Sort by
Items per page

Send to

Choose Destination

Search results

Items: 1 to 50 of 100


Insights into the Substrate Specificity of Archaeal Entner-Doudoroff Aldolases: The Structures of Picrophilus torridus 2-Keto-3-deoxygluconate Aldolase and Sulfolobus solfataricus 2-Keto-3-deoxy-6-phosphogluconate Aldolase in Complex with 2-Keto-3-deoxy-6-phosphogluconate.

Zaitsev V, Johnsen U, Reher M, Ortjohann M, Taylor GL, Danson MJ, Schönheit P, Crennell SJ.

Biochemistry. 2018 Jul 3;57(26):3797-3806. doi: 10.1021/acs.biochem.8b00535. Epub 2018 Jun 13.


Unravelling the specificity and mechanism of sialic acid recognition by the gut symbiont Ruminococcus gnavus.

Owen CD, Tailford LE, Monaco S, Šuligoj T, Vaux L, Lallement R, Khedri Z, Yu H, Lecointe K, Walshaw J, Tribolo S, Horrex M, Bell A, Chen X, Taylor GL, Varki A, Angulo J, Juge N.

Nat Commun. 2017 Dec 19;8(1):2196. doi: 10.1038/s41467-017-02109-8.


PRIMA-1Met suppresses colorectal cancer independent of p53 by targeting MEK.

Lu T, Zou Y, Xu G, Potter JA, Taylor GL, Duan Q, Yang Q, Xiong H, Qiu H, Ye D, Zhang P, Yu S, Yuan X, Zhu F, Wang Y, Xiong H.

Oncotarget. 2016 Dec 13;7(50):83017-83030. doi: 10.18632/oncotarget.12940.


Erratum to: Structural characterization of the carbohydrate-binding module of NanA sialidase, a pneumococcal virulence factor.

Yang L, Connaris H, Potter JA, Taylor GL.

BMC Struct Biol. 2015 Oct 6;15:19. doi: 10.1186/s12900-015-0047-z. No abstract available.



Owen CD, Lukacik P, Potter JA, Sleator O, Taylor GL, Walsh MA.

J Biol Chem. 2015 Nov 13;290(46):27736-48. doi: 10.1074/jbc.M115.673632. Epub 2015 Sep 14.


Structural characterization of the carbohydrate-binding module of NanA sialidase, a pneumococcal virulence factor.

Yang L, Connaris H, Potter JA, Taylor GL.

BMC Struct Biol. 2015 Aug 20;15:15. doi: 10.1186/s12900-015-0042-4. Erratum in: BMC Struct Biol. 2015;15:19.


Discovery of intramolecular trans-sialidases in human gut microbiota suggests novel mechanisms of mucosal adaptation.

Tailford LE, Owen CD, Walshaw J, Crost EH, Hardy-Goddard J, Le Gall G, de Vos WM, Taylor GL, Juge N.

Nat Commun. 2015 Jul 8;6:7624. doi: 10.1038/ncomms8624.


Sialic acid-binding protein Sp2CBMTD protects mice against lethal challenge with emerging influenza A (H7N9) virus.

Govorkova EA, Baranovich T, Marathe BM, Yang L, Taylor MA, Webster RG, Taylor GL, Connaris H.

Antimicrob Agents Chemother. 2015 Mar;59(3):1495-504. doi: 10.1128/AAC.04431-14. Epub 2014 Dec 22.


Prevention of influenza by targeting host receptors using engineered proteins.

Connaris H, Govorkova EA, Ligertwood Y, Dutia BM, Yang L, Tauber S, Taylor MA, Alias N, Hagan R, Nash AA, Webster RG, Taylor GL.

Proc Natl Acad Sci U S A. 2014 Apr 29;111(17):6401-6. doi: 10.1073/pnas.1404205111. Epub 2014 Apr 14.


Kinetic and structural evaluation of selected active site mutants of the Aspergillus fumigatus KDNase (sialidase).

Yeung JH, Telford JC, Shidmoossavee FS, Bennet AJ, Taylor GL, Moore MM.

Biochemistry. 2013 Dec 23;52(51):9177-86. doi: 10.1021/bi401166f. Epub 2013 Dec 10.


Synthesis and structural characterisation of selective non-carbohydrate-based inhibitors of bacterial sialidases.

Brear P, Telford J, Taylor GL, Westwood NJ.

Chembiochem. 2012 Nov 5;13(16):2374-83. doi: 10.1002/cbic.201200433. Epub 2012 Oct 15.


