Sort by
Items per page

Send to

Choose Destination

Search results

Items: 1 to 50 of 82


The missing link: allostery and catalysis in the anti-viral protein SAMHD1.

Morris ER, Taylor IA.

Biochem Soc Trans. 2019 Jul 11. pii: BST20180348. doi: 10.1042/BST20180348. [Epub ahead of print] Review.


IMP1 KH1 and KH2 domains create a structural platform with unique RNA recognition and re-modelling properties.

Dagil R, Ball NJ, Ogrodowicz RW, Hobor F, Purkiss AG, Kelly G, Martin SR, Taylor IA, Ramos A.

Nucleic Acids Res. 2019 May 7;47(8):4334-4348. doi: 10.1093/nar/gkz136.


Structural basis of dimerization and dual W-box DNA recognition by rice WRKY domain.

Cheng X, Zhao Y, Jiang Q, Yang J, Zhao W, Taylor IA, Peng YL, Wang D, Liu J.

Nucleic Acids Res. 2019 May 7;47(8):4308-4318. doi: 10.1093/nar/gkz113.


A positive-charged patch and stabilized hydrophobic core are essential for avirulence function of AvrPib in the rice blast fungus.

Zhang X, He D, Zhao Y, Cheng X, Zhao W, Taylor IA, Yang J, Liu J, Peng YL.

Plant J. 2018 Oct;96(1):133-146. doi: 10.1111/tpj.14023. Epub 2018 Aug 1.


Structure based function-annotation of hypothetical protein MGG_01005 from Magnaporthe oryzae reveals it is the dynein light chain orthologue of dynlt1/3.

Li G, Huang J, Yang J, He D, Wang C, Qi X, Taylor IA, Liu J, Peng YL.

Sci Rep. 2018 Mar 2;8(1):3952. doi: 10.1038/s41598-018-21667-5.


A cryptic RNA-binding domain mediates Syncrip recognition and exosomal partitioning of miRNA targets.

Hobor F, Dallmann A, Ball NJ, Cicchini C, Battistelli C, Ogrodowicz RW, Christodoulou E, Martin SR, Castello A, Tripodi M, Taylor IA, Ramos A.

Nat Commun. 2018 Feb 26;9(1):831. doi: 10.1038/s41467-018-03182-3.


DNA damage induced by topoisomerase inhibitors activates SAMHD1 and blocks HIV-1 infection of macrophages.

Mlcochova P, Caswell SJ, Taylor IA, Towers GJ, Gupta RK.

EMBO J. 2018 Jan 4;37(1):50-62. doi: 10.15252/embj.201796880. Epub 2017 Oct 30.


An RRM-ZnF RNA recognition module targets RBM10 to exonic sequences to promote exon exclusion.

Collins KM, Kainov YA, Christodolou E, Ray D, Morris Q, Hughes T, Taylor IA, Makeyev EV, Ramos A.

Nucleic Acids Res. 2017 Jun 20;45(11):6761-6774. doi: 10.1093/nar/gkx225.


A comparative analysis of the foamy and ortho virus capsid structures reveals an ancient domain duplication.

Taylor WR, Stoye JP, Taylor IA.

BMC Struct Biol. 2017 Apr 4;17(1):3. doi: 10.1186/s12900-017-0073-0.


SAMHD1 enhances nucleoside-analogue efficacy against HIV-1 in myeloid cells.

Ordonez P, Kunzelmann S, Groom HC, Yap MW, Weising S, Meier C, Bishop KN, Taylor IA, Stoye JP.

Sci Rep. 2017 Feb 21;7:42824. doi: 10.1038/srep42824.


New insights into the GINS complex explain the controversy between existing structural models.

Carroni M, De March M, Medagli B, Krastanova I, Taylor IA, Amenitsch H, Araki H, Pisani FM, Patwardhan A, Onesti S.

Sci Rep. 2017 Jan 10;7:40188. doi: 10.1038/srep40188.


A supramolecular assembly mediates lentiviral DNA integration.

Ballandras-Colas A, Maskell DP, Serrao E, Locke J, Swuec P, Jónsson SR, Kotecha A, Cook NJ, Pye VE, Taylor IA, Andrésdóttir V, Engelman AN, Costa A, Cherepanov P.

Science. 2017 Jan 6;355(6320):93-95. doi: 10.1126/science.aah7002.


Eleventh International Foamy Virus Conference-Meeting Report.

