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Prolyl Hydroxylase Inhibition Mitigates Pouchitis.

Harnoss JM, Gebhardt JM, Radhakrishnan P, Leowardi C, Burmeister J, Halligan DN, Yuan S, Kennel KB, Strowitzki MJ, Schaible A, Lasitschka F, Taylor CT, Schneider M.

Inflamm Bowel Dis. 2019 Oct 16. pii: izz218. doi: 10.1093/ibd/izz218. [Epub ahead of print]


Facial Affect and Interpersonal Affiliation: Displays of Emotion During Relationship Formation in Social Anxiety Disorder.

Pearlstein SL, Taylor CT, Stein MB.

Clin Psychol Sci. 2019 Jul;7(4):826-839. doi: 10.1177/2167702619825857. Epub 2019 Mar 12.


Mechanisms and consequences of oxygen- and carbon dioxide-sensing in mammals.

Cummins EP, Strowitzki MJ, Taylor CT.

Physiol Rev. 2019 Sep 20. doi: 10.1152/physrev.00003.2019. [Epub ahead of print]


Phase 1b study of a small molecule antagonist of human chemokine (C-C motif) receptor 2 (PF-04136309) in combination with nab-paclitaxel/gemcitabine in first-line treatment of metastatic pancreatic ductal adenocarcinoma.

Noel M, O'Reilly EM, Wolpin BM, Ryan DP, Bullock AJ, Britten CD, Linehan DC, Belt BA, Gamelin EC, Ganguly B, Yin D, Joh T, Jacobs IA, Taylor CT, Lowery MA.

Invest New Drugs. 2019 Jul 12. doi: 10.1007/s10637-019-00830-3. [Epub ahead of print]


Preliminary evidence that computerized approach avoidance training is not associated with changes in fMRI cannabis cue reactivity in non-treatment-seeking adolescent cannabis users.

Karoly HC, Schacht JP, Jacobus J, Meredith LR, Taylor CT, Tapert SF, Gray KM, Squeglia LM.

Drug Alcohol Depend. 2019 Jul 1;200:145-152. doi: 10.1016/j.drugalcdep.2019.04.007. Epub 2019 May 14.


Hypoxia-inducible factor hydroxylase inhibition enhances the protective effects of cyclosporine in colitis.

Halligan DN, Khan MN, Brown E, Rowan CR, Coulter IS, Doherty GA, Tambuwala MM, Taylor CT.

Am J Physiol Gastrointest Liver Physiol. 2019 Aug 1;317(2):G90-G97. doi: 10.1152/ajpgi.00049.2019. Epub 2019 May 9.


Protein Hydroxylation by Hypoxia-Inducible Factor (HIF) Hydroxylases: Unique or Ubiquitous?

Strowitzki MJ, Cummins EP, Taylor CT.

Cells. 2019 Apr 26;8(5). pii: E384. doi: 10.3390/cells8050384. Review.


Hydroxylase Inhibition Selectively Induces Cell Death in Monocytes.

Crifo B, Schaible B, Brown E, Halligan DN, Scholz CC, Fitzpatrick SF, Kirwan A, Roche HM, Criscuoli M, Naldini A, Giffney H, Crean D, Blanco A, Cavadas MA, Cummins EP, Fabian Z, Taylor CT.

J Immunol. 2019 Mar 1;202(5):1521-1530. doi: 10.4049/jimmunol.1800912. Epub 2019 Jan 30.


Neutropenia in Barth syndrome: characteristics, risks, and management.

Steward CG, Groves SJ, Taylor CT, Maisenbacher MK, Versluys B, Newbury-Ecob RA, Ozsahin H, Damin MK, Bowen VM, McCurdy KR, Mackey MC, Bolyard AA, Dale DC.

Curr Opin Hematol. 2019 Jan;26(1):6-15. doi: 10.1097/MOH.0000000000000472.


Increased Virulence of Bloodstream Over Peripheral Isolates of P. aeruginosa Identified Through Post-transcriptional Regulation of Virulence Factors.

