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Items: 1 to 50 of 152

1.

Progranulin deficiency confers resistance to autoimmune encephalomyelitis in mice.

Schmitz K, Wilken-Schmitz A, Vasic V, Brunkhorst R, Schmidt M, Tegeder I.

Cell Mol Immunol. 2019 Aug 29. doi: 10.1038/s41423-019-0274-5. [Epub ahead of print]

PMID:
31467413
2.

Sensory neuropathy and nociception in rodent models of Parkinson's disease.

Valek L, Auburger G, Tegeder I.

Dis Model Mech. 2019 Jun 27;12(6). pii: dmm039396. doi: 10.1242/dmm.039396. Review.

3.

Targeted lipidomics reveal derangement of ceramides in major depression and bipolar disorder.

Brunkhorst-Kanaan N, Klatt-Schreiner K, Hackel J, Schröter K, Trautmann S, Hahnefeld L, Wicker S, Reif A, Thomas D, Geisslinger G, Kittel-Schneider S, Tegeder I.

Metabolism. 2019 Jun;95:65-76. doi: 10.1016/j.metabol.2019.04.002. Epub 2019 Apr 5.

PMID:
30954559
4.

Distal infraorbital nerve injury: a model for persistent facial pain in mice.

Hardt S, Fischer C, Vogel A, Wilken-Schmitz A, Tegeder I.

Pain. 2019 Jun;160(6):1431-1447. doi: 10.1097/j.pain.0000000000001518.

PMID:
30747909
5.

Identification of genes functionally involved in the detrimental effects of mutant histone H3.3-K27M in Drosophila melanogaster.

Berlandi J, Chaouch A, De Jay N, Tegeder I, Thiel K, Shirinian M, Kleinman CL, Jeibmann A, Lasko P, Jabado N, Hasselblatt M.

Neuro Oncol. 2019 May 6;21(5):628-639. doi: 10.1093/neuonc/noz021.

PMID:
30715493
6.

Correction: Synaptic phospholipids as a new target for cortical hyperexcitability and E/I balance in psychiatric disorders.

Thalman C, Horta G, Qiao L, Endle H, Tegeder I, Cheng H, Laube G, Sigurdsson T, Hauser MJ, Tenzer S, Distler U, Aoki J, Morris AJ, Geisslinger G, Röper J, Kirischuk S, Luhmann HJ, Radyushkin K, Nitsch R, Vogt J.

Mol Psychiatry. 2019 Jan 2. doi: 10.1038/s41380-018-0320-1. [Epub ahead of print]

PMID:
30602735
7.

Deep proteome of human nNOS/NOS1-positive versus MOCK SH-SY5Y neuroblastoma cells under full nutrition, serum free starvation and rapamycin treatment.

Heidler J, Valek L, Wittig I, Tegeder I.

Data Brief. 2018 Oct 26;21:1309-1314. doi: 10.1016/j.dib.2018.10.079. eCollection 2018 Dec.

8.

Redox-proteomes of human NOS1-transduced versus MOCK SH-SY5Y neuroblastoma cells under full nutrition, serum-free starvation, and rapamycin treatment.

Heidler J, Valek L, Wittig I, Tegeder I.

Data Brief. 2018 Oct 26;21:1302-1308. doi: 10.1016/j.dib.2018.10.078. eCollection 2018 Dec.

9.

Mast cell tetrahydrobiopterin contributes to itch in mice.

Zschiebsch K, Fischer C, Wilken-Schmitz A, Geisslinger G, Channon K, Watschinger K, Tegeder I.

J Cell Mol Med. 2019 Feb;23(2):985-1000. doi: 10.1111/jcmm.13999. Epub 2018 Nov 18.

10.

Functional relevance of genes predicted to be affected by epigenetic alterations in atypical teratoid/rhabdoid tumors.

Tegeder I, Thiel K, Erkek S, Johann PD, Berlandi J, Thatikonda V, Frühwald MC, Kool M, Jeibmann A, Hasselblatt M.

