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Targeting CD34+ cells of the inflamed synovial endothelium by guided nanoparticles for the treatment of rheumatoid arthritis.

Colombo F, Durigutto P, De Maso L, Biffi S, Belmonte B, Tripodo C, Oliva R, Bardini P, Marini GM, Terreno E, Pozzato G, Rampazzo E, Bertrand J, Feuerstein B, Javurek J, Havrankova J, Pitzalis C, Nuñez L, Meroni P, Tedesco F, Sblattero D, Macor P.

J Autoimmun. 2019 Jun 15. pii: S0896-8411(19)30105-2. doi: 10.1016/j.jaut.2019.05.016. [Epub ahead of print]


Pericytes in Muscular Dystrophies.

Moyle LA, Tedesco FS, Benedetti S.

Adv Exp Med Biol. 2019;1147:319-344. doi: 10.1007/978-3-030-16908-4_15.


Cognitive disorders in migrants: retrospective analysis in a Center for Cognitive Disorders and Dementia in Milan.

Cova I, Del Tedesco F, Maggiore L, Pantoni L, Pomati S.

Aging Clin Exp Res. 2019 May 27. doi: 10.1007/s40520-019-01224-4. [Epub ahead of print]


Blood Cell-Bound C4d as a Marker of Complement Activation in Patients With the Antiphospholipid Syndrome.

Lonati PA, Scavone M, Gerosa M, Borghi MO, Pregnolato F, Curreli D, Podda G, Femia EA, Barcellini W, Cattaneo M, Tedesco F, Meroni PL.

Front Immunol. 2019 Apr 12;10:773. doi: 10.3389/fimmu.2019.00773. eCollection 2019.


Stem cell culture conditions and stability: a joint workshop of the PluriMes Consortium and Pluripotent Stem Cell Platform.

Stacey GN, Andrews PW, Barbaric I, Boiers C, Chandra A, Cossu G, Csontos L, Frith TJ, Halliwell JA, Hewitt Z, McCall M, Moore HD, Parmar M, Panico MB, Pisupati V, Shichkin VP, Stacey AR, Tedesco FS, Thompson O, Wagey R.

Regen Med. 2019 Mar;14(3):243-255. doi: 10.2217/rme-2019-0001. Epub 2019 Apr 2.


Evidence of complement activation in the thrombotic small vessels of a patient with catastrophic antiphospholipid syndrome treated with eculizumab.

Ruffatti A, Tarzia V, Fedrigo M, Calligaro A, Favaro M, Macor P, Tison T, Cucchini U, Cosmi E, Tedesco F, Angelini A, Gerosa G.

Autoimmun Rev. 2019 May;18(5):561-563. doi: 10.1016/j.autrev.2019.03.015. Epub 2019 Mar 4. No abstract available.


Combined Notch and PDGF Signaling Enhances Migration and Expression of Stem Cell Markers while Inducing Perivascular Cell Features in Muscle Satellite Cells.

Gerli MFM, Moyle LA, Benedetti S, Ferrari G, Ucuncu E, Ragazzi M, Constantinou C, Louca I, Sakai H, Ala P, De Coppi P, Tajbakhsh S, Cossu G, Tedesco FS.

Stem Cell Reports. 2019 Mar 5;12(3):461-473. doi: 10.1016/j.stemcr.2019.01.007. Epub 2019 Feb 7.


Age and Sex-Associated Changes of Complement Activity and Complement Levels in a Healthy Caucasian Population.

Gaya da Costa M, Poppelaars F, van Kooten C, Mollnes TE, Tedesco F, Würzner R, Trouw LA, Truedsson L, Daha MR, Roos A, Seelen MA.

Front Immunol. 2018 Nov 20;9:2664. doi: 10.3389/fimmu.2018.02664. eCollection 2018.


New insight into antiphospholipid syndrome: antibodies to β2glycoprotein I-domain 5 fail to induce thrombi in rats.

Durigutto P, Grossi C, Borghi MO, Macor P, Pregnolato F, Raschi E, Myers MP, de Groot PG, Meroni PL, Tedesco F.

Haematologica. 2019 Apr;104(4):819-826. doi: 10.3324/haematol.2018.198119. Epub 2018 Nov 15.


Modeling Skeletal Muscle Laminopathies Using Human Induced Pluripotent Stem Cells Carrying Pathogenic LMNA Mutations.

Steele-Stallard HB, Pinton L, Sarcar S, Ozdemir T, Maffioletti SM, Zammit PS, Tedesco FS.