Optimization of a direct spectrophotometric method to investigate the kinetics and inhibition of sialidases.

Hayre JK, Xu G, Borgianni L, Taylor GL, Andrew PW, Docquier JD, Oggioni MR.

BMC Biochem. 2012 Oct 2;13:19. doi: 10.1186/1471-2091-13-19.


Toward a hepatitis C virus vaccine: the structural basis of hepatitis C virus neutralization by AP33, a broadly neutralizing antibody.

Potter JA, Owsianka AM, Jeffery N, Matthews DJ, Keck ZY, Lau P, Foung SK, Taylor GL, Patel AH.

J Virol. 2012 Dec;86(23):12923-32. doi: 10.1128/JVI.02052-12. Epub 2012 Sep 19.


Results from an experimental trial at a Head Start center to evaluate two meal service approaches to increase fruit and vegetable intake of preschool aged children.

Harnack LJ, Oakes JM, French SA, Rydell SA, Farah FM, Taylor GL.

Int J Behav Nutr Phys Act. 2012 Apr 30;9:51. doi: 10.1186/1479-5868-9-51.


Receptor-binding specificity of the human parainfluenza virus type 1 hemagglutinin-neuraminidase glycoprotein.

Alymova IV, Portner A, Mishin VP, McCullers JA, Freiden P, Taylor GL.

Glycobiology. 2012 Feb;22(2):174-80. doi: 10.1093/glycob/cwr112. Epub 2011 Aug 16.


Structural basis for Streptococcus pneumoniae NanA inhibition by influenza antivirals zanamivir and oseltamivir carboxylate.

Gut H, Xu G, Taylor GL, Walsh MA.

J Mol Biol. 2011 Jun 17;409(4):496-503. doi: 10.1016/j.jmb.2011.04.016. Epub 2011 Apr 14.


The Aspergillus fumigatus sialidase is a 3-deoxy-D-glycero-D-galacto-2-nonulosonic acid hydrolase (KDNase): structural and mechanistic insights.

Telford JC, Yeung JH, Xu G, Kiefel MJ, Watts AG, Hader S, Chan J, Bennet AJ, Moore MM, Taylor GL.

J Biol Chem. 2011 Mar 25;286(12):10783-92. doi: 10.1074/jbc.M110.207043. Epub 2011 Jan 19.


Three Streptococcus pneumoniae sialidases: three different products.

Xu G, Kiefel MJ, Wilson JC, Andrew PW, Oggioni MR, Taylor GL.

J Am Chem Soc. 2011 Feb 16;133(6):1718-21. doi: 10.1021/ja110733q. Epub 2011 Jan 18.


The Scottish Structural Proteomics Facility: targets, methods and outputs.

Oke M, Carter LG, Johnson KA, Liu H, McMahon SA, Yan X, Kerou M, Weikart ND, Kadi N, Sheikh MA, Schmelz S, Dorward M, Zawadzki M, Cozens C, Falconer H, Powers H, Overton IM, van Niekerk CA, Peng X, Patel P, Garrett RA, Prangishvili D, Botting CH, Coote PJ, Dryden DT, Barton GJ, Schwarz-Linek U, Challis GL, Taylor GL, White MF, Naismith JH.

J Struct Funct Genomics. 2010 Jun;11(2):167-80. doi: 10.1007/s10969-010-9090-y. Epub 2010 Apr 24.


Introduction to phasing.

Taylor GL.

Acta Crystallogr D Biol Crystallogr. 2010 Apr;66(Pt 4):325-38. doi: 10.1107/S0907444910006694. Epub 2010 Mar 24.


Insights into the biosynthesis of the Vibrio cholerae major autoinducer CAI-1 from the crystal structure of the PLP-dependent enzyme CqsA.

Jahan N, Potter JA, Sheikh MA, Botting CH, Shirran SL, Westwood NJ, Taylor GL.

J Mol Biol. 2009 Sep 25;392(3):763-73. doi: 10.1016/j.jmb.2009.07.042. Epub 2009 Jul 22.


Crystal structure of the Vibrio cholerae ferric uptake regulator (Fur) reveals insights into metal co-ordination.

Sheikh MA, Taylor GL.

Mol Microbiol. 2009 Jun;72(5):1208-20. doi: 10.1111/j.1365-2958.2009.06718.x. Epub 2009 Apr 28.


Structural studies on the Pseudomonas aeruginosa sialidase-like enzyme PA2794 suggest substrate and mechanistic variations.

