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Items: 1 to 50 of 197

1.

Short and simple sequences favored the emergence of N-helix phospho-ligand binding sites in the first enzymes.

Longo LM, Petrović D, Kamerlin SCL, Tawfik DS.

Proc Natl Acad Sci U S A. 2020 Feb 20. pii: 201911742. doi: 10.1073/pnas.1911742117. [Epub ahead of print]

PMID:
32079722
2.

Health and Economic Outcomes of Posterior Spinal Fusion for Children With Neuromuscular Scoliosis.

Lin JL, Tawfik DS, Gupta R, Imrie M, Bendavid E, Owens DK.

Hosp Pediatr. 2020 Feb 20. pii: hpeds.2019-0153. doi: 10.1542/hpeds.2019-0153. [Epub ahead of print]

PMID:
32079619
3.

How evolution shapes enzyme selectivity - lessons from aminoacyl-tRNA synthetases and other amino acid utilizing enzymes.

Tawfik DS, Gruic-Sovulj I.

FEBS J. 2019 Dec 31. doi: 10.1111/febs.15199. [Epub ahead of print] Review.

PMID:
31891445
4.

Enzyme neo- versus re-functionalization - an epistatic ratchet versus a smooth reversible transition.

Ben-David M, Soskine M, Dubovetskyi A, Cherukuri KP, Dym O, Sussman JL, Liao Q, Szeler K, Kamerlin SCL, Tawfik DS.

Mol Biol Evol. 2019 Dec 24. pii: msz298. doi: 10.1093/molbev/msz298. [Epub ahead of print]

PMID:
31873734
5.

Development and use of an adjusted nurse staffing metric in the neonatal intensive care unit.

Tawfik DS, Profit J, Lake ET, Liu JB, Sanders LM, Phibbs CS.

Health Serv Res. 2019 Dec 23. doi: 10.1111/1475-6773.13249. [Epub ahead of print]

PMID:
31869865
6.

Methanol-free biosynthesis of fatty acid methyl ester (FAME) in Synechocystis sp. PCC 6803.

Yunus IS, Palma A, Trudeau DL, Tawfik DS, Jones PR.

Metab Eng. 2020 Jan;57:217-227. doi: 10.1016/j.ymben.2019.12.001. Epub 2019 Dec 9.

PMID:
31821864
7.

Safety climate, safety climate strength, and length of stay in the NICU.

Tawfik DS, Thomas EJ, Vogus TJ, Liu JB, Sharek PJ, Nisbet CC, Lee HC, Sexton JB, Profit J.

BMC Health Serv Res. 2019 Oct 22;19(1):738. doi: 10.1186/s12913-019-4592-1.

8.

Organizational factors affecting physician well-being.

Tawfik DS, Profit J, Webber S, Shanafelt TD.

Curr Treat Options Pediatr. 2019 Mar;5(1):11-25. doi: 10.1007/s40746-019-00147-6. Epub 2019 Feb 9.

PMID:
31632895
9.

A mixture of three engineered phosphotriesterases enables rapid detoxification of the entire spectrum of known threat nerve agents.

Despotović D, Aharon E, Dubovetskyi A, Leader H, Ashani Y, Tawfik DS.

Protein Eng Des Sel. 2019 Dec 31;32(4):169-174. doi: 10.1093/protein/gzz039.

PMID:
31612205
10.

Evidence Relating Health Care Provider Burnout and Quality of Care: A Systematic Review and Meta-analysis.

Tawfik DS, Scheid A, Profit J, Shanafelt T, Trockel M, Adair KC, Sexton JB, Ioannidis JPA.

Ann Intern Med. 2019 Oct 8. doi: 10.7326/M19-1152. [Epub ahead of print]

PMID:
31590181
11.

Response by Itoga et al to Letter Regarding Article, "Association of Blood Pressure Measurements With Peripheral Arterial Disease Events".

Itoga NK, Tawfik DS, Leeper NJ, Chang TI.

Circulation. 2019 Apr 9;139(15):1855-1856. doi: 10.1161/CIRCULATIONAHA.119.039293. No abstract available.

PMID:
30958720
12.

Chance and pleiotropy dominate genetic diversity in complex bacterial environments.

Noda-García L, Davidi D, Korenblum E, Elazar A, Putintseva E, Aharoni A, Tawfik DS.

Nat Microbiol. 2019 Jul;4(7):1221-1230. doi: 10.1038/s41564-019-0412-y. Epub 2019 Apr 1.

PMID:
30936490
13.

The number and type of oxygen-utilizing enzymes indicates aerobic vs. anaerobic phenotype.

Jabłońska J, Tawfik DS.

