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Items: 18


High-affinity caspase-4 binding to LPS presented as high molecular mass aggregates or in outer membrane vesicles.

Wacker MA, Teghanemt A, Weiss JP, Barker JH.

Innate Immun. 2017 May;23(4):336-344. doi: 10.1177/1753425917695446. Epub 2017 Jan 1.


Purified monomeric ligand.MD-2 complexes reveal molecular and structural requirements for activation and antagonism of TLR4 by Gram-negative bacterial endotoxins.

Gioannini TL, Teghanemt A, Zhang D, Esparza G, Yu L, Weiss J.

Immunol Res. 2014 Aug;59(1-3):3-11. doi: 10.1007/s12026-014-8543-y. Review.


Radioiodination of an endotoxin·MD-2 complex generates a novel sensitive, high-affinity ligand for TLR4.

Teghanemt A, Weiss JP, Gioannini TL.

Innate Immun. 2013 Oct;19(5):545-60. doi: 10.1177/1753425913475688. Epub 2013 Feb 25.


NMR studies of hexaacylated endotoxin bound to wild-type and F126A mutant MD-2 and MD-2·TLR4 ectodomain complexes.

Yu L, Phillips RL, Zhang D, Teghanemt A, Weiss JP, Gioannini TL.

J Biol Chem. 2012 May 11;287(20):16346-55. doi: 10.1074/jbc.M112.343467. Epub 2012 Mar 20.


Endotoxin{middle dot}albumin complexes transfer endotoxin monomers to MD-2 resulting in activation of TLR4.

Esparza GA, Teghanemt A, Zhang D, Gioannini TL, Weiss JP.

Innate Immun. 2012 Jun;18(3):478-91. doi: 10.1177/1753425911422723. Epub 2011 Oct 12.


Evidence of a specific interaction between new synthetic antisepsis agents and CD14.

Piazza M, Yu L, Teghanemt A, Gioannini T, Weiss J, Peri F.

Biochemistry. 2009 Dec 29;48(51):12337-44. doi: 10.1021/bi901601b.


Isolation of monomeric and dimeric secreted MD-2. Endotoxin.sCD14 and Toll-like receptor 4 ectodomain selectively react with the monomeric form of secreted MD-2.

Teghanemt A, Widstrom RL, Gioannini TL, Weiss JP.

J Biol Chem. 2008 Aug 8;283(32):21881-9. doi: 10.1074/jbc.M800672200. Epub 2008 Jun 2.


Novel roles in human MD-2 of phenylalanines 121 and 126 and tyrosine 131 in activation of Toll-like receptor 4 by endotoxin.

Teghanemt A, Re F, Prohinar P, Widstrom R, Gioannini TL, Weiss JP.

J Biol Chem. 2008 Jan 18;283(3):1257-66. Epub 2007 Oct 30.


Transfer of monomeric endotoxin from MD-2 to CD14: characterization and functional consequences.

Teghanemt A, Prohinar P, Gioannini TL, Weiss JP.

J Biol Chem. 2007 Dec 14;282(50):36250-6. Epub 2007 Oct 13.


Endotoxin-binding proteins modulate the susceptibility of bacterial endotoxin to deacylation by acyloxyacyl hydrolase.

Gioannini TL, Teghanemt A, Zhang D, Prohinar P, Levis EN, Munford RS, Weiss JP.

J Biol Chem. 2007 Mar 16;282(11):7877-84. Epub 2007 Jan 16.


Specific high affinity interactions of monomeric endotoxin.protein complexes with Toll-like receptor 4 ectodomain.

Prohinar P, Re F, Widstrom R, Zhang D, Teghanemt A, Weiss JP, Gioannini TL.

J Biol Chem. 2007 Jan 12;282(2):1010-7. Epub 2006 Nov 22.


Molecular basis of reduced potency of underacylated endotoxins.

Teghanemt A, Zhang D, Levis EN, Weiss JP, Gioannini TL.

J Immunol. 2005 Oct 1;175(7):4669-76.


Biochemical and functional characterization of membrane blebs purified from Neisseria meningitidis serogroup B.

Post DM, Zhang D, Eastvold JS, Teghanemt A, Gibson BW, Weiss JP.

J Biol Chem. 2005 Nov 18;280(46):38383-94. Epub 2005 Aug 15.


Monomeric endotoxin:protein complexes are essential for TLR4-dependent cell activation.

Gioannini TL, Teghanemt A, Zhang D, Levis EN, Weiss JP.

J Endotoxin Res. 2005;11(2):117-23.


Isolation of an endotoxin-MD-2 complex that produces Toll-like receptor 4-dependent cell activation at picomolar concentrations.

Gioannini TL, Teghanemt A, Zhang D, Coussens NP, Dockstader W, Ramaswamy S, Weiss JP.

Proc Natl Acad Sci U S A. 2004 Mar 23;101(12):4186-91. Epub 2004 Mar 9.


Regulation of interactions of endotoxin with host cells.

Gioannini TL, Teghanemt A, Zarember KA, Weiss JP.

J Endotoxin Res. 2003;9(6):401-8.


An essential role for albumin in the interaction of endotoxin with lipopolysaccharide-binding protein and sCD14 and resultant cell activation.

Gioannini TL, Zhang D, Teghanemt A, Weiss JP.

J Biol Chem. 2002 Dec 6;277(49):47818-25. Epub 2002 Oct 7.


Construction of acetate auxotrophs of Neisseria meningitidis to study host-meningococcal endotoxin interactions.

Giardina PC, Gioannini T, Buscher BA, Zaleski A, Zheng DS, Stoll L, Teghanemt A, Apicella MA, Weiss J.

J Biol Chem. 2001 Feb 23;276(8):5883-91. Epub 2000 Nov 17.

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