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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1995 1
1999 1
2000 4
2001 5
2002 35
2003 33
2004 42
2005 73
2006 84
2007 68
2008 73
2009 123
2010 90
2011 117
2012 129
2013 129
2014 136
2015 137
2016 146
2017 135
2018 117
2019 137
2020 90
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2024 18

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1,938 results

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Page 1
TBX21 attenuates colorectal cancer progression via an ARHGAP29/RSK/GSK3beta dependent manner.
Jiang X, Du W, Yang C, Wang S, Li Y, Shen X, Yang X, Yao J, Du R, Zhang X, Huang Y, Shen W. Jiang X, et al. Cell Oncol (Dordr). 2023 Oct;46(5):1269-1283. doi: 10.1007/s13402-023-00809-6. Epub 2023 Apr 17. Cell Oncol (Dordr). 2023. PMID: 37067748
However, the function of TBX21 in colorectal cancer (CRC) remains unclear. METHODS: IHC to investigate TBX21 expression in CRC tissues. Cell proliferation and apoptosis assays to validate TBX21 function in vitro and in vivo. RNA-seq assay to explore target ge …
However, the function of TBX21 in colorectal cancer (CRC) remains unclear. METHODS: IHC to investigate TBX21 expression in CRC …
TBX21 Methylation as a Potential Regulator of Immune Suppression in CMS1 Subtype Colorectal Cancer.
Shen Y, Nussbaum YI, Manjunath Y, Hummel JJ, Ciorba MA, Warren WC, Kaifi JT, Papageorgiou C, Cortese R, Shyu CR, Mitchem JB. Shen Y, et al. Cancers (Basel). 2022 Sep 22;14(19):4594. doi: 10.3390/cancers14194594. Cancers (Basel). 2022. PMID: 36230517 Free PMC article.
To confirm the role of Tbx21 in CTL function, we utilized scRNAseq data, demonstrating the association of TBX21 with markers of enhanced CTL function. Further analysis using pathway enrichment found that the genes TBX21, MX1, and SP140 had altered expression …
To confirm the role of Tbx21 in CTL function, we utilized scRNAseq data, demonstrating the association of TBX21 with markers o …
TBX21, the Master regulator of the type 1 immune response, overexpresses in the leukocytes of peripheral blood in patients with late-onset Alzheimer's disease.
Fatemi Langroudi SR, Zeinaly M, Ajamian F. Fatemi Langroudi SR, et al. Immun Ageing. 2023 Nov 10;20(1):59. doi: 10.1186/s12979-023-00385-1. Immun Ageing. 2023. PMID: 37950255 Free PMC article.

We also found an upward trend in TBX21 expression with increasing age in LOAD patients compared to the control group (P < 0.05; CI = 95%). ...CONCLUSIONS: Our results show for the first time the likely impact of the TBX21 (T-bet) immune gene in LOAD development a

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We also found an upward trend in TBX21 expression with increasing age in LOAD patients compared to the control group (P < 0.05; CI

