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The combined effect of sprint interval training and blood flow restriction on critical power, capillary growth and mitochondrial proteins in trained cyclists.

Mitchell EA, Martin NRW, Turner MC, Taylor CW, Ferguson RA.

J Appl Physiol (1985). 2018 Oct 18. doi: 10.1152/japplphysiol.01082.2017. [Epub ahead of print]


All three IP3 receptor subtypes generate Ca2+ puffs, the universal building blocks of IP3-evoked Ca2+ signals.

Mataragka S, Taylor CW.

J Cell Sci. 2018 Aug 23;131(16). pii: jcs220848. doi: 10.1242/jcs.220848.


A synthetic diphosphoinositol phosphate analogue of inositol trisphosphate.

Riley AM, Unterlass J, Konieczny V, Taylor CW, Helleday T, Potter BVL.

Medchemcomm. 2018 Jul 1;9(7):1105-1113. doi: 10.1039/C8MD00149A. Epub 2018 Jun 4.


Cardiovascular disease incidence after internal mammary chain irradiation and anthracycline-based chemotherapy for breast cancer.

Boekel NB, Jacobse JN, Schaapveld M, Hooning MJ, Gietema JA, Duane FK, Taylor CW, Darby SC, Hauptmann M, Seynaeve CM, Baaijens MHA, Sonke GS, Rutgers EJT, Russell NS, Aleman BMP, van Leeuwen FE.

Br J Cancer. 2018 Aug;119(4):408-418. doi: 10.1038/s41416-018-0159-x. Epub 2018 Aug 1.


Selective inhibition of histamine-evoked Ca2+ signals by compartmentalized cAMP in human bronchial airway smooth muscle cells.

Dale P, Head V, Dowling MR, Taylor CW.

Cell Calcium. 2018 May;71:53-64. doi: 10.1016/j.ceca.2017.12.002. Epub 2017 Dec 15.


The acute angiogenic signalling response to low-load resistance exercise with blood flow restriction.

Ferguson RA, Hunt JEA, Lewis MP, Martin NRW, Player DJ, Stangier C, Taylor CW, Turner MC.

Eur J Sport Sci. 2018 Apr;18(3):397-406. doi: 10.1080/17461391.2017.1422281. Epub 2018 Jan 17.


Exposure of the lungs in breast cancer radiotherapy: A systematic review of lung doses published 2010-2015.

Aznar MC, Duane FK, Darby SC, Wang Z, Taylor CW.

Radiother Oncol. 2018 Jan;126(1):148-154. doi: 10.1016/j.radonc.2017.11.022. Epub 2017 Dec 12. Review.


Ca2+ signals initiate at immobile IP3 receptors adjacent to ER-plasma membrane junctions.

Thillaiappan NB, Chavda AP, Tovey SC, Prole DL, Taylor CW.

Nat Commun. 2017 Nov 15;8(1):1505. doi: 10.1038/s41467-017-01644-8.


Endogenous signalling pathways and caged IP3 evoke Ca2+ puffs at the same abundant immobile intracellular sites.

Keebler MV, Taylor CW.

J Cell Sci. 2017 Nov 1;130(21):3728-3739. doi: 10.1242/jcs.208520. Epub 2017 Sep 11.


Prostaglandin E2 Inhibits Histamine-Evoked Ca2+ Release in Human Aortic Smooth Muscle Cells through Hyperactive cAMP Signaling Junctions and Protein Kinase A.

Taylor EJA, Pantazaka E, Shelley KL, Taylor CW.

Mol Pharmacol. 2017 Nov;92(5):533-545. doi: 10.1124/mol.117.109249. Epub 2017 Sep 6.


ATP evokes Ca2+ signals in cultured foetal human cortical astrocytes entirely through G protein-coupled P2Y receptors.

Muller MS, Taylor CW.

J Neurochem. 2017 Jul 5. doi: 10.1111/jnc.14119. [Epub ahead of print]


A cardiac contouring atlas for radiotherapy.

Duane F, Aznar MC, Bartlett F, Cutter DJ, Darby SC, Jagsi R, Lorenzen EL, McArdle O, McGale P, Myerson S, Rahimi K, Vivekanandan S, Warren S, Taylor CW.

