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Items: 1 to 50 of 501

1.

Cushing's syndrome driver mutation disrupts protein kinase A allosteric network, altering both regulation and substrate specificity.

Walker C, Wang Y, Olivieri C, Karamafrooz A, Casby J, Bathon K, Calebiro D, Gao J, Bernlohr DA, Taylor SS, Veglia G.

Sci Adv. 2019 Aug 28;5(8):eaaw9298. doi: 10.1126/sciadv.aaw9298. eCollection 2019 Aug.

2.

Activation of PKA via asymmetric allosteric coupling of structurally conserved cyclic nucleotide binding domains.

Hao Y, England JP, Bellucci L, Paci E, Hodges HC, Taylor SS, Maillard RA.

Nat Commun. 2019 Sep 4;10(1):3984. doi: 10.1038/s41467-019-11930-2.

3.

Oncogenic MYC amplifies mitotic perturbations.

Littler S, Sloss O, Geary B, Pierce A, Whetton AD, Taylor SS.

Open Biol. 2019 Aug 30;9(8):190136. doi: 10.1098/rsob.190136. Epub 2019 Aug 28.

4.

BRAF inhibitors promote intermediate BRAF(V600E) conformations and binary interactions with activated RAS.

Röck R, Mayrhofer JE, Torres-Quesada O, Enzler F, Raffeiner A, Raffeiner P, Feichtner A, Huber RG, Koide S, Taylor SS, Troppmair J, Stefan E.

Sci Adv. 2019 Aug 14;5(8):eaav8463. doi: 10.1126/sciadv.aav8463. eCollection 2019 Aug.

5.

Two PKA RIα holoenzyme states define ATP as an isoform-specific orthosteric inhibitor that competes with the allosteric activator, cAMP.

Lu TW, Wu J, Aoto PC, Weng JH, Ahuja LG, Sun N, Cheng CY, Zhang P, Taylor SS.

Proc Natl Acad Sci U S A. 2019 Aug 13;116(33):16347-16356. doi: 10.1073/pnas.1906036116. Epub 2019 Jul 30.

PMID:
31363049
6.

The dynamic switch mechanism that leads to activation of LRRK2 is embedded in the DFGψ motif in the kinase domain.

Schmidt SH, Knape MJ, Boassa D, Mumdey N, Kornev AP, Ellisman MH, Taylor SS, Herberg FW.

Proc Natl Acad Sci U S A. 2019 Jul 23;116(30):14979-14988. doi: 10.1073/pnas.1900289116. Epub 2019 Jul 10.

7.

Dynamic allostery-based molecular workings of kinase:peptide complexes.

Ahuja LG, Aoto PC, Kornev AP, Veglia G, Taylor SS.

Proc Natl Acad Sci U S A. 2019 Jul 23;116(30):15052-15061. doi: 10.1073/pnas.1900163116. Epub 2019 Jul 8.

PMID:
31285328
8.

Development of germplasm repositories to assist conservation of endangered fishes: Examples from small-bodied livebearing fishes.

Liu Y, Blackburn H, Taylor SS, Tiersch TR.

Theriogenology. 2019 Sep 1;135:138-151. doi: 10.1016/j.theriogenology.2019.05.020. Epub 2019 May 28.

PMID:
31220687
9.

GPCR signaling inhibits mTORC1 via PKA phosphorylation of Raptor.

Jewell JL, Fu V, Hong AW, Yu FX, Meng D, Melick CH, Wang H, Lam WM, Yuan HX, Taylor SS, Guan KL.

Elife. 2019 May 21;8. pii: e43038. doi: 10.7554/eLife.43038.

10.

Tuning the "violin" of protein kinases: The role of dynamics-based allostery.

Ahuja LG, Taylor SS, Kornev AP.

IUBMB Life. 2019 Jun;71(6):685-696. doi: 10.1002/iub.2057. Epub 2019 May 7. Review.

