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Items: 11

1.

Discovery of substituted 4-aminoquinazolines as selective Toll-like receptor 4 ligands.

Nour A, Hayashi T, Chan M, Yao S, Tawatao RI, Crain B, Tsigelny IF, Kouznetsova VL, Ahmadiiveli A, Messer K, Pu M, Corr M, Carson DA, Cottam HB.

Bioorg Med Chem Lett. 2014 Nov 1;24(21):4931-8. doi: 10.1016/j.bmcl.2014.09.039. Epub 2014 Sep 22.

2.

Innate immune protection against infectious diseases by pulmonary administration of a phospholipid-conjugated TLR7 ligand.

Wu CC, Crain B, Yao S, Sabet M, Lao FS, Tawatao RI, Chan M, Smee DF, Julander JG, Cottam HB, Guiney DG, Corr M, Carson DA, Hayashi T.

J Innate Immun. 2014;6(3):315-24. doi: 10.1159/000355217. Epub 2013 Nov 1.

3.

Identification of substituted pyrimido[5,4-b]indoles as selective Toll-like receptor 4 ligands.

Chan M, Hayashi T, Mathewson RD, Nour A, Hayashi Y, Yao S, Tawatao RI, Crain B, Tsigelny IF, Kouznetsova VL, Messer K, Pu M, Corr M, Carson DA, Cottam HB.

J Med Chem. 2013 Jun 13;56(11):4206-23. doi: 10.1021/jm301694x. Epub 2013 May 24.

4.

Treatment of autoimmune inflammation by a TLR7 ligand regulating the innate immune system.

Hayashi T, Yao S, Crain B, Chan M, Tawatao RI, Gray C, Vuong L, Lao F, Cottam HB, Carson DA, Corr M.

PLoS One. 2012;7(9):e45860. doi: 10.1371/journal.pone.0045860. Epub 2012 Sep 28.

5.

Synthesis and characterization of PEGylated toll like receptor 7 ligands.

Chan M, Hayashi T, Mathewson RD, Yao S, Gray C, Tawatao RI, Kalenian K, Zhang Y, Hayashi Y, Lao FS, Cottam HB, Carson DA.

Bioconjug Chem. 2011 Mar 16;22(3):445-54. doi: 10.1021/bc1004813. Epub 2011 Feb 21.

6.

Additive melanoma suppression with intralesional phospholipid-conjugated TLR7 agonists and systemic IL-2.

Hayashi T, Chan M, Norton JT, Wu CC, Yao S, Cottam HB, Tawatao RI, Corr M, Carson DA, Daniels GA.

Melanoma Res. 2011 Feb;21(1):66-75. doi: 10.1097/CMR.0b013e328340ce6c.

7.

Prevention of autoimmune disease by induction of tolerance to Toll-like receptor 7.

Hayashi T, Gray CS, Chan M, Tawatao RI, Ronacher L, McGargill MA, Datta SK, Carson DA, Corr M.

Proc Natl Acad Sci U S A. 2009 Feb 24;106(8):2764-9. doi: 10.1073/pnas.0813037106. Epub 2009 Feb 2.

8.

Mast cell-dependent anorexia and hypothermia induced by mucosal activation of Toll-like receptor 7.

Hayashi T, Cottam HB, Chan M, Jin G, Tawatao RI, Crain B, Ronacher L, Messer K, Carson DA, Corr M.

Am J Physiol Regul Integr Comp Physiol. 2008 Jul;295(1):R123-32. doi: 10.1152/ajpregu.00527.2007. Epub 2008 May 14.

9.

Synthesis and immunostimulatory activity of 8-substituted amino 9-benzyladenines as potent Toll-like receptor 7 agonists.

Jin G, Wu CC, Tawatao RI, Chan M, Carson DA, Cottam HB.

Bioorg Med Chem Lett. 2006 Sep 1;16(17):4559-63. Epub 2006 Jun 19.

PMID:
16784848
10.

Inhibitors of apoptosis in lymphocytes: synthesis and biological evaluation of compounds related to pifithrin-alpha.

Barch├ęchath SD, Tawatao RI, Corr M, Carson DA, Cottam HB.

J Med Chem. 2005 Oct 6;48(20):6409-22.

PMID:
16190767
11.

Quinolinium salt as a potent inhibitor of lymphocyte apoptosis.

Barch├ęchath SD, Tawatao RI, Corr M, Carson DA, Cottam HB.

Bioorg Med Chem Lett. 2005 Apr 1;15(7):1785-8.

PMID:
15780606

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