Radiother Oncol. 2017 Mar;122(3):416-422. doi: 10.1016/j.radonc.2017.01.008. Epub 2017 Feb 21.


Cyclic AMP Recruits a Discrete Intracellular Ca2+ Store by Unmasking Hypersensitive IP3 Receptors.

Konieczny V, Tovey SC, Mataragka S, Prole DL, Taylor CW.

Cell Rep. 2017 Jan 17;18(3):711-722. doi: 10.1016/j.celrep.2016.12.058.


Synthesis of dimeric analogs of adenophostin A that potently evoke Ca2+ release through IP3 receptors.

Vibhute AM, Pushpanandan P, Varghese M, Koniecnzy V, Taylor CW, Sureshan KM.

RSC Adv. 2016 Nov 3;6(89):86346-86351. doi: 10.1039/c6ra19413c. Epub 2016 Sep 5.


Regulation of IP3 receptors by cyclic AMP.

Taylor CW.

Cell Calcium. 2017 May;63:48-52. doi: 10.1016/j.ceca.2016.10.005. Epub 2016 Nov 6. Review.


Dose and Fractionation in Radiation Therapy of Curative Intent for Non-Small Cell Lung Cancer: Meta-Analysis of Randomized Trials.

Ramroth J, Cutter DJ, Darby SC, Higgins GS, McGale P, Partridge M, Taylor CW.

Int J Radiat Oncol Biol Phys. 2016 Nov 15;96(4):736-747. doi: 10.1016/j.ijrobp.2016.07.022. Epub 2016 Jul 25.


Chemerin Elicits Potent Constrictor Actions via Chemokine-Like Receptor 1 (CMKLR1), not G-Protein-Coupled Receptor 1 (GPR1), in Human and Rat Vasculature.

Kennedy AJ, Yang P, Read C, Kuc RE, Yang L, Taylor EJ, Taylor CW, Maguire JJ, Davenport AP.

J Am Heart Assoc. 2016 Oct 14;5(10). pii: e004421.


Mutant IP3 receptors attenuate store-operated Ca2+ entry by destabilizing STIM-Orai interactions in Drosophila neurons.

Chakraborty S, Deb BK, Chorna T, Konieczny V, Taylor CW, Hasan G.

J Cell Sci. 2016 Oct 15;129(20):3903-3910. Epub 2016 Sep 2.


Can Observational Data Replace Randomized Trials?

McGale P, Cutter D, Darby SC, Henson KE, Jagsi R, Taylor CW.

J Clin Oncol. 2016 Sep 20;34(27):3355-7. doi: 10.1200/JCO.2016.68.8879. Epub 2016 Jul 25. No abstract available.


Exercise duration-matched interval and continuous sprint cycling induce similar increases in AMPK phosphorylation, PGC-1α and VEGF mRNA expression in trained individuals.

Taylor CW, Ingham SA, Hunt JE, Martin NR, Pringle JS, Ferguson RA.

Eur J Appl Physiol. 2016 Aug;116(8):1445-54. doi: 10.1007/s00421-016-3402-2. Epub 2016 Jun 1.


Sigma1 receptors inhibit store-operated Ca2+ entry by attenuating coupling of STIM1 to Orai1.

Srivats S, Balasuriya D, Pasche M, Vistal G, Edwardson JM, Taylor CW, Murrell-Lagnado RD.

J Cell Biol. 2016 Apr 11;213(1):65-79. doi: 10.1083/jcb.201506022.


IP3 receptors: Take four IP3 to open.

Taylor CW, Konieczny V.

Sci Signal. 2016 Apr 5;9(422):pe1. doi: 10.1126/scisignal.aaf6029.


Uncertainties in estimating heart doses from 2D-tangential breast cancer radiotherapy.

Lorenzen EL, Brink C, Taylor CW, Darby SC, Ewertz M.

Radiother Oncol. 2016 Apr;119(1):71-6. doi: 10.1016/j.radonc.2016.02.017. Epub 2016 Feb 27.


Inositol 1,4,5-trisphosphate receptors and their protein partners as signalling hubs.

Prole DL, Taylor CW.

J Physiol. 2016 Jun 1;594(11):2849-66. doi: 10.1113/JP271139. Epub 2016 Feb 24. Review.