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Autoimmunity in Down's syndrome via cytokines, CD4 T cells and CD11c+ B cells.
Malle L, Patel RS, Martin-Fernandez M, Stewart OJ, Philippot Q, Buta S, Richardson A, Barcessat V, Taft J, Bastard P, Samuels J, Mircher C, Rebillat AS, Maillebouis L, Vilaire-Meunier M, Tuballes K, Rosenberg BR, Trachtman R, Casanova JL, Notarangelo LD, Gnjatic S, Bush D, Bogunovic D. Malle L, et al. Nature. 2023 Mar;615(7951):305-314. doi: 10.1038/s41586-023-05736-y. Epub 2023 Feb 22. Nature. 2023. PMID: 36813963 Free PMC article.
We found a persistent elevation of up to 22 cytokines at steady state (at levels often exceeding those in patients with acute infection) and detected basal cellular activation: chronic IL-6 signalling in CD4 T cells and a high proportion of plasmablasts and CD11c(+)Tbet(high)CD21 …
We found a persistent elevation of up to 22 cytokines at steady state (at levels often exceeding those in patients with acute infection) and …
TBX21-1993T/C polymorphism association with Th1 and Th17 response at periapex and with periapical lesions development risk.
Colavite PM, Cavalla F, Garlet TP, Azevedo MCS, Melchiades JL, Campanelli AP, Letra A, Trombone APF, Silva RM, Garlet GP. Colavite PM, et al. J Leukoc Biol. 2019 Mar;105(3):609-619. doi: 10.1002/JLB.6A0918-339R. Epub 2018 Dec 13. J Leukoc Biol. 2019. PMID: 30548981
TBX21-1993T/C (rs4794067) polymorphism increases the transcriptional activity of the Tbx21, essential for interferon gamma (IFNg) transcription, but its functional impact on development Th1- response in vivo remains unclear, as well its potential influence over infl …
TBX21-1993T/C (rs4794067) polymorphism increases the transcriptional activity of the Tbx21, essential for interferon gamma (IF …
T-bet+ B cells accumulate in adipose tissue and exacerbate metabolic disorder during obesity.
Hägglöf T, Vanz C, Kumagai A, Dudley E, Ortega V, Siller M, Parthasarathy R, Keegan J, Koenigs A, Shute T, Leadbetter EA. Hägglöf T, et al. Cell Metab. 2022 Aug 2;34(8):1121-1136.e6. doi: 10.1016/j.cmet.2022.07.002. Epub 2022 Jul 21. Cell Metab. 2022. PMID: 35868310 Free PMC article.
Transfer of B cells enriched for T-bet(+) cells exacerbates metabolic disorder in obesity, while ablation of Tbx21 specifically in B cells reduces serum IgG2c levels, inflammatory cytokines, and inflammatory macrophages in adipose tissue, ameliorating metabolic symptoms. . …
Transfer of B cells enriched for T-bet(+) cells exacerbates metabolic disorder in obesity, while ablation of Tbx21 specifically in B …
Association of TBX21 gene polymorphisms and acute anterior uveitis risk in a Chinese population: A case-control study.
Shan J, Li L, Du L, Yang P. Shan J, et al. Exp Eye Res. 2023 Apr;229:109417. doi: 10.1016/j.exer.2023.109417. Epub 2023 Feb 14. Exp Eye Res. 2023. PMID: 36796535
Copy number variations (CNVs) in TBX21 gene have been reported to be significantly and positively correlated with acute anterior uveitis (AAU). ...No significant association was observed between two candidate SNPs of TBX21 gene (rs4794067, rs11657479) and susceptibi …
Copy number variations (CNVs) in TBX21 gene have been reported to be significantly and positively correlated with acute anterior uvei …
TBX21 and HLX1 polymorphisms influence cytokine secretion at birth.
Casaca VI, Illi S, Suttner K, Schleich I, Ballenberger N, Klucker E, Turan E, von Mutius E, Kabesch M, Schaub B. Casaca VI, et al. PLoS One. 2012;7(1):e31069. doi: 10.1371/journal.pone.0031069. Epub 2012 Jan 30. PLoS One. 2012. PMID: 22303482 Free PMC article.
This study investigated the influence of TBX21 and HLX1 single nucleotide polymorphisms (SNPs), which have previously been shown to be associated with asthma, on T(H)1/T(H)2 lineage cytokines at birth. ...TBX21 SNP rs11079788 carriers developed less symptoms of atop …
This study investigated the influence of TBX21 and HLX1 single nucleotide polymorphisms (SNPs), which have previously been shown to b …
Tbx21 and Foxp3 Are Epigenetically Stabilized in T-Bet(+) Tregs That Transiently Accumulate in Influenza A Virus-Infected Lungs.
Elfaki Y, Yang J, Boehme J, Schultz K, Bruder D, Falk CS, Huehn J, Floess S. Elfaki Y, et al. Int J Mol Sci. 2021 Jul 14;22(14):7522. doi: 10.3390/ijms22147522. Int J Mol Sci. 2021. PMID: 34299148 Free PMC article.
Interestingly, T-bet(+) Tregs accumulating in IAV-infected lungs displayed a strongly demethylated Tbx21 locus, similarly as in T-bet(+) conventional T cells, and a fully demethylated Treg-specific demethylated region (TSDR) within the Foxp3 locus. ...
Interestingly, T-bet(+) Tregs accumulating in IAV-infected lungs displayed a strongly demethylated Tbx21 locus, similarly as in T-bet …
BATF regulates progenitor to cytolytic effector CD8+ T cell transition during chronic viral infection.
Chen Y, Zander RA, Wu X, Schauder DM, Kasmani MY, Shen J, Zheng S, Burns R, Taparowsky EJ, Cui W. Chen Y, et al. Nat Immunol. 2021 Aug;22(8):996-1007. doi: 10.1038/s41590-021-00965-7. Epub 2021 Jul 19. Nat Immunol. 2021. PMID: 34282329 Free PMC article.
Notably, our data demonstrate that CX(3)CR1(+) effector cells bear a striking similarity to short-lived effector cells during acute infection. Genetic deletion of Tbx21 significantly diminished formation of the CX(3)CR1(+) subset. Importantly, we further identify a previou …
Notably, our data demonstrate that CX(3)CR1(+) effector cells bear a striking similarity to short-lived effector cells during acute infectio …
1,938 results