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Cholinergic synapse pathway gene polymorphisms associated with allergen-induced late asthmatic responses.

Rajasekaran A, He D, Yue A, Singh A, Shannon CP, FitzGerald JM, Boulet LP, O'Byrne PM, Gauvreau GM, Tebbutt SJ.

ERJ Open Res. 2019 Nov 4;5(4). pii: 00107-2019. doi: 10.1183/23120541.00107-2019. eCollection 2019 Oct.


Proteomic Profiling to Identify Blood Biomarkers Predictive of Response to Azithromycin in Children and Adolescents With Cystic Fibrosis.

Dong K, Singh A, Ng RT, Sin DD, Tebbutt SJ, Ratjen F, Quon BS.

Chest. 2019 Oct;156(4):667-673. doi: 10.1016/j.chest.2019.05.017. Epub 2019 Jun 12.


Blood biomarkers to predict short-term pulmonary exacerbation risk in children and adolescents with CF: A pilot study.

Singh A, He M, Chen V, Hollander Z, Tebbutt SJ, Ng RT, McManus BM, Sin DD, Ratjen F, Quon BS.

J Cyst Fibros. 2019 Jun 5. pii: S1569-1993(19)30774-X. doi: 10.1016/j.jcf.2019.05.020. [Epub ahead of print]


Dynamic molecular changes during the first week of human life follow a robust developmental trajectory.

Lee AH, Shannon CP, Amenyogbe N, Bennike TB, Diray-Arce J, Idoko OT, Gill EE, Ben-Othman R, Pomat WS, van Haren SD, Cao KL, Cox M, Darboe A, Falsafi R, Ferrari D, Harbeson DJ, He D, Bing C, Hinshaw SJ, Ndure J, Njie-Jobe J, Pettengill MA, Richmond PC, Ford R, Saleu G, Masiria G, Matlam JP, Kirarock W, Roberts E, Malek M, Sanchez-Schmitz G, Singh A, Angelidou A, Smolen KK; EPIC Consortium, Brinkman RR, Ozonoff A, Hancock REW, van den Biggelaar AHJ, Steen H, Tebbutt SJ, Kampmann B, Levy O, Kollmann TR.

Nat Commun. 2019 Mar 12;10(1):1092. doi: 10.1038/s41467-019-08794-x.


Phagocytosis of Aspergillus fumigatus by Human Bronchial Epithelial Cells Is Mediated by the Arp2/3 Complex and WIPF2.

Culibrk L, Croft CA, Toor A, Yang SJ, Singhera GK, Dorscheid DR, Moore MM, Tebbutt SJ.

Front Cell Infect Microbiol. 2019 Feb 7;9:16. doi: 10.3389/fcimb.2019.00016. eCollection 2019.


Treg gene signatures predict and measure type 1 diabetes trajectory.

Pesenacker AM, Chen V, Gillies J, Speake C, Marwaha AK, Sun A, Chow S, Tan R, Elliott T, Dutz JP, Tebbutt SJ, Levings MK.

JCI Insight. 2019 Mar 21;4(6). pii: 123879. doi: 10.1172/jci.insight.123879. eCollection 2019 Mar 21.


DIABLO: an integrative approach for identifying key molecular drivers from multi-omics assays.

Singh A, Shannon CP, Gautier B, Rohart F, Vacher M, Tebbutt SJ, Lê Cao KA.

Bioinformatics. 2019 Sep 1;35(17):3055-3062. doi: 10.1093/bioinformatics/bty1054.


Transcriptomic and proteomic host response to Aspergillus fumigatus conidia in an air-liquid interface model of human bronchial epithelium.

Toor A, Culibrk L, Singhera GK, Moon KM, Prudova A, Foster LJ, Moore MM, Dorscheid DR, Tebbutt SJ.

PLoS One. 2018 Dec 27;13(12):e0209652. doi: 10.1371/journal.pone.0209652. eCollection 2018.


The effect of low and high-intensity cycling in diesel exhaust on flow-mediated dilation, circulating NOx, endothelin-1 and blood pressure.

Giles LV, Tebbutt SJ, Carlsten C, Koehle MS.

PLoS One. 2018 Feb 21;13(2):e0192419. doi: 10.1371/journal.pone.0192419. eCollection 2018.


A Bloody Primer: Analysis of RNA-Seq from Tissue Admixtures.

