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Complement alone drives efficacy of a chimeric antigonococcal monoclonal antibody.

Gulati S, Beurskens FJ, de Kreuk BJ, Roza M, Zheng B, DeOliveira RB, Shaughnessy J, Nowak NA, Taylor RP, Botto M, He X, Ingalls RR, Woodruff TM, Song WC, Schuurman J, Rice PA, Ram S.

PLoS Biol. 2019 Jun 19;17(6):e3000323. doi: 10.1371/journal.pbio.3000323. eCollection 2019 Jun.


Null donors favor prepared immunologists.

Taylor RP.

Blood. 2019 Mar 28;133(13):1389-1390. doi: 10.1182/blood-2019-01-898775. No abstract available.


CD20 and CD37 antibodies synergize to activate complement by Fc-mediated clustering.

Oostindie SC, van der Horst HJ, Lindorfer MA, Cook EM, Tupitza JC, Zent CS, Burack R, VanDerMeid KR, Strumane K, Chamuleau MED, Mutis T, de Jong RN, Schuurman J, Breij ECW, Beurskens FJ, Parren PWHI, Taylor RP.

Haematologica. 2019 Feb 21. pii: haematol.2018.207266. doi: 10.3324/haematol.2018.207266. [Epub ahead of print]


Critical role of C5a in sickle cell disease.

Vercellotti GM, Dalmasso AP, Schaid TR Jr, Nguyen J, Chen C, Ericson ME, Abdulla F, Killeen T, Lindorfer MA, Taylor RP, Belcher JD.

Am J Hematol. 2019 Mar;94(3):327-337. doi: 10.1002/ajh.25384. Epub 2019 Jan 3.


Nature's Fractal Similarities: Integrating Art and Science.

Taylor RP.

Nonlinear Dynamics Psychol Life Sci. 2019 Jan;23(1):173-176.


Mechanisms of Complement-Mediated Damage in Hematological Disorders.

Taylor RP, Lindorfer MA.

Semin Hematol. 2018 Jul;55(3):118-123. doi: 10.1053/j.seminhematol.2018.02.003. Epub 2018 Feb 14. Review.


Endothelial Microparticles and Systemic Complement Activation in Patients With Chronic Kidney Disease.

Jalal D, Renner B, Laskowski J, Stites E, Cooper J, Valente K, You Z, Perrenoud L, Le Quintrec M, Muhamed I, Christians U, Klawitter J, Lindorfer MA, Taylor RP, Holers VM, Thurman JM.

J Am Heart Assoc. 2018 Jul 13;7(14). pii: e007818. doi: 10.1161/JAHA.117.007818.


Modeling the Improved Visual Acuity Using Photodiode Based Retinal Implants Featuring Fractal Electrodes.

Watterson WJ, Montgomery RD, Taylor RP.

Front Neurosci. 2018 Apr 24;12:277. doi: 10.3389/fnins.2018.00277. eCollection 2018.


An Eye for Nature.

Taylor RP.

Nonlinear Dynamics Psychol Life Sci. 2018 Apr;22(2):283-287.


Corrigendum: IgG Fc domains that bind C1q but not effector Fcγ receptors delineate the importance of complement-mediated effector functions.

Lee CH, Romain G, Yan W, Watanabe M, Charab W, Todorova B, Lee J, Triplett K, Donkor M, Lungu OI, Lux A, Marshall N, Lindorfer MA, Goff OR, Balbino B, Kang TH, Tanno H, Delidakis G, Alford C, Taylor RP, Nimmerjahn F, Varadarajan N, Bruhns P, Zhang YJ, Georgiou G.

Nat Immunol. 2017 Sep 19;18(10):1173. doi: 10.1038/ni1017-1173c. No abstract available.


Fractal Electrodes as a Generic Interface for Stimulating Neurons.

Watterson WJ, Montgomery RD, Taylor RP.

Sci Rep. 2017 Jul 27;7(1):6717. doi: 10.1038/s41598-017-06762-3.


Complement C5a-Induced Changes in Neutrophil Morphology During Inflammation.

Denk S, Taylor RP, Wiegner R, Cook EM, Lindorfer MA, Pfeiffer K, Paschke S, Eiseler T, Weiss M, Barth E, Lambris JD, Kalbitz M, Martin T, Barth H, Messerer DAC, Gebhard F, Huber-Lang MS.

Scand J Immunol. 2017 Sep;86(3):143-155. doi: 10.1111/sji.12580.


IgG Fc domains that bind C1q but not effector Fcγ receptors delineate the importance of complement-mediated effector functions.