Buseyne F, Gessain A, Soares MA, Santos AF, Materniak-Kornas M, Lesage P, Zamborlini A, Löchelt M, Qiao W, Lindemann D, Wöhrl BM, Stoye JP, Taylor IA, Khan AS.

Viruses. 2016 Nov 23;8(11). pii: E318.


Structure of a Spumaretrovirus Gag Central Domain Reveals an Ancient Retroviral Capsid.

Ball NJ, Nicastro G, Dutta M, Pollard DJ, Goldstone DC, Sanz-Ramos M, Ramos A, Müllers E, Stirnnagel K, Stanke N, Lindemann D, Stoye JP, Taylor WR, Rosenthal PB, Taylor IA.

PLoS Pathog. 2016 Nov 9;12(11):e1005981. doi: 10.1371/journal.ppat.1005981. eCollection 2016 Nov.


The Eukaryotic-Specific ISD11 Is a Complex-Orphan Protein with Ability to Bind the Prokaryotic IscS.

Yan R, Friemel M, Aloisi C, Huynen M, Taylor IA, Leimkühler S, Pastore A.

PLoS One. 2016 Jul 18;11(7):e0157895. doi: 10.1371/journal.pone.0157895. eCollection 2016.


Functional role of TRIM E3 ligase oligomerization and regulation of catalytic activity.

Koliopoulos MG, Esposito D, Christodoulou E, Taylor IA, Rittinger K.

EMBO J. 2016 Jun 1;35(11):1204-18. doi: 10.15252/embj.201593741. Epub 2016 May 6.


Phospho-dependent Regulation of SAMHD1 Oligomerisation Couples Catalysis and Restriction.

Arnold LH, Groom HC, Kunzelmann S, Schwefel D, Caswell SJ, Ordonez P, Mann MC, Rueschenbaum S, Goldstone DC, Pennell S, Howell SA, Stoye JP, Webb M, Taylor IA, Bishop KN.

PLoS Pathog. 2015 Oct 2;11(10):e1005194. doi: 10.1371/journal.ppat.1005194. eCollection 2015 Oct.


Sedimentation equilibrium studies.

Taylor IA, Rittinger K, Eccleston JF.

Methods Mol Biol. 2015;1278:205-22. doi: 10.1007/978-1-4939-2425-7_12.


Molecular determinants for recognition of divergent SAMHD1 proteins by the lentiviral accessory protein Vpx.

Schwefel D, Boucherit VC, Christodoulou E, Walker PA, Stoye JP, Bishop KN, Taylor IA.

Cell Host Microbe. 2015 Apr 8;17(4):489-99. doi: 10.1016/j.chom.2015.03.004.


Substitution of tryptophan 89 with tyrosine switches the DNA binding mode of PC4.

Huang J, Zhao Y, Liu H, Huang D, Cheng X, Zhao W, Taylor IA, Liu J, Peng YL.

Sci Rep. 2015 Mar 5;5:8789. doi: 10.1038/srep08789.


KH-RNA interactions: back in the groove.

Nicastro G, Taylor IA, Ramos A.

Curr Opin Struct Biol. 2015 Feb;30:63-70. doi: 10.1016/ Epub 2015 Jan 24. Review.


Unexplained weight loss in an 80-year-old woman.

Taylor IA, Gill I, Harripaul A.

BMJ Case Rep. 2015 Jan 23;2015. pii: bcr2014206847. doi: 10.1136/bcr-2014-206847.


Structural basis of DNA recognition by PCG2 reveals a novel DNA binding mode for winged helix-turn-helix domains.

Liu J, Huang J, Zhao Y, Liu H, Wang D, Yang J, Zhao W, Taylor IA, Peng YL.

Nucleic Acids Res. 2015 Jan;43(2):1231-40. doi: 10.1093/nar/gku1351. Epub 2014 Dec 29.


The eukaryotic elongation factor eEF1A1 interacts with SAMHD1.

Morrissey C, Schwefel D, Ennis-Adeniran V, Taylor IA, Crow YJ, Webb M.

Biochem J. 2015 Feb 15;466(1):69-76. doi: 10.1042/BJ20140203.


A continuous enzyme-coupled assay for triphosphohydrolase activity of HIV-1 restriction factor SAMHD1.

Arnold LH, Kunzelmann S, Webb MR, Taylor IA.

Antimicrob Agents Chemother. 2015 Jan;59(1):186-92. doi: 10.1128/AAC.03903-14. Epub 2014 Oct 20.


