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Items: 23

1.

Mutant p53 controls tumor metabolism and metastasis by regulating PGC-1α.

Basu S, Gnanapradeepan K, Barnoud T, Kung CP, Tavecchio M, Scott J, Watters A, Chen Q, Kossenkov AV, Murphy ME.

Genes Dev. 2018 Feb 1;32(3-4):230-243. doi: 10.1101/gad.309062.117. Epub 2018 Feb 20.

2.

Transgenic Expression of the Mitochondrial Chaperone TNFR-associated Protein 1 (TRAP1) Accelerates Prostate Cancer Development.

Lisanti S, Garlick DS, Bryant KG, Tavecchio M, Mills GB, Lu Y, Kossenkov AV, Showe LC, Languino LR, Altieri DC.

J Biol Chem. 2016 Nov 25;291(48):25247-25254. Epub 2016 Oct 17.

3.

Deletion of Cyclophilin D Impairs β-Oxidation and Promotes Glucose Metabolism.

Tavecchio M, Lisanti S, Bennett MJ, Languino LR, Altieri DC.

Sci Rep. 2015 Oct 30;5:15981. doi: 10.1038/srep15981.

4.

Adaptive mitochondrial reprogramming and resistance to PI3K therapy.

Ghosh JC, Siegelin MD, Vaira V, Faversani A, Tavecchio M, Chae YC, Lisanti S, Rampini P, Giroda M, Caino MC, Seo JH, Kossenkov AV, Michalek RD, Schultz DC, Bosari S, Languino LR, Altieri DC.

J Natl Cancer Inst. 2015 Feb 3;107(3). pii: dju502. doi: 10.1093/jnci/dju502. Print 2015 Mar.

5.

Deletion of the mitochondrial chaperone TRAP-1 uncovers global reprogramming of metabolic networks.

Lisanti S, Tavecchio M, Chae YC, Liu Q, Brice AK, Thakur ML, Languino LR, Altieri DC.

Cell Rep. 2014 Aug 7;8(3):671-7. doi: 10.1016/j.celrep.2014.06.061. Epub 2014 Jul 31.

6.

DNA-PK inhibition by NU7441 sensitizes breast cancer cells to ionizing radiation and doxorubicin.

Ciszewski WM, Tavecchio M, Dastych J, Curtin NJ.

Breast Cancer Res Treat. 2014 Jan;143(1):47-55. doi: 10.1007/s10549-013-2785-6. Epub 2013 Nov 29.

PMID:
24292814
7.

Cyclophilin D extramitochondrial signaling controls cell cycle progression and chemokine-directed cell motility.

Tavecchio M, Lisanti S, Lam A, Ghosh JC, Martin NM, O'Connell M, Weeraratna AT, Kossenkov AV, Showe LC, Altieri DC.

J Biol Chem. 2013 Feb 22;288(8):5553-61. doi: 10.1074/jbc.M112.433045. Epub 2013 Jan 9.

8.

Chk2 phosphorylation of survivin-DeltaEx3 contributes to a DNA damage-sensing checkpoint in cancer.

Lopergolo A, Tavecchio M, Lisanti S, Ghosh JC, Dohi T, Faversani A, Vaira V, Bosari S, Tanigawa N, Delia D, Kossenkov AV, Showe LC, Altieri DC.

Cancer Res. 2012 Jul 1;72(13):3251-9. doi: 10.1158/0008-5472.CAN-11-4035. Epub 2012 May 14.

9.

Chemosensitization of cancer cells by KU-0060648, a dual inhibitor of DNA-PK and PI-3K.

Munck JM, Batey MA, Zhao Y, Jenkins H, Richardson CJ, Cano C, Tavecchio M, Barbeau J, Bardos J, Cornell L, Griffin RJ, Menear K, Slade A, Thommes P, Martin NM, Newell DR, Smith GC, Curtin NJ.

Mol Cancer Ther. 2012 Aug;11(8):1789-98. doi: 10.1158/1535-7163.MCT-11-0535. Epub 2012 May 10.

10.

Further characterisation of the cellular activity of the DNA-PK inhibitor, NU7441, reveals potential cross-talk with homologous recombination.

Tavecchio M, Munck JM, Cano C, Newell DR, Curtin NJ.

Cancer Chemother Pharmacol. 2012 Jan;69(1):155-64. doi: 10.1007/s00280-011-1662-4. Epub 2011 Jun 1.

PMID:
21630086
11.

Targeted inhibition of mitochondrial Hsp90 suppresses localised and metastatic prostate cancer growth in a genetic mouse model of disease.

Kang BH, Tavecchio M, Goel HL, Hsieh CC, Garlick DS, Raskett CM, Lian JB, Stein GS, Languino LR, Altieri DC.

Br J Cancer. 2011 Feb 15;104(4):629-34. doi: 10.1038/bjc.2011.9. Epub 2011 Feb 1.

