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Items: 1 to 50 of 93

1.

Senolytics decrease senescent cells in humans: Preliminary report from a clinical trial of Dasatinib plus Quercetin in individuals with diabetic kidney disease.

Hickson LJ, Langhi Prata LGP, Bobart SA, Evans TK, Giorgadze N, Hashmi SK, Herrmann SM, Jensen MD, Jia Q, Jordan KL, Kellogg TA, Khosla S, Koerber DM, Lagnado AB, Lawson DK, LeBrasseur NK, Lerman LO, McDonald KM, McKenzie TJ, Passos JF, Pignolo RJ, Pirtskhalava T, Saadiq IM, Schaefer KK, Textor SC, Victorelli SG, Volkman TL, Xue A, Wentworth MA, Wissler Gerdes EO, Zhu Y, Tchkonia T, Kirkland JL.

EBioMedicine. 2019 Sep;47:446-456. doi: 10.1016/j.ebiom.2019.08.069. Epub 2019 Sep 18.

2.

Targeting senescence improves angiogenic potential of adipose-derived mesenchymal stem cells in patients with preeclampsia.

Suvakov S, Cubro H, White WM, Butler Tobah YS, Weissgerber TL, Jordan KL, Zhu XY, Woollard JR, Chebib FT, Milic NM, Grande JP, Xu M, Tchkonia T, Kirkland JL, Lerman LO, Garovic VD.

Biol Sex Differ. 2019 Sep 14;10(1):49. doi: 10.1186/s13293-019-0263-5.

3.

The enigmatic role of growth hormone in age-related diseases, cognition, and longevity.

Colon G, Saccon T, Schneider A, Cavalcante MB, Huffman DM, Berryman D, List E, Ikeno Y, Musi N, Bartke A, Kopchick J, Kirkland JL, Tchkonia T, Masternak MM.

Geroscience. 2019 Sep 4. doi: 10.1007/s11357-019-00096-w. [Epub ahead of print] Review.

PMID:
31485887
4.

Increased renal cellular senescence in murine high-fat diet: effect of the senolytic drug quercetin.

Kim SR, Jiang K, Ogrodnik M, Chen X, Zhu XY, Lohmeier H, Ahmed L, Tang H, Tchkonia T, Hickson LJ, Kirkland JL, Lerman LO.

Transl Res. 2019 Nov;213:112-123. doi: 10.1016/j.trsl.2019.07.005. Epub 2019 Jul 15.

PMID:
31356770
5.

Senescent cell clearance by the immune system: Emerging therapeutic opportunities.

Prata LGPL, Ovsyannikova IG, Tchkonia T, Kirkland JL.

Semin Immunol. 2019 May 11:101275. doi: 10.1016/j.smim.2019.04.003. [Epub ahead of print] Review.

PMID:
31088710
6.

Obesity-Induced Cellular Senescence Drives Anxiety and Impairs Neurogenesis.

Ogrodnik M, Zhu Y, Langhi LGP, Tchkonia T, Krüger P, Fielder E, Victorelli S, Ruswhandi RA, Giorgadze N, Pirtskhalava T, Podgorni O, Enikolopov G, Johnson KO, Xu M, Inman C, Palmer AK, Schafer M, Weigl M, Ikeno Y, Burns TC, Passos JF, von Zglinicki T, Kirkland JL, Jurk D.

Cell Metab. 2019 May 7;29(5):1233. doi: 10.1016/j.cmet.2019.01.013. No abstract available.

7.

The NADase CD38 is induced by factors secreted from senescent cells providing a potential link between senescence and age-related cellular NAD+ decline.

Chini C, Hogan KA, Warner GM, Tarragó MG, Peclat TR, Tchkonia T, Kirkland JL, Chini E.

Biochem Biophys Res Commun. 2019 May 28;513(2):486-493. doi: 10.1016/j.bbrc.2019.03.199. Epub 2019 Apr 8.

8.

Independent Roles of Estrogen Deficiency and Cellular Senescence in the Pathogenesis of Osteoporosis: Evidence in Young Adult Mice and Older Humans.

Farr JN, Rowsey JL, Eckhardt BA, Thicke BS, Fraser DG, Tchkonia T, Kirkland JL, Monroe DG, Khosla S.