Free Radic Biol Med. 2019 Aug 20;140:84-92. doi: 10.1016/j.freeradbiomed.2019.03.031. Epub 2019 Mar 29. Review.

PMID:
30935870
14.

Quantifying and understanding the fitness effects of protein mutations: Laboratory versus nature.

Boucher JI, Bolon DNA, Tawfik DS.

Protein Sci. 2019 Mar;28(3):671. doi: 10.1002/pro.3476. No abstract available.

15.

On the Mechanism and Origin of Isoleucyl-tRNA Synthetase Editing against Norvaline.

Bilus M, Semanjski M, Mocibob M, Zivkovic I, Cvetesic N, Tawfik DS, Toth-Petroczy A, Macek B, Gruic-Sovulj I.

J Mol Biol. 2019 Mar 15;431(6):1284-1297. doi: 10.1016/j.jmb.2019.01.029. Epub 2019 Jan 31.

PMID:
30711543
16.

The Limited Information Capacity of Cross-Reactive Sensors Drives the Evolutionary Expansion of Signaling.

Komorowski M, Tawfik DS.

Cell Syst. 2019 Jan 23;8(1):76-85.e6. doi: 10.1016/j.cels.2018.12.006. Epub 2019 Jan 16.

17.

Perinatal Risk Factors and Outcome Coding in Clinical and Administrative Databases.

Tawfik DS, Gould JB, Profit J.

Pediatrics. 2019 Feb;143(2). pii: e20181487. doi: 10.1542/peds.2018-1487. Epub 2019 Jan 9.

18.

Protein engineers turned evolutionists-the quest for the optimal starting point.

Trudeau DL, Tawfik DS.

Curr Opin Biotechnol. 2019 Dec;60:46-52. doi: 10.1016/j.copbio.2018.12.002. Epub 2019 Jan 2. Review.

PMID:
30611116
19.

Simple yet functional phosphate-loop proteins.

Romero Romero ML, Yang F, Lin YR, Toth-Petroczy A, Berezovsky IN, Goncearenco A, Yang W, Wellner A, Kumar-Deshmukh F, Sharon M, Baker D, Varani G, Tawfik DS.

Proc Natl Acad Sci U S A. 2018 Dec 18;115(51):E11943-E11950. doi: 10.1073/pnas.1812400115. Epub 2018 Nov 30.

20.

Design and in vitro realization of carbon-conserving photorespiration.

Trudeau DL, Edlich-Muth C, Zarzycki J, Scheffen M, Goldsmith M, Khersonsky O, Avizemer Z, Fleishman SJ, Cotton CAR, Erb TJ, Tawfik DS, Bar-Even A.

Proc Natl Acad Sci U S A. 2018 Dec 4;115(49):E11455-E11464. doi: 10.1073/pnas.1812605115. Epub 2018 Nov 20.

21.

The Correlation Between Neonatal Intensive Care Unit Safety Culture and Quality of Care.

Profit J, Sharek PJ, Cui X, Nisbet CC, Thomas EJ, Tawfik DS, Lee HC, Draper D, Sexton JB.

J Patient Saf. 2018 Nov 7. doi: 10.1097/PTS.0000000000000546. [Epub ahead of print]

PMID:
30407963
22.

In Reply-Burnout Is Not Associated With Increased Medical Errors.

Tawfik DS, Profit J, Morgenthaler TI, Satele DV, Sinsky C, Dyrbye L, Tutty M, West CP, Shanafelt TD.

Mayo Clin Proc. 2018 Nov;93(11):1683-1684. doi: 10.1016/j.mayocp.2018.08.014. No abstract available.

PMID:
30392548
23.

Automated Design of Efficient and Functionally Diverse Enzyme Repertoires.

Khersonsky O, Lipsh R, Avizemer Z, Ashani Y, Goldsmith M, Leader H, Dym O, Rogotner S, Trudeau DL, Prilusky J, Amengual-Rigo P, Guallar V, Tawfik DS, Fleishman SJ.

Mol Cell. 2018 Oct 4;72(1):178-186.e5. doi: 10.1016/j.molcel.2018.08.033. Epub 2018 Sep 27.

24.

A Bird's-Eye View of Enzyme Evolution: Chemical, Physicochemical, and Physiological Considerations.

Davidi D, Longo LM, Jabłońska J, Milo R, Tawfik DS.

Chem Rev. 2018 Sep 26;118(18):8786-8797. doi: 10.1021/acs.chemrev.8b00039. Epub 2018 Aug 22. Review.

PMID:
30133258
25.

Physician Burnout, Well-being, and Work Unit Safety Grades in Relationship to Reported Medical Errors.

Tawfik DS, Profit J, Morgenthaler TI, Satele DV, Sinsky CA, Dyrbye LN, Tutty MA, West CP, Shanafelt TD.