Synthesis of inositol phosphate-based competitive antagonists of inositol 1,4,5-trisphosphate receptors.

Konieczny V, Stefanakis JG, Sitsanidis ED, Ioannidou NA, Papadopoulos NV, Fylaktakidou KC, Taylor CW, Koumbis AE.

Org Biomol Chem. 2016 Feb 28;14(8):2504-14. doi: 10.1039/c5ob02623g.


Exposure of the Heart in Breast Cancer Radiation Therapy: A Systematic Review of Heart Doses Published During 2003 to 2013.

Taylor CW, Wang Z, Macaulay E, Jagsi R, Duane F, Darby SC.

Int J Radiat Oncol Biol Phys. 2015 Nov 15;93(4):845-53. doi: 10.1016/j.ijrobp.2015.07.2292. Epub 2015 Aug 3. Review.


Acute and chronic effect of sprint interval training combined with postexercise blood-flow restriction in trained individuals.

Taylor CW, Ingham SA, Ferguson RA.

Exp Physiol. 2016 Jan;101(1):143-54. doi: 10.1113/EP085293. Epub 2015 Oct 30.


Cardiac Side-effects From Breast Cancer Radiotherapy.

Taylor CW, Kirby AM.

Clin Oncol (R Coll Radiol). 2015 Nov;27(11):621-9. doi: 10.1016/j.clon.2015.06.007. Epub 2015 Jun 28. Review.


Microtubule-Associated Protein EB3 Regulates IP3 Receptor Clustering and Ca(2+) Signaling in Endothelial Cells.

Geyer M, Huang F, Sun Y, Vogel SM, Malik AB, Taylor CW, Komarova YA.

Cell Rep. 2015 Jul 7;12(1):79-89. doi: 10.1016/j.celrep.2015.06.001. Epub 2015 Jun 25.


Triazolophostins: a library of novel and potent agonists of IP3 receptors.

Vibhute AM, Konieczny V, Taylor CW, Sureshan KM.

Org Biomol Chem. 2015 Jun 28;13(24):6698-710. doi: 10.1039/c5ob00440c.


Golgi anti-apoptotic proteins are highly conserved ion channels that affect apoptosis and cell migration.

Carrara G, Saraiva N, Parsons M, Byrne B, Prole DL, Taylor CW, Smith GL.

J Biol Chem. 2015 May 1;290(18):11785-801. doi: 10.1074/jbc.M115.637306. Epub 2015 Feb 24.


Fluorescence methods for analysis of interactions between Ca(2+) signaling, lysosomes, and endoplasmic reticulum.

Prole DL, López-Sanjurjo CI, Tovey SC, Taylor CW.

Methods Cell Biol. 2015;126:237-59. doi: 10.1016/bs.mcb.2014.10.024. Epub 2015 Jan 16.


Sustained signalling by PTH modulates IP3 accumulation and IP3 receptors through cyclic AMP junctions.

Meena A, Tovey SC, Taylor CW.

J Cell Sci. 2015 Jan 15;128(2):408-20. doi: 10.1242/jcs.163071. Epub 2014 Nov 27.


Rapid recycling of Ca2+ between IP3-sensitive stores and lysosomes.

López Sanjurjo CI, Tovey SC, Taylor CW.

PLoS One. 2014 Oct 22;9(10):e111275. doi: 10.1371/journal.pone.0111275. eCollection 2014.


Red fluorescent genetically encoded Ca2+ indicators for use in mitochondria and endoplasmic reticulum.

Wu J, Prole DL, Shen Y, Lin Z, Gnanasekaran A, Liu Y, Chen L, Zhou H, Chen SR, Usachev YM, Taylor CW, Campbell RE.

Biochem J. 2014 Nov 15;464(1):13-22. doi: 10.1042/BJ20140931.


Reliable encoding of stimulus intensities within random sequences of intracellular Ca2+ spikes.

Thurley K, Tovey SC, Moenke G, Prince VL, Meena A, Thomas AP, Skupin A, Taylor CW, Falcke M.

Sci Signal. 2014 Jun 24;7(331):ra59. doi: 10.1126/scisignal.2005237.


Interactions of antagonists with subtypes of inositol 1,4,5-trisphosphate (IP3) receptor.