J Bone Miner Res. 2019 Aug;34(8):1407-1418. doi: 10.1002/jbmr.3729. Epub 2019 Jun 21.

PMID:
30913313
9.

Targeting senescent cells alleviates obesity-induced metabolic dysfunction.

Palmer AK, Xu M, Zhu Y, Pirtskhalava T, Weivoda MM, Hachfeld CM, Prata LG, van Dijk TH, Verkade E, Casaclang-Verzosa G, Johnson KO, Cubro H, Doornebal EJ, Ogrodnik M, Jurk D, Jensen MD, Chini EN, Miller JD, Matveyenko A, Stout MB, Schafer MJ, White TA, Hickson LJ, Demaria M, Garovic V, Grande J, Arriaga EA, Kuipers F, von Zglinicki T, LeBrasseur NK, Campisi J, Tchkonia T, Kirkland JL.

Aging Cell. 2019 Jun;18(3):e12950. doi: 10.1111/acel.12950. Epub 2019 Mar 25.

10.

Aged-senescent cells contribute to impaired heart regeneration.

Lewis-McDougall FC, Ruchaya PJ, Domenjo-Vila E, Shin Teoh T, Prata L, Cottle BJ, Clark JE, Punjabi PP, Awad W, Torella D, Tchkonia T, Kirkland JL, Ellison-Hughes GM.

Aging Cell. 2019 Jun;18(3):e12931. doi: 10.1111/acel.12931. Epub 2019 Mar 10.

11.

Therapeutic Approaches to Aging-Reply.

Tchkonia T, Kirkland JL.

JAMA. 2019 Mar 5;321(9):901-902. doi: 10.1001/jama.2018.20554. No abstract available.

PMID:
30835305
12.

Length-independent telomere damage drives post-mitotic cardiomyocyte senescence.

Anderson R, Lagnado A, Maggiorani D, Walaszczyk A, Dookun E, Chapman J, Birch J, Salmonowicz H, Ogrodnik M, Jurk D, Proctor C, Correia-Melo C, Victorelli S, Fielder E, Berlinguer-Palmini R, Owens A, Greaves LC, Kolsky KL, Parini A, Douin-Echinard V, LeBrasseur NK, Arthur HM, Tual-Chalot S, Schafer MJ, Roos CM, Miller JD, Robertson N, Mann J, Adams PD, Tchkonia T, Kirkland JL, Mialet-Perez J, Richardson GD, Passos JF.

EMBO J. 2019 Mar 1;38(5). pii: e100492. doi: 10.15252/embj.2018100492. Epub 2019 Feb 8.

13.

Senolytics in idiopathic pulmonary fibrosis: Results from a first-in-human, open-label, pilot study.

Justice JN, Nambiar AM, Tchkonia T, LeBrasseur NK, Pascual R, Hashmi SK, Prata L, Masternak MM, Kritchevsky SB, Musi N, Kirkland JL.

EBioMedicine. 2019 Feb;40:554-563. doi: 10.1016/j.ebiom.2018.12.052. Epub 2019 Jan 5.

14.

Obesity-Induced Cellular Senescence Drives Anxiety and Impairs Neurogenesis.

Ogrodnik M, Zhu Y, Langhi LGP, Tchkonia T, Krüger P, Fielder E, Victorelli S, Ruswhandi RA, Giorgadze N, Pirtskhalava T, Podgorni O, Enikolopov G, Johnson KO, Xu M, Inman C, Palmer AK, Schafer M, Weigl M, Ikeno Y, Burns TC, Passos JF, von Zglinicki T, Kirkland JL, Jurk D.

Cell Metab. 2019 May 7;29(5):1061-1077.e8. doi: 10.1016/j.cmet.2018.12.008. Epub 2019 Jan 3. Erratum in: Cell Metab. 2019 May 7;29(5):1233.

15.

Fisetin is a senotherapeutic that extends health and lifespan.

Yousefzadeh MJ, Zhu Y, McGowan SJ, Angelini L, Fuhrmann-Stroissnigg H, Xu M, Ling YY, Melos KI, Pirtskhalava T, Inman CL, McGuckian C, Wade EA, Kato JI, Grassi D, Wentworth M, Burd CE, Arriaga EA, Ladiges WL, Tchkonia T, Kirkland JL, Robbins PD, Niedernhofer LJ.