FAN1 activity on asymmetric repair intermediates is mediated by an atypical monomeric virus-type replication-repair nuclease domain.

Pennell S, Déclais AC, Li J, Haire LF, Berg W, Saldanha JW, Taylor IA, Rouse J, Lilley DM, Smerdon SJ.

Cell Rep. 2014 Jul 10;8(1):84-93. doi: 10.1016/j.celrep.2014.06.001. Epub 2014 Jun 26.


Structural studies of postentry restriction factors reveal antiparallel dimers that enable avid binding to the HIV-1 capsid lattice.

Goldstone DC, Walker PA, Calder LJ, Coombs PJ, Kirkpatrick J, Ball NJ, Hilditch L, Yap MW, Rosenthal PB, Stoye JP, Taylor IA.

Proc Natl Acad Sci U S A. 2014 Jul 1;111(26):9609-14. doi: 10.1073/pnas.1402448111. Epub 2014 Jun 16.


Structural basis of lentiviral subversion of a cellular protein degradation pathway.

Schwefel D, Groom HC, Boucherit VC, Christodoulou E, Walker PA, Stoye JP, Bishop KN, Taylor IA.

Nature. 2014 Jan 9;505(7482):234-8. doi: 10.1038/nature12815. Epub 2013 Dec 15.


A unique spumavirus Gag N-terminal domain with functional properties of orthoretroviral matrix and capsid.

Goldstone DC, Flower TG, Ball NJ, Sanz-Ramos M, Yap MW, Ogrodowicz RW, Stanke N, Reh J, Lindemann D, Stoye JP, Taylor IA.

PLoS Pathog. 2013 May;9(5):e1003376. doi: 10.1371/journal.ppat.1003376. Epub 2013 May 9.


The gammaretroviral p12 protein has multiple domains that function during the early stages of replication.

Wight DJ, Boucherit VC, Nader M, Allen DJ, Taylor IA, Bishop KN.

Retrovirology. 2012 Oct 4;9:83. doi: 10.1186/1742-4690-9-83.


Large multimeric assemblies of nucleosome assembly protein and histones revealed by small-angle X-ray scattering and electron microscopy.

Newman ER, Kneale GG, Ravelli RB, Karuppasamy M, Karimi Nejadasl F, Taylor IA, McGeehan JE.

J Biol Chem. 2012 Aug 3;287(32):26657-65. doi: 10.1074/jbc.M112.340422. Epub 2012 Jun 15.


Diffuse scattering resulting from macromolecular frustration.

Welberry TR, Heerdegen AP, Goldstone DC, Taylor IA.

Acta Crystallogr B. 2011 Dec;67(Pt 6):516-24. doi: 10.1107/S0108768111037542. Epub 2011 Oct 13.


HIV-1 restriction factor SAMHD1 is a deoxynucleoside triphosphate triphosphohydrolase.

Goldstone DC, Ennis-Adeniran V, Hedden JJ, Groom HC, Rice GI, Christodoulou E, Walker PA, Kelly G, Haire LF, Yap MW, de Carvalho LP, Stoye JP, Crow YJ, Taylor IA, Webb M.

Nature. 2011 Nov 6;480(7377):379-82. doi: 10.1038/nature10623.


Novel escape mutants suggest an extensive TRIM5α binding site spanning the entire outer surface of the murine leukemia virus capsid protein.

Ohkura S, Goldstone DC, Yap MW, Holden-Dye K, Taylor IA, Stoye JP.

PLoS Pathog. 2011 Mar;7(3):e1002011. doi: 10.1371/journal.ppat.1002011. Epub 2011 Mar 31.


Ordered assembly of murine leukemia virus capsid protein on lipid nanotubes directs specific binding by the restriction factor, Fv1.

Hilditch L, Matadeen R, Goldstone DC, Rosenthal PB, Taylor IA, Stoye JP.

Proc Natl Acad Sci U S A. 2011 Apr 5;108(14):5771-6. doi: 10.1073/pnas.1100118108. Epub 2011 Mar 21.


Structural and functional analysis of prehistoric lentiviruses uncovers an ancient molecular interface.

Goldstone DC, Yap MW, Robertson LE, Haire LF, Taylor WR, Katzourakis A, Stoye JP, Taylor IA.

Cell Host Microbe. 2010 Sep 16;8(3):248-59. doi: 10.1016/j.chom.2010.08.006.


Structure of the amino-terminal domain from the cell-cycle regulator Swi6.