Xu G, Ryan C, Kiefel MJ, Wilson JC, Taylor GL.

J Mol Biol. 2009 Feb 27;386(3):828-40. doi: 10.1016/j.jmb.2008.12.084. Epub 2009 Jan 10.


Enhancing the receptor affinity of the sialic acid-binding domain of Vibrio cholerae sialidase through multivalency.

Connaris H, Crocker PR, Taylor GL.

J Biol Chem. 2009 Mar 13;284(11):7339-51. doi: 10.1074/jbc.M807398200. Epub 2009 Jan 5.


The structure of Sulfolobus solfataricus 2-keto-3-deoxygluconate kinase.

Potter JA, Kerou M, Lamble HJ, Bull SD, Hough DW, Danson MJ, Taylor GL.

Acta Crystallogr D Biol Crystallogr. 2008 Dec;64(Pt 12):1283-7. doi: 10.1107/S0907444908036111. Epub 2008 Nov 18.


Crystal structure of the NanB sialidase from Streptococcus pneumoniae.

Xu G, Potter JA, Russell RJ, Oggioni MR, Andrew PW, Taylor GL.

J Mol Biol. 2008 Dec 12;384(2):436-49. doi: 10.1016/j.jmb.2008.09.032. Epub 2008 Sep 21.


Structure of the catalytic domain of Streptococcus pneumoniae sialidase NanA.

Xu G, Li X, Andrew PW, Taylor GL.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2008 Sep 1;64(Pt 9):772-5. doi: 10.1107/S1744309108024044. Epub 2008 Aug 20.


Crystal structure of human IPS-1/MAVS/VISA/Cardif caspase activation recruitment domain.

Potter JA, Randall RE, Taylor GL.

BMC Struct Biol. 2008 Feb 28;8:11. doi: 10.1186/1472-6807-8-11.


Crystal structure of VC1805, a conserved hypothetical protein from a Vibrio cholerae pathogenicity island, reveals homology to human p32.

Sheikh MA, Potter JA, Johnson KA, Sim RB, Boyd EF, Taylor GL.

Proteins. 2008 May 15;71(3):1563-71. doi: 10.1002/prot.21993. No abstract available.


The structure of Clostridium perfringens NanI sialidase and its catalytic intermediates.

Newstead SL, Potter JA, Wilson JC, Xu G, Chien CH, Watts AG, Withers SG, Taylor GL.

J Biol Chem. 2008 Apr 4;283(14):9080-8. doi: 10.1074/jbc.M710247200. Epub 2008 Jan 24.


Long-term outcome of low-risk patients attending a rapid-assessment chest pain clinic.

Taylor GL, Murphy NF, Berry C, Christie J, Finlayson A, MacIntyre K, Morrison C, McMurray J.

Heart. 2008 May;94(5):628-32. Epub 2007 Oct 4.


Evaluation of blood flow parameters in addition to blood pressure and electrocardiogram in the conscious telemetered beagle dog.

Taylor GL, Patel B, Sullivan AT.

J Pharmacol Toxicol Methods. 2007 Sep-Oct;56(2):212-7. Epub 2007 May 24.


Expression, purification, crystallization, data collection and preliminary biochemical characterization of methicillin-resistant Staphylococcus aureus Sar2028, an aspartate/tyrosine/phenylalanine pyridoxal-5'-phosphate-dependent aminotransferase.

Seetharamappa J, Oke M, Liu H, McMahon SA, Johnson KA, Carter L, Dorward M, Zawadzki M, Overton IM, van Niekirk CA, Graham S, Botting CH, Taylor GL, White MF, Barton GJ, Coote PJ, Naismith JH.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2007 May 1;63(Pt 5):452-6. Epub 2007 Apr 28.


Purification, crystallization and data collection of methicillin-resistant Staphylococcus aureus Sar2676, a pantothenate synthetase.

Seetharamappa J, Oke M, Liu H, McMahon SA, Johnson KA, Carter L, Dorward M, Zawadzki M, Overton IM, van Niekirk CA, Graham S, Botting CH, Taylor GL, White MF, Barton GJ, Coote PJ, Naismith JH.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2007 Jun 1;63(Pt 6):488-91. Epub 2007 May 5.


An acetylase with relaxed specificity catalyses protein N-terminal acetylation in Sulfolobus solfataricus.

Mackay DT, Botting CH, Taylor GL, White MF.

Mol Microbiol. 2007 Jun;64(6):1540-8. Epub 2007 May 18.


