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Year Number of Results
1990 1
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1998 7
1999 18
2000 22
2001 38
2002 42
2003 43
2004 51
2005 58
2006 58
2007 67
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Page 1
A TCF4-dependent gene regulatory network confers resistance to immunotherapy in melanoma.
Pozniak J, Pedri D, Landeloos E, Van Herck Y, Antoranz A, Vanwynsberghe L, Nowosad A, Roda N, Makhzami S, Bervoets G, Maciel LF, Pulido-Vicuña CA, Pollaris L, Seurinck R, Zhao F, Flem-Karlsen K, Damsky W, Chen L, Karagianni D, Cinque S, Kint S, Vandereyken K, Rombaut B, Voet T, Vernaillen F, Annaert W, Lambrechts D, Boecxstaens V, Saeys Y, van den Oord J, Bosisio F, Karras P, Shain AH, Bosenberg M, Leucci E, Paschen A, Rambow F, Bechter O, Marine JC. Pozniak J, et al. Cell. 2024 Jan 4;187(1):166-183.e25. doi: 10.1016/j.cell.2023.11.037. Cell. 2024. PMID: 38181739 Free article.
Targeting TCF4 genetically or pharmacologically, using a bromodomain inhibitor, increased immunogenicity and sensitivity of MES cells to ICB and targeted therapy. We thereby uncovered a TCF4-dependent regulatory network that orchestrates multiple transcriptional pro …
Targeting TCF4 genetically or pharmacologically, using a bromodomain inhibitor, increased immunogenicity and sensitivity of MES cells …
TCF4-mediated Fuchs endothelial corneal dystrophy: Insights into a common trinucleotide repeat-associated disease.
Fautsch MP, Wieben ED, Baratz KH, Bhattacharyya N, Sadan AN, Hafford-Tear NJ, Tuft SJ, Davidson AE. Fautsch MP, et al. Prog Retin Eye Res. 2021 Mar;81:100883. doi: 10.1016/j.preteyeres.2020.100883. Epub 2020 Jul 28. Prog Retin Eye Res. 2021. PMID: 32735996 Free PMC article. Review.
Since the first description of an association between FECD and common polymorphisms situated within the transcription factor 4 (TCF4) gene, genetic and molecular studies have implicated an intronic CTG trinucleotide repeat (CTG18.1) expansion as a causal variant in the maj …
Since the first description of an association between FECD and common polymorphisms situated within the transcription factor 4 (TCF4) …
Oridonin promotes endoplasmic reticulum stress via TP53-repressed TCF4 transactivation in colorectal cancer.
Zhou F, Gao H, Shang L, Li J, Zhang M, Wang S, Li R, Ye L, Yang S. Zhou F, et al. J Exp Clin Cancer Res. 2023 Jun 19;42(1):150. doi: 10.1186/s13046-023-02702-4. J Exp Clin Cancer Res. 2023. PMID: 37337284 Free PMC article.
Therefore, TCF4 may be one of the important nodes for tumor cells to regulate ER stress and maintain protein synthesis homeostasis. And the inhibition of the TP53/TCF4 axis plays a key role in the anti-cancer effects of oridonin....
Therefore, TCF4 may be one of the important nodes for tumor cells to regulate ER stress and maintain protein synthesis homeostasis. A …
TCF4 promotes erythroid development.
In 't Hout FEM, van Duren J, Monteferrario D, Brinkhuis E, Mariani N, Westers TM, Chitu D, Nikoloski G, van de Loosdrecht AA, van der Reijden BA, Jansen JH, Huls G. In 't Hout FEM, et al. Exp Hematol. 2019 Jan;69:17-21.e1. doi: 10.1016/j.exphem.2018.10.002. Epub 2018 Oct 10. Exp Hematol. 2019. PMID: 30315825 Free article.
Here, we investigated the role of TCF4 in myelopoiesis. Overexpression of TCF4 (TCF4(OE)) in umbilical cord blood (UCB) cells resulted in a twofold increase in erythroid colony forming units (CFU-Es), whereas knock-down (KD) of TCF4 (TCF4(KD)) c …
Here, we investigated the role of TCF4 in myelopoiesis. Overexpression of TCF4 (TCF4(OE)) in umbilical cord blood (UCB) …
Impact of TCF4 on the genetics of schizophrenia.
Lennertz L, Quednow BB, Benninghoff J, Wagner M, Maier W, Mössner R. Lennertz L, et al. Eur Arch Psychiatry Clin Neurosci. 2011 Nov;261 Suppl 2:S161-5. doi: 10.1007/s00406-011-0256-9. Epub 2011 Sep 20. Eur Arch Psychiatry Clin Neurosci. 2011. PMID: 21932083 Free article. Review.
