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Items: 46


Intradermal vaccination prevents anti-MOG autoimmune encephalomyelitis in macaques.

Fovet CM, Stimmer L, Contreras V, Horellou P, Hubert A, Seddiki N, Chapon C, Tricot S, Leroy C, Flament J, Massonneau J, Tchitchek N, 't Hart BA, Zurawski S, Klucar P, Hantraye P, Deiva K, Zurawski G, Oh S, Le Grand R, Serguera C.

EBioMedicine. 2019 Sep;47:492-505. doi: 10.1016/j.ebiom.2019.08.052. Epub 2019 Sep 3.


Characterization of Leukocytes From HIV-ART Patients Using Combined Cytometric Profiles of 72 Cell Markers.

Leite Pereira A, Tchitchek N, Lambotte O, Le Grand R, Cosma A.

Front Immunol. 2019 Aug 6;10:1777. doi: 10.3389/fimmu.2019.01777. eCollection 2019.


Dynamics of Vaginal and Rectal Microbiota Over Several Menstrual Cycles in Female Cynomolgus Macaques.

Nugeyre MT, Tchitchek N, Adapen C, Cannou C, Contreras V, Benjelloun F, Ravel J, Le Grand R, Marlin R, Menu E.

Front Cell Infect Microbiol. 2019 Jun 12;9:188. doi: 10.3389/fcimb.2019.00188. eCollection 2019.


Cynomolgus macaque IL37 polymorphism and control of SIV infection.

Shiina T, Suzuki S, Congy-Jolivet N, Aarnink A, Garchon HJ, Dereuddre-Bosquet N, Vaslin B, Tchitchek N, Desjardins D, Autran B, Lambotte O, Theodorou I, Le Grand R, Blancher A.

Sci Rep. 2019 May 28;9(1):7981. doi: 10.1038/s41598-019-44235-x.


Progenitors from the central nervous system drive neurogenesis in cancer.

Mauffrey P, Tchitchek N, Barroca V, Bemelmans A, Firlej V, Allory Y, Roméo PH, Magnon C.

Nature. 2019 May;569(7758):672-678. doi: 10.1038/s41586-019-1219-y. Epub 2019 May 15.


Seminal Plasma Exposures Strengthen Vaccine Responses in the Female Reproductive Tract Mucosae.

Marlin R, Nugeyre MT, Tchitchek N, Parenti M, Lefebvre C, Hocini H, Benjelloun F, Cannou C, Nozza S, Dereuddre-Bosquet N, Levy Y, Barré-Sinoussi F, Scarlatti G, Le Grand R, Menu E.

Front Immunol. 2019 Mar 12;10:430. doi: 10.3389/fimmu.2019.00430. eCollection 2019.


CytoBackBone: an algorithm for merging of phenotypic information from different cytometric profiles.

Leite Pereira A, Lambotte O, Le Grand R, Cosma A, Tchitchek N.

Bioinformatics. 2019 Oct 15;35(20):4187-4189. doi: 10.1093/bioinformatics/btz212.


Early blood transcriptomic signature predicts patients' outcome after out-of-hospital cardiac arrest.

Tissier R, Hocini H, Tchitchek N, Deye N, Legriel S, Pichon N, Daubin C, Hermine O, Carli P, Vivien B, Tréluyer JM, Lefebvre C, Tisserand P, Dubois-Randé JL, Berdeaux A, Ghaleh B, Lelièvre JD, Levy Y, Cariou A.

Resuscitation. 2019 May;138:222-232. doi: 10.1016/j.resuscitation.2019.03.006. Epub 2019 Mar 15.


Innate gene signature distinguishes humoral versus cytotoxic responses to influenza vaccination.

Gonçalves E, Bonduelle O, Soria A, Loulergue P, Rousseau A, Cachanado M, Bonnabau H, Thiebaut R, Tchitchek N, Behillil S, van der Werf S, Vogt A, Simon T, Launay O, Combadière B.

J Clin Invest. 2019 Mar 7;129(5):1960-1971. doi: 10.1172/JCI125372. Print 2019 May 1.


NK cell immune responses differ after prime and boost vaccination.

Palgen JL, Tchitchek N, Huot N, Elhmouzi-Younes J, Lefebvre C, Rosenbaum P, Dereuddre-Bosquet N, Martinon F, Hocini H, Cosma A, Müller-Trutwin M, Lévy Y, Le Grand R, Beignon AS.