PMID:
31063633
11.

Evolution of a dynamic molecular switch.

Taylor SS, Meharena HS, Kornev AP.

IUBMB Life. 2019 Jun;71(6):672-684. doi: 10.1002/iub.2059. Epub 2019 May 6. Review.

PMID:
31059206
12.

Composite measures of physical activity and pain associate better with functional assessments than pain alone in knee osteoarthritis.

Allen KD, Lo G, Abbate LM, Floegel TA, Lindquist JH, Coffman C, Oddone EZ, Taylor SS, Hall K.

Clin Rheumatol. 2019 Aug;38(8):2241-2247. doi: 10.1007/s10067-019-04530-4. Epub 2019 Mar 30.

PMID:
30929153
13.

Zooming in on protons: Neutron structure of protein kinase A trapped in a product complex.

Gerlits O, Weiss KL, Blakeley MP, Veglia G, Taylor SS, Kovalevsky A.

Sci Adv. 2019 Mar 20;5(3):eaav0482. doi: 10.1126/sciadv.aav0482. eCollection 2019 Mar.

14.

Structures of the PKA RIα Holoenzyme with the FLHCC Driver J-PKAcα or Wild-Type PKAcα.

Cao B, Lu TW, Martinez Fiesco JA, Tomasini M, Fan L, Simon SM, Taylor SS, Zhang P.

Structure. 2019 May 7;27(5):816-828.e4. doi: 10.1016/j.str.2019.03.001. Epub 2019 Mar 21.

PMID:
30905674
15.

DNA Replication Vulnerabilities Render Ovarian Cancer Cells Sensitive to Poly(ADP-Ribose) Glycohydrolase Inhibitors.

Pillay N, Tighe A, Nelson L, Littler S, Coulson-Gilmer C, Bah N, Golder A, Bakker B, Spierings DCJ, James DI, Smith KM, Jordan AM, Morgan RD, Ogilvie DJ, Foijer F, Jackson DA, Taylor SS.

Cancer Cell. 2019 Mar 18;35(3):519-533.e8. doi: 10.1016/j.ccell.2019.02.004.

16.

Self-reported medication nonadherence predicts cholesterol levels over time.

Blalock DV, Zullig LL, Bosworth HB, Taylor SS, Voils CI.

J Psychosom Res. 2019 Mar;118:49-55. doi: 10.1016/j.jpsychores.2019.01.010. Epub 2019 Jan 18.

PMID:
30782354
17.

Globally correlated conformational entropy underlies positive and negative cooperativity in a kinase's enzymatic cycle.

Wang Y, V S M, Kim J, Li G, Ahuja LG, Aoto P, Taylor SS, Veglia G.

Nat Commun. 2019 Feb 18;10(1):799. doi: 10.1038/s41467-019-08655-7.

18.

Crystal structure of the WD40 domain dimer of LRRK2.

Zhang P, Fan Y, Ru H, Wang L, Magupalli VG, Taylor SS, Alessi DR, Wu H.

Proc Natl Acad Sci U S A. 2019 Jan 29;116(5):1579-1584. doi: 10.1073/pnas.1817889116. Epub 2019 Jan 11.

19.

Disordered Protein Kinase Regions in Regulation of Kinase Domain Cores.

Gógl G, Kornev AP, Reményi A, Taylor SS.

Trends Biochem Sci. 2019 Apr;44(4):300-311. doi: 10.1016/j.tibs.2018.12.002. Epub 2019 Jan 2. Review.

PMID:
30611608
20.

cAMP-dependent activation of the Rac guanine exchange factor P-REX1 by type I protein kinase A (PKA) regulatory subunits.

Adame-García SR, Cervantes-Villagrana RD, Orduña-Castillo LB, Del Rio JC, Gutkind JS, Reyes-Cruz G, Taylor SS, Vázquez-Prado J.

J Biol Chem. 2019 Feb 15;294(7):2232-2246. doi: 10.1074/jbc.RA118.006691. Epub 2018 Dec 10.