EBioMedicine. 2018 Oct;36:18-28. doi: 10.1016/j.ebiom.2018.09.015. Epub 2018 Sep 29.

16.

Aging, Cell Senescence, and Chronic Disease: Emerging Therapeutic Strategies.

Tchkonia T, Kirkland JL.

JAMA. 2018 Oct 2;320(13):1319-1320. doi: 10.1001/jama.2018.12440. No abstract available.

PMID:
30242336
17.

Vamorolone treatment improves skeletal muscle outcome in a critical illness myopathy rat model.

Akkad H, Cacciani N, Llano-Diez M, Corpeno Kalamgi R, Tchkonia T, Kirkland JL, Larsson L.

Acta Physiol (Oxf). 2019 Feb;225(2):e13172. doi: 10.1111/apha.13172. Epub 2018 Sep 6.

PMID:
30120816
18.

The murine dialysis fistula model exhibits a senescence phenotype: pathobiological mechanisms and therapeutic potential.

Nath KA, O'Brien DR, Croatt AJ, Grande JP, Ackerman AW, Nath MC, Yamada S, Terzic A, Tchkonia T, Kirkland JL, Katusic ZS.

Am J Physiol Renal Physiol. 2018 Nov 1;315(5):F1493-F1499. doi: 10.1152/ajprenal.00308.2018. Epub 2018 Jul 18.

19.

Senolytics improve physical function and increase lifespan in old age.

Xu M, Pirtskhalava T, Farr JN, Weigand BM, Palmer AK, Weivoda MM, Inman CL, Ogrodnik MB, Hachfeld CM, Fraser DG, Onken JL, Johnson KO, Verzosa GC, Langhi LGP, Weigl M, Giorgadze N, LeBrasseur NK, Miller JD, Jurk D, Singh RJ, Allison DB, Ejima K, Hubbard GB, Ikeno Y, Cubro H, Garovic VD, Hou X, Weroha SJ, Robbins PD, Niedernhofer LJ, Khosla S, Tchkonia T, Kirkland JL.

Nat Med. 2018 Aug;24(8):1246-1256. doi: 10.1038/s41591-018-0092-9. Epub 2018 Jul 9.

20.

Premature Physiologic Aging as a Paradigm for Understanding Increased Risk of Adverse Health Across the Lifespan of Survivors of Childhood Cancer.

Ness KK, Kirkland JL, Gramatges MM, Wang Z, Kundu M, McCastlain K, Li-Harms X, Zhang J, Tchkonia T, Pluijm SMF, Armstrong GT.

J Clin Oncol. 2018 Jul 20;36(21):2206-2215. doi: 10.1200/JCO.2017.76.7467. Epub 2018 Jun 6. Review.

21.

Biology of premature ageing in survivors of cancer.

Cupit-Link MC, Kirkland JL, Ness KK, Armstrong GT, Tchkonia T, LeBrasseur NK, Armenian SH, Ruddy KJ, Hashmi SK.

ESMO Open. 2017 Dec 18;2(5):e000250. doi: 10.1136/esmoopen-2017-000250. eCollection 2017. Review.

22.

TNFα-senescence initiates a STAT-dependent positive feedback loop, leading to a sustained interferon signature, DNA damage, and cytokine secretion.

Kandhaya-Pillai R, Miro-Mur F, Alijotas-Reig J, Tchkonia T, Kirkland JL, Schwartz S.

Aging (Albany NY). 2017 Nov 22;9(11):2411-2435. doi: 10.18632/aging.101328.

23.

Corrigendum: Targeting cellular senescence prevents age-related bone loss in mice.

Farr JN, Xu M, Weivoda MM, Monroe DG, Fraser DG, Onken JL, Negley BA, Sfeir JG, Ogrodnik MB, Hachfeld CM, LeBrasseur NK, Drake MT, Pignolo RJ, Pirtskhalava T, Tchkonia T, Oursler MJ, Kirkland JL, Khosla S.

Nat Med. 2017 Nov 7;23(11):1384. doi: 10.1038/nm1117-1384c.

PMID:
29117174
24.