J Neurooncol. 2019 Jan;141(1):43-55. doi: 10.1007/s11060-018-03018-6. Epub 2018 Nov 16.

PMID:
30446899
11.

Nitric oxide mediated redox regulation of protein homeostasis.

Tegeder I.

Cell Signal. 2019 Jan;53:348-356. doi: 10.1016/j.cellsig.2018.10.019. Epub 2018 Nov 5.

PMID:
30408515
12.

Nitric oxide contributes to protein homeostasis by S-nitrosylations of the chaperone HSPA8 and the ubiquitin ligase UBE2D.

Valek L, Heidler J, Scheving R, Wittig I, Tegeder I.

Redox Biol. 2019 Jan;20:217-235. doi: 10.1016/j.redox.2018.10.002. Epub 2018 Oct 16.

13.

Hypoxia-inducible factor 1α protects peripheral sensory neurons from diabetic peripheral neuropathy by suppressing accumulation of reactive oxygen species.

Rojas DR, Tegeder I, Kuner R, Agarwal N.

J Mol Med (Berl). 2018 Dec;96(12):1395-1405. doi: 10.1007/s00109-018-1707-9. Epub 2018 Oct 25.

PMID:
30361814
14.

Machine-learning based lipid mediator serum concentration patterns allow identification of multiple sclerosis patients with high accuracy.

Lötsch J, Schiffmann S, Schmitz K, Brunkhorst R, Lerch F, Ferreiros N, Wicker S, Tegeder I, Geisslinger G, Ultsch A.

Sci Rep. 2018 Oct 5;8(1):14884. doi: 10.1038/s41598-018-33077-8.

15.

Progranulin Deficient Mice Develop Nephrogenic Diabetes Insipidus.

Hardt S, Valek L, Zeng-Brouwers J, Wilken-Schmitz A, Schaefer L, Tegeder I.

Aging Dis. 2018 Oct 1;9(5):817-830. doi: 10.14336/AD.2017.1127. eCollection 2018 Oct.

16.

Synaptic phospholipids as a new target for cortical hyperexcitability and E/I balance in psychiatric disorders.

Thalman C, Horta G, Qiao L, Endle H, Tegeder I, Cheng H, Laube G, Sigurdsson T, Hauser MJ, Tenzer S, Distler U, Aoki J, Morris AJ, Geisslinger G, Röper J, Kirischuk S, Luhmann HJ, Radyushkin K, Nitsch R, Vogt J.

Mol Psychiatry. 2018 Aug;23(8):1699-1710. doi: 10.1038/s41380-018-0053-1. Epub 2018 May 9. Erratum in: Mol Psychiatry. 2019 Jan 2;:.

17.

Current evidence of cannabinoid-based analgesia obtained in preclinical and human experimental settings.

Lötsch J, Weyer-Menkhoff I, Tegeder I.

Eur J Pain. 2018 Mar;22(3):471-484. doi: 10.1002/ejp.1148. Epub 2017 Nov 21. Review.

PMID:
29160600
18.

NG2/CSPG4 and progranulin in the posttraumatic glial scar.

Schäfer MKE, Tegeder I.

Matrix Biol. 2018 Aug;68-69:571-588. doi: 10.1016/j.matbio.2017.10.002. Epub 2017 Oct 17. Review.

PMID:
29054751
19.

Monoclonal Antibodies in Preclinical EAE Models of Multiple Sclerosis: A Systematic Review.

Schmitz K, Geisslinger G, Tegeder I.

Int J Mol Sci. 2017 Sep 16;18(9). pii: E1992. doi: 10.3390/ijms18091992. Review.

20.

Progression of pathology in PINK1-deficient mouse brain from splicing via ubiquitination, ER stress, and mitophagy changes to neuroinflammation.

Torres-Odio S, Key J, Hoepken HH, Canet-Pons J, Valek L, Roller B, Walter M, Morales-Gordo B, Meierhofer D, Harter PN, Mittelbronn M, Tegeder I, Gispert S, Auburger G.

J Neuroinflammation. 2017 Aug 2;14(1):154. doi: 10.1186/s12974-017-0928-0.