Front Physiol. 2018 Oct 15;9:1332. doi: 10.3389/fphys.2018.01332. eCollection 2018.


Complement as a Biological Tool to Control Tumor Growth.

Macor P, Capolla S, Tedesco F.

Front Immunol. 2018 Sep 25;9:2203. doi: 10.3389/fimmu.2018.02203. eCollection 2018. Review.


Pathogenic Role of Complement in Antiphospholipid Syndrome and Therapeutic Implications.

Tedesco F, Borghi MO, Gerosa M, Chighizola CB, Macor P, Lonati PA, Gulino A, Belmonte B, Meroni PL.

Front Immunol. 2018 Jun 19;9:1388. doi: 10.3389/fimmu.2018.01388. eCollection 2018.


Efficient CRISPR/Cas9-mediated editing of trinucleotide repeat expansion in myotonic dystrophy patient-derived iPS and myogenic cells.

Dastidar S, Ardui S, Singh K, Majumdar D, Nair N, Fu Y, Reyon D, Samara E, Gerli MFM, Klein AF, De Schrijver W, Tipanee J, Seneca S, Tulalamba W, Wang H, Chai YC, In't Veld P, Furling D, Tedesco FS, Vermeesch JR, Joung JK, Chuah MK, VandenDriessche T.

Nucleic Acids Res. 2018 Sep 19;46(16):8275-8298. doi: 10.1093/nar/gky548.


Obstetric and vascular antiphospholipid syndrome: same antibodies but different diseases?

Meroni PL, Borghi MO, Grossi C, Chighizola CB, Durigutto P, Tedesco F.

Nat Rev Rheumatol. 2018 Jul;14(7):433-440. doi: 10.1038/s41584-018-0032-6. Review.


Three-Dimensional Human iPSC-Derived Artificial Skeletal Muscles Model Muscular Dystrophies and Enable Multilineage Tissue Engineering.

Maffioletti SM, Sarcar S, Henderson ABH, Mannhardt I, Pinton L, Moyle LA, Steele-Stallard H, Cappellari O, Wells KE, Ferrari G, Mitchell JS, Tyzack GE, Kotiadis VN, Khedr M, Ragazzi M, Wang W, Duchen MR, Patani R, Zammit PS, Wells DJ, Eschenhagen T, Tedesco FS.

Cell Rep. 2018 Apr 17;23(3):899-908. doi: 10.1016/j.celrep.2018.03.091.


Reversible immortalisation enables genetic correction of human muscle progenitors and engineering of next-generation human artificial chromosomes for Duchenne muscular dystrophy.

Benedetti S, Uno N, Hoshiya H, Ragazzi M, Ferrari G, Kazuki Y, Moyle LA, Tonlorenzi R, Lombardo A, Chaouch S, Mouly V, Moore M, Popplewell L, Kazuki K, Katoh M, Naldini L, Dickson G, Messina G, Oshimura M, Cossu G, Tedesco FS.

EMBO Mol Med. 2018 Feb;10(2):254-275. doi: 10.15252/emmm.201607284.


Complement Protein C1q Binds to Hyaluronic Acid in the Malignant Pleural Mesothelioma Microenvironment and Promotes Tumor Growth.

Agostinis C, Vidergar R, Belmonte B, Mangogna A, Amadio L, Geri P, Borelli V, Zanconati F, Tedesco F, Confalonieri M, Tripodo C, Kishore U, Bulla R.

Front Immunol. 2017 Nov 20;8:1559. doi: 10.3389/fimmu.2017.01559. eCollection 2017.


Targeted Delivery of Neutralizing Anti-C5 Antibody to Renal Endothelium Prevents Complement-Dependent Tissue Damage.

Durigutto P, Sblattero D, Biffi S, De Maso L, Garrovo C, Baj G, Colombo F, Fischetti F, Di Naro AF, Tedesco F, Macor P.

Front Immunol. 2017 Sep 6;8:1093. doi: 10.3389/fimmu.2017.01093. eCollection 2017.


Enhanced Energetic State and Protection from Oxidative Stress in Human Myoblasts Overexpressing BMI1.

Dibenedetto S, Niklison-Chirou M, Cabrera CP, Ellis M, Robson LG, Knopp P, Tedesco FS, Ragazzi M, Di Foggia V, Barnes MR, Radunovic A, Marino S.