Shannon CP, Yang CX, Tebbutt SJ.

Methods Mol Biol. 2018;1712:175-201. doi: 10.1007/978-1-4939-7514-3_12.


Immunological Serum Protein Profiles for Noninvasive Detection of Acute Cellular Rejection After Heart Transplantation.

Sukma Dewi I, Gidlöf O, Hollander Z, Lam KK, Benson MD, Braun OO, Nilsson J, Tebbutt SJ, Ng RT, Öhman J, McManus BM, Smith JG.

J Am Coll Cardiol. 2017 Dec 12;70(23):2946-2947. doi: 10.1016/j.jacc.2017.10.012. No abstract available.


Multiple reaction monitoring mass spectrometry to identify novel plasma protein biomarkers of treatment response in cystic fibrosis pulmonary exacerbations.

Roberts JM, Dai DLY, Hollander Z, Ng RT, Tebbutt SJ, Wilcox PG, Sin DD, Quon BS.

J Cyst Fibros. 2018 May;17(3):333-340. doi: 10.1016/j.jcf.2017.10.013. Epub 2017 Nov 22.


Novel Blood-based Transcriptional Biomarker Panels Predict the Late-Phase Asthmatic Response.

Singh A, Shannon CP, Kim YW, Yang CX, Balshaw R, Cohen Freue GV, Gauvreau GM, FitzGerald JM, Boulet LP, O'Byrne PM, Tebbutt SJ.

Am J Respir Crit Care Med. 2018 Feb 15;197(4):450-462. doi: 10.1164/rccm.201701-0110OC.


Investigating Immune Gene Signatures in Peripheral Blood from Subjects with Allergic Rhinitis Undergoing Nasal Allergen Challenge.

Kim YW, Singh A, Shannon CP, Thiele J, Steacy LM, Ellis AK, Neighbour H, Gliddon DR, Hickey PLC, Larché M, Tebbutt SJ.

J Immunol. 2017 Nov 15;199(10):3395-3405. doi: 10.4049/jimmunol.1700378. Epub 2017 Oct 18.


Differentiating heart failure phenotypes using sex-specific transcriptomic and proteomic biomarker panels.

Toma M, Mak GJ, Chen V, Hollander Z, Shannon CP, Lam KKY, Ng RT, Tebbutt SJ, Wilson-McManus JE, Ignaszewski A, Anderson T, Dyck JRB, Howlett J, Ezekowitz J, McManus BM, Oudit GY.

ESC Heart Fail. 2017 Aug;4(3):301-311. doi: 10.1002/ehf2.12136. Epub 2017 Mar 4.


Diagnosis of Western Red Cedar Asthma Using a Blood-based Gene Expression Biomarker Panel.

Yang CX, Singh A, Kim YW, Conway EM, Carlsten C, Tebbutt SJ.

Am J Respir Crit Care Med. 2017 Dec 15;196(12):1615-1617. doi: 10.1164/rccm.201608-1740LE. No abstract available.


Angiopoietin-like 4 Enhances the Proliferation and Migration of Tendon Fibroblasts.

Jamil S, Mousavizadeh R, Roshan-Moniri M, Tebbutt SJ, McCormack RG, Duronio V, Scott A.

Med Sci Sports Exerc. 2017 Sep;49(9):1769-1777. doi: 10.1249/MSS.0000000000001294.


Association of Serum MiR-142-3p and MiR-101-3p Levels with Acute Cellular Rejection after Heart Transplantation.

Sukma Dewi I, Hollander Z, Lam KK, McManus JW, Tebbutt SJ, Ng RT, Keown PA, McMaster RW, McManus BM, Gidlöf O, Öhman J.

PLoS One. 2017 Jan 26;12(1):e0170842. doi: 10.1371/journal.pone.0170842. eCollection 2017.


Enumerateblood - an R package to estimate the cellular composition of whole blood from Affymetrix Gene ST gene expression profiles.

Shannon CP, Balshaw R, Chen V, Hollander Z, Toma M, McManus BM, FitzGerald JM, Sin DD, Ng RT, Tebbutt SJ.

BMC Genomics. 2017 Jan 6;18(1):43. doi: 10.1186/s12864-016-3460-1.


SABRE: a method for assessing the stability of gene modules in complex tissues and subject populations.