21.

Loss of synaptic zinc transport in progranulin deficient mice may contribute to progranulin-associated psychopathology and chronic pain.

Hardt S, Heidler J, Albuquerque B, Valek L, Altmann C, Wilken-Schmitz A, Schäfer MKE, Wittig I, Tegeder I.

Biochim Biophys Acta Mol Basis Dis. 2017 Nov;1863(11):2727-2745. doi: 10.1016/j.bbadis.2017.07.014. Epub 2017 Jul 15.

22.

Dysregulation of lysophosphatidic acids in multiple sclerosis and autoimmune encephalomyelitis.

Schmitz K, Brunkhorst R, de Bruin N, Mayer CA, Häussler A, Ferreiros N, Schiffmann S, Parnham MJ, Tunaru S, Chun J, Offermanns S, Foerch C, Scholich K, Vogt J, Wicker S, Lötsch J, Geisslinger G, Tegeder I.

Acta Neuropathol Commun. 2017 Jun 2;5(1):42. doi: 10.1186/s40478-017-0446-4.

23.

Ceramide synthase 2 deficiency aggravates AOM-DSS-induced colitis in mice: role of colon barrier integrity.

Oertel S, Scholich K, Weigert A, Thomas D, Schmetzer J, Trautmann S, Wegner MS, Radeke HH, Filmann N, Brüne B, Geisslinger G, Tegeder I, Grösch S.

Cell Mol Life Sci. 2017 Aug;74(16):3039-3055. doi: 10.1007/s00018-017-2518-9. Epub 2017 Apr 12.

PMID:
28405720
24.

Rab7-a novel redox target that modulates inflammatory pain processing.

Kallenborn-Gerhardt W, Möser CV, Lorenz JE, Steger M, Heidler J, Scheving R, Petersen J, Kennel L, Flauaus C, Lu R, Edinger AL, Tegeder I, Geisslinger G, Heide H, Wittig I, Schmidtko A.

Pain. 2017 Jul;158(7):1354-1365. doi: 10.1097/j.pain.0000000000000920.

PMID:
28394828
25.
26.

SMAD dependent signaling plays a detrimental role in a fly model of SMARCB1-deficiency and the biology of atypical teratoid/rhabdoid tumors.

Jeibmann A, Schulz J, Eikmeier K, Johann PD, Thiel K, Tegeder I, Ambrée O, Frühwald MC, Pfister SM, Kool M, Paulus W, Hasselblatt M.

J Neurooncol. 2017 Feb;131(3):477-484. doi: 10.1007/s11060-016-2326-3. Epub 2017 Jan 20.

PMID:
28108836
27.

R-Flurbiprofen Traps Prostaglandins within Cells by Inhibition of Multidrug Resistance-Associated Protein-4.

Wobst I, Ebert L, Birod K, Wegner MS, Hoffmann M, Thomas D, Angioni C, Parnham MJ, Steinhilber D, Tegeder I, Geisslinger G, Grösch S.

Int J Mol Sci. 2016 Dec 30;18(1). pii: E68. doi: 10.3390/ijms18010068.

28.

Redox-guided axonal regrowth requires cyclic GMP dependent protein kinase 1: Implication for neuropathic pain.

Valek L, Häussler A, Dröse S, Eaton P, Schröder K, Tegeder I.

Redox Biol. 2017 Apr;11:176-191. doi: 10.1016/j.redox.2016.12.004. Epub 2016 Dec 7.

29.
30.
31.

Progranulin protects against exaggerated axonal injury and astrogliosis following traumatic brain injury.

Menzel L, Kleber L, Friedrich C, Hummel R, Dangel L, Winter J, Schmitz K, Tegeder I, Schäfer MK.

Glia. 2017 Feb;65(2):278-292. doi: 10.1002/glia.23091. Epub 2016 Oct 25.

PMID:
27778404
32.

Progranulin promotes peripheral nerve regeneration and reinnervation: role of notch signaling.