Lee CH, Romain G, Yan W, Watanabe M, Charab W, Todorova B, Lee J, Triplett K, Donkor M, Lungu OI, Lux A, Marshall N, Lindorfer MA, Goff OR, Balbino B, Kang TH, Tanno H, Delidakis G, Alford C, Taylor RP, Nimmerjahn F, Varadarajan N, Bruhns P, Zhang YJ, Georgiou G.

Nat Immunol. 2017 Aug;18(8):889-898. doi: 10.1038/ni.3770. Epub 2017 Jun 12. Erratum in: Nat Immunol. 2017 Sep 19;18(10 ):1173.


Hexamerization-enhanced CD20 antibody mediates complement-dependent cytotoxicity in serum genetically deficient in C9.

Taylor RP, Lindorfer MA, Cook EM, Beurskens FJ, Schuurman J, Parren PWHI, Zent CS, VanDerMeid KR, Burack R, Mizuno M, Morgan BP.

Clin Immunol. 2017 Aug;181:24-28. doi: 10.1016/j.clim.2017.05.016. Epub 2017 May 31.


Neutrophils: positive or negative?

Taylor RP.

Blood. 2017 May 11;129(19):2596-2597. doi: 10.1182/blood-2017-03-774695. No abstract available.


Seeing shapes in seemingly random spatial patterns: Fractal analysis of Rorschach inkblots.

Taylor RP, Martin TP, Montgomery RD, Smith JH, Micolich AP, Boydston C, Scannell BC, Fairbanks MS, Spehar B.

PLoS One. 2017 Feb 14;12(2):e0171289. doi: 10.1371/journal.pone.0171289. eCollection 2017.


Pericytes and immune cells contribute to complement activation in tubulointerstitial fibrosis.

Xavier S, Sahu RK, Landes SG, Yu J, Taylor RP, Ayyadevara S, Megyesi J, Stallcup WB, Duffield JS, Reis ES, Lambris JD, Portilla D.

Am J Physiol Renal Physiol. 2017 Mar 1;312(3):F516-F532. doi: 10.1152/ajprenal.00604.2016. Epub 2017 Jan 4.


Compstatin Cp40 blocks hematin-mediated deposition of C3b fragments on erythrocytes: Implications for treatment of malarial anemia.

Lindorfer MA, Cook EM, Reis ES, Ricklin D, Risitano AM, Lambris JD, Taylor RP.

Clin Immunol. 2016 Oct;171:32-35. doi: 10.1016/j.clim.2016.08.017. Epub 2016 Aug 18.


Antibodies That Efficiently Form Hexamers upon Antigen Binding Can Induce Complement-Dependent Cytotoxicity under Complement-Limiting Conditions.

Cook EM, Lindorfer MA, van der Horst H, Oostindie S, Beurskens FJ, Schuurman J, Zent CS, Burack R, Parren PW, Taylor RP.

J Immunol. 2016 Sep 1;197(5):1762-75. doi: 10.4049/jimmunol.1600648. Epub 2016 Jul 29.


Taxonomy of Individual Variations in Aesthetic Responses to Fractal Patterns.

Spehar B, Walker N, Taylor RP.

Front Hum Neurosci. 2016 Jul 8;10:350. doi: 10.3389/fnhum.2016.00350. eCollection 2016.


Navigation performance in virtual environments varies with fractal dimension of landscape.

Juliani AW, Bies AJ, Boydston CR, Taylor RP, Sereno ME.

J Environ Psychol. 2016 Sep;47:155-165.


Echocardiographic Ischemic Memory Imaging Through Complement-Mediated Vascular Adhesion of Phosphatidylserine-Containing Microbubbles.

Mott B, Packwood W, Xie A, Belcik JT, Taylor RP, Zhao Y, Davidson BP, Lindner JR.

JACC Cardiovasc Imaging. 2016 Aug;9(8):937-46. doi: 10.1016/j.jcmg.2015.11.031. Epub 2016 Jun 15.


Aesthetic Responses to Exact Fractals Driven by Physical Complexity.

Bies AJ, Blanc-Goldhammer DR, Boydston CR, Taylor RP, Sereno ME.

Front Hum Neurosci. 2016 May 20;10:210. doi: 10.3389/fnhum.2016.00210. eCollection 2016.


Study Design and Rationale for the Phase 3 Clinical Development Program of Enobosarm, a Selective Androgen Receptor Modulator, for the Prevention and Treatment of Muscle Wasting in Cancer Patients (POWER Trials).

Crawford J, Prado CM, Johnston MA, Gralla RJ, Taylor RP, Hancock ML, Dalton JT.

Curr Oncol Rep. 2016 Jun;18(6):37. doi: 10.1007/s11912-016-0522-0. Review.


Cytotoxic mechanisms of immunotherapy: Harnessing complement in the action of anti-tumor monoclonal antibodies.

Taylor RP, Lindorfer MA.