Muscle-specific differences in expression and phosphorylation of the Janus kinase 2/Signal Transducer and Activator of Transcription 3 following long-term mechanical ventilation and immobilization in rats.

Salah H, Fury W, Gromada J, Bai Y, Tchkonia T, Kirkland JL, Larsson L.

Acta Physiol (Oxf). 2018 Mar;222(3). doi: 10.1111/apha.12980. Epub 2017 Oct 30.

PMID:
29032602
25.

Identification of HSP90 inhibitors as a novel class of senolytics.

Fuhrmann-Stroissnigg H, Ling YY, Zhao J, McGowan SJ, Zhu Y, Brooks RW, Grassi D, Gregg SQ, Stripay JL, Dorronsoro A, Corbo L, Tang P, Bukata C, Ring N, Giacca M, Li X, Tchkonia T, Kirkland JL, Niedernhofer LJ, Robbins PD.

Nat Commun. 2017 Sep 4;8(1):422. doi: 10.1038/s41467-017-00314-z.

26.

The Clinical Potential of Senolytic Drugs.

Kirkland JL, Tchkonia T, Zhu Y, Niedernhofer LJ, Robbins PD.

J Am Geriatr Soc. 2017 Oct;65(10):2297-2301. doi: 10.1111/jgs.14969. Epub 2017 Sep 4.

27.

Targeting cellular senescence prevents age-related bone loss in mice.

Farr JN, Xu M, Weivoda MM, Monroe DG, Fraser DG, Onken JL, Negley BA, Sfeir JG, Ogrodnik MB, Hachfeld CM, LeBrasseur NK, Drake MT, Pignolo RJ, Pirtskhalava T, Tchkonia T, Oursler MJ, Kirkland JL, Khosla S.

Nat Med. 2017 Sep;23(9):1072-1079. doi: 10.1038/nm.4385. Epub 2017 Aug 21. Erratum in: Nat Med. 2017 Nov 7;23 (11):1384.

28.

Targeting senescent cholangiocytes and activated fibroblasts with B-cell lymphoma-extra large inhibitors ameliorates fibrosis in multidrug resistance 2 gene knockout (Mdr2-/- ) mice.

Moncsek A, Al-Suraih MS, Trussoni CE, O'Hara SP, Splinter PL, Zuber C, Patsenker E, Valli PV, Fingas CD, Weber A, Zhu Y, Tchkonia T, Kirkland JL, Gores GJ, Müllhaupt B, LaRusso NF, Mertens JC.

Hepatology. 2018 Jan;67(1):247-259. doi: 10.1002/hep.29464. Epub 2017 Nov 29.

29.

Cellular Senescence Biomarker p16INK4a+ Cell Burden in Thigh Adipose is Associated With Poor Physical Function in Older Women.

Justice JN, Gregory H, Tchkonia T, LeBrasseur NK, Kirkland JL, Kritchevsky SB, Nicklas BJ.

J Gerontol A Biol Sci Med Sci. 2018 Jun 14;73(7):939-945. doi: 10.1093/gerona/glx134.

30.

Cellular senescence drives age-dependent hepatic steatosis.

Ogrodnik M, Miwa S, Tchkonia T, Tiniakos D, Wilson CL, Lahat A, Day CP, Burt A, Palmer A, Anstee QM, Grellscheid SN, Hoeijmakers JHJ, Barnhoorn S, Mann DA, Bird TG, Vermeij WP, Kirkland JL, Passos JF, von Zglinicki T, Jurk D.

Nat Commun. 2017 Jun 13;8:15691. doi: 10.1038/ncomms15691.

31.

Cellular Senescence: A Translational Perspective.

Kirkland JL, Tchkonia T.

EBioMedicine. 2017 Jul;21:21-28. doi: 10.1016/j.ebiom.2017.04.013. Epub 2017 Apr 12. Review.

32.

New agents that target senescent cells: the flavone, fisetin, and the BCL-XL inhibitors, A1331852 and A1155463.

Zhu Y, Doornebal EJ, Pirtskhalava T, Giorgadze N, Wentworth M, Fuhrmann-Stroissnigg H, Niedernhofer LJ, Robbins PD, Tchkonia T, Kirkland JL.