Hickey C, Schaible B, Nguyen S, Hurley D, Srikumar S, Fanning S, Brown E, Crifo B, Matallanas D, McClean S, Taylor CT, Schaffer K.

Front Cell Infect Microbiol. 2018 Oct 26;8:357. doi: 10.3389/fcimb.2018.00357. eCollection 2018.


Pharmacologic inhibition of hypoxia-inducible factor (HIF)-hydroxylases ameliorates allergic contact dermatitis.

Manresa MC, Smith L, Casals-Diaz L, Fagundes RR, Brown E, Radhakrishnan P, Murphy SJ, Crifo B, Strowitzki MJ, Halligan DN, van den Bogaard EH, Niehues H, Schneider M, Taylor CT, Steinhoff M.

Allergy. 2019 Apr;74(4):753-766. doi: 10.1111/all.13655. Epub 2018 Dec 12.


Detection of Specific ZIKV IgM in Travelers Using a Multiplexed Flavivirus Microsphere Immunoassay.

Taylor CT, Mackay IM, McMahon JL, Wheatley SL, Moore PR, Finger MJ, Hewitson GR, Moore FA.

Viruses. 2018 May 12;10(5). pii: E253. doi: 10.3390/v10050253.


A multi-site proof-of-concept investigation of computerized approach-avoidance training in adolescent cannabis users.

Jacobus J, Taylor CT, Gray KM, Meredith LR, Porter AM, Li I, Castro N, Squeglia LM.

Drug Alcohol Depend. 2018 Jun 1;187:195-204. doi: 10.1016/j.drugalcdep.2018.03.007. Epub 2018 Apr 11.


The PHD1 oxygen sensor in health and disease.

Kennel KB, Burmeister J, Schneider M, Taylor CT.

J Physiol. 2018 Sep;596(17):3899-3913. doi: 10.1113/JP275327. Epub 2018 Mar 5.


Acquisition of Temporal HIF Transcriptional Activity Using a Secreted Luciferase Assay.

Cavadas MAS, Taylor CT, Cheong A.

Methods Mol Biol. 2018;1742:37-44. doi: 10.1007/978-1-4939-7665-2_4.


Genetic Knockdown and Pharmacologic Inhibition of Hypoxia-Inducible Factor (HIF) Hydroxylases.

Pickel C, Taylor CT, Scholz CC.

Methods Mol Biol. 2018;1742:1-14. doi: 10.1007/978-1-4939-7665-2_1.


Hypoxia in the Gut.

Taylor CT.

Cell Mol Gastroenterol Hepatol. 2017 Sep 19;5(1):61-62. doi: 10.1016/j.jcmgh.2017.09.005. eCollection 2018. No abstract available.


Neural mechanisms of interference control in working memory capacity.

Bomyea J, Taylor CT, Spadoni AD, Simmons AN.

Hum Brain Mapp. 2018 Feb;39(2):772-782. doi: 10.1002/hbm.23881. Epub 2017 Nov 14.


Hypoxia-sensitive pathways in intestinal inflammation.

Brown E, Taylor CT.

J Physiol. 2018 Aug;596(15):2985-2989. doi: 10.1113/JP274350. Epub 2017 Nov 28. Review.


Predictive validity and correlates of self-assessed resilience among U.S. Army soldiers.

Campbell-Sills L, Kessler RC, Ursano RJ, Sun X, Taylor CT, Heeringa SG, Nock MK, Sampson NA, Jain S, Stein MB.

Depress Anxiety. 2018 Feb;35(2):122-131. doi: 10.1002/da.22694. Epub 2017 Nov 2.


Regulation of immunity and inflammation by hypoxia in immunological niches.

Taylor CT, Colgan SP.

Nat Rev Immunol. 2017 Dec;17(12):774-785. doi: 10.1038/nri.2017.103. Epub 2017 Oct 3. Review.


Changes in marijuana use symptoms and emotional functioning over 28-days of monitored abstinence in adolescent marijuana users.