Semin Immunol. 2016 Jun;28(3):309-16. doi: 10.1016/j.smim.2016.03.003. Epub 2016 Mar 19. Review.


Real-time analysis of the detailed sequence of cellular events in mAb-mediated complement-dependent cytotoxicity of B-cell lines and of chronic lymphocytic leukemia B-cells.

Lindorfer MA, Cook EM, Tupitza JC, Zent CS, Burack R, de Jong RN, Beurskens FJ, Schuurman J, Parren PW, Taylor RP.

Mol Immunol. 2016 Feb;70:13-23. doi: 10.1016/j.molimm.2015.12.007. Epub 2015 Dec 12.


Beauty and the beholder: the role of visual sensitivity in visual preference.

Spehar B, Wong S, van de Klundert S, Lui J, Clifford CW, Taylor RP.

Front Hum Neurosci. 2015 Sep 23;9:514. doi: 10.3389/fnhum.2015.00514. eCollection 2015.


Temporal Structure of Human Gaze Dynamics Is Invariant During Free Viewing.

Marlow CA, Viskontas IV, Matlin A, Boydston C, Boxer A, Taylor RP.

PLoS One. 2015 Sep 30;10(9):e0139379. doi: 10.1371/journal.pone.0139379. eCollection 2015.


Human IgG is produced in a pro-form that requires clipping of C-terminal lysines for maximal complement activation.

van den Bremer ET, Beurskens FJ, Voorhorst M, Engelberts PJ, de Jong RN, van der Boom BG, Cook EM, Lindorfer MA, Taylor RP, van Berkel PH, Parren PW.

MAbs. 2015;7(4):672-80. doi: 10.1080/19420862.2015.1046665.


Human physiological benefits of viewing nature: EEG responses to exact and statistical fractal patterns.

Hagerhall CM, Laike T, Küller M, Marcheschi E, Boydston C, Taylor RP.

Nonlinear Dynamics Psychol Life Sci. 2015 Jan;19(1):1-12.


Fcγ-receptor-mediated trogocytosis impacts mAb-based therapies: historical precedence and recent developments.

Taylor RP, Lindorfer MA.

Blood. 2015 Jan 29;125(5):762-6. doi: 10.1182/blood-2014-10-569244. Epub 2014 Dec 10. Review.


Ibrutinib interferes with the cell-mediated anti-tumor activities of therapeutic CD20 antibodies: implications for combination therapy.

Da Roit F, Engelberts PJ, Taylor RP, Breij EC, Gritti G, Rambaldi A, Introna M, Parren PW, Beurskens FJ, Golay J.

Haematologica. 2015 Jan;100(1):77-86. doi: 10.3324/haematol.2014.107011. Epub 2014 Oct 24.


Fractal images induce fractal pupil dilations and constrictions.

Moon P, Muday J, Raynor S, Schirillo J, Boydston C, Fairbanks MS, Taylor RP.

Int J Psychophysiol. 2014 Sep;93(3):316-21. doi: 10.1016/j.ijpsycho.2014.06.013. Epub 2014 Jun 27.


Analyses of CD20 monoclonal antibody-mediated tumor cell killing mechanisms: rational design of dosing strategies.

Taylor RP, Lindorfer MA.

Mol Pharmacol. 2014 Nov;86(5):485-91. doi: 10.1124/mol.114.092684. Epub 2014 Jun 18. Review.


A humanized antibody that regulates the alternative pathway convertase: potential for therapy of renal disease associated with nephritic factors.

Paixão-Cavalcante D, Torreira E, Lindorfer MA, Rodriguez de Cordoba S, Morgan BP, Taylor RP, Llorca O, Harris CL.

J Immunol. 2014 May 15;192(10):4844-51. doi: 10.4049/jimmunol.1303131. Epub 2014 Apr 11.


Chemoimmunotherapy for relapsed/refractory and progressive 17p13-deleted chronic lymphocytic leukemia (CLL) combining pentostatin, alemtuzumab, and low-dose rituximab is effective and tolerable and limits loss of CD20 expression by circulating CLL cells.

Zent CS, Taylor RP, Lindorfer MA, Beum PV, LaPlant B, Wu W, Call TG, Bowen DA, Conte MJ, Frederick LA, Link BK, Blackwell SE, Veeramani S, Baig NA, Viswanatha DS, Weiner GJ, Witzig TE.

Am J Hematol. 2014 Jul;89(7):757-65. doi: 10.1002/ajh.23737. Epub 2014 Apr 26.


Complement is activated by IgG hexamers assembled at the cell surface.

Diebolder CA, Beurskens FJ, de Jong RN, Koning RI, Strumane K, Lindorfer MA, Voorhorst M, Ugurlar D, Rosati S, Heck AJ, van de Winkel JG, Wilson IA, Koster AJ, Taylor RP, Saphire EO, Burton DR, Schuurman J, Gros P, Parren PW.