Aging (Albany NY). 2017 Mar 8;9(3):955-963. doi: 10.18632/aging.101202.

33.

Cellular senescence mediates fibrotic pulmonary disease.

Schafer MJ, White TA, Iijima K, Haak AJ, Ligresti G, Atkinson EJ, Oberg AL, Birch J, Salmonowicz H, Zhu Y, Mazula DL, Brooks RW, Fuhrmann-Stroissnigg H, Pirtskhalava T, Prakash YS, Tchkonia T, Robbins PD, Aubry MC, Passos JF, Kirkland JL, Tschumperlin DJ, Kita H, LeBrasseur NK.

Nat Commun. 2017 Feb 23;8:14532. doi: 10.1038/ncomms14532.

34.

Effect of Low-Dose Rapamycin on Senescence Markers and Physical Functioning in Older Adults with Coronary Artery Disease: Results of a Pilot Study.

Singh M, Jensen MD, Lerman A, Kushwaha S, Rihal CS, Gersh BJ, Behfar A, Tchkonia T, Thomas RJ, Lennon RJ, Keenan LR, Moore AG, Kirkland JL.

J Frailty Aging. 2016;5(4):204-207.

PMID:
27883166
35.

Identification of Senescent Cells in the Bone Microenvironment.

Farr JN, Fraser DG, Wang H, Jaehn K, Ogrodnik MB, Weivoda MM, Drake MT, Tchkonia T, LeBrasseur NK, Kirkland JL, Bonewald LF, Pignolo RJ, Monroe DG, Khosla S.

J Bone Miner Res. 2016 Nov;31(11):1920-1929. doi: 10.1002/jbmr.2892. Epub 2016 Oct 24.

36.

Transplanted Senescent Cells Induce an Osteoarthritis-Like Condition in Mice.

Xu M, Bradley EW, Weivoda MM, Hwang SM, Pirtskhalava T, Decklever T, Curran GL, Ogrodnik M, Jurk D, Johnson KO, Lowe V, Tchkonia T, Westendorf JJ, Kirkland JL.

J Gerontol A Biol Sci Med Sci. 2017 Jun 1;72(6):780-785. doi: 10.1093/gerona/glw154.

37.

Histone deacetylase 3 supports endochondral bone formation by controlling cytokine signaling and matrix remodeling.

Carpio LR, Bradley EW, McGee-Lawrence ME, Weivoda MM, Poston DD, Dudakovic A, Xu M, Tchkonia T, Kirkland JL, van Wijnen AJ, Oursler MJ, Westendorf JJ.

Sci Signal. 2016 Aug 9;9(440):ra79. doi: 10.1126/scisignal.aaf3273.

38.

Perspective: Targeting the JAK/STAT pathway to fight age-related dysfunction.

Xu M, Tchkonia T, Kirkland JL.

Pharmacol Res. 2016 Sep;111:152-154. doi: 10.1016/j.phrs.2016.05.015. Epub 2016 May 27. Review.

39.

Exercise Prevents Diet-Induced Cellular Senescence in Adipose Tissue.

Schafer MJ, White TA, Evans G, Tonne JM, Verzosa GC, Stout MB, Mazula DL, Palmer AK, Baker DJ, Jensen MD, Torbenson MS, Miller JD, Ikeda Y, Tchkonia T, van Deursen JM, Kirkland JL, LeBrasseur NK.

Diabetes. 2016 Jun;65(6):1606-15. doi: 10.2337/db15-0291. Epub 2016 Mar 16.

40.

Chronic senolytic treatment alleviates established vasomotor dysfunction in aged or atherosclerotic mice.

Roos CM, Zhang B, Palmer AK, Ogrodnik MB, Pirtskhalava T, Thalji NM, Hagler M, Jurk D, Smith LA, Casaclang-Verzosa G, Zhu Y, Schafer MJ, Tchkonia T, Kirkland JL, Miller JD.

Aging Cell. 2016 Oct;15(5):973-7. doi: 10.1111/acel.12458. Epub 2016 Aug 5.

41.

17α-Estradiol Alleviates Age-related Metabolic and Inflammatory Dysfunction in Male Mice Without Inducing Feminization.