Mayo Clin Proc. 2018 Nov;93(11):1571-1580. doi: 10.1016/j.mayocp.2018.05.014. Epub 2018 Jul 9.

26.

Association of Blood Pressure Measurements With Peripheral Artery Disease Events.

Itoga NK, Tawfik DS, Lee CK, Maruyama S, Leeper NJ, Chang TI.

Circulation. 2018 Oct 23;138(17):1805-1814. doi: 10.1161/CIRCULATIONAHA.118.033348.

27.

Metabolite-Enzyme Coevolution: From Single Enzymes to Metabolic Pathways and Networks.

Noda-Garcia L, Liebermeister W, Tawfik DS.

Annu Rev Biochem. 2018 Jun 20;87:187-216. doi: 10.1146/annurev-biochem-062917-012023. Review.

PMID:
29925259
28.

Biochemical Profiling of DMSP Lyases.

Lei L, Alcolombri U, Tawfik DS.

Methods Enzymol. 2018;605:269-289. doi: 10.1016/bs.mie.2018.03.004. Epub 2018 Apr 27. Review.

PMID:
29909827
29.

Publisher Correction: Evolution of chalcone isomerase from a noncatalytic ancestor.

Kaltenbach M, Burke JR, Dindo M, Pabis A, Munsberg FS, Rabin A, Kamerlin SCL, Noel JP, Tawfik DS.

Nat Chem Biol. 2018 Oct;14(10):988. doi: 10.1038/s41589-018-0079-3.

PMID:
29760514
30.

Evolution of chalcone isomerase from a noncatalytic ancestor.

Kaltenbach M, Burke JR, Dindo M, Pabis A, Munsberg FS, Rabin A, Kamerlin SCL, Noel JP, Tawfik DS.

Nat Chem Biol. 2018 Jun;14(6):548-555. doi: 10.1038/s41589-018-0042-3. Epub 2018 Apr 23. Erratum in: Nat Chem Biol. 2018 May 14;:.

PMID:
29686356
31.

Automated Structure- and Sequence-Based Design of Proteins for High Bacterial Expression and Stability.

Goldenzweig A, Goldsmith M, Hill SE, Gertman O, Laurino P, Ashani Y, Dym O, Unger T, Albeck S, Prilusky J, Lieberman RL, Aharoni A, Silman I, Sussman JL, Tawfik DS, Fleishman SJ.

Mol Cell. 2018 Apr 19;70(2):380. doi: 10.1016/j.molcel.2018.03.035. No abstract available.

32.

Rescue of conformational dynamics in enzyme catalysis by directed evolution.

Otten R, Liu L, Kenner LR, Clarkson MW, Mavor D, Tawfik DS, Kern D, Fraser JS.

Nat Commun. 2018 Apr 3;9(1):1314. doi: 10.1038/s41467-018-03562-9.

33.

The Dimethylsulfoniopropionate (DMSP) Lyase and Lyase-Like Cupin Family Consists of Bona Fide DMSP lyases as Well as Other Enzymes with Unknown Function.

Lei L, Cherukuri KP, Alcolombri U, Meltzer D, Tawfik DS.

Biochemistry. 2018 Jun 19;57(24):3364-3377. doi: 10.1021/acs.biochem.8b00097. Epub 2018 Apr 3.

PMID:
29561599
34.

Enzyme engineering: reaching the maximal catalytic efficiency peak.

Goldsmith M, Tawfik DS.

Curr Opin Struct Biol. 2017 Dec;47:140-150. doi: 10.1016/j.sbi.2017.09.002. Epub 2017 Oct 16. Review.

PMID:
29035814
35.

Context in Quality of Care: Improving Teamwork and Resilience.

Tawfik DS, Sexton JB, Adair KC, Kaplan HC, Profit J.

Clin Perinatol. 2017 Sep;44(3):541-552. doi: 10.1016/j.clp.2017.04.004. Epub 2017 Jul 8. Review.

36.

Factors Associated With Provider Burnout in the NICU.

Tawfik DS, Phibbs CS, Sexton JB, Kan P, Sharek PJ, Nisbet CC, Rigdon J, Trockel M, Profit J.

Pediatrics. 2017 May;139(5). pii: e20164134. doi: 10.1542/peds.2016-4134. Epub 2017 Apr 18.

37.

Diadenosine tetraphosphate (Ap4A) - an E. coli alarmone or a damage metabolite?

Despotović D, Brandis A, Savidor A, Levin Y, Fumagalli L, Tawfik DS.

FEBS J. 2017 Jul;284(14):2194-2215. doi: 10.1111/febs.14113. Epub 2017 Jun 9.

38.

Bacilli glutamate dehydrogenases diverged via coevolution of transcription and enzyme regulation.