21.

The p38α Stress Kinase Suppresses Aneuploidy Tolerance by Inhibiting Hif-1α.

Simões-Sousa S, Littler S, Thompson SL, Minshall P, Whalley H, Bakker B, Belkot K, Moralli D, Bronder D, Tighe A, Spierings DCJ, Bah N, Graham J, Nelson L, Green CM, Foijer F, Townsend PA, Taylor SS.

Cell Rep. 2018 Oct 16;25(3):749-760.e6. doi: 10.1016/j.celrep.2018.09.060.

22.

Corrigendum to "A Catalytically-Disabled Double Mutant of Src Tyrosine Kinase Can Be Stabilized into an Active-Like Conformation." J. Mol. Biol. 430(6) (Mar 16 2018), 881-889.

Meng Y, Ahuja LG, Kornev AP, Taylor SS, Roux B.

J Mol Biol. 2018 Oct 19;430(21):4439. doi: 10.1016/j.jmb.2018.09.001. Epub 2018 Sep 13. No abstract available.

PMID:
30220583
23.

Kinase domain dimerization drives RIPK3-dependent necroptosis.

Raju S, Whalen DM, Mengistu M, Swanson C, Quinn JG, Taylor SS, Webster JD, Newton K, Shaw AS.

Sci Signal. 2018 Aug 21;11(544). pii: eaar2188. doi: 10.1126/scisignal.aar2188.

24.

AKAP1 Protects from Cerebral Ischemic Stroke by Inhibiting Drp1-Dependent Mitochondrial Fission.

Flippo KH, Gnanasekaran A, Perkins GA, Ajmal A, Merrill RA, Dickey AS, Taylor SS, McKnight GS, Chauhan AK, Usachev YM, Strack S.

J Neurosci. 2018 Sep 19;38(38):8233-8242. doi: 10.1523/JNEUROSCI.0649-18.2018. Epub 2018 Aug 9.

25.

The role of group cohesion in a group-based behavioral weight loss intervention.

Taylor SS, Olsen MK, McVay MA, Grubber J, Gierisch JM, Yancy WS Jr, Voils CI.

J Behav Med. 2019 Feb;42(1):162-168. doi: 10.1007/s10865-018-9953-4. Epub 2018 Aug 3.

PMID:
30076501
26.

Switching of the folding-energy landscape governs the allosteric activation of protein kinase A.

England JP, Hao Y, Bai L, Glick V, Hodges HC, Taylor SS, Maillard RA.

Proc Natl Acad Sci U S A. 2018 Aug 7;115(32):E7478-E7485. doi: 10.1073/pnas.1802510115. Epub 2018 Jul 23.

27.

Reframing and addressing horizontal violence as a workplace quality improvement concern.

Taylor RA, Taylor SS.

Nurs Forum. 2018 Oct;53(4):459-465. doi: 10.1111/nuf.12273. Epub 2018 Jun 27.

PMID:
29949182
28.

Purifying Selection in the Toll-Like Receptors of Song Sparrows Melospiza melodia.

Nelson-Flower MJ, Germain RR, MacDougall-Shackleton EA, Taylor SS, Arcese P.

J Hered. 2018 Jun 27;109(5):501-509. doi: 10.1093/jhered/esy027.

PMID:
29893971
29.

Effects of a Home-Based Telephone-Supported Physical Activity Program for Older Adult Veterans With Chronic Low Back Pain.

Goode AP, Taylor SS, Hastings SN, Stanwyck C, Coffman CJ, Allen KD.

Phys Ther. 2018 May 1;98(5):369-380. doi: 10.1093/ptj/pzy026.

30.

Polycyclic aromatic hydrocarbon exposure in seaside sparrows (Ammodramus maritimus) following the 2010 Deepwater Horizon oil spill.

Perez-Umphrey AA, Bergeon Burns CM, Stouffer PC, Woltmann S, Taylor SS.