Jacobus J, Squeglia LM, Escobar S, McKenna BM, Hernandez MM, Bagot KS, Taylor CT, Huestis MA.

Psychopharmacology (Berl). 2017 Dec;234(23-24):3431-3442. doi: 10.1007/s00213-017-4725-3. Epub 2017 Sep 12.


Prolyl hydroxylase 2 inactivation enhances glycogen storage and promotes excessive neutrophilic responses.

Sadiku P, Willson JA, Dickinson RS, Murphy F, Harris AJ, Lewis A, Sammut D, Mirchandani AS, Ryan E, Watts ER, Thompson AAR, Marriott HM, Dockrell DH, Taylor CT, Schneider M, Maxwell PH, Chilvers ER, Mazzone M, Moral V, Pugh CW, Ratcliffe PJ, Schofield CJ, Ghesquiere B, Carmeliet P, Whyte MK, Walmsley SR.

J Clin Invest. 2017 Sep 1;127(9):3407-3420. doi: 10.1172/JCI90848. Epub 2017 Aug 14.


Hypoxia Inducible Factor (HIF) Hydroxylases as Regulators of Intestinal Epithelial Barrier Function.

Manresa MC, Taylor CT.

Cell Mol Gastroenterol Hepatol. 2017 Feb 20;3(3):303-315. doi: 10.1016/j.jcmgh.2017.02.004. eCollection 2017 May. Review.


Determinants of hypoxia-inducible factor activity in the intestinal mucosa.

Fagundes RR, Taylor CT.

J Appl Physiol (1985). 2017 Nov 1;123(5):1328-1334. doi: 10.1152/japplphysiol.00203.2017. Epub 2017 Apr 13. Review.


The affective tie that binds: Examining the contribution of positive emotions and anxiety to relationship formation in social anxiety disorder.

Taylor CT, Pearlstein SL, Stein MB.

J Anxiety Disord. 2017 Jun;49:21-30. doi: 10.1016/j.janxdis.2017.03.007. Epub 2017 Mar 31.


Hypoxia Reduces the Pathogenicity of Pseudomonas aeruginosa by Decreasing the Expression of Multiple Virulence Factors.

Schaible B, Rodriguez J, Garcia A, von Kriegsheim A, McClean S, Hickey C, Keogh CE, Brown E, Schaffer K, Broquet A, Taylor CT.

J Infect Dis. 2017 May 1;215(9):1459-1467. doi: 10.1093/infdis/jix139.


What good are positive emotions for treatment? Trait positive emotionality predicts response to Cognitive Behavioral Therapy for anxiety.

Taylor CT, Knapp SE, Bomyea JA, Ramsawh HJ, Paulus MP, Stein MB.

Behav Res Ther. 2017 Jun;93:6-12. doi: 10.1016/j.brat.2017.03.006. Epub 2017 Mar 22.


The regulation of transcriptional repression in hypoxia.

Cavadas MAS, Cheong A, Taylor CT.

Exp Cell Res. 2017 Jul 15;356(2):173-181. doi: 10.1016/j.yexcr.2017.02.024. Epub 2017 Feb 20. Review.


Latent variable analysis of positive and negative valence processing focused on symptom and behavioral units of analysis in mood and anxiety disorders.

Paulus MP, Stein MB, Craske MG, Bookheimer S, Taylor CT, Simmons AN, Sidhu N, Young KS, Fan B.

J Affect Disord. 2017 Jul;216:17-29. doi: 10.1016/j.jad.2016.12.046. Epub 2017 Jan 11.


First-in-human trial of an anti-5T4 antibody-monomethylauristatin conjugate, PF-06263507, in patients with advanced solid tumors.

Shapiro GI, Vaishampayan UN, LoRusso P, Barton J, Hua S, Reich SD, Shazer R, Taylor CT, Xuan D, Borghaei H.

Invest New Drugs. 2017 Jun;35(3):315-323. doi: 10.1007/s10637-016-0419-7. Epub 2017 Jan 9.


Upregulating the positive affect system in anxiety and depression: Outcomes of a positive activity intervention.

