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The structure of the Shiga toxin 2a A-subunit dictates the interactions of the toxin with blood components.
Brigotti M, Orth-Höller D, Carnicelli D, Porcellini E, Galassi E, Tazzari PL, Ricci F, Manoli F, Manet I, Talasz H, Lindner HH, Speth C, Erbeznik T, Fuchs S, Posch W, Chatterjee S, Würzner R.
Cell Microbiol. 2019 May;21(5):e13000. doi: 10.1111/cmi.13000. Epub 2019 Jan 18.
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Circulating megakaryocyte and platelet microvesicles correlate with response to ruxolitinib and distinct disease severity in patients with myelofibrosis.
Barone M, Ricci F, Sollazzo D, Ottaviani E, Romano M, Auteri G, Bartoletti D, Reggiani MLB, Vianelli N, Tazzari PL, Cavo M, Forte D, Palandri F, Catani L.
Br J Haematol. 2019 Jun;185(5):987-991. doi: 10.1111/bjh.15682. Epub 2018 Nov 18. No abstract available.
Soluble Toll-Like Receptor 4 Impairs the Interaction of Shiga Toxin 2a with Human Serum Amyloid P Component.
Brigotti M, Arfilli V, Carnicelli D, Ricci F, Tazzari PL, Ardissino G, Scavia G, Morabito S, He X.
Toxins (Basel). 2018 Sep 18;10(9). pii: E379. doi: 10.3390/toxins10090379.
Restored in vivo-like membrane lipidomics positively influence in vitro features of cultured mesenchymal stromal/stem cells derived from human placenta.
Chatgilialoglu A, Rossi M, Alviano F, Poggi P, Zannini C, Marchionni C, Ricci F, Tazzari PL, Taglioli V, Calder PC, Bonsi L.
Stem Cell Res Ther. 2017 Feb 7;8(1):31. doi: 10.1186/s13287-017-0487-4.
The Antibiotic Polymyxin B Impairs the Interactions between Shiga Toxins and Human Neutrophils.
Carnicelli D, Arfilli V, Ricci F, Velati C, Tazzari PL, Brigotti M.
J Immunol. 2016 Feb 1;196(3):1177-85. doi: 10.4049/jimmunol.1500671. Epub 2015 Dec 22.
Transfusion-related Listeria monocytogenes infection in a patient with acute myeloid leukaemia.
Tolomelli G, Tazzari PL, Paolucci M, Arpinati M, Landini MP, Pagliaro P.
Blood Transfus. 2014 Oct;12(4):611-4. doi: 10.2450/2014.0322-13. Epub 2014 Jun 5. No abstract available.
A non-invasive strategy for haemoglobin screening of blood donors.
Pagliaro P, Belardinelli A, Boko V, Salamon P, Manfroi S, Tazzari PL.
Blood Transfus. 2014 Oct;12(4):458-63. doi: 10.2450/2014.0284-13. Epub 2014 Jun 5.
Isolation and in vitro characterization of bovine amniotic fluid derived stem cells at different trimesters of pregnancy.
Rossi B, Merlo B, Colleoni S, Iacono E, Tazzari PL, Ricci F, Lazzari G, Galli C.
Stem Cell Rev. 2014 Oct;10(5):712-24. doi: 10.1007/s12015-014-9525-0. Review.
Targeting signaling pathways in T-cell acute lymphoblastic leukemia initiating cells.
Martelli AM, Lonetti A, Buontempo F, Ricci F, Tazzari PL, Evangelisti C, Bressanin D, Cappellini A, Orsini E, Chiarini F.
Adv Biol Regul. 2014 Sep;56:6-21. doi: 10.1016/j.jbior.2014.04.004. Epub 2014 Apr 30. Review.
Neutrophil gelatinase-associated lipocalin increases HLA-G(+)/FoxP3(+) T-regulatory cell population in an in vitro model of PBMC.
La Manna G, Ghinatti G, Tazzari PL, Alviano F, Ricci F, Capelli I, Cuna V, Todeschini P, Brunocilla E, Pagliaro P, Bonsi L, Stefoni S.
PLoS One. 2014 Feb 27;9(2):e89497. doi: 10.1371/journal.pone.0089497. eCollection 2014.
Platelet-derived growth factor alpha mediates the proliferation of peripheral T-cell lymphoma cells via an autocrine regulatory pathway.