Shannon CP, Chen V, Takhar M, Hollander Z, Balshaw R, McManus BM, Tebbutt SJ, Sin DD, Ng RT.

BMC Bioinformatics. 2016 Nov 14;17(1):460.


COPD Exacerbation Biomarkers Validated Using Multiple Reaction Monitoring Mass Spectrometry.

Leung JM, Chen V, Hollander Z, Dai D, Tebbutt SJ, Aaron SD, Vandemheen KL, Rennard SI, FitzGerald JM, Woodruff PG, Lazarus SC, Connett JE, Coxson HO, Miller B, Borchers C, McManus BM, Ng RT, Sin DD.

PLoS One. 2016 Aug 15;11(8):e0161129. doi: 10.1371/journal.pone.0161129. eCollection 2016.


Controlled diesel exhaust and allergen coexposure modulates microRNA and gene expression in humans: Effects on inflammatory lung markers.

Rider CF, Yamamoto M, Günther OP, Hirota JA, Singh A, Tebbutt SJ, Carlsten C.

J Allergy Clin Immunol. 2016 Dec;138(6):1690-1700. doi: 10.1016/j.jaci.2016.02.038. Epub 2016 Apr 24.


The Effect of Different Case Definitions of Current Smoking on the Discovery of Smoking-Related Blood Gene Expression Signatures in Chronic Obstructive Pulmonary Disease.

Obeidat M, Ding X, Fishbane N, Hollander Z, Ng RT, McManus B, Tebbutt SJ, Miller BE, Rennard S, Paré PD, Sin DD.

Nicotine Tob Res. 2016 Sep;18(9):1903-9. doi: 10.1093/ntr/ntw129. Epub 2016 May 6.


Interactions of Aspergillus fumigatus Conidia with Airway Epithelial Cells: A Critical Review.

Croft CA, Culibrk L, Moore MM, Tebbutt SJ.

Front Microbiol. 2016 Apr 7;7:472. doi: 10.3389/fmicb.2016.00472. eCollection 2016. Review.


Identifying Molecular Mechanisms of the Late-Phase Asthmatic Response by Integrating Cellular, Gene, and Metabolite Levels in Blood.

Singh A, Shannon CP, Kim YW, DeMarco ML, Gauvreau GM, FitzGerald JM, Boulet LP, O'Byrne PM, Le Cao KA, Tebbutt SJ.

Ann Am Thorac Soc. 2016 Mar;13 Suppl 1:S98. doi: 10.1513/AnnalsATS.201510-694MG.


Systems Biology Approaches for Host-Fungal Interactions: An Expanding Multi-Omics Frontier.

Culibrk L, Croft CA, Tebbutt SJ.

OMICS. 2016 Mar;20(3):127-38. doi: 10.1089/omi.2015.0185. Epub 2016 Feb 17. Review.


A Regulatory T-Cell Gene Signature Is a Specific and Sensitive Biomarker to Identify Children With New-Onset Type 1 Diabetes.

Pesenacker AM, Wang AY, Singh A, Gillies J, Kim Y, Piccirillo CA, Nguyen D, Haining WN, Tebbutt SJ, Panagiotopoulos C, Levings MK.

Diabetes. 2016 Apr;65(4):1031-9. doi: 10.2337/db15-0572. Epub 2016 Jan 19.


Impact of Statins on Gene Expression in Human Lung Tissues.

Lane J, van Eeden SF, Obeidat M, Sin DD, Tebbutt SJ, Timens W, Postma DS, Laviolette M, Paré PD, Bossé Y.

PLoS One. 2015 Nov 4;10(11):e0142037. doi: 10.1371/journal.pone.0142037. eCollection 2015.


The Effect of Statins on Blood Gene Expression in COPD.

Obeidat M, Fishbane N, Nie Y, Chen V, Hollander Z, Tebbutt SJ, Bossé Y, Ng RT, Miller BE, McManus B, Rennard S, Paré PD, Sin DD.

PLoS One. 2015 Oct 13;10(10):e0140022. doi: 10.1371/journal.pone.0140022. eCollection 2015.


Discovery of novel plasma protein biomarkers to predict imminent cystic fibrosis pulmonary exacerbations using multiple reaction monitoring mass spectrometry.

Quon BS, Dai DL, Hollander Z, Ng RT, Tebbutt SJ, Man SF, Wilcox PG, Sin DD.