Altmann C, Vasic V, Hardt S, Heidler J, Häussler A, Wittig I, Schmidt MHH, Tegeder I.

Mol Neurodegener. 2016 Oct 22;11(1):69.

33.

Progranulin overexpression in sensory neurons attenuates neuropathic pain in mice: Role of autophagy.

Altmann C, Hardt S, Fischer C, Heidler J, Lim HY, Häussler A, Albuquerque B, Zimmer B, Möser C, Behrends C, Koentgen F, Wittig I, Schmidt MHH, Clement AM, Deller T, Tegeder I.

Neurobiol Dis. 2016 Dec;96:294-311. doi: 10.1016/j.nbd.2016.09.010. Epub 2016 Sep 11.

PMID:
27629805
34.

Tetrahydrobiopterin Attenuates DSS-evoked Colitis in Mice by Rebalancing Redox and Lipid Signalling.

Zschiebsch K, Fischer C, Pickert G, Häussler A, Radeke H, Grösch S, Ferreirós N, Geisslinger G, Werner ER, Tegeder I.

J Crohns Colitis. 2016 Aug;10(8):965-78. doi: 10.1093/ecco-jcc/jjw056. Epub 2016 Feb 29.

PMID:
26928964
35.

Endocannabinoids as Guardians of Metastasis.

Tegeder I.

Int J Mol Sci. 2016 Feb 10;17(2):230. doi: 10.3390/ijms17020230. Review.

36.

Expression and regulation of redoxins at nociceptive signaling sites after sciatic nerve injury in mice.

Valek L, Kanngießer M, Tegeder I.

Data Brief. 2015 Nov 10;5:834-45. doi: 10.1016/j.dib.2015.10.038. eCollection 2015 Dec.

37.

Multiple rodent models and behavioral measures reveal unexpected responses to FTY720 and DMF in experimental autoimmune encephalomyelitis.

de Bruin NM, Schmitz K, Schiffmann S, Tafferner N, Schmidt M, Jordan H, Häußler A, Tegeder I, Geisslinger G, Parnham MJ.

Behav Brain Res. 2016 Mar 1;300:160-74. doi: 10.1016/j.bbr.2015.12.006. Epub 2015 Dec 12.

PMID:
26692368
38.

Molecular cause and functional impact of altered synaptic lipid signaling due to a prg-1 gene SNP.

Vogt J, Yang JW, Mobascher A, Cheng J, Li Y, Liu X, Baumgart J, Thalman C, Kirischuk S, Unichenko P, Horta G, Radyushkin K, Stroh A, Richers S, Sahragard N, Distler U, Tenzer S, Qiao L, Lieb K, Tüscher O, Binder H, Ferreiros N, Tegeder I, Morris AJ, Gropa S, Nürnberg P, Toliat MR, Winterer G, Luhmann HJ, Huai J, Nitsch R.

EMBO Mol Med. 2016 Jan 1;8(1):25-38. doi: 10.15252/emmm.201505677.

39.

Redoxins in peripheral neurons after sciatic nerve injury.

Valek L, Kanngießer M, Häussler A, Agarwal N, Lillig CH, Tegeder I.

Free Radic Biol Med. 2015 Dec;89:581-92. doi: 10.1016/j.freeradbiomed.2015.09.008. Epub 2015 Oct 9.

PMID:
26456799
40.

COX-2-Derived Prostaglandin E2 Produced by Pyramidal Neurons Contributes to Neurovascular Coupling in the Rodent Cerebral Cortex.

Lacroix A, Toussay X, Anenberg E, Lecrux C, Ferreirós N, Karagiannis A, Plaisier F, Chausson P, Jarlier F, Burgess SA, Hillman EM, Tegeder I, Murphy TH, Hamel E, Cauli B.

J Neurosci. 2015 Aug 26;35(34):11791-810. doi: 10.1523/JNEUROSCI.0651-15.2015.

41.

Pro-inflammatory obesity in aged cannabinoid-2 receptor-deficient mice.

Schmitz K, Mangels N, Häussler A, Ferreirós N, Fleming I, Tegeder I.