Piccaluga PP, Rossi M, Agostinelli C, Ricci F, Gazzola A, Righi S, Fuligni F, Laginestra MA, Mancini M, Sapienza MR, De Renzo A, Tazzari PL, Gibellini D, Went P, Alviano F, Zinzani PL, Bagnara GP, Inghirami G, Tripodo C, Pileri SA.
Leukemia. 2014 Aug;28(8):1687-97. doi: 10.1038/leu.2014.50. Epub 2014 Jan 31.
Human cadaver multipotent stromal/stem cells isolated from arteries stored in liquid nitrogen for 5 years.
Valente S, Alviano F, Ciavarella C, Buzzi M, Ricci F, Tazzari PL, Pagliaro P, Pasquinelli G.
Stem Cell Res Ther. 2014 Jan 15;5(1):8. doi: 10.1186/scrt397.
Activity of the pan-class I phosphoinositide 3-kinase inhibitor NVP-BKM120 in T-cell acute lymphoblastic leukemia.
Lonetti A, Antunes IL, Chiarini F, Orsini E, Buontempo F, Ricci F, Tazzari PL, Pagliaro P, Melchionda F, Pession A, Bertaina A, Locatelli F, McCubrey JA, Barata JT, Martelli AM.
Leukemia. 2014 Jun;28(6):1196-206. doi: 10.1038/leu.2013.369. Epub 2013 Nov 6.
Identification of TLR4 as the receptor that recognizes Shiga toxins in human neutrophils.
Brigotti M, Carnicelli D, Arfilli V, Tamassia N, Borsetti F, Fabbri E, Tazzari PL, Ricci F, Pagliaro P, Spisni E, Cassatella MA.
J Immunol. 2013 Nov 1;191(9):4748-58. doi: 10.4049/jimmunol.1300122. Epub 2013 Sep 25.
Targeting the PI3K/Akt/mTOR signaling pathway in B-precursor acute lymphoblastic leukemia and its therapeutic potential.
Neri LM, Cani A, Martelli AM, Simioni C, Junghanss C, Tabellini G, Ricci F, Tazzari PL, Pagliaro P, McCubrey JA, Capitani S.
Leukemia. 2014 Apr;28(4):739-48. doi: 10.1038/leu.2013.226. Epub 2013 Jul 29.
Noninvasive methods for haemoglobin screening in prospective blood donors.
Belardinelli A, Benni M, Tazzari PL, Pagliaro P.
Vox Sang. 2013 Aug;105(2):116-20. doi: 10.1111/vox.12033. Epub 2013 Apr 19.
Shiga toxin 1, as DNA repair inhibitor, synergistically potentiates the activity of the anticancer drug, mafosfamide, on raji cells.
Brigotti M, Arfilli V, Carnicelli D, Rocchi L, Calcabrini C, Ricci F, Pagliaro P, Tazzari PL, Alfieri RR, Petronini PG, Sestili P.
Toxins (Basel). 2013 Feb 21;5(2):431-44. doi: 10.3390/toxins5020431.
A combination of temsirolimus, an allosteric mTOR inhibitor, with clofarabine as a new therapeutic option for patients with acute myeloid leukemia.
Chiarini F, Lonetti A, Teti G, Orsini E, Bressanin D, Cappellini A, Ricci F, Tazzari PL, Ognibene A, Falconi M, Pagliaro P, Iacobucci I, Martinelli G, Amadori S, McCubrey JA, Martelli AM.
Oncotarget. 2012 Dec;3(12):1615-28.
Experience in the evaluation of foeto-maternal haemorrhage by flow cytometry.
Tazzari PL, Ricci F, Manfroi S, Pagliaro P.
Blood Transfus. 2013 Jul;11(3):462-3. doi: 10.2450/2012.0064-12. Epub 2012 Oct 10. No abstract available.
Harnessing the PI3K/Akt/mTOR pathway in T-cell acute lymphoblastic leukemia: eliminating activity by targeting at different levels.
Bressanin D, Evangelisti C, Ricci F, Tabellini G, Chiarini F, Tazzari PL, Melchionda F, Buontempo F, Pagliaro P, Pession A, McCubrey JA, Martelli AM.
Oncotarget. 2012 Aug;3(8):811-23.
A rapid method for obtaining mesenchymal stem cells and platelets from bone marrow aspirate.
Dozza B, Gobbi G, Lucarelli E, Pierini M, Di Bella C, Frisoni T, Tazzari PL, Ricci F, Mirandola P, Carubbi C, Giannini S, Donati D, Vitale M.