Taylor CT, Lyubomirsky S, Stein MB.

Depress Anxiety. 2017 Mar;34(3):267-280. doi: 10.1002/da.22593. Epub 2017 Jan 6.


Trypanosoma brucei metabolite indolepyruvate decreases HIF-1α and glycolysis in macrophages as a mechanism of innate immune evasion.

McGettrick AF, Corcoran SE, Barry PJ, McFarland J, Crès C, Curtis AM, Franklin E, Corr SC, Mok KH, Cummins EP, Taylor CT, O'Neill LA, Nolan DP.

Proc Natl Acad Sci U S A. 2016 Nov 29;113(48):E7778-E7787. Epub 2016 Nov 15.


Hydroxylase inhibition regulates inflammation-induced intestinal fibrosis through the suppression of ERK-mediated TGF-β1 signaling. [corrected].

Manresa MC, Tambuwala MM, Radhakrishnan P, Harnoss JM, Brown E, Cavadas MA, Keogh CE, Cheong A, Barrett KE, Cummins EP, Schneider M, Taylor CT.

Am J Physiol Gastrointest Liver Physiol. 2016 Dec 1;311(6):G1076-G1090. doi: 10.1152/ajpgi.00229.2016. Epub 2016 Oct 27. Erratum in: Am J Physiol Gastrointest Liver Physiol. 2017 Apr 1;312(4):G405.


The hypoxia-inducible factor (HIF) couples immunity with metabolism.

Halligan DN, Murphy SJ, Taylor CT.

Semin Immunol. 2016 Oct;28(5):469-477. doi: 10.1016/j.smim.2016.09.004. Epub 2016 Oct 4. Review.


Assessment of Local Mosquito Species Incriminates Aedes aegypti as the Potential Vector of Zika Virus in Australia.

Hall-Mendelin S, Pyke AT, Moore PR, Mackay IM, McMahon JL, Ritchie SA, Taylor CT, Moore FA, van den Hurk AF.

PLoS Negl Trop Dis. 2016 Sep 19;10(9):e0004959. doi: 10.1371/journal.pntd.0004959. eCollection 2016 Sep.


REST is a hypoxia-responsive transcriptional repressor.

Cavadas MA, Mesnieres M, Crifo B, Manresa MC, Selfridge AC, Keogh CE, Fabian Z, Scholz CC, Nolan KA, Rocha LM, Tambuwala MM, Brown S, Wdowicz A, Corbett D, Murphy KJ, Godson C, Cummins EP, Taylor CT, Cheong A.

Sci Rep. 2016 Aug 17;6:31355. doi: 10.1038/srep31355.


Hypoxia-dependent regulation of inflammatory pathways in immune cells.

Taylor CT, Doherty G, Fallon PG, Cummins EP.

J Clin Invest. 2016 Oct 3;126(10):3716-3724. doi: 10.1172/JCI84433. Epub 2016 Jul 25. Review.


Anoxia and glucose supplementation preserve neutrophil viability and function.

Monceaux V, Chiche-Lapierre C, Chaput C, Witko-Sarsat V, Prevost MC, Taylor CT, Ungeheuer MN, Sansonetti PJ, Marteyn BS.

Blood. 2016 Aug 18;128(7):993-1002. doi: 10.1182/blood-2015-11-680918. Epub 2016 Jul 8.


Prolyl hydroxylase-1 regulates hepatocyte apoptosis in an NF-κB-dependent manner.

Fitzpatrick SF, Fábián Z, Schaible B, Lenihan CR, Schwarzl T, Rodriguez J, Zheng X, Li Z, Tambuwala MM, Higgins DG, O'Meara Y, Slattery C, Manresa MC, Fraisl P, Bruning U, Baes M, Carmeliet P, Doherty G, von Kriegsheim A, Cummins EP, Taylor CT.

Biochem Biophys Res Commun. 2016 Jun 3;474(3):579-586. doi: 10.1016/j.bbrc.2016.04.085. Epub 2016 Apr 27.


Wnt6 regulates epithelial cell differentiation and is dysregulated in renal fibrosis.