Saleem H, Tovey SC, Molinski TF, Taylor CW.

Br J Pharmacol. 2014 Jul;171(13):3298-312. doi: 10.1111/bph.12685.


Structural organization of signalling to and from IP3 receptors.

Taylor CW, Tovey SC, Rossi AM, Lopez Sanjurjo CI, Prole DL, Rahman T.

Biochem Soc Trans. 2014 Feb;42(1):63-70. doi: 10.1042/BST20130205. Review.


High-throughput fluorescence polarization assay of ligand binding to IP3 receptors.

Rossi AM, Taylor CW.

Cold Spring Harb Protoc. 2013 Oct 1;2013(10):938-46. doi: 10.1101/pdb.prot073080.


High-throughput functional assays of IP3-evoked Ca2+ release.

Tovey SC, Taylor CW.

Cold Spring Harb Protoc. 2013 Oct 1;2013(10):930-7. doi: 10.1101/pdb.prot073072.


High-throughput analyses of IP3 receptor behavior.

Taylor CW, Tovey SC, Rossi AM.

Cold Spring Harb Protoc. 2013 Oct 1;2013(10):914-7. doi: 10.1101/pdb.top066100.


hGAAP promotes cell adhesion and migration via the stimulation of store-operated Ca2+ entry and calpain 2.

Saraiva N, Prole DL, Carrara G, Johnson BF, Taylor CW, Parsons M, Smith GL.

J Cell Biol. 2013 Aug 19;202(4):699-713. doi: 10.1083/jcb.201301016. Epub 2013 Aug 12.


Inter-observer variation in delineation of the heart and left anterior descending coronary artery in radiotherapy for breast cancer: a multi-centre study from Denmark and the UK.

Lorenzen EL, Taylor CW, Maraldo M, Nielsen MH, Offersen BV, Andersen MR, O'Dwyer D, Larsen L, Duxbury S, Jhitta B, Darby SC, Ewertz M, Brink C.

Radiother Oncol. 2013 Aug;108(2):254-8. doi: 10.1016/j.radonc.2013.06.025. Epub 2013 Jul 25.


Identification and analysis of putative homologues of mechanosensitive channels in pathogenic protozoa.

Prole DL, Taylor CW.

PLoS One. 2013 Jun 13;8(6):e66068. doi: 10.1371/journal.pone.0066068. Print 2013.


CaBP1, a neuronal Ca2+ sensor protein, inhibits inositol trisphosphate receptors by clamping intersubunit interactions.

Li C, Enomoto M, Rossi AM, Seo MD, Rahman T, Stathopulos PB, Taylor CW, Ikura M, Ames JB.

Proc Natl Acad Sci U S A. 2013 May 21;110(21):8507-12. doi: 10.1073/pnas.1220847110. Epub 2013 May 6.


Ca(2+) signals evoked by histamine H1 receptors are attenuated by activation of prostaglandin EP2 and EP4 receptors in human aortic smooth muscle cells.

Pantazaka E, Taylor EJ, Bernard WG, Taylor CW.

Br J Pharmacol. 2013 Aug;169(7):1624-34. doi: 10.1111/bph.12239.


Cyclic AMP directs inositol (1,4,5)-trisphosphate-evoked Ca2+ signalling to different intracellular Ca2+ stores.

Tovey SC, Taylor CW.

J Cell Sci. 2013 May 15;126(Pt 10):2305-13. doi: 10.1242/jcs.126144. Epub 2013 Mar 22.


Human and viral Golgi anti-apoptotic proteins (GAAPs) oligomerize via different mechanisms and monomeric GAAP inhibits apoptosis and modulates calcium.

Saraiva N, Prole DL, Carrara G, Maluquer de Motes C, Johnson BF, Byrne B, Taylor CW, Smith GL.

J Biol Chem. 2013 May 3;288(18):13057-67. doi: 10.1074/jbc.M112.414367. Epub 2013 Mar 18.


Stimulation of inositol 1,4,5-trisphosphate (IP3) receptor subtypes by adenophostin A and its analogues.

Saleem H, Tovey SC, Riley AM, Potter BV, Taylor CW.

PLoS One. 2013;8(2):e58027. doi: 10.1371/journal.pone.0058027. Epub 2013 Feb 28.

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