Stem Cell Reports. 2017 Aug 8;9(2):528-542. doi: 10.1016/j.stemcr.2017.06.009. Epub 2017 Jul 20.


C1q: A fresh look upon an old molecule.

Thielens NM, Tedesco F, Bohlson SS, Gaboriaud C, Tenner AJ.

Mol Immunol. 2017 Sep;89:73-83. doi: 10.1016/j.molimm.2017.05.025. Epub 2017 Jun 7. Review.


Muscle Interstitial Cells: A Brief Field Guide to Non-satellite Cell Populations in Skeletal Muscle.

Tedesco FS, Moyle LA, Perdiguero E.

Methods Mol Biol. 2017;1556:129-147. doi: 10.1007/978-1-4939-6771-1_7. Review.


Intra-arterial transplantation of HLA-matched donor mesoangioblasts in Duchenne muscular dystrophy.

Cossu G, Previtali SC, Napolitano S, Cicalese MP, Tedesco FS, Nicastro F, Noviello M, Roostalu U, Natali Sora MG, Scarlato M, De Pellegrin M, Godi C, Giuliani S, Ciotti F, Tonlorenzi R, Lorenzetti I, Rivellini C, Benedetti S, Gatti R, Marktel S, Mazzi B, Tettamanti A, Ragazzi M, Imro MA, Marano G, Ambrosi A, Fiori R, Sormani MP, Bonini C, Venturini M, Politi LS, Torrente Y, Ciceri F.

EMBO Mol Med. 2016 Dec 1;8(12):1470-1471. doi: 10.15252/emmm.201607129. No abstract available.


Ret function in muscle stem cells points to tyrosine kinase inhibitor therapy for facioscapulohumeral muscular dystrophy.

Moyle LA, Blanc E, Jaka O, Prueller J, Banerji CR, Tedesco FS, Harridge SD, Knight RD, Zammit PS.

Elife. 2016 Nov 14;5. pii: e11405. doi: 10.7554/eLife.11405.


Tibialis anterior muscle herniation with superficial peroneal nerve involvement: Ultrasound role for diagnosis and treatment.

Paolasso I, Cambise C, Coraci D, Del Tedesco FM, Erra C, Fernandez E, Padua L.

Clin Neurol Neurosurg. 2016 Dec;151:6-8. doi: 10.1016/j.clineuro.2016.09.019. Epub 2016 Oct 6.


Alternative functions of the complement protein C1q at embryo implantation site.

Agostinis C, Tedesco F, Bulla R.

J Reprod Immunol. 2017 Feb;119:74-80. doi: 10.1016/j.jri.2016.09.001. Epub 2016 Sep 17.


Complement component C1q as potential diagnostic but not predictive marker of preeclampsia.

Agostinis C, Stampalija T, Tannetta D, Loganes C, Vecchi Brumatti L, De Seta F, Celeghini C, Radillo O, Sargent I, Tedesco F, Bulla R.

Am J Reprod Immunol. 2016 Dec;76(6):475-481. doi: 10.1111/aji.12586. Epub 2016 Sep 26.


Skeletal Muscle Differentiation on a Chip Shows Human Donor Mesoangioblasts' Efficiency in Restoring Dystrophin in a Duchenne Muscular Dystrophy Model.

Serena E, Zatti S, Zoso A, Lo Verso F, Tedesco FS, Cossu G, Elvassore N.

Stem Cells Transl Med. 2016 Dec;5(12):1676-1683. Epub 2016 Aug 8.


Fibular nerve palsy after hip replacement: Not only surgeon responsibility. Hereditary neuropathy with liability to pressure palsies (HNPP) a rare cause of nerve liability.

Logroscino G, Del Tedesco F, Cambise C, Coraci D, Donati F, Santilli V, Padua L.

Orthop Traumatol Surg Res. 2016 Jun;102(4):529-31. doi: 10.1016/j.otsr.2016.02.013. Epub 2016 Apr 12.



Cambise C, Del Tedesco F, Fernandez E, Coraci D, Santilli V, Padua L.

Muscle Nerve. 2016 Sep;54(3):515-6. doi: 10.1002/mus.25131. Epub 2016 May 24. No abstract available.


The hallucinogenic diterpene salvinorin A inhibits leukotriene synthesis in experimental models of inflammation.

Rossi A, Pace S, Tedesco F, Pagano E, Guerra G, Troisi F, Werner M, Roviezzo F, Zjawiony JK, Werz O, Izzo AA, Capasso R.

