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Scaffold hybridization strategy towards potent hydroxamate-based inhibitors of Flaviviridae viruses and Trypanosoma species.

Giannakopoulou E, Pardali V, Frakolaki E, Siozos V, Myrianthopoulos V, Mikros E, Taylor MC, Kelly JM, Vassilaki N, Zoidis G.

Medchemcomm. 2019 May 16;10(6):991-1006. doi: 10.1039/c9md00200f. eCollection 2019 Jun 1.


Expanding Beyond Vancomycin and Aminoglycosides: A Novel Foscarnet Pharmacist-Managed Dosing Service.

Pillinger KE, McClanahan S, Arnall J, Taylor MC.

Ann Pharmacother. 2019 Oct;53(10):1069-1070. doi: 10.1177/1060028019860515. Epub 2019 Jun 26. No abstract available.


Novel 2,6-diketopiperazine-derived acetohydroxamic acids as promising anti-Trypanosoma brucei agents.

Fytas G, Zoidis G, Taylor MC, Kelly JM, Tsatsaroni A, Tsotinis A.

Future Med Chem. 2019 Jun;11(11):1259-1266. doi: 10.4155/fmc-2018-0599. Epub 2019 Jun 4.


A single dose of antibody-drug conjugate cures a stage 1 model of African trypanosomiasis.

MacGregor P, Gonzalez-Munoz AL, Jobe F, Taylor MC, Rust S, Sandercock AM, Macleod OJS, Van Bocxlaer K, Francisco AF, D'Hooge F, Tiberghien A, Barry CS, Howard P, Higgins MK, Vaughan TJ, Minter R, Carrington M.

PLoS Negl Trop Dis. 2019 May 23;13(5):e0007373. doi: 10.1371/journal.pntd.0007373. eCollection 2019 May.


Recombinant Aflatoxin-Degrading F420H2-Dependent Reductase from Mycobacterium smegmatis Protects Mammalian Cells from Aflatoxin Toxicity.

Li CH, Li WY, Hsu IN, Liao YY, Yang CY, Taylor MC, Liu YF, Huang WH, Chang HH, Huang HL, Lo SC, Lin TY, Sun WC, Chuang YY, Yang YC, Fu RH, Tsai RT.

Toxins (Basel). 2019 May 8;11(5). pii: E259. doi: 10.3390/toxins11050259.


Synthesis and Evaluation of Nifurtimox-Adamantane Adducts with Trypanocidal Activity.

Foscolos AS, Papanastasiou I, Tsotinis A, Taylor MC, Kelly JM.

ChemMedChem. 2019 Jul 3;14(13):1227-1231. doi: 10.1002/cmdc.201900165. Epub 2019 May 27.


Novel symmetric bis-benzimidazoles: Synthesis, DNA/RNA binding and antitrypanosomal activity.

Popov AB, Stolić I, Krstulović L, Taylor MC, Kelly JM, Tomić S, Tumir L, Bajić M, Raić-Malić S.

Eur J Med Chem. 2019 Jul 1;173:63-75. doi: 10.1016/j.ejmech.2019.04.007. Epub 2019 Apr 7.


Synthesis of diphenoxyadamantane alkylamines with pharmacological interest.

Georgiadis MO, Kourbeli V, Ioannidou V, Karakitsios E, Papanastasiou I, Tsotinis A, Komiotis D, Vocat A, Cole ST, Taylor MC, Kelly JM.

Bioorg Med Chem Lett. 2019 Jun 1;29(11):1278-1281. doi: 10.1016/j.bmcl.2019.04.010. Epub 2019 Apr 6.


Exploiting Genetically Modified Dual-Reporter Strains to Monitor Experimental Trypanosoma cruzi Infections and Host-Parasite Interactions.

Taylor MC, Francisco AF, Jayawardhana S, Mann GS, Ward AI, Olmo F, Lewis MD, Kelly JM.

Methods Mol Biol. 2019;1955:147-163. doi: 10.1007/978-1-4939-9148-8_11.


Nitrogen deprivation in Fusarium oxysporum promotes mycotoxin production via intermediates in the Krebs cycle and unreported methylmalonyl-CoA mutase activity.