Int J Obes (Lond). 2016 Feb;40(2):366-79. doi: 10.1038/ijo.2015.169. Epub 2015 Aug 25.

PMID:
26303348
42.

Reduction of Neuropathic and Inflammatory Pain through Inhibition of the Tetrahydrobiopterin Pathway.

Latremoliere A, Latini A, Andrews N, Cronin SJ, Fujita M, Gorska K, Hovius R, Romero C, Chuaiphichai S, Painter M, Miracca G, Babaniyi O, Remor AP, Duong K, Riva P, Barrett LB, Ferreirós N, Naylor A, Penninger JM, Tegeder I, Zhong J, Blagg J, Channon KM, Johnsson K, Costigan M, Woolf CJ.

Neuron. 2015 Jun 17;86(6):1393-406. doi: 10.1016/j.neuron.2015.05.033.

43.

Regulation of circulating endocannabinoids associated with cancer and metastases in mice and humans.

Sailler S, Schmitz K, Jäger E, Ferreiros N, Wicker S, Zschiebsch K, Pickert G, Geisslinger G, Walter C, Tegeder I, Lötsch J.

Oncoscience. 2014 Apr 30;1(4):272-282. eCollection 2014.

44.

"Disease modifying nutricals" for multiple sclerosis.

Schmitz K, Barthelmes J, Stolz L, Beyer S, Diehl O, Tegeder I.

Pharmacol Ther. 2015 Apr;148:85-113. doi: 10.1016/j.pharmthera.2014.11.015. Epub 2014 Nov 27. Review.

PMID:
25435020
45.

R-flurbiprofen attenuates experimental autoimmune encephalomyelitis in mice.

Schmitz K, de Bruin N, Bishay P, Männich J, Häussler A, Altmann C, Ferreirós N, Lötsch J, Ultsch A, Parnham MJ, Geisslinger G, Tegeder I.

EMBO Mol Med. 2014 Nov;6(11):1398-422. doi: 10.15252/emmm.201404168.

46.

H3K79 methylation: a new conserved mark that accompanies H4 hyperacetylation prior to histone-to-protamine transition in Drosophila and rat.

Dottermusch-Heidel C, Gärtner SM, Tegeder I, Rathke C, Barckmann B, Bartkuhn M, Bhushan S, Steger K, Meinhardt A, Renkawitz-Pohl R.

Biol Open. 2014 May 2;3(6):444-52. doi: 10.1242/bio.20147302.

47.

Congenital taurine deficiency in mice is associated with reduced sensitivity to nociceptive chemical stimulation.

Lötsch J, Hummel T, Warskulat U, Coste O, Häussinger D, Geisslinger G, Tegeder I.

Neuroscience. 2014 Feb 14;259:63-70. doi: 10.1016/j.neuroscience.2013.11.037. Epub 2013 Dec 7.

PMID:
24321512
48.

Learning and memory with neuropathic pain: impact of old age and progranulin deficiency.

Albuquerque B, Häussler A, Vannoni E, Wolfer DP, Tegeder I.

Front Behav Neurosci. 2013 Nov 22;7:174. doi: 10.3389/fnbeh.2013.00174. eCollection 2013.

49.

Hypoxia-inducible factor 1 regulates heat and cold pain sensitivity and persistence.

Kanngiesser M, Mair N, Lim HY, Zschiebsch K, Blees J, Häussler A, Brüne B, Ferreiròs N, Kress M, Tegeder I.

Antioxid Redox Signal. 2014 Jun 1;20(16):2555-71. doi: 10.1089/ars.2013.5494. Epub 2014 Jan 30.

PMID:
24144405
50.

Exogenous delta⁹-tetrahydrocannabinol influences circulating endogenous cannabinoids in humans.

Walter C, Ferreirós N, Bishay P, Geisslinger G, Tegeder I, Lötsch J.

J Clin Psychopharmacol. 2013 Oct;33(5):699-705. doi: 10.1097/JCP.0b013e3182984015.

PMID:
23899642

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