Pharmacol Res. 2016 Apr;106:64-71. doi: 10.1016/j.phrs.2016.01.032. Epub 2016 Feb 6.


C1q acts in the tumour microenvironment as a cancer-promoting factor independently of complement activation.

Bulla R, Tripodo C, Rami D, Ling GS, Agostinis C, Guarnotta C, Zorzet S, Durigutto P, Botto M, Tedesco F.

Nat Commun. 2016 Feb 1;7:10346. doi: 10.1038/ncomms10346.


Mammalian glomus tumor: Contribution of nerve ultrasound.

Cambise C, Del Tedesco F, Fernandez E, Coraci D, Santilli V, Padua L.

Muscle Nerve. 2016 Aug;54(2):336-8. doi: 10.1002/mus.25032. Epub 2016 Feb 25. No abstract available.


piggyBac transposons expressing full-length human dystrophin enable genetic correction of dystrophic mesoangioblasts.

Loperfido M, Jarmin S, Dastidar S, Di Matteo M, Perini I, Moore M, Nair N, Samara-Kuko E, Athanasopoulos T, Tedesco FS, Dickson G, Sampaolesi M, VandenDriessche T, Chuah MK.

Nucleic Acids Res. 2016 Jan 29;44(2):744-60. doi: 10.1093/nar/gkv1464. Epub 2015 Dec 17.


Complement activation in antiphospholipid syndrome and its inhibition to prevent rethrombosis after arterial surgery.

Meroni PL, Macor P, Durigutto P, De Maso L, Gerosa M, Ferraresso M, Borghi MO, Mollnes TE, Tedesco F.

Blood. 2016 Jan 21;127(3):365-7. doi: 10.1182/blood-2015-09-672139. Epub 2015 Dec 7. No abstract available.


Critical Role and Therapeutic Control of the Lectin Pathway of Complement Activation in an Abortion-Prone Mouse Mating.

Petitbarat M, Durigutto P, Macor P, Bulla R, Palmioli A, Bernardi A, De Simoni MG, Ledee N, Chaouat G, Tedesco F.

J Immunol. 2015 Dec 15;195(12):5602-7. doi: 10.4049/jimmunol.1501361. Epub 2015 Nov 11.


Intra-arterial transplantation of HLA-matched donor mesoangioblasts in Duchenne muscular dystrophy.

Cossu G, Previtali SC, Napolitano S, Cicalese MP, Tedesco FS, Nicastro F, Noviello M, Roostalu U, Natali Sora MG, Scarlato M, De Pellegrin M, Godi C, Giuliani S, Ciotti F, Tonlorenzi R, Lorenzetti I, Rivellini C, Benedetti S, Gatti R, Marktel S, Mazzi B, Tettamanti A, Ragazzi M, Imro MA, Marano G, Ambrosi A, Fiori R, Sormani MP, Bonini C, Venturini M, Politi LS, Torrente Y, Ciceri F.

EMBO Mol Med. 2015 Dec;7(12):1513-28. doi: 10.15252/emmm.201505636. Erratum in: EMBO Mol Med. 2016 Dec 1;8(12 ):1470-1471.


Corrigendum: Efficient derivation and inducible differentiation of expandable skeletal myogenic cells from human ES and patient-specific iPS cells.

Maffioletti SM, Gerli MF, Ragazzi M, Dastidar S, Benedetti S, Loperfido M, VandenDriessche T, Chuah MK, Tedesco FS.

Nat Protoc. 2015 Sep;10(9):1457. doi: 10.1038/nprot0915-1457d. Epub 2015 Aug 27. No abstract available.


Pluripotent Stem Cells for Gene Therapy of Degenerative Muscle Diseases.

Loperfido M, Steele-Stallard HB, Tedesco FS, VandenDriessche T.

Curr Gene Ther. 2015;15(4):364-80. Review.


Efficient derivation and inducible differentiation of expandable skeletal myogenic cells from human ES and patient-specific iPS cells.

Maffioletti SM, Gerli MF, Ragazzi M, Dastidar S, Benedetti S, Loperfido M, VandenDriessche T, Chuah MK, Tedesco FS.

Nat Protoc. 2015 Jul;10(7):941-58. doi: 10.1038/nprot.2015.057. Epub 2015 Jun 4. Erratum in: Nat Protoc. 2015 Sep;10(9):1457.


European Union funded project on the development of a whole complement deficiency screening ELISA-A story of success and an exceptional manager: Mohamed R. Daha.