Karpe AV, Dunn MS, Taylor MC, Nguyen T, Ong C, Karla T, Rockman S, Beale DJ.

Metabolomics. 2018 Dec 11;14(12):160. doi: 10.1007/s11306-018-1459-0.


Loss of Phosphoethanolamine N-Methyltransferases Abolishes Phosphatidylcholine Synthesis and Is Lethal.

Chen W, Taylor MC, Barrow RA, Croyal M, Masle J.

Plant Physiol. 2019 Jan;179(1):124-142. doi: 10.1104/pp.18.00694. Epub 2018 Oct 31.


Increased DHA Production in Seed Oil Using a Selective Lysophosphatidic Acid Acyltransferase.

Shrestha P, Hussain D, Mulder RJ, Taylor MC, Singh SP, Petrie JR, Zhou XR.

Front Plant Sci. 2018 Aug 22;9:1234. doi: 10.3389/fpls.2018.01234. eCollection 2018.


Liquid chromatography-mass spectrometry based approach for rapid comparison of lysophosphatidic acid acyltransferase activity on multiple substrates.

Hou T, Taylor MC, Shrestha P, Singh S, Zhang ZJ, Zhou XR.

J Chromatogr A. 2018 Oct 19;1572:100-105. doi: 10.1016/j.chroma.2018.08.054. Epub 2018 Aug 29.


Synthesis, anti-bacterial and anti-protozoal activities of amidinobenzimidazole derivatives and their interactions with DNA and RNA.

Bistrović A, Krstulović L, Stolić I, Drenjančević D, Talapko J, Taylor MC, Kelly JM, Bajić M, Raić-Malić S.

J Enzyme Inhib Med Chem. 2018 Dec;33(1):1323-1334. doi: 10.1080/14756366.2018.1484733.


Assessing the Effectiveness of Curative Benznidazole Treatment in Preventing Chronic Cardiac Pathology in Experimental Models of Chagas Disease.

Francisco AF, Jayawardhana S, Taylor MC, Lewis MD, Kelly JM.

Antimicrob Agents Chemother. 2018 Sep 24;62(10). pii: e00832-18. doi: 10.1128/AAC.00832-18. Print 2018 Oct.


Imaging the development of chronic Chagas disease after oral transmission.

Lewis MD, Francisco AF, Jayawardhana S, Langston H, Taylor MC, Kelly JM.

Sci Rep. 2018 Jul 26;8(1):11292. doi: 10.1038/s41598-018-29564-7.


Shaving Is an Epiphenomenon of Type I and II Anti-CD20-Mediated Phagocytosis, whereas Antigenic Modulation Limits Type I Monoclonal Antibody Efficacy.

Dahal LN, Huang CY, Stopforth RJ, Mead A, Chan K, Bowater JX, Taylor MC, Narang P, Chan HTC, Kim JH, Vaughan AT, Forconi F, Beers SA.

J Immunol. 2018 Aug 15;201(4):1211-1221. doi: 10.4049/jimmunol.1701122. Epub 2018 Jul 11.


Optimising genetic transformation of Trypanosoma cruzi using hydroxyurea-induced cell-cycle synchronisation.

Olmo F, Costa FC, Mann GS, Taylor MC, Kelly JM.

Mol Biochem Parasitol. 2018 Dec;226:34-36. doi: 10.1016/j.molbiopara.2018.07.002. Epub 2018 Jul 7.


The Dynamics of Blood Drop Release from Swinging Objects in the Creation of Cast-off Bloodstain Patterns.

Williams EMP, Graham ES, Jermy MC, Kieser DC, Taylor MC.

J Forensic Sci. 2019 Mar;64(2):413-421. doi: 10.1111/1556-4029.13855. Epub 2018 Jul 5.


An automated approach to the classification of impact spatter and cast-off bloodstain patterns.

Arthur RM, Hoogenboom J, Baiker M, Taylor MC, de Bruin KG.

Forensic Sci Int. 2018 Aug;289:310-319. doi: 10.1016/j.forsciint.2018.05.019. Epub 2018 Jun 20.