J Tissue Eng Regen Med. 2014 Jun;8(6):483-92. doi: 10.1002/term.1551. Epub 2012 Jun 19.
Cytotoxic activity of the novel Akt inhibitor, MK-2206, in T-cell acute lymphoblastic leukemia.
Simioni C, Neri LM, Tabellini G, Ricci F, Bressanin D, Chiarini F, Evangelisti C, Cani A, Tazzari PL, Melchionda F, Pagliaro P, Pession A, McCubrey JA, Capitani S, Martelli AM.
Leukemia. 2012 Nov;26(11):2336-42. doi: 10.1038/leu.2012.136. Epub 2012 May 22.
Efficient isolation and enrichment of mesenchymal stem cells from bone marrow.
Pierini M, Dozza B, Lucarelli E, Tazzari PL, Ricci F, Remondini D, di Bella C, Giannini S, Donati D.
Cytotherapy. 2012 Jul;14(6):686-93. doi: 10.3109/14653249.2012.677821. Epub 2012 May 10.
Could fetal fluid and membranes be an alternative source for mesenchymal stem cells (MSCs) in the feline species? A preliminary study.
Iacono E, Cunto M, Zambelli D, Ricci F, Tazzari PL, Merlo B.
Vet Res Commun. 2012 Jun;36(2):107-18. doi: 10.1007/s11259-012-9520-3. Epub 2012 Feb 12.
Isolation, characterization and differentiation of mesenchymal stem cells from amniotic fluid, umbilical cord blood and Wharton's jelly in the horse.
Iacono E, Brunori L, Pirrone A, Pagliaro PP, Ricci F, Tazzari PL, Merlo B.
Reproduction. 2012 Apr;143(4):455-68. doi: 10.1530/REP-10-0408. Epub 2012 Jan 24.
Analysis of the effects of HIV-1 Tat on the survival and differentiation of vessel wall-derived mesenchymal stem cells.
Gibellini D, Miserocchi A, Tazzari PL, Ricci F, Clò A, Morini S, Ponti C, Pasquinelli G, Bon I, Pagliaro P, Borderi M, Re MC.
J Cell Biochem. 2012 Apr;113(4):1132-41. doi: 10.1002/jcb.23446.
AMP-dependent kinase/mammalian target of rapamycin complex 1 signaling in T-cell acute lymphoblastic leukemia: therapeutic implications.
Grimaldi C, Chiarini F, Tabellini G, Ricci F, Tazzari PL, Battistelli M, Falcieri E, Bortul R, Melchionda F, Iacobucci I, Pagliaro P, Martinelli G, Pession A, Barata JT, McCubrey JA, Martelli AM.
Leukemia. 2012 Jan;26(1):91-100. doi: 10.1038/leu.2011.269. Epub 2011 Oct 4.
Change in conformation with reduction of alpha-helix content causes loss of neutrophil binding activity in fully cytotoxic Shiga toxin 1.
Brigotti M, Carnicelli D, Arfilli V, Rocchi L, Ricci F, Pagliaro P, Tazzari PL, Vara AG, Amelia M, Manoli F, Monti S.
J Biol Chem. 2011 Oct 7;286(40):34514-21. doi: 10.1074/jbc.M111.255414. Epub 2011 Aug 8.
HIV-1 and recombinant gp120 affect the survival and differentiation of human vessel wall-derived mesenchymal stem cells.
Gibellini D, Alviano F, Miserocchi A, Tazzari PL, Ricci F, Clò A, Morini S, Borderi M, Viale P, Pasquinelli G, Pagliaro P, Bagnara GP, Re MC.
Retrovirology. 2011 May 25;8:40. doi: 10.1186/1742-4690-8-40.
Comparison of alternative mesenchymal stem cell sources for cell banking and musculoskeletal advanced therapies.
Cavallo C, Cuomo C, Fantini S, Ricci F, Tazzari PL, Lucarelli E, Donati D, Facchini A, Lisignoli G, Fornasari PM, Grigolo B, Moroni L.
J Cell Biochem. 2011 May;112(5):1418-30. doi: 10.1002/jcb.23058.
Mesenchymal stem cells and platelet lysate in fibrin or collagen scaffold promote non-cemented hip prosthesis integration.
Dozza B, Di Bella C, Lucarelli E, Giavaresi G, Fini M, Tazzari PL, Giannini S, Donati D.