Würzner R, Tedesco F, Garred P, Mollnes TE, Truedsson L, Turner MW, Sommarin Y, Wieslander J, Sim RB.

Mol Immunol. 2015 Nov;68(1):63-6. doi: 10.1016/j.molimm.2015.05.003. Epub 2015 May 23. Review.


PW1/Peg3 expression regulates key properties that determine mesoangioblast stem cell competence.

Bonfanti C, Rossi G, Tedesco FS, Giannotta M, Benedetti S, Tonlorenzi R, Antonini S, Marazzi G, Dejana E, Sassoon D, Cossu G, Messina G.

Nat Commun. 2015 Mar 9;6:6364. doi: 10.1038/ncomms7364.


Human artificial chromosomes for Duchenne muscular dystrophy and beyond: challenges and hopes.

Tedesco FS.

Chromosome Res. 2015 Feb;23(1):135-41. doi: 10.1007/s10577-014-9460-6. Review.


Stem cell transplantation for muscular dystrophy: the challenge of immune response.

Maffioletti SM, Noviello M, English K, Tedesco FS.

Biomed Res Int. 2014;2014:964010. doi: 10.1155/2014/964010. Epub 2014 Jun 26. Review.


Dynamics of complement activation in aHUS and how to monitor eculizumab therapy.

Noris M, Galbusera M, Gastoldi S, Macor P, Banterla F, Bresin E, Tripodo C, Bettoni S, Donadelli R, Valoti E, Tedesco F, Amore A, Coppo R, Ruggenenti P, Gotti E, Remuzzi G.

Blood. 2014 Sep 11;124(11):1715-26. doi: 10.1182/blood-2014-02-558296. Epub 2014 Jul 18.


Bispecific antibodies targeting tumor-associated antigens and neutralizing complement regulators increase the efficacy of antibody-based immunotherapy in mice.

Macor P, Secco E, Mezzaroba N, Zorzet S, Durigutto P, Gaiotto T, De Maso L, Biffi S, Garrovo C, Capolla S, Tripodo C, Gattei V, Marzari R, Tedesco F, Sblattero D.

Leukemia. 2015 Feb;29(2):406-14. doi: 10.1038/leu.2014.185. Epub 2014 Jun 6.


Inflammation converts human mesoangioblasts into targets of alloreactive immune responses: implications for allogeneic cell therapy of DMD.

Noviello M, Tedesco FS, Bondanza A, Tonlorenzi R, Rosaria Carbone M, Gerli MFM, Marktel S, Napolitano S, Cicalese MP, Ciceri F, Peretti G, Cossu G, Bonini C.

Mol Ther. 2014 Jul;22(7):1342-1352. doi: 10.1038/mt.2014.62. Epub 2014 Apr 16.


A non-complement-fixing antibody to β2 glycoprotein I as a novel therapy for antiphospholipid syndrome.

Agostinis C, Durigutto P, Sblattero D, Borghi MO, Grossi C, Guida F, Bulla R, Macor P, Pregnolato F, Meroni PL, Tedesco F.

Blood. 2014 May 29;123(22):3478-87. doi: 10.1182/blood-2013-11-537704. Epub 2014 Mar 18.


C1q as a unique player in angiogenesis with therapeutic implication in wound healing.

Bossi F, Tripodo C, Rizzi L, Bulla R, Agostinis C, Guarnotta C, Munaut C, Baldassarre G, Papa G, Zorzet S, Ghebrehiwet B, Ling GS, Botto M, Tedesco F.

Proc Natl Acad Sci U S A. 2014 Mar 18;111(11):4209-14. doi: 10.1073/pnas.1311968111. Epub 2014 Mar 3.


Transplantation of induced pluripotent stem cell-derived mesoangioblast-like myogenic progenitors in mouse models of muscle regeneration.

Gerli MF, Maffioletti SM, Millet Q, Tedesco FS.

J Vis Exp. 2014 Jan 20;(83):e50532. doi: 10.3791/50532.


Targeting endothelial junctional adhesion molecule-A/ EPAC/ Rap-1 axis as a novel strategy to increase stem cell engraftment in dystrophic muscles.

Giannotta M, Benedetti S, Tedesco FS, Corada M, Trani M, D'Antuono R, Millet Q, Orsenigo F, Gálvez BG, Cossu G, Dejana E.

EMBO Mol Med. 2014 Feb;6(2):239-58. doi: 10.1002/emmm.201302520. Epub 2013 Dec 30.

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