Up-regulation of lipid biosynthesis increases the oil content in leaves of Sorghum bicolor.

Vanhercke T, Belide S, Taylor MC, El Tahchy A, Okada S, Rolland V, Liu Q, Mitchell M, Shrestha P, Venables I, Ma L, Blundell C, Mathew A, Ziolkowski L, Niesner N, Hussain D, Dong B, Liu G, Godwin ID, Lee J, Rug M, Zhou XR, Singh SP, Petrie JR.

Plant Biotechnol J. 2019 Jan;17(1):220-232. doi: 10.1111/pbi.12959. Epub 2018 Jul 13.


NMT1 and NMT3 N-Methyltransferase Activity Is Critical to Lipid Homeostasis, Morphogenesis, and Reproduction.

Chen W, Salari H, Taylor MC, Jost R, Berkowitz O, Barrow R, Qiu D, Branco R, Masle J.

Plant Physiol. 2018 Aug;177(4):1605-1628. doi: 10.1104/pp.18.00457. Epub 2018 May 18.


Contextual information management: An example of independent-checking in the review of laboratory-based bloodstain pattern analysis.

Osborne NKP, Taylor MC.

Sci Justice. 2018 May;58(3):226-231. doi: 10.1016/j.scijus.2018.01.001. Epub 2018 Jan 16.


Expanding the toolbox for Trypanosoma cruzi: A parasite line incorporating a bioluminescence-fluorescence dual reporter and streamlined CRISPR/Cas9 functionality for rapid in vivo localisation and phenotyping.

Costa FC, Francisco AF, Jayawardhana S, Calderano SG, Lewis MD, Olmo F, Beneke T, Gluenz E, Sunter J, Dean S, Kelly JM, Taylor MC.

PLoS Negl Trop Dis. 2018 Apr 2;12(4):e0006388. doi: 10.1371/journal.pntd.0006388. eCollection 2018 Apr.


Comparison of Etomidate, Benzocaine, and MS222 Anesthesia with and without Subsequent Flunixin Meglumine Analgesia in African Clawed Frogs (Xenopus laevis).

Smith BD, Vail KJ, Carroll GL, Taylor MC, Jeffery ND, Vemulapalli TH, Elliott JJ.

J Am Assoc Lab Anim Sci. 2018 Mar 1;57(2):202-209.


Seed-specific RNAi in safflower generates a superhigh oleic oil with extended oxidative stability.

Wood CC, Okada S, Taylor MC, Menon A, Mathew A, Cullerne D, Stephen SJ, Allen RS, Zhou XR, Liu Q, Oakeshott JG, Singh SP, Green AG.

Plant Biotechnol J. 2018 Oct;16(10):1788-1796. doi: 10.1111/pbi.12915. Epub 2018 Apr 2.


Tetrasubstituted Imidazolium Salts as Potent Antiparasitic Agents against African and American Trypanosomiases.

Ghashghaei O, Kielland N, Revés M, Taylor MC, Kelly JM, Di Pietro O, Muñoz-Torrero D, Pérez B, Lavilla R.

Molecules. 2018 Jan 16;23(1). pii: E177. doi: 10.3390/molecules23010177.


Letter to the Editor-A Contribution to Contextual Information Management in Bloodstain Pattern Analysis: Preliminary Idea for a Two-Step Method of Analysis.

Taylor MC, Osborne NKP.

J Forensic Sci. 2018 Jan;63(1):341. doi: 10.1111/1556-4029.13705. No abstract available.


Sacral Skin Temperature Assessed by Thermal Imaging: Role of Patient Vascular Attributes.

Mayrovitz HN, Spagna PE, Taylor MC.

J Wound Ostomy Continence Nurs. 2018 Jan/Feb;45(1):17-21. doi: 10.1097/WON.0000000000000392.


Sugar analog synthesis by in vitro biocatalytic cascade: A comparison of alternative enzyme complements for dihydroxyacetone phosphate production as a precursor to rare chiral sugar synthesis.