Thorax. 2016 Mar;71(3):216-22. doi: 10.1136/thoraxjnl-2014-206710. Epub 2015 Mar 16.


Serum proteomics in multiple sclerosis disease progression.

Tremlett H, Dai DL, Hollander Z, Kapanen A, Aziz T, Wilson-McManus JE, Tebbutt SJ, Borchers CH, Oger J, Cohen Freue GV.

J Proteomics. 2015 Apr 6;118:2-11. doi: 10.1016/j.jprot.2015.02.018. Epub 2015 Mar 6.


Granzyme B mediates both direct and indirect cleavage of extracellular matrix in skin after chronic low-dose ultraviolet light irradiation.

Parkinson LG, Toro A, Zhao H, Brown K, Tebbutt SJ, Granville DJ.

Aging Cell. 2015 Feb;14(1):67-77. doi: 10.1111/acel.12298. Epub 2014 Dec 11.


Novel multivariate methods for integration of genomics and proteomics data: applications in a kidney transplant rejection study.

Günther OP, Shin H, Ng RT, McMaster WR, McManus BM, Keown PA, Tebbutt SJ, Lê Cao KA.

OMICS. 2014 Nov;18(11):682-95. doi: 10.1089/omi.2014.0062.


Th17/Treg ratio derived using DNA methylation analysis is associated with the late phase asthmatic response.

Singh A, Yamamoto M, Ruan J, Choi JY, Gauvreau GM, Olek S, Hoffmueller U, Carlsten C, FitzGerald JM, Boulet LP, O'Byrne PM, Tebbutt SJ.

Allergy Asthma Clin Immunol. 2014 Jun 24;10(1):32. doi: 10.1186/1710-1492-10-32. eCollection 2014.


Two-stage, in silico deconvolution of the lymphocyte compartment of the peripheral whole blood transcriptome in the context of acute kidney allograft rejection.

Shannon CP, Balshaw R, Ng RT, Wilson-McManus JE, Keown P, McMaster R, McManus BM, Landsberg D, Isbel NM, Knoll G, Tebbutt SJ.

PLoS One. 2014 Apr 14;9(4):e95224. doi: 10.1371/journal.pone.0095224. eCollection 2014.


Variation in RNA-Seq transcriptome profiles of peripheral whole blood from healthy individuals with and without globin depletion.

Shin H, Shannon CP, Fishbane N, Ruan J, Zhou M, Balshaw R, Wilson-McManus JE, Ng RT, McManus BM, Tebbutt SJ; PROOF Centre of Excellence Team.

PLoS One. 2014 Mar 7;9(3):e91041. doi: 10.1371/journal.pone.0091041. eCollection 2014.


Proteomic biomarkers of recovered heart function.

Hollander Z, Lazárová M, Lam KK, Ignaszewski A, Oudit GY, Dyck JR, Schreiner G, Pauwels J, Chen V, Cohen Freue GV, Ng RT, Wilson-McManus JE, Balshaw R, Tebbutt SJ, McMaster RW, Keown PA, McManus BM; NCE CECR PROOF Prevention of Organ Failure (PROOF) Centre of Excellence.

Eur J Heart Fail. 2014 May;16(5):551-9. doi: 10.1002/ejhf.65. Epub 2014 Feb 23.


Longitudinal analysis of whole blood transcriptomes to explore molecular signatures associated with acute renal allograft rejection.

Shin H, Günther O, Hollander Z, Wilson-McManus JE, Ng RT, Balshaw R, Keown PA, McMaster R, McManus BM, Isbel NM, Knoll G, Tebbutt SJ.

Bioinform Biol Insights. 2014 Jan 22;8:17-33. doi: 10.4137/BBI.S13376.. eCollection 2014.


Gene-metabolite expression in blood can discriminate allergen-induced isolated early from dual asthmatic responses.

Singh A, Yamamoto M, Kam SH, Ruan J, Gauvreau GM, O'Byrne PM, FitzGerald JM, Schellenberg R, Boulet LP, Wojewodka G, Kanagaratham C, De Sanctis JB, Radzioch D, Tebbutt SJ.

PLoS One. 2013 Jul 2;8(7):e67907. doi: 10.1371/journal.pone.0067907. Print 2013.


MicroRNA expression in response to controlled exposure to diesel exhaust: attenuation by the antioxidant N-acetylcysteine in a randomized crossover study.