Taylor IA, Goldstone DC, Pala P, Haire LF, Smerdon SJ.

Proteins. 2010 Oct;78(13):2861-5. doi: 10.1002/prot.22795. No abstract available.


Structure of the Rna15 RRM-RNA complex reveals the molecular basis of GU specificity in transcriptional 3'-end processing factors.

Pancevac C, Goldstone DC, Ramos A, Taylor IA.

Nucleic Acids Res. 2010 May;38(9):3119-32. doi: 10.1093/nar/gkq002. Epub 2010 Jan 21.


Assembly of a 20-nm protein cage by Escherichia coli 2-hydroxypentadienoic acid hydratase.

Montgomery MG, Coker AR, Taylor IA, Wood SP.

J Mol Biol. 2010 Mar 12;396(5):1379-91. doi: 10.1016/j.jmb.2009.12.056. Epub 2010 Jan 4.


NEMO oligomerization and its ubiquitin-binding properties.

Ivins FJ, Montgomery MG, Smith SJ, Morris-Davies AC, Taylor IA, Rittinger K.

Biochem J. 2009 Jun 26;421(2):243-51. doi: 10.1042/BJ20090427.


A competition assay for DNA binding using the fluorescent probe ANS.

Taylor IA, Kneale GG.

Methods Mol Biol. 2009;543:577-87. doi: 10.1007/978-1-60327-015-1_34.


A study of the ultrastructure of fragile-X-related proteins.

Sjekloća L, Konarev PV, Eccleston J, Taylor IA, Svergun DI, Pastore A.

Biochem J. 2009 Apr 15;419(2):347-57. doi: 10.1042/BJ20082197.


Structure of the capsid amino-terminal domain from the betaretrovirus, Jaagsiekte sheep retrovirus.

Mortuza GB, Goldstone DC, Pashley C, Haire LF, Palmarini M, Taylor WR, Stoye JP, Taylor IA.

J Mol Biol. 2009 Mar 6;386(4):1179-92. doi: 10.1016/j.jmb.2008.10.066. Epub 2008 Nov 5.


Chk2 oligomerization studied by phosphopeptide ligation: implications for regulation and phosphodependent interactions.

Li J, Taylor IA, Lloyd J, Clapperton JA, Howell S, MacMillan D, Smerdon SJ.

J Biol Chem. 2008 Dec 19;283(51):36019-30. doi: 10.1074/jbc.M804075200. Epub 2008 Oct 23.


Identification of miRNA changes in Alzheimer's disease brain and CSF yields putative biomarkers and insights into disease pathways.

Cogswell JP, Ward J, Taylor IA, Waters M, Shi Y, Cannon B, Kelnar K, Kemppainen J, Brown D, Chen C, Prinjha RK, Richardson JC, Saunders AM, Roses AD, Richards CA.

J Alzheimers Dis. 2008 May;14(1):27-41.


Structural properties of the human respiratory syncytial virus P protein: evidence for an elongated homotetrameric molecule that is the smallest orthologue within the family of paramyxovirus polymerase cofactors.

Llorente MT, Taylor IA, López-Viñas E, Gomez-Puertas P, Calder LJ, García-Barreno B, Melero JA.

Proteins. 2008 Aug 15;72(3):946-58. doi: 10.1002/prot.21988.


Structure of B-MLV capsid amino-terminal domain reveals key features of viral tropism, gag assembly and core formation.

Mortuza GB, Dodding MP, Goldstone DC, Haire LF, Stoye JP, Taylor IA.

J Mol Biol. 2008 Mar 7;376(5):1493-508. doi: 10.1016/j.jmb.2007.12.043. Epub 2007 Dec 28.


Scaffold-independent analysis of RNA-protein interactions: the Nova-1 KH3-RNA complex.

Beuth B, García-Mayoral MF, Taylor IA, Ramos A.

J Am Chem Soc. 2007 Aug 22;129(33):10205-10. Epub 2007 Jul 26.


The design of artificial retroviral restriction factors.

Yap MW, Mortuza GB, Taylor IA, Stoye JP.

Virology. 2007 Sep 1;365(2):302-14. Epub 2007 May 9.


Structure of a nucleotide-bound Clp1-Pcf11 polyadenylation factor.

Noble CG, Beuth B, Taylor IA.

Nucleic Acids Res. 2007;35(1):87-99. Epub 2006 Dec 6.

Supplemental Content

Loading ...
Support Center