Hartley CJ, French NG, Scoble JA, Williams CC, Churches QI, Frazer AR, Taylor MC, Coia G, Simpson G, Turner NJ, Scott C.

PLoS One. 2017 Nov 7;12(11):e0184183. doi: 10.1371/journal.pone.0184183. eCollection 2017.


Genome-wide mutagenesis and multi-drug resistance in American trypanosomes induced by the front-line drug benznidazole.

Campos MC, Phelan J, Francisco AF, Taylor MC, Lewis MD, Pain A, Clark TG, Kelly JM.

Sci Rep. 2017 Oct 31;7(1):14407. doi: 10.1038/s41598-017-14986-6.


An eye tracking study of bloodstain pattern analysts during pattern classification.

Arthur RM, Hoogenboom J, Green RD, Taylor MC, de Bruin KG.

Int J Legal Med. 2018 May;132(3):875-885. doi: 10.1007/s00414-017-1711-6. Epub 2017 Oct 18.


Syntheses of three naturally occurring polybrominated 3,3'-bi-1H-indoles.

Ansari NH, Taylor MC, Söderberg BCG.

Tetrahedron Lett. 2017 Mar 15;58(11):1053-1056. doi: 10.1016/j.tetlet.2017.01.103. Epub 2017 Feb 3.


Pathogen imaging applications.

Taylor MC, Ward TH.

Methods. 2017 Aug 15;127:1-2. doi: 10.1016/j.ymeth.2017.08.011. No abstract available.


Lipophilic conformationally constrained spiro carbocyclic 2,6-diketopiperazine-1-acetohydroxamic acid analogues as trypanocidal and leishmanicidal agents: An extended SAR study.

Zoidis G, Tsotinis A, Tsatsaroni A, Taylor MC, Kelly JM, Efstathiou A, Smirlis D, Fytas G.

Chem Biol Drug Des. 2018 Feb;91(2):408-421. doi: 10.1111/cbdd.13088. Epub 2017 Sep 18.


Biological factors that impinge on Chagas disease drug development.

Francisco AF, Jayawardhana S, Lewis MD, Taylor MC, Kelly JM.

Parasitology. 2017 Dec;144(14):1871-1880. doi: 10.1017/S0031182017001469. Epub 2017 Aug 23. Review.


Comparative Lipidomics and Proteomics of Lipid Droplets in the Mesocarp and Seed Tissues of Chinese Tallow (Triadica sebifera).

Zhi Y, Taylor MC, Campbell PM, Warden AC, Shrestha P, El Tahchy A, Rolland V, Vanhercke T, Petrie JR, White RG, Chen W, Singh SP, Liu Q.

Front Plant Sci. 2017 Aug 2;8:1339. doi: 10.3389/fpls.2017.01339. eCollection 2017.


An image-processing methodology for extracting bloodstain pattern features.

Arthur RM, Humburg PJ, Hoogenboom J, Baiker M, Taylor MC, de Bruin KG.

Forensic Sci Int. 2017 Aug;277:122-132. doi: 10.1016/j.forsciint.2017.05.022. Epub 2017 Jun 3.


Mycobacterial F420H2-Dependent Reductases Promiscuously Reduce Diverse Compounds through a Common Mechanism.

Greening C, Jirapanjawat T, Afroze S, Ney B, Scott C, Pandey G, Lee BM, Russell RJ, Jackson CJ, Oakeshott JG, Taylor MC, Warden AC.

Front Microbiol. 2017 May 31;8:1000. doi: 10.3389/fmicb.2017.01000. eCollection 2017.


The Reliability of Swipe/Wipe Classification and Directionality Determination Methods in Bloodstain Pattern Analysis.

Yuen SKY, Taylor MC, Owens G, Elliot DA.

J Forensic Sci. 2017 Jul;62(4):1037-1042. doi: 10.1111/1556-4029.13298. Epub 2017 May 3.


A reconfigured Kennedy pathway which promotes efficient accumulation of medium-chain fatty acids in leaf oils.

Reynolds KB, Taylor MC, Cullerne DP, Blanchard CL, Wood CC, Singh SP, Petrie JR.