12.

Antitumor and anti-inflammatory effects of trabectedin on human myxoid liposarcoma cells.

Germano G, Frapolli R, Simone M, Tavecchio M, Erba E, Pesce S, Pasqualini F, Grosso F, Sanfilippo R, Casali PG, Gronchi A, Virdis E, Tarantino E, Pilotti S, Greco A, Nebuloni M, Galmarini CM, Tercero JC, Mantovani A, D'Incalci M, Allavena P.

Cancer Res. 2010 Mar 15;70(6):2235-44. doi: 10.1158/0008-5472.CAN-09-2335. Epub 2010 Mar 9.

13.

The isothiocyanate produced from glucomoringin inhibits NF-kB and reduces myeloma growth in nude mice in vivo.

Brunelli D, Tavecchio M, Falcioni C, Frapolli R, Erba E, Iori R, Rollin P, Barillari J, Manzotti C, Morazzoni P, D'Incalci M.

Biochem Pharmacol. 2010 Apr 15;79(8):1141-8. doi: 10.1016/j.bcp.2009.12.008. Epub 2009 Dec 16.

PMID:
20006591
14.

Trabectedin (ET-743) promotes differentiation in myxoid liposarcoma tumors.

Forni C, Minuzzo M, Virdis E, Tamborini E, Simone M, Tavecchio M, Erba E, Grosso F, Gronchi A, Aman P, Casali P, D'Incalci M, Pilotti S, Mantovani R.

Mol Cancer Ther. 2009 Feb;8(2):449-57. doi: 10.1158/1535-7163.MCT-08-0848. Epub 2009 Feb 3.

15.

The expression of the DeltaNp73beta isoform of p73 leads to tetraploidy.

Marrazzo E, Marchini S, Tavecchio M, Alberio T, Previdi S, Erba E, Rotter V, Broggini M.

Eur J Cancer. 2009 Feb;45(3):443-53. doi: 10.1016/j.ejca.2008.09.024. Epub 2008 Nov 12.

PMID:
19008096
16.

Atypical retinoids ST1926 and CD437 are S-phase-specific agents causing DNA double-strand breaks: significance for the cytotoxic and antiproliferative activity.

Valli C, Paroni G, Di Francesco AM, Riccardi R, Tavecchio M, Erba E, Boldetti A, Gianni' M, Fratelli M, Pisano C, Merlini L, Antoccia A, Cenciarelli C, Terao M, Garattini E.

Mol Cancer Ther. 2008 Sep;7(9):2941-54. doi: 10.1158/1535-7163.MCT-08-0419.

17.

Checkpoint kinase 1 down-regulation by an inducible small interfering RNA expression system sensitized in vivo tumors to treatment with 5-fluorouracil.

Ganzinelli M, Carrassa L, Crippa F, Tavecchio M, Broggini M, Damia G.

Clin Cancer Res. 2008 Aug 15;14(16):5131-41. doi: 10.1158/1078-0432.CCR-08-0304.

18.

Role of homologous recombination in trabectedin-induced DNA damage.

Tavecchio M, Simone M, Erba E, Chiolo I, Liberi G, Foiani M, D'Incalci M, Damia G.

Eur J Cancer. 2008 Mar;44(4):609-18. doi: 10.1016/j.ejca.2008.01.003. Epub 2008 Feb 19.

PMID:
18243687
19.

Multi-parametric flow cytometric cell cycle analysis using TO-PRO-3 iodide (TP3): detailed protocols.

Tavecchio M, Simone M, Bernasconi S, Tognon G, Mazzini G, Erba E.

Acta Histochem. 2008;110(3):232-44. Epub 2007 Dec 26.

PMID:
18160099
21.

Modulation of gene transcription by natural products--a viable anticancer strategy.

D'Incalci M, Brunelli D, Marangon E, Simone M, Tavecchio M, Gescher A, Mantovani R.

Curr Pharm Des. 2007;13(27):2744-50. Review.

PMID:
17897020
22.

Antitumor activity of the retinoid-related molecules (E)-3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid (ST1926) and 6-[3-(1-adamantyl)-4-hydroxyphenyl]-2-naphthalene carboxylic acid (CD437) in F9 teratocarcinoma: Role of retinoic acid receptor gamma and retinoid-independent pathways.

Parrella E, Giannì M, Fratelli M, Barzago MM, Raska I Jr, Diomede L, Kurosaki M, Pisano C, Carminati P, Merlini L, Dallavalle S, Tavecchio M, Rochette-Egly C, Terao M, Garattini E.

Mol Pharmacol. 2006 Sep;70(3):909-24. Epub 2006 Jun 20.

PMID:
16788091
23.

New drugs from the sea.

D'Incalci M, Simone M, Tavecchio M, Damia G, Garbi A, Erba E.

J Chemother. 2004 Nov;16 Suppl 4:86-9. Review.

PMID:
15688619

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