J Leukoc Biol. 2019 May;105(5):1055-1073. doi: 10.1002/JLB.4A1018-391RR. Epub 2019 Feb 22.


A high-resolution mass cytometry analysis reveals a delay of cytokines production after TLR4 or TLR7/8 engagements in HIV-1 infected humans.

Leite Pereira A, Tchitchek N, Marcos Lopez E, Lambotte O, Le Grand R, Cosma A.

Cytokine. 2018 Nov;111:97-105. doi: 10.1016/j.cyto.2018.08.018. Epub 2018 Aug 20.


Molecular and Cellular Dynamics in the Skin, the Lymph Nodes, and the Blood of the Immune Response to Intradermal Injection of Modified Vaccinia Ankara Vaccine.

Rosenbaum P, Tchitchek N, Joly C, Stimmer L, Hocini H, Dereuddre-Bosquet N, Beignon AS, Chapon C, Levy Y, Le Grand R, Martinon F.

Front Immunol. 2018 Apr 25;9:870. doi: 10.3389/fimmu.2018.00870. eCollection 2018.


Mass Cytometry Analysis Reveals the Landscape and Dynamics of CD32a+ CD4+ T Cells From Early HIV Infection to Effective cART.

Coindre S, Tchitchek N, Alaoui L, Vaslin B, Bourgeois C, Goujard C, Avettand-Fenoel V, Lecuroux C, Bruhns P, Le Grand R, Beignon AS, Lambotte O, Favier B; ANRS CO6 PRIMO Cohort.

Front Immunol. 2018 Jun 4;9:1217. doi: 10.3389/fimmu.2018.01217. eCollection 2018.


Correction: Stage-specific IFN-induced and IFN gene expression reveal convergence of type I and type II IFN and highlight their role in both acute and chronic stage of pathogenic SIV infection.

Echebli N, Tchitchek N, Dupuy S, Bruel T, Passaes C, Bosquet N, Le Grand R, Bourgeois C, Favier B, Cheynier R, Lambotte O, Vaslin B.

PLoS One. 2018 Feb 23;13(2):e0193629. doi: 10.1371/journal.pone.0193629. eCollection 2018.


Prime and Boost Vaccination Elicit a Distinct Innate Myeloid Cell Immune Response.

Palgen JL, Tchitchek N, Elhmouzi-Younes J, Delandre S, Namet I, Rosenbaum P, Dereuddre-Bosquet N, Martinon F, Cosma A, Lévy Y, Le Grand R, Beignon AS.

Sci Rep. 2018 Feb 15;8(1):3087. doi: 10.1038/s41598-018-21222-2.


Stage-specific IFN-induced and IFN gene expression reveal convergence of type I and type II IFN and highlight their role in both acute and chronic stage of pathogenic SIV infection.

Echebli N, Tchitchek N, Dupuy S, Bruel T, Peireira Bittencourt Passaes C, Bosquet N, Le Grand R, Bourgeois C, Favier B, Cheynier R, Lambotte O, Vaslin B.

PLoS One. 2018 Jan 11;13(1):e0190334. doi: 10.1371/journal.pone.0190334. eCollection 2018. Erratum in: PLoS One. 2018 Feb 23;13(2):e0193629.


Navigating in the vast and deep oceans of high-dimensional biological data.

Tchitchek N.

Methods. 2018 Jan 1;132:1-2. doi: 10.1016/j.ymeth.2017.11.009. Epub 2017 Nov 21. No abstract available.


A computational approach for phenotypic comparisons of cell populations in high-dimensional cytometry data.

Platon L, Pejoski D, Gautreau G, Targat B, Le Grand R, Beignon AS, Tchitchek N.

Methods. 2018 Jan 1;132:66-75. doi: 10.1016/j.ymeth.2017.09.005. Epub 2017 Sep 14.


Modified Vaccinia Virus Ankara Vector Induces Specific Cellular and Humoral Responses in the Female Reproductive Tract, the Main HIV Portal of Entry.

Marlin R, Nugeyre MT, Tchitchek N, Parenti M, Hocini H, Benjelloun F, Cannou C, Dereuddre-Bosquet N, Levy Y, Barré-Sinoussi F, Scarlatti G, Le Grand R, Menu E.