Sci Total Environ. 2018 Jul 15;630:1086-1094. doi: 10.1016/j.scitotenv.2018.02.281. Epub 2018 Mar 7.

PMID:
29554730
31.

The Effectiveness of Health Coaching [Internet].

Gierisch JM, Hughes JM, Edelman D, Bosworth HB, Oddone EZ, Taylor SS, Kosinski AS, McDuffie JR, Swinkels CM, Razouki Z, Masilamani V.

Washington (DC): Department of Veterans Affairs (US); 2017 Apr.

32.

Prevalence of and characteristics associated with insomnia and obstructive sleep apnea among veterans with knee and hip osteoarthritis.

Taylor SS, Hughes JM, Coffman CJ, Jeffreys AS, Ulmer CS, Oddone EZ, Bosworth HB, Yancy WS Jr, Allen KD.

BMC Musculoskelet Disord. 2018 Mar 9;19(1):79. doi: 10.1186/s12891-018-1993-y.

33.

Cognitive Mediators of Change in Physical Functioning in Response to a Multifaceted Intervention for Managing Osteoarthritis.

Taylor SS, Oddone EZ, Coffman CJ, Jeffreys AS, Bosworth HB, Allen KD.

Int J Behav Med. 2018 Apr;25(2):162-170. doi: 10.1007/s12529-017-9689-5.

PMID:
29453622
34.

A Catalytically Disabled Double Mutant of Src Tyrosine Kinase Can Be Stabilized into an Active-Like Conformation.

Meng Y, Ahuja LG, Kornev AP, Taylor SS, Roux B.

J Mol Biol. 2018 Mar 16;430(6):881-889. doi: 10.1016/j.jmb.2018.01.019. Epub 2018 Feb 2. Erratum in: J Mol Biol. 2018 Oct 19;430(21):4439.

35.

Phosphorylation of protein kinase A (PKA) regulatory subunit RIα by protein kinase G (PKG) primes PKA for catalytic activity in cells.

Haushalter KJ, Casteel DE, Raffeiner A, Stefan E, Patel HH, Taylor SS.

J Biol Chem. 2018 Mar 23;293(12):4411-4421. doi: 10.1074/jbc.M117.809988. Epub 2018 Jan 29.

36.
37.

Conformational Landscape of the PRKACA-DNAJB1 Chimeric Kinase, the Driver for Fibrolamellar Hepatocellular Carcinoma.

Tomasini MD, Wang Y, Karamafrooz A, Li G, Beuming T, Gao J, Taylor SS, Veglia G, Simon SM.

Sci Rep. 2018 Jan 15;8(1):720. doi: 10.1038/s41598-017-18956-w.

38.

The gene product of a Trypanosoma equiperdum ortholog of the cAMP-dependent protein kinase regulatory subunit is a monomeric protein that is not capable of binding cyclic nucleotides.

Bubis J, Martínez JC, Calabokis M, Ferreira J, Sanz-Rodríguez CE, Navas V, Escalona JL, Guo Y, Taylor SS.

Biochimie. 2018 Mar;146:166-180. doi: 10.1016/j.biochi.2017.12.010. Epub 2017 Dec 27.

39.

Expression of an active Gαs mutant in skeletal stem cells is sufficient and necessary for fibrous dysplasia initiation and maintenance.

Zhao X, Deng P, Iglesias-Bartolome R, Amornphimoltham P, Steffen DJ, Jin Y, Molinolo AA, de Castro LF, Ovejero D, Yuan Q, Chen Q, Han X, Bai D, Taylor SS, Yang Y, Collins MT, Gutkind JS.

Proc Natl Acad Sci U S A. 2018 Jan 16;115(3):E428-E437. doi: 10.1073/pnas.1713710115. Epub 2017 Dec 27.

40.

Electronic Health Records and Preparedness: Lessons from Hurricanes Katrina and Harvey.