Plant Biotechnol J. 2017 Nov;15(11):1397-1408. doi: 10.1111/pbi.12724. Epub 2017 May 3.


Experimental measurement of breath exit velocity and expirated bloodstain patterns produced under different exhalation mechanisms.

Geoghegan PH, Laffra AM, Hoogendorp NK, Taylor MC, Jermy MC.

Int J Legal Med. 2017 Sep;131(5):1193-1201. doi: 10.1007/s00414-017-1545-2. Epub 2017 Feb 2.


Step changes in leaf oil accumulation via iterative metabolic engineering.

Vanhercke T, Divi UK, El Tahchy A, Liu Q, Mitchell M, Taylor MC, Eastmond PJ, Bryant F, Mechanicos A, Blundell C, Zhi Y, Belide S, Shrestha P, Zhou XR, Ral JP, White RG, Green A, Singh SP, Petrie JR.

Metab Eng. 2017 Jan;39:237-246. doi: 10.1016/j.ymben.2016.12.007. Epub 2016 Dec 18.


Passive Drip Stain Formation Dynamics of Blood onto Hard Surfaces and Comparison with Simple Fluids for Blood Substitute Development and Assessment<sup/>.

Stotesbury T, Taylor MC, Jermy MC.

J Forensic Sci. 2017 Jan;62(1):74-82. doi: 10.1111/1556-4029.13217. Epub 2016 Nov 22.


The Reliability of Pattern Classification in Bloodstain Pattern Analysis-PART 2: Bloodstain Patterns on Fabric Surfaces.

Taylor MC, Laber TL, Kish PE, Owens G, Osborne NK.

J Forensic Sci. 2016 Nov;61(6):1461-1466. doi: 10.1111/1556-4029.13191. Epub 2016 Sep 19.


The Redox Cofactor F420 Protects Mycobacteria from Diverse Antimicrobial Compounds and Mediates a Reductive Detoxification System.

Jirapanjawat T, Ney B, Taylor MC, Warden AC, Afroze S, Russell RJ, Lee BM, Jackson CJ, Oakeshott JG, Pandey G, Greening C.

Appl Environ Microbiol. 2016 Dec 1;82(23):6810-6818. doi: 10.1128/AEM.02500-16. Epub 2016 Sep 16.


Synthesis and biological evaluation of N-cyanoalkyl-, N-aminoalkyl-, and N-guanidinoalkyl-substituted 4-aminoquinoline derivatives as potent, selective, brain permeable antitrypanosomal agents.

Sola I, Artigas A, Taylor MC, Pérez-Areales FJ, Viayna E, Clos MV, Pérez B, Wright CW, Kelly JM, Muñoz-Torrero D.

Bioorg Med Chem. 2016 Nov 1;24(21):5162-5171. doi: 10.1016/j.bmc.2016.08.036. Epub 2016 Aug 22.


The methanogenic redox cofactor F420 is widely synthesized by aerobic soil bacteria.

Ney B, Ahmed FH, Carere CR, Biswas A, Warden AC, Morales SE, Pandey G, Watt SJ, Oakeshott JG, Taylor MC, Stott MB, Jackson CJ, Greening C.

ISME J. 2017 Jan;11(1):125-137. doi: 10.1038/ismej.2016.100. Epub 2016 Aug 9.


Drip bloodstain appearance on inclined apparel fabrics: Effect of prior-laundering, fibre content and fabric structure.

de Castro TC, Carr DJ, Taylor MC, Kieser JA, Duncan W.

Forensic Sci Int. 2016 Sep;266:488-501. doi: 10.1016/j.forsciint.2016.07.008. Epub 2016 Jul 18.


Physiology, Biochemistry, and Applications of F420- and Fo-Dependent Redox Reactions.

Greening C, Ahmed FH, Mohamed AE, Lee BM, Pandey G, Warden AC, Scott C, Oakeshott JG, Taylor MC, Jackson CJ.

Microbiol Mol Biol Rev. 2016 Apr 27;80(2):451-93. doi: 10.1128/MMBR.00070-15. Print 2016 Jun. Review.

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