Noda-Garcia L, Romero Romero ML, Longo LM, Kolodkin-Gal I, Tawfik DS.

EMBO Rep. 2017 Jul;18(7):1139-1149. doi: 10.15252/embr.201743990. Epub 2017 May 3.

39.

Teamwork in the NICU Setting and Its Association with Health Care-Associated Infections in Very Low-Birth-Weight Infants.

Profit J, Sharek PJ, Kan P, Rigdon J, Desai M, Nisbet CC, Tawfik DS, Thomas EJ, Lee HC, Sexton JB.

Am J Perinatol. 2017 Aug;34(10):1032-1040. doi: 10.1055/s-0037-1601563. Epub 2017 Apr 10.

40.

Native Mass Spectrometry of Recombinant Proteins from Crude Cell Lysates.

Gan J, Ben-Nissan G, Arkind G, Tarnavsky M, Trudeau D, Noda Garcia L, Tawfik DS, Sharon M.

Anal Chem. 2017 Apr 18;89(8):4398-4404. doi: 10.1021/acs.analchem.7b00398. Epub 2017 Apr 5.

41.

Overcoming an optimization plateau in the directed evolution of highly efficient nerve agent bioscavengers.

Goldsmith M, Aggarwal N, Ashani Y, Jubran H, Greisen PJ, Ovchinnikov S, Leader H, Baker D, Sussman JL, Goldenzweig A, Fleishman SJ, Tawfik DS.

Protein Eng Des Sel. 2017 Apr 1;30(4):333-345. doi: 10.1093/protein/gzx003.

PMID:
28159998
42.

Assigning the Algal Source of Dimethylsulfide Using a Selective Lyase Inhibitor.

Alcolombri U, Lei L, Meltzer D, Vardi A, Tawfik DS.

ACS Chem Biol. 2017 Jan 20;12(1):41-46. doi: 10.1021/acschembio.6b00844. Epub 2016 Dec 6.

PMID:
28103686
43.

Spontaneous Emergence of S-Adenosylmethionine and the Evolution of Methylation.

Laurino P, Tawfik DS.

Angew Chem Int Ed Engl. 2017 Jan 2;56(1):343-345. doi: 10.1002/anie.201609615. Epub 2016 Nov 30.

PMID:
27901309
44.

Functional Proteins from Short Peptides: Dayhoff's Hypothesis Turns 50.

Romero Romero ML, Rabin A, Tawfik DS.

Angew Chem Int Ed Engl. 2016 Dec 23;55(52):15966-15971. doi: 10.1002/anie.201609977. Epub 2016 Nov 16. Review.

PMID:
27865046
45.

Burnout in the neonatal intensive care unit and its relation to healthcare-associated infections.

Tawfik DS, Sexton JB, Kan P, Sharek PJ, Nisbet CC, Rigdon J, Lee HC, Profit J.

J Perinatol. 2017 Mar;37(3):315-320. doi: 10.1038/jp.2016.211. Epub 2016 Nov 17.

46.

Engineering and Directed Evolution of DNA Methyltransferases.

Laurino P, Rockah-Shmuel L, Tawfik DS.

Adv Exp Med Biol. 2016;945:491-509. Review.

PMID:
27826849
47.

Editorial overview: Engineering and design.

Tawfik DS, Varadarajan R.

Curr Opin Struct Biol. 2016 Aug;39:v-vi. doi: 10.1016/j.sbi.2016.08.004. Epub 2016 Aug 29. No abstract available.

PMID:
27595363
48.

Antibiotic resistance evolved via inactivation of a ribosomal RNA methylating enzyme.

Stojković V, Noda-Garcia L, Tawfik DS, Fujimori DG.

Nucleic Acids Res. 2016 Oct 14;44(18):8897-8907. Epub 2016 Aug 5.

49.

Automated Structure- and Sequence-Based Design of Proteins for High Bacterial Expression and Stability.

Goldenzweig A, Goldsmith M, Hill SE, Gertman O, Laurino P, Ashani Y, Dym O, Unger T, Albeck S, Prilusky J, Lieberman RL, Aharoni A, Silman I, Sussman JL, Tawfik DS, Fleishman SJ.

Mol Cell. 2016 Jul 21;63(2):337-346. doi: 10.1016/j.molcel.2016.06.012. Epub 2016 Jul 14. Erratum in: Mol Cell. 2018 Apr 19;70(2):380.

50.

On the Potential Origins of the High Stability of Reconstructed Ancestral Proteins.

Trudeau DL, Kaltenbach M, Tawfik DS.

Mol Biol Evol. 2016 Oct;33(10):2633-41. doi: 10.1093/molbev/msw138. Epub 2016 Jul 12.

PMID:
27413048

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