J Immunol. 2017 Sep 1;199(5):1923-1932. doi: 10.4049/jimmunol.1700320. Epub 2017 Jul 31.


In depth comparative phenotyping of blood innate myeloid leukocytes from healthy humans and macaques using mass cytometry.

Elhmouzi-Younes J, Palgen JL, Tchitchek N, Delandre S, Namet I, Bodinham CL, Pizzoferro K, Lewis DJM, Le Grand R, Cosma A, Beignon AS.

Cytometry A. 2017 Oct;91(10):969-982. doi: 10.1002/cyto.a.23107. Epub 2017 Apr 26.


Attenuated and vectored vaccines protect nonhuman primates against Chikungunya virus.

Roques P, Ljungberg K, Kümmerer BM, Gosse L, Dereuddre-Bosquet N, Tchitchek N, Hallengärd D, García-Arriaza J, Meinke A, Esteban M, Merits A, Le Grand R, Liljeström P.

JCI Insight. 2017 Mar 23;2(6):e83527. doi: 10.1172/jci.insight.83527.


Listeriomics: an Interactive Web Platform for Systems Biology of Listeria.

Bécavin C, Koutero M, Tchitchek N, Cerutti F, Lechat P, Maillet N, Hoede C, Chiapello H, Gaspin C, Cossart P.

mSystems. 2017 Mar 14;2(2). pii: e00186-16. doi: 10.1128/mSystems.00186-16. eCollection 2017 Mar-Apr.


Analysis methodology and development of a statistical tool for biodistribution data from internal contamination with actinides.

Lamart S, Griffiths NM, Tchitchek N, Angulo JF, Van der Meeren A.

J Radiol Prot. 2017 Mar;37(1):296-308. doi: 10.1088/1361-6498/37/1/296.


SPADEVizR: an R package for visualization, analysis and integration of SPADE results.

Gautreau G, Pejoski D, Le Grand R, Cosma A, Beignon AS, Tchitchek N.

Bioinformatics. 2017 Mar 1;33(5):779-781. doi: 10.1093/bioinformatics/btw708.


Myocardial Gene Expression Profiling to Predict and Identify Cardiac Allograft Acute Cellular Rejection: The GET-Study.

Bodez D, Hocini H, Tchitchek N, Tisserand P, Benhaiem N, Barau C, Kharoubi M, Guellich A, Guendouz S, Radu C, Couetil JP, Ghaleh B, Dubois-Randé JL, Teiger E, Hittinger L, Levy Y, Damy T.

PLoS One. 2016 Nov 29;11(11):e0167213. doi: 10.1371/journal.pone.0167213. eCollection 2016.


Erythropoietin Levels Increase during Cerebral Malaria and Correlate with Heme, Interleukin-10 and Tumor Necrosis Factor-Alpha in India.

Dalko E, Tchitchek N, Pays L, Herbert F, Cazenave PA, Ravindran B, Sharma S, Nataf S, Das B, Pied S.

PLoS One. 2016 Jul 21;11(7):e0158420. doi: 10.1371/journal.pone.0158420. eCollection 2016.


Identification of Vaccine-Altered Circulating B Cell Phenotypes Using Mass Cytometry and a Two-Step Clustering Analysis.

Pejoski D, Tchitchek N, Rodriguez Pozo A, Elhmouzi-Younes J, Yousfi-Bogniaho R, Rogez-Kreuz C, Clayette P, Dereuddre-Bosquet N, Lévy Y, Cosma A, Le Grand R, Beignon AS.

J Immunol. 2016 Jun 1;196(11):4814-31. doi: 10.4049/jimmunol.1502005. Epub 2016 May 2.


The 1918 Influenza Virus PB2 Protein Enhances Virulence through the Disruption of Inflammatory and Wnt-Mediated Signaling in Mice.

Forero A, Tisoncik-Go J, Watanabe T, Zhong G, Hatta M, Tchitchek N, Selinger C, Chang J, Barker K, Morrison J, Berndt JD, Moon RT, Josset L, Kawaoka Y, Katze MG.

J Virol. 2015 Dec 9;90(5):2240-53. doi: 10.1128/JVI.02974-15.


Evidence of IL-17, IP-10, and IL-10 involvement in multiple-organ dysfunction and IL-17 pathway in acute renal failure associated to Plasmodium falciparum malaria.