Crystallization of Ranasmurfin, a blue-coloured protein from Polypedates leucomystax.

McMahon SA, Walsh MA, Ching RT, Carter LG, Dorward M, Johnson KA, Liu H, Oke M, Bloch C Jr, Kennedy MW, Latiff AA, Cooper A, Taylor GL, White MF, Naismith JH.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2006 Nov 1;62(Pt 11):1124-6. Epub 2006 Oct 20.


Structure of the heterotrimeric PCNA from Sulfolobus solfataricus.

Williams GJ, Johnson K, Rudolf J, McMahon SA, Carter L, Oke M, Liu H, Taylor GL, White MF, Naismith JH.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2006 Oct 1;62(Pt 10):944-8. Epub 2006 Sep 19.


The structural basis of substrate promiscuity in glucose dehydrogenase from the hyperthermophilic archaeon Sulfolobus solfataricus.

Milburn CC, Lamble HJ, Theodossis A, Bull SD, Hough DW, Danson MJ, Taylor GL.

J Biol Chem. 2006 May 26;281(21):14796-804. Epub 2006 Mar 23.


Preliminary crystallographic studies of glucose dehydrogenase from the promiscuous Entner-Doudoroff pathway in the hyperthermophilic archaeon Sulfolobus solfataricus.

Theodossis A, Milburn CC, Heyer NI, Lamble HJ, Hough DW, Danson MJ, Taylor GL.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2005 Jan 1;61(Pt 1):112-5. Epub 2004 Dec 24.


Promiscuity in the part-phosphorylative Entner-Doudoroff pathway of the archaeon Sulfolobus solfataricus.

Lamble HJ, Theodossis A, Milburn CC, Taylor GL, Bull SD, Hough DW, Danson MJ.

FEBS Lett. 2005 Dec 19;579(30):6865-9. Epub 2005 Dec 1.


Evaluating consumer acceptability and willingness to pay for various beef chuck muscles.

Kukowski AC, Maddock RJ, Wulf DM, Fausti SW, Taylor GL.

J Anim Sci. 2005 Nov;83(11):2605-10.


Obligate heterodimerization of the archaeal Alba2 protein with Alba1 provides a mechanism for control of DNA packaging.

Jelinska C, Conroy MJ, Craven CJ, Hounslow AM, Bullough PA, Waltho JP, Taylor GL, White MF.

Structure. 2005 Jul;13(7):963-71.


Gluconate dehydratase from the promiscuous Entner-Doudoroff pathway in Sulfolobus solfataricus.

Lamble HJ, Milburn CC, Taylor GL, Hough DW, Danson MJ.

FEBS Lett. 2004 Oct 8;576(1-2):133-6.


Structure and function of a regulated archaeal triosephosphate isomerase adapted to high temperature.

Walden H, Taylor GL, Lorentzen E, Pohl E, Lilie H, Schramm A, Knura T, Stubbe K, Tjaden B, Hensel R.

J Mol Biol. 2004 Sep 17;342(3):861-75.


The structural basis for substrate promiscuity in 2-keto-3-deoxygluconate aldolase from the Entner-Doudoroff pathway in Sulfolobus solfataricus.

Theodossis A, Walden H, Westwick EJ, Connaris H, Lamble HJ, Hough DW, Danson MJ, Taylor GL.

J Biol Chem. 2004 Oct 15;279(42):43886-92. Epub 2004 Jul 20.


A randomized school trial of environmental strategies to encourage fruit and vegetable consumption among children.

Perry CL, Bishop DB, Taylor GL, Davis M, Story M, Gray C, Bishop SC, Mays RA, Lytle LA, Harnack L.

Health Educ Behav. 2004 Feb;31(1):65-76.


Validation of MRI measurement of cardiac output in the dog: the effects of dobutamine and minoxidil.

Hockings PD, Busza AL, Byrne J, Patel B, Smart SC, Reid DG, Lloyd HL, White A, Pointing K, Farnfield BA, Criado-Gonzalez A, Whelan GA, Taylor GL, Birmingham JM, Slaughter MR, Osborne JA, Krebs-Brown A, Templeton D.

Toxicol Mech Methods. 2003;13(1):39-43. doi: 10.1080/15376510309822.


Stepwise adaptations of citrate synthase to survival at life's extremes. From psychrophile to hyperthermophile.

Bell GS, Russell RJ, Connaris H, Hough DW, Danson MJ, Taylor GL.

Eur J Biochem. 2002 Dec;269(24):6250-60.

Supplemental Content

Loading ...
Support Center