J Orthop Res. 2011 Jun;29(6):961-8. doi: 10.1002/jor.21333. Epub 2011 Jan 31.
A simple method for identifying bone marrow mesenchymal stromal cells with a high immunosuppressive potential.
Rizzo R, Lanzoni G, Stignani M, Campioni D, Alviano F, Ricci F, Tazzari PL, Melchiorri L, Scalinci SZ, Cuneo A, Bonsi L, Lanza F, Bagnara GP, Baricordi OR.
Cytotherapy. 2011 May;13(5):523-7. doi: 10.3109/14653249.2010.542460. Epub 2010 Dec 20.
Clinical relevance of shiga toxin concentrations in the blood of patients with hemolytic uremic syndrome.
Brigotti M, Tazzari PL, Ravanelli E, Carnicelli D, Rocchi L, Arfilli V, Scavia G, Minelli F, Ricci F, Pagliaro P, Ferretti AV, Pecoraro C, Paglialonga F, Edefonti A, Procaccino MA, Tozzi AE, Caprioli A.
Pediatr Infect Dis J. 2011 Jun;30(6):486-90. doi: 10.1097/INF.0b013e3182074d22.
Quantitatively different red cell/nucleated cell chimerism in patients with long-term, persistent hematopoietic mixed chimerism after bone marrow transplantation for thalassemia major or sickle cell disease.
Andreani M, Testi M, Gaziev J, Condello R, Bontadini A, Tazzari PL, Ricci F, De Felice L, Agostini F, Fraboni D, Ferrari G, Battarra M, Troiano M, Sodani P, Lucarelli G.
Haematologica. 2011 Jan;96(1):128-33. doi: 10.3324/haematol.2010.031013. Epub 2010 Oct 7.
Activity of the novel dual phosphatidylinositol 3-kinase/mammalian target of rapamycin inhibitor NVP-BEZ235 against T-cell acute lymphoblastic leukemia.
Chiarini F, Grimaldi C, Ricci F, Tazzari PL, Evangelisti C, Ognibene A, Battistelli M, Falcieri E, Melchionda F, Pession A, Pagliaro P, McCubrey JA, Martelli AM.
Cancer Res. 2010 Oct 15;70(20):8097-107. doi: 10.1158/0008-5472.CAN-10-1814. Epub 2010 Sep 28.
Shiga toxin 1 and ricin A chain bind to human polymorphonuclear leucocytes through a common receptor.
Arfilli V, Carnicelli D, Rocchi L, Ricci F, Pagliaro P, Tazzari PL, Brigotti M.
Biochem J. 2010 Nov 15;432(1):173-80. doi: 10.1042/BJ20100455.
A recently developed bifacial platelet-rich fibrin matrix.
Lucarelli E, Beretta R, Dozza B, Tazzari PL, O'Connel SM, Ricci F, Pierini M, Squarzoni S, Pagliaro PP, Oprita EI, Donati D.
Eur Cell Mater. 2010 Jul 1;20:13-23.
Dysfunctional vasa vasorum in diabetic peripheral artery obstructive disease with critical lower limb ischaemia.
Orrico C, Pasquinelli G, Foroni L, Muscarà D, Tazzari PL, Ricci F, Buzzi M, Baldi E, Muccini N, Gargiulo M, Stella A.
Eur J Vasc Endovasc Surg. 2010 Sep;40(3):365-74. doi: 10.1016/j.ejvs.2010.04.011. Epub 2010 Jun 1.
Endothelial damage induced by Shiga toxins delivered by neutrophils during transmigration.
Brigotti M, Tazzari PL, Ravanelli E, Carnicelli D, Barbieri S, Rocchi L, Arfilli V, Scavia G, Ricci F, Bontadini A, Alfieri RR, Petronini PG, Pecoraro C, Tozzi AE, Caprioli A.
J Leukoc Biol. 2010 Jul;88(1):201-10. doi: 10.1189/jlb.0709475. Epub 2010 Apr 6.
Erucylphosphohomocholine, the first intravenously applicable alkylphosphocholine, is cytotoxic to acute myelogenous leukemia cells through JNK- and PP2A-dependent mechanisms.
Martelli AM, Papa V, Tazzari PL, Ricci F, Evangelisti C, Chiarini F, Grimaldi C, Cappellini A, Martinelli G, Ottaviani E, Pagliaro P, Horn S, Bäsecke J, Lindner LH, Eibl H, McCubrey JA.