Herbert F, Tchitchek N, Bansal D, Jacques J, Pathak S, Bécavin C, Fesel C, Dalko E, Cazenave PA, Preda C, Ravindran B, Sharma S, Das B, Pied S.

J Transl Med. 2015 Nov 24;13:369. doi: 10.1186/s12967-015-0731-6.


Delayed inflammatory and cell death responses are associated with reduced pathogenicity in Lujo virus-infected cynomolgus macaques.

Rasmussen AL, Tchitchek N, Safronetz D, Carter VS, Williams CM, Haddock E, Korth MJ, Feldmann H, Katze MG.

J Virol. 2015 Mar;89(5):2543-52. doi: 10.1128/JVI.02246-14. Epub 2014 Dec 17.


Sequencing, annotation and analysis of the Syrian hamster (Mesocricetus auratus) transcriptome.

Tchitchek N, Safronetz D, Rasmussen AL, Martens C, Virtaneva K, Porcella SF, Feldmann H, Ebihara H, Katze MG.

PLoS One. 2014 Nov 14;9(11):e112617. doi: 10.1371/journal.pone.0112617. eCollection 2014. Erratum in: PLoS One. 2015;10(2):e0117958.


H7N9 and other pathogenic avian influenza viruses elicit a three-pronged transcriptomic signature that is reminiscent of 1918 influenza virus and is associated with lethal outcome in mice.

Morrison J, Josset L, Tchitchek N, Chang J, Belser JA, Swayne DE, Pantin-Jackwood MJ, Tumpey TM, Katze MG.

J Virol. 2014 Sep;88(18):10556-68. doi: 10.1128/JVI.00570-14. Epub 2014 Jul 2.


Annotation of long non-coding RNAs expressed in collaborative cross founder mice in response to respiratory virus infection reveals a new class of interferon-stimulated transcripts.

Josset L, Tchitchek N, Gralinski LE, Ferris MT, Eisfeld AJ, Green RR, Thomas MJ, Tisoncik-Go J, Schroth GP, Kawaoka Y, Manuel de Villena FP, Baric RS, Heise MT, Peng X, Katze MG.

RNA Biol. 2014;11(7):875-90. doi: 10.4161/rna.29442. Epub 2014 Jun 12.


A comprehensive collection of systems biology data characterizing the host response to viral infection.

Aevermann BD, Pickett BE, Kumar S, Klem EB, Agnihothram S, Askovich PS, Bankhead A 3rd, Bolles M, Carter V, Chang J, Clauss TR, Dash P, Diercks AH, Eisfeld AJ, Ellis A, Fan S, Ferris MT, Gralinski LE, Green RR, Gritsenko MA, Hatta M, Heegel RA, Jacobs JM, Jeng S, Josset L, Kaiser SM, Kelly S, Law GL, Li C, Li J, Long C, Luna ML, Matzke M, McDermott J, Menachery V, Metz TO, Mitchell H, Monroe ME, Navarro G, Neumann G, Podyminogin RL, Purvine SO, Rosenberger CM, Sanders CJ, Schepmoes AA, Shukla AK, Sims A, Sova P, Tam VC, Tchitchek N, Thomas PG, Tilton SC, Totura A, Wang J, Webb-Robertson BJ, Wen J, Weiss JM, Yang F, Yount B, Zhang Q, McWeeney S, Smith RD, Waters KM, Kawaoka Y, Baric R, Aderem A, Katze MG, Scheuermann RH.

Sci Data. 2014 Oct 14;1:140033. doi: 10.1038/sdata.2014.33. eCollection 2014.


A network integration approach to predict conserved regulators related to pathogenicity of influenza and SARS-CoV respiratory viruses.

Mitchell HD, Eisfeld AJ, Sims AC, McDermott JE, Matzke MM, Webb-Robertson BJ, Tilton SC, Tchitchek N, Josset L, Li C, Ellis AL, Chang JH, Heegel RA, Luna ML, Schepmoes AA, Shukla AK, Metz TO, Neumann G, Benecke AG, Smith RD, Baric RS, Kawaoka Y, Katze MG, Waters KM.

PLoS One. 2013 Jul 25;8(7):e69374. doi: 10.1371/journal.pone.0069374. Print 2013.


Specific mutations in H5N1 mainly impact the magnitude and velocity of the host response in mice.

