virus infection.

Teijaro JR, Turner D, Pham Q, Wherry EJ, Lefrançois L, Farber DL.

J Immunol. 2011 Dec 1;187(11):5510-4. doi: 10.4049/jimmunol.1102243. Epub 2011 Nov 4.


Endothelial cells are central orchestrators of cytokine amplification during influenza virus infection.

Teijaro JR, Walsh KB, Cahalan S, Fremgen DM, Roberts E, Scott F, Martinborough E, Peach R, Oldstone MB, Rosen H.

Cell. 2011 Sep 16;146(6):980-91. doi: 10.1016/j.cell.2011.08.015.


Quelling the storm: utilization of sphingosine-1-phosphate receptor signaling to ameliorate influenza virus-induced cytokine storm.

Walsh KB, Teijaro JR, Rosen H, Oldstone MB.

Immunol Res. 2011 Oct;51(1):15-25. doi: 10.1007/s12026-011-8240-z. Review.


PAD4-mediated neutrophil extracellular trap formation is not required for immunity against influenza infection.

Hemmers S, Teijaro JR, Arandjelovic S, Mowen KA.

PLoS One. 2011;6(7):e22043. doi: 10.1371/journal.pone.0022043. Epub 2011 Jul 11.


Suppression of cytokine storm with a sphingosine analog provides protection against pathogenic influenza virus.

Walsh KB, Teijaro JR, Wilker PR, Jatzek A, Fremgen DM, Das SC, Watanabe T, Hatta M, Shinya K, Suresh M, Kawaoka Y, Rosen H, Oldstone MB.

Proc Natl Acad Sci U S A. 2011 Jul 19;108(29):12018-23. doi: 10.1073/pnas.1107024108. Epub 2011 Jun 29.


Expanded potential for recombinant trisegmented lymphocytic choriomeningitis viruses: protein production, antibody production, and in vivo assessment of biological function of genes of interest.

Popkin DL, Teijaro JR, Lee AM, Lewicki H, Emonet S, de la Torre JC, Oldstone M.

J Virol. 2011 Aug;85(15):7928-32. doi: 10.1128/JVI.00486-11. Epub 2011 May 25.


Bordetella pertussis infection exacerbates influenza virus infection through pertussis toxin-mediated suppression of innate immunity.

Ayala VI, Teijaro JR, Farber DL, Dorsey SG, Carbonetti NH.

PLoS One. 2011 Apr 20;6(4):e19016. doi: 10.1371/journal.pone.0019016.


Hypomorphic mutation in the site-1 protease Mbtps1 endows resistance to persistent viral infection in a cell-specific manner.

Popkin DL, Teijaro JR, Sullivan BM, Urata S, Rutschmann S, de la Torre JC, Kunz S, Beutler B, Oldstone M.

Cell Host Microbe. 2011 Mar 17;9(3):212-222. doi: 10.1016/j.chom.2011.02.006.


The anti-tumor agent, 5,6-dimethylxanthenone-4-acetic acid (DMXAA), induces IFN-beta-mediated antiviral activity in vitro and in vivo.

Shirey KA, Nhu QM, Yim KC, Roberts ZJ, Teijaro JR, Farber DL, Blanco JC, Vogel SN.

J Leukoc Biol. 2011 Mar;89(3):351-7. doi: 10.1189/jlb.0410216. Epub 2010 Nov 17.


Memory CD4 T cells direct protective responses to influenza virus in the lungs through helper-independent mechanisms.

Teijaro JR, Verhoeven D, Page CA, Turner D, Farber DL.

J Virol. 2010 Sep;84(18):9217-26. doi: 10.1128/JVI.01069-10. Epub 2010 Jun 30.


TLR2 engagement on dendritic cells promotes high frequency effector and memory CD4 T cell responses.

Chandran SS, Verhoeven D, Teijaro JR, Fenton MJ, Farber DL.

J Immunol. 2009 Dec 15;183(12):7832-41. doi: 10.4049/jimmunol.0901683.


Novel signaling interactions between proteinase-activated receptor 2 and Toll-like receptors in vitro and in vivo.

Nhu QM, Shirey K, Teijaro JR, Farber DL, Netzel-Arnett S, Antalis TM, Fasano A, Vogel SN.

Mucosal Immunol. 2010 Jan;3(1):29-39. doi: 10.1038/mi.2009.120. Epub 2009 Oct 28.


Pulse-oximetry accurately predicts lung pathology and the immune response during influenza infection.

Verhoeven D, Teijaro JR, Farber DL.

Virology. 2009 Aug 1;390(2):151-6. doi: 10.1016/j.virol.2009.05.004. Epub 2009 Jun 2.


Costimulation modulation uncouples protection from immunopathology in memory T cell responses to influenza virus.

Teijaro JR, Njau MN, Verhoeven D, Chandran S, Nadler SG, Hasday J, Farber DL.

J Immunol. 2009 Jun 1;182(11):6834-43. doi: 10.4049/jimmunol.0803860.


CTLA4 expression is an indicator and regulator of steady-state CD4+ FoxP3+ T cell homeostasis.

Tang AL, Teijaro JR, Njau MN, Chandran SS, Azimzadeh A, Nadler SG, Rothstein DM, Farber DL.

J Immunol. 2008 Aug 1;181(3):1806-13.


A peptide-major histocompatibility complex II chimera favors survival of pancreatic beta-islets grafted in type 1 diabetic mice.

Casares S, Lin M, Zhang N, Teijaro JR, Stoica C, McEvoy R, Farber DL, Bona C, Brumeanu TD.

Transplantation. 2008 Jun 27;85(12):1717-25. doi: 10.1097/TP.0b013e31817752cc.


Heterogeneous memory T cells in antiviral immunity and immunopathology.

Verhoeven D, Teijaro JR, Farber DL.

Viral Immunol. 2008 Jun;21(2):99-113. doi: 10.1089/vim.2007.0002. Review.


Control of memory CD4 T cell recall by the CD28/B7 costimulatory pathway.

Ndejembi MP, Teijaro JR, Patke DS, Bingaman AW, Chandok MR, Azimzadeh A, Nadler SG, Farber DL.

J Immunol. 2006 Dec 1;177(11):7698-706.

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