Beaton H, Andrews D, Parsons M, Murphy M, Gaffney A, Kavanagh D, McKay GJ, Maxwell AP, Taylor CT, Cummins EP, Godson C, Higgins DF, Murphy P, Crean J.

Am J Physiol Renal Physiol. 2016 Jul 1;311(1):F35-45. doi: 10.1152/ajprenal.00136.2016. Epub 2016 Apr 27.


Hypercapnia Suppresses the HIF-dependent Adaptive Response to Hypoxia.

Selfridge AC, Cavadas MA, Scholz CC, Campbell EL, Welch LC, Lecuona E, Colgan SP, Barrett KE, Sporn PH, Sznajder JI, Cummins EP, Taylor CT.

J Biol Chem. 2016 May 27;291(22):11800-8. doi: 10.1074/jbc.M116.713941. Epub 2016 Apr 4.


Substrate-Trapped Interactors of PHD3 and FIH Cluster in Distinct Signaling Pathways.

Rodriguez J, Pilkington R, Garcia Munoz A, Nguyen LK, Rauch N, Kennedy S, Monsefi N, Herrero A, Taylor CT, von Kriegsheim A.

Cell Rep. 2016 Mar 22;14(11):2745-60. doi: 10.1016/j.celrep.2016.02.043. Epub 2016 Mar 10.


Highly divergent dengue virus type 1 genotype sets a new distance record.

Pyke AT, Moore PR, Taylor CT, Hall-Mendelin S, Cameron JN, Hewitson GR, Pukallus DS, Huang B, Warrilow D, van den Hurk AF.

Sci Rep. 2016 Feb 29;6:22356. doi: 10.1038/srep22356.


Understanding complexity in the HIF signaling pathway using systems biology and mathematical modeling.

Fábián Z, Taylor CT, Nguyen LK.

J Mol Med (Berl). 2016 Apr;94(4):377-90. doi: 10.1007/s00109-016-1383-6. Epub 2016 Jan 29. Review.


The role of HIF in immunity and inflammation.

Cummins EP, Keogh CE, Crean D, Taylor CT.

Mol Aspects Med. 2016 Feb-Mar;47-48:24-34. doi: 10.1016/j.mam.2015.12.004. Epub 2016 Jan 6. Review.


FIH Regulates Cellular Metabolism through Hydroxylation of the Deubiquitinase OTUB1.

Scholz CC, Rodriguez J, Pickel C, Burr S, Fabrizio JA, Nolan KA, Spielmann P, Cavadas MA, Crifo B, Halligan DN, Nathan JA, Peet DJ, Wenger RH, Von Kriegsheim A, Cummins EP, Taylor CT.

PLoS Biol. 2016 Jan 11;14(1):e1002347. doi: 10.1371/journal.pbio.1002347. eCollection 2016 Jan.


Report of the 2014-2015 Professional Affairs Standing Committee: Producing Practice-Ready Pharmacy Graduates in an Era of Value-Based Health Care.

Taylor CT, Adams AJ, Albert EL, Cardello EA, Clifford K, Currie JD, Gonyeau M, Nelson SP, Bradley-Baker LR.

Am J Pharm Educ. 2015 Oct 25;79(8):S12. doi: 10.5688/ajpe798S12. No abstract available.


REST mediates resolution of HIF-dependent gene expression in prolonged hypoxia.

Cavadas MA, Mesnieres M, Crifo B, Manresa MC, Selfridge AC, Scholz CC, Cummins EP, Cheong A, Taylor CT.

Sci Rep. 2015 Dec 9;5:17851. doi: 10.1038/srep17851.


Targeted delivery of the hydroxylase inhibitor DMOG provides enhanced efficacy with reduced systemic exposure in a murine model of colitis.

Tambuwala MM, Manresa MC, Cummins EP, Aversa V, Coulter IS, Taylor CT.

J Control Release. 2015 Nov 10;217:221-7. doi: 10.1016/j.jconrel.2015.09.022. Epub 2015 Sep 16.


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