Tchitchek N, Eisfeld AJ, Tisoncik-Go J, Josset L, Gralinski LE, Bécavin C, Tilton SC, Webb-Robertson BJ, Ferris MT, Totura AL, Li C, Neumann G, Metz TO, Smith RD, Waters KM, Baric R, Kawaoka Y, Katze MG.

BMC Syst Biol. 2013 Jul 29;7:69. doi: 10.1186/1752-0509-7-69.


1918 Influenza virus hemagglutinin (HA) and the viral RNA polymerase complex enhance viral pathogenicity, but only HA induces aberrant host responses in mice.

Watanabe T, Tisoncik-Go J, Tchitchek N, Watanabe S, Benecke AG, Katze MG, Kawaoka Y.

J Virol. 2013 May;87(9):5239-54. doi: 10.1128/JVI.02753-12. Epub 2013 Feb 28.


Systems approaches to influenza-virus host interactions and the pathogenesis of highly virulent and pandemic viruses.

Korth MJ, Tchitchek N, Benecke AG, Katze MG.

Semin Immunol. 2013 Oct 31;25(3):228-39. doi: 10.1016/j.smim.2012.11.001. Epub 2012 Dec 5. Review.


2009 pandemic H1N1 influenza virus elicits similar clinical course but differential host transcriptional response in mouse, macaque, and swine infection models.

Go JT, Belisle SE, Tchitchek N, Tumpey TM, Ma W, Richt JA, Safronetz D, Feldmann H, Katze MG.

BMC Genomics. 2012 Nov 15;13:627. doi: 10.1186/1471-2164-13-627.


CDS: a fold-change based statistical test for concomitant identification of distinctness and similarity in gene expression analysis.

Tchitchek N, Dzib JF, Targat B, Noth S, Benecke A, Lesne A.

Genomics Proteomics Bioinformatics. 2012 Jun;10(3):127-35. doi: 10.1016/j.gpb.2012.06.002. Epub 2012 Jun 25.


Expression sequence tag library derived from peripheral blood mononuclear cells of the chlorocebus sabaeus.

Tchitchek N, Jacquelin B, Wincker P, Dossat C, Silva CD, Weissenbach J, Blancher A, Müller-Trutwin M, Benecke A.

BMC Genomics. 2012 Jun 22;13:279. doi: 10.1186/1471-2164-13-279.


Early transcriptional programming links progression to hepatitis C virus-induced severe liver disease in transplant patients.

Rasmussen AL, Tchitchek N, Susnow NJ, Krasnoselsky AL, Diamond DL, Yeh MM, Proll SC, Korth MJ, Walters KA, Lederer S, Larson AM, Carithers RL, Benecke A, Katze MG.

Hepatology. 2012 Jul;56(1):17-27. doi: 10.1002/hep.25612. Epub 2012 Jun 5.


A chemokine gene expression signature derived from meta-analysis predicts the pathogenicity of viral respiratory infections.

Chang ST, Tchitchek N, Ghosh D, Benecke A, Katze MG.

BMC Syst Biol. 2011 Dec 22;5:202. doi: 10.1186/1752-0509-5-202.


Improving the efficiency of multidimensional scaling in the analysis of high-dimensional data using singular value decomposition.

Bécavin C, Tchitchek N, Mintsa-Eya C, Lesne A, Benecke A.

Bioinformatics. 2011 May 15;27(10):1413-21. doi: 10.1093/bioinformatics/btr143. Epub 2011 Mar 17.


Mineralocorticoid receptor mutations differentially affect individual gene expression profiles in pseudohypoaldosteronism type 1.

Fernandes-Rosa FL, Hubert EL, Fagart J, Tchitchek N, Gomes D, Jouanno E, Benecke A, Rafestin-Oblin ME, Jeunemaitre X, Antonini SR, Zennaro MC.

J Clin Endocrinol Metab. 2011 Mar;96(3):E519-27. doi: 10.1210/jc.2010-1486. Epub 2010 Dec 15.


The microbiota mediates pathogen clearance from the gut lumen after non-typhoidal Salmonella diarrhea.

Endt K, Stecher B, Chaffron S, Slack E, Tchitchek N, Benecke A, Van Maele L, Sirard JC, Mueller AJ, Heikenwalder M, Macpherson AJ, Strugnell R, von Mering C, Hardt WD.

PLoS Pathog. 2010 Sep 9;6(9):e1001097. doi: 10.1371/journal.ppat.1001097.

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