Leukemia. 2010 Apr;24(4):687-98. doi: 10.1038/leu.2010.32. Epub 2010 Mar 4.
A novel stem cell tag-less sorting method.
Roda B, Lanzoni G, Alviano F, Zattoni A, Costa R, Di Carlo A, Marchionni C, Franchina M, Ricci F, Tazzari PL, Pagliaro P, Scalinci SZ, Bonsi L, Reschiglian P, Bagnara GP.
Stem Cell Rev. 2009 Dec;5(4):420-7. doi: 10.1007/s12015-009-9088-7.
Identification of a functional nuclear export sequence in diacylglycerol kinase-zeta.
Evangelisti C, Gaboardi GC, Billi AM, Ognibene A, Goto K, Tazzari PL, McCubrey JA, Martelli AM.
Cell Cycle. 2010 Jan 15;9(2):384-8. Epub 2010 Jan 29.
Angiogenic potential of human dental pulp stromal (stem) cells.
Marchionni C, Bonsi L, Alviano F, Lanzoni G, Di Tullio A, Costa R, Montanari M, Tazzari PL, Ricci F, Pasquinelli G, Orrico C, Grossi A, Prati C, Bagnara GP.
Int J Immunopathol Pharmacol. 2009 Jul-Sep;22(3):699-706.
ATG-saporin-S6 immunotoxin: a new potent and selective drug to eliminate activated lymphocytes and lymphoma cells.
Polito L, Bortolotti M, Farini V, Pedrazzi M, Tazzari PL, Bolognesi A.
Br J Haematol. 2009 Dec;147(5):710-8. doi: 10.1111/j.1365-2141.2009.07904.x. Epub 2009 Sep 18.
Gravitational field-flow fractionation of human hemopoietic stem cells.
Roda B, Reschiglian P, Alviano F, Lanzoni G, Bagnara GP, Ricci F, Buzzi M, Tazzari PL, Pagliaro P, Michelini E, Roda A.
J Chromatogr A. 2009 Dec 25;1216(52):9081-7. doi: 10.1016/j.chroma.2009.07.024. Epub 2009 Jul 17.
Dual inhibition of class IA phosphatidylinositol 3-kinase and mammalian target of rapamycin as a new therapeutic option for T-cell acute lymphoblastic leukemia.
Chiarini F, Falà F, Tazzari PL, Ricci F, Astolfi A, Pession A, Pagliaro P, McCubrey JA, Martelli AM.
Cancer Res. 2009 Apr 15;69(8):3520-8. doi: 10.1158/0008-5472.CAN-08-4884. Epub 2009 Apr 7.
Synergistic proapoptotic activity of recombinant TRAIL plus the Akt inhibitor Perifosine in acute myelogenous leukemia cells.
Tazzari PL, Tabellini G, Ricci F, Papa V, Bortul R, Chiarini F, Evangelisti C, Martinelli G, Bontadini A, Cocco L, McCubrey JA, Martelli AM.
Cancer Res. 2008 Nov 15;68(22):9394-403. doi: 10.1158/0008-5472.CAN-08-2815.
Human lymphocyte sorting by gravitational field-flow fractionation.
Roda B, Reschiglian P, Zattoni A, Tazzari PL, Buzzi M, Ricci F, Bontadini A.
Anal Bioanal Chem. 2008 Sep;392(1-2):137-45. doi: 10.1007/s00216-008-2271-x. Epub 2008 Jul 24.
Interactions between Shiga toxins and human polymorphonuclear leukocytes.
Brigotti M, Carnicelli D, Ravanelli E, Barbieri S, Ricci F, Bontadini A, Tozzi AE, Scavia G, Caprioli A, Tazzari PL.
J Leukoc Biol. 2008 Oct;84(4):1019-27. doi: 10.1189/jlb.0308157. Epub 2008 Jul 14.
Proapoptotic activity and chemosensitizing effect of the novel Akt inhibitor (2S)-1-(1H-Indol-3-yl)-3-[5-(3-methyl-2H-indazol-5-yl)pyridin-3-yl]oxypropan2-amine (A443654) in T-cell acute lymphoblastic leukemia.
Falà F, Blalock WL, Tazzari PL, Cappellini A, Chiarini F, Martinelli G, Tafuri A, McCubrey JA, Cocco L, Martelli AM.
Mol Pharmacol. 2008 Sep;74(3):884-95. doi: 10.1124/mol.108.047639. Epub 2008 Jun 24.
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