Stout MB, Steyn FJ, Jurczak MJ, Camporez JG, Zhu Y, Hawse JR, Jurk D, Palmer AK, Xu M, Pirtskhalava T, Evans GL, de Souza Santos R, Frank AP, White TA, Monroe DG, Singh RJ, Casaclang-Verzosa G, Miller JD, Clegg DJ, LeBrasseur NK, von Zglinicki T, Shulman GI, Tchkonia T, Kirkland JL.

J Gerontol A Biol Sci Med Sci. 2017 Jan;72(1):3-15. Epub 2016 Jan 24.

42.

Identification of a novel senolytic agent, navitoclax, targeting the Bcl-2 family of anti-apoptotic factors.

Zhu Y, Tchkonia T, Fuhrmann-Stroissnigg H, Dai HM, Ling YY, Stout MB, Pirtskhalava T, Giorgadze N, Johnson KO, Giles CB, Wren JD, Niedernhofer LJ, Robbins PD, Kirkland JL.

Aging Cell. 2016 Jun;15(3):428-35. doi: 10.1111/acel.12445. Epub 2016 Mar 18.

43.

Targeting senescent cells enhances adipogenesis and metabolic function in old age.

Xu M, Palmer AK, Ding H, Weivoda MM, Pirtskhalava T, White TA, Sepe A, Johnson KO, Stout MB, Giorgadze N, Jensen MD, LeBrasseur NK, Tchkonia T, Kirkland JL.

Elife. 2015 Dec 19;4:e12997. doi: 10.7554/eLife.12997.

44.

JAK inhibition alleviates the cellular senescence-associated secretory phenotype and frailty in old age.

Xu M, Tchkonia T, Ding H, Ogrodnik M, Lubbers ER, Pirtskhalava T, White TA, Johnson KO, Stout MB, Mezera V, Giorgadze N, Jensen MD, LeBrasseur NK, Kirkland JL.

Proc Natl Acad Sci U S A. 2015 Nov 17;112(46):E6301-10. doi: 10.1073/pnas.1515386112. Epub 2015 Nov 2.

45.

Cellular Senescence and the Biology of Aging, Disease, and Frailty.

LeBrasseur NK, Tchkonia T, Kirkland JL.

Nestle Nutr Inst Workshop Ser. 2015;83:11-8. doi: 10.1159/000382054. Epub 2015 Oct 20. Review.

46.

Growth Hormone Receptor Antagonist Transgenic Mice Have Increased Subcutaneous Adipose Tissue Mass, Altered Glucose Homeostasis and No Change in White Adipose Tissue Cellular Senescence.

Comisford R, Lubbers ER, Householder LA, Suer O, Tchkonia T, Kirkland JL, List EO, Kopchick JJ, Berryman DE.

Gerontology. 2016;62(2):163-72. doi: 10.1159/000439050. Epub 2015 Sep 16.

47.

Removal of growth hormone receptor (GHR) in muscle of male mice replicates some of the health benefits seen in global GHR-/- mice.

List EO, Berryman DE, Ikeno Y, Hubbard GB, Funk K, Comisford R, Young JA, Stout MB, Tchkonia T, Masternak MM, Bartke A, Kirkland JL, Miller RA, Kopchick JJ.

Aging (Albany NY). 2015 Jul;7(7):500-12.

48.

Cellular Senescence in Type 2 Diabetes: A Therapeutic Opportunity.

Palmer AK, Tchkonia T, LeBrasseur NK, Chini EN, Xu M, Kirkland JL.

Diabetes. 2015 Jul;64(7):2289-98. doi: 10.2337/db14-1820. Review.

49.

Pathogenesis of pancreatic cancer exosome-induced lipolysis in adipose tissue.

Sagar G, Sah RP, Javeed N, Dutta SK, Smyrk TC, Lau JS, Giorgadze N, Tchkonia T, Kirkland JL, Chari ST, Mukhopadhyay D.

Gut. 2016 Jul;65(7):1165-74. doi: 10.1136/gutjnl-2014-308350. Epub 2015 Apr 28.

50.

Growth hormone in adipose dysfunction and senescence.

Stout MB, Tchkonia T, Kirkland JL.

Oncotarget. 2015 May 10;6(13):10667-8. No abstract available.

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