Yamamoto M, Singh A, Sava F, Pui M, Tebbutt SJ, Carlsten C.

Environ Health Perspect. 2013 Jun;121(6):670-5. doi: 10.1289/ehp.1205963. Epub 2013 Apr 12.


Association of common single-nucleotide polymorphisms in innate immune genes with differences in TLR-induced cytokine production in neonates.

Cho P, Gelinas L, Corbett NP, Tebbutt SJ, Turvey SE, Fortuno ES 3rd, Kollmann TR.

Genes Immun. 2013 Jun;14(4):199-211. doi: 10.1038/gene.2013.5. Epub 2013 Mar 7.


Predicting acute cardiac rejection from donor heart and pre-transplant recipient blood gene expression.

Hollander Z, Chen V, Sidhu K, Lin D, Ng RT, Balshaw R, Cohen-Freue GV, Ignaszewski A, Imai C, Kaan A, Tebbutt SJ, Wilson-McManus JE, McMaster RW, Keown PA, McManus BM; NCE CECR PROOF Centre of Excellence.

J Heart Lung Transplant. 2013 Feb;32(2):259-65. doi: 10.1016/j.healun.2012.11.008. Epub 2012 Dec 21.


A computational pipeline for the development of multi-marker bio-signature panels and ensemble classifiers.

Günther OP, Chen V, Freue GC, Balshaw RF, Tebbutt SJ, Hollander Z, Takhar M, McMaster WR, McManus BM, Keown PA, Ng RT.

BMC Bioinformatics. 2012 Dec 8;13:326. doi: 10.1186/1471-2105-13-326.


Decreased miR-192 expression in peripheral blood of asthmatic individuals undergoing an allergen inhalation challenge.

Yamamoto M, Singh A, Ruan J, Gauvreau GM, O'Byrne PM, Carlsten CR, FitzGerald JM, Boulet LP, Tebbutt SJ.

BMC Genomics. 2012 Nov 21;13:655. doi: 10.1186/1471-2164-13-655.


Combined polymorphisms in oxidative stress genes predict coronary artery disease and oxidative stress in coronary angiography patients.

Heslop CL, Tebbutt SJ, Podder M, Ruan J, Hill JS.

Ann Hum Genet. 2012 Nov;76(6):435-47. doi: 10.1111/j.1469-1809.2012.00731.x. Epub 2012 Sep 25.


Plasma proteomics can discriminate isolated early from dual responses in asthmatic individuals undergoing an allergen inhalation challenge.

Singh A, Cohen Freue GV, Oosthuizen JL, Kam SH, Ruan J, Takhar MK, Gauvreau GM, O'Byrne PM, Fitzgerald JM, Boulet LP, Borchers CH, Tebbutt SJ.

Proteomics Clin Appl. 2012 Oct;6(9-10):476-85. doi: 10.1002/prca.201200013.


White blood cell differentials enrich whole blood expression data in the context of acute cardiac allograft rejection.

Shannon CP, Hollander Z, Wilson-McManus J, Balshaw R, Ng RT, McMaster R, McManus BM, Keown PA, Tebbutt SJ.

Bioinform Biol Insights. 2012;6:49-61. doi: 10.4137/BBI.S9197. Epub 2012 Apr 10.


Peripheral blood gene expression changes during allergen inhalation challenge in atopic asthmatic individuals.

Kam SH, Singh A, He JQ, Ruan J, Gauvreau GM, O'Byrne PM, Fitzgerald JM, Tebbutt SJ.

J Asthma. 2012 Apr;49(3):219-26. doi: 10.3109/02770903.2011.654300. Epub 2012 Feb 9.


Transcriptional Changes of Blood Eosinophils After Methacholine Inhalation Challenge in Asthmatics.

Tebbutt SJ, He JQ, Singh A, Shannon CP, Ruan J, Carlsten C.

Genomics Insights. 2012 Jan 30;5:1-12. doi: 10.4137/GEI.S9125. eCollection 2012.


Dual organism transcriptomics of airway epithelial cells interacting with conidia of Aspergillus fumigatus.

Oosthuizen JL, Gomez P, Ruan J, Hackett TL, Moore MM, Knight DA, Tebbutt SJ.

PLoS One. 2011;6(5):e20527. doi: 10.1371/journal.pone.0020527. Epub 2011 May 31.

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