Contrary to expectations, carriers of the schizophrenia-associated allele showed better recognition, thus indicating that while TCF4 influences verbal memory, the TCF4-mediated schizophrenia risk is not determined by the influence of TCF4 on verbal memory. .. …
Contrary to expectations, carriers of the schizophrenia-associated allele showed better recognition, thus indicating that while TCF4 …
The emerging roles of TCF4 in disease and development.
Forrest MP, Hill MJ, Quantock AJ, Martin-Rendon E, Blake DJ. Forrest MP, et al. Trends Mol Med. 2014 Jun;20(6):322-31. doi: 10.1016/j.molmed.2014.01.010. Epub 2014 Mar 1. Trends Mol Med. 2014. PMID: 24594265 Review.
TCF4 therefore sits at the nexus between common and rare disorders. ...Here, we review the role of TCF4 in these seemingly diverse disorders and discuss recent data implicating TCF4 as an important regulator of neurodevelopment and epithelial-mesenchymal tran …
TCF4 therefore sits at the nexus between common and rare disorders. ...Here, we review the role of TCF4 in these seemingly div …
Knockdown of lncRNA MFI2-AS1 inhibits lipopolysaccharide-induced osteoarthritis progression by miR-130a-3p/TCF4.
Luo X, Wang J, Wei X, Wang S, Wang A. Luo X, et al. Life Sci. 2020 Jan 1;240:117019. doi: 10.1016/j.lfs.2019.117019. Epub 2019 Oct 31. Life Sci. 2020. PMID: 31678554 Review.
Silence of MFI2-AS1 attenuated LPS-induced viability suppression, apoptosis production, inflammatory response and extracellular matrix degradation. MFI2-AS1 was validated as a decoy of miR-130a-3p and TCF4 was confirmed as a target of miR-130a-3p. miR-130a-3p overexpressio …
Silence of MFI2-AS1 attenuated LPS-induced viability suppression, apoptosis production, inflammatory response and extracellular matrix degra …
TCF4 (e2-2; ITF2): a schizophrenia-associated gene with pleiotropic effects on human disease.
Navarrete K, Pedroso I, De Jong S, Stefansson H, Steinberg S, Stefansson K, Ophoff RA, Schalkwyk LC, Collier DA. Navarrete K, et al. Am J Med Genet B Neuropsychiatr Genet. 2013 Jan;162B(1):1-16. doi: 10.1002/ajmg.b.32109. Epub 2012 Nov 5. Am J Med Genet B Neuropsychiatr Genet. 2013. PMID: 23129290 Review.
Common SNPs in the transcription factor 4 (TCF4; ITF2, E2-2, SEF-2) gene, which encodes a basic Helix-Loop-Helix (bHLH) transcription factor, are associated with schizophrenia, conferring a small increase in risk. ...In this review, we present a systematic bioinformatics a …
Common SNPs in the transcription factor 4 (TCF4; ITF2, E2-2, SEF-2) gene, which encodes a basic Helix-Loop-Helix (bHLH) transcription …
TCF4, schizophrenia, and Pitt-Hopkins Syndrome.
Blake DJ, Forrest M, Chapman RM, Tinsley CL, O'Donovan MC, Owen MJ. Blake DJ, et al. Schizophr Bull. 2010 May;36(3):443-7. doi: 10.1093/schbul/sbq035. Epub 2010 Apr 26. Schizophr Bull. 2010. PMID: 20421335 Free PMC article.
TCF4 mutations also cause Pitt-Hopkins Syndrome, an autosomal-dominant neurodevelopmental disorder associated with severe mental retardation. Variants in the TCF4 gene may therefore be associated with a range of neuropsychiatric phenotypes, including schizophrenia. …
TCF4 mutations also cause Pitt-Hopkins Syndrome, an autosomal-dominant neurodevelopmental disorder associated with severe mental reta …
TCF4 trinucleotide repeat expansion in Swedish cases with Fuchs' endothelial corneal dystrophy.
Viberg A, Westin IM, Golovleva I, Byström B. Viberg A, et al. Acta Ophthalmol. 2022 Aug;100(5):541-548. doi: 10.1111/aos.15032. Epub 2021 Oct 13. Acta Ophthalmol. 2022. PMID: 34644448 Free article.
Short tandem repeat PCR and triplet repeat-primed PCR were applied in order to determine TCF4 (CTG)(n) genotype. RESULTS: A (CTG)(n) repeat expansion (n > 50) in TCF4 was identified in 76 of 85 FECD cases (89.4%) and in four of 102 controls (3.9%). ...Furthermore …
Short tandem repeat PCR and triplet repeat-primed PCR were applied in order to determine TCF4 (CTG)(n) genotype. RESULTS: A (CTG)(n) …
2,268 results