Taylor SS, Ehrenfeld JM.

J Med Syst. 2017 Nov;41(11):173. doi: 10.1007/s10916-017-0822-4. No abstract available.

PMID:
28929422
41.

Integrated Method to Attach DNA Handles and Functionally Select Proteins to Study Folding and Protein-Ligand Interactions with Optical Tweezers.

Hao Y, Canavan C, Taylor SS, Maillard RA.

Sci Rep. 2017 Sep 7;7(1):10843. doi: 10.1038/s41598-017-11214-z.

42.

Sub-mitochondrial localization of the genetic-tagged mitochondrial intermembrane space-bridging components Mic19, Mic60 and Sam50.

Sastri M, Darshi M, Mackey M, Ramachandra R, Ju S, Phan S, Adams S, Stein K, Douglas CR, Kim JJ, Ellisman MH, Taylor SS, Perkins GA.

J Cell Sci. 2017 Oct 1;130(19):3248-3260. doi: 10.1242/jcs.201400. Epub 2017 Aug 14.

43.

Enactors of horizontal violence: The pathological bully, the self-justified bully and the unprofessional co-worker.

Taylor RA, Taylor SS.

J Adv Nurs. 2017 Dec;73(12):3111-3118. doi: 10.1111/jan.13382. Epub 2017 Aug 4.

PMID:
28714096
44.

Making power visible: Doing theatre-based status work with nursing students.

Taylor SS, Taylor RA.

Nurse Educ Pract. 2017 Sep;26:1-5. doi: 10.1016/j.nepr.2017.06.003. Epub 2017 Jun 15.

PMID:
28644980
45.

A dynamic hydrophobic core orchestrates allostery in protein kinases.

Kim J, Ahuja LG, Chao FA, Xia Y, McClendon CL, Kornev AP, Taylor SS, Veglia G.

Sci Adv. 2017 Apr 7;3(4):e1600663. doi: 10.1126/sciadv.1600663. eCollection 2017 Apr.

46.

Neutral Genetic Processes Influence MHC Evolution in Threatened Gopher Tortoises (Gopherus polyphemus).

Elbers JP, Clostio RW, Taylor SS.

J Hered. 2017 Jul 1;108(5):515-523. doi: 10.1093/jhered/esx034.

PMID:
28387863
47.

Fear of Movement and Associated Factors Among Adults With Symptomatic Knee Osteoarthritis.

Gunn AH, Schwartz TA, Arbeeva LS, Callahan LF, Golightly Y, Goode A, Hill CH, Huffman K, Iversen MD, Pathak A, Taylor SS, Allen KD.

Arthritis Care Res (Hoboken). 2017 Dec;69(12):1826-1833. doi: 10.1002/acr.23226. Epub 2017 Nov 6.

48.

ISFM Consensus Guidelines on the Diagnosis and Management of Hypertension in Cats.

Taylor SS, Sparkes AH, Briscoe K, Carter J, Sala SC, Jepson RE, Reynolds BS, Scansen BA.

J Feline Med Surg. 2017 Mar;19(3):288-303. doi: 10.1177/1098612X17693500.

PMID:
28245741
49.

Electrostatic Interactions as Mediators in the Allosteric Activation of Protein Kinase A RIα.

P Barros E, Malmstrom RD, Nourbakhsh K, Del Rio JC, Kornev AP, Taylor SS, Amaro RE.

Biochemistry. 2017 Mar 14;56(10):1536-1545. doi: 10.1021/acs.biochem.6b01152. Epub 2017 Mar 6.

50.

Mutation of a kinase allosteric node uncouples dynamics linked to phosphotransfer.

Ahuja LG, Kornev AP, McClendon CL, Veglia G, Taylor SS.

Proc Natl Acad Sci U S A. 2017 Feb 7;114(6):E931-E940. doi: 10.1073/pnas.1620667114. Epub 2017 Jan 23.

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