Science. 2014 Mar 14;343(6176):1260-3. doi: 10.1126/science.1248943.


Induced resistance to ofatumumab-mediated cell clearance mechanisms, including complement-dependent cytotoxicity, in chronic lymphocytic leukemia.

Baig NA, Taylor RP, Lindorfer MA, Church AK, LaPlant BR, Pettinger AM, Shanafelt TD, Nowakowski GS, Zent CS.

J Immunol. 2014 Feb 15;192(4):1620-9. doi: 10.4049/jimmunol.1302954. Epub 2014 Jan 15.


Selective androgen receptor modulators for the prevention and treatment of muscle wasting associated with cancer.

Dalton JT, Taylor RP, Mohler ML, Steiner MS.

Curr Opin Support Palliat Care. 2013 Dec;7(4):345-51. doi: 10.1097/SPC.0000000000000015. Review.


Mechanisms of enhanced neutralization of botulinum neurotoxin by monoclonal antibodies conjugated to antibodies specific for the erythrocyte complement receptor.

Sharma R, Zhao H, Al-Saleem FH, Ubaid AS, Puligedda RD, Segan AT, Lindorfer MA, Bermudez R, Elias M, Adekar SP, Simpson LL, Taylor RP, Dessain SK.

Mol Immunol. 2014 Feb;57(2):247-54. doi: 10.1016/j.molimm.2013.09.005. Epub 2013 Nov 1.


Gnawing at Metchnikoff's paradigm.

Taylor RP.

Blood. 2013 Oct 24;122(17):2922-4. doi: 10.1182/blood-2013-07-514083.


Activation of complement by monoclonal antibodies that target cell-associated β₂-microglobulin: implications for cancer immunotherapy.

Pokrass MJ, Liu MF, Lindorfer MA, Taylor RP.

Mol Immunol. 2013 Dec;56(4):549-60. doi: 10.1016/j.molimm.2013.05.242. Epub 2013 Aug 1.


The role of complement in mAb-based therapies of cancer.

Taylor RP, Lindorfer MA.

Methods. 2014 Jan 1;65(1):18-27. doi: 10.1016/j.ymeth.2013.07.027. Epub 2013 Jul 22. Review.


Rapid clearance of rituximab may contribute to the continued high incidence of autoimmune hematologic complications of chemoimmunotherapy for chronic lymphocytic leukemia.

Mo CC, Njuguna N, Beum PV, Lindorfer MA, Vire B, Lee E, Marti G, Wilson WH, Taylor RP, Wiestner A.

Haematologica. 2013 Aug;98(8):1259-63. doi: 10.3324/haematol.2012.080929. Epub 2013 May 28.


The art and science of hyperbolic tessellations.

Van Dusen B, Taylor RP.

Nonlinear Dynamics Psychol Life Sci. 2013 Apr;17(2):317-23.


Monoclonal antibody (mAb)-based cancer therapy: Is it time to reevaluate dosing strategies?

Lindorfer MA, Wiestner A, Zent CS, Taylor RP.

Oncoimmunology. 2012 Sep 1;1(6):959-961.


Impact of small-angle scattering on ballistic transport in quantum dots.

See AM, Pilgrim I, Scannell BC, Montgomery RD, Klochan O, Burke AM, Aagesen M, Lindelof PE, Farrer I, Ritchie DA, Taylor RP, Hamilton AR, Micolich AP.

Phys Rev Lett. 2012 May 11;108(19):196807. Epub 2012 May 11.


Reactive oxygen species are not a required trigger for exercise-induced late preconditioning in the rat heart.

Taylor RP, Starnes JW.

Am J Physiol Regul Integr Comp Physiol. 2012 Nov 1;303(9):R968-74. doi: 10.1152/ajpregu.00024.2012. Epub 2012 Sep 5.


Anti-CD20 antibody therapy for B-cell lymphomas.

Taylor RP, Lindorfer MA, Zent CS.

N Engl J Med. 2012 Aug 30;367(9):876-7; author reply 878. doi: 10.1056/NEJMc1207378. No abstract available.


The complement receptor 2/factor H fusion protein TT30 protects paroxysmal nocturnal hemoglobinuria erythrocytes from complement-mediated hemolysis and C3 fragment.

Risitano AM, Notaro R, Pascariello C, Sica M, del Vecchio L, Horvath CJ, Fridkis-Hareli M, Selleri C, Lindorfer MA, Taylor RP, Luzzatto L, Holers VM.

Blood. 2012 Jun 28;119(26):6307-16. doi: 10.1182/blood-2011-12